Timing of biomarker changes preceding Alzheimer’s disease: for diagnosis, treatment or prevention? DOI
Meina Quan

Science China Life Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 12, 2024

Language: Английский

Palmitoyl-L-carnitine induces tau phosphorylation and mitochondrial dysfunction in neuronal cells DOI Creative Commons
Gwangho Yoon,

Min Kyoung Kam,

Young Ho Koh

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(11), P. e0313507 - e0313507

Published: Nov. 13, 2024

Alzheimer’s disease (AD) is characterized by cognitive decline and memory loss, involving mechanisms such as tau hyperphosphorylation mitochondrial dysfunction. Increasing evidence suggests that age-related alterations in metabolite levels are crucial for the pathogenesis of AD. Here, we analyzed serum metabolites from mice various ages (2, 4, 14, 21 months old) using mass spectrometry. We identified palmitoyl-L-carnitine a key with significantly increased aged mice. In vitro experiments SH-SY5Y neuronal cells demonstrated treatment enhanced phosphorylation, fission, elevated intracellular calcium levels. Furthermore, phosphorylation were reduced inhibition GSK-3β, CDK5, calpain, indicating kinases activated overload directly involved increase phosphorylation. Considering fission related to dysfunction, propose level during aging contributes AD pathology through these pathways. These findings highlight significant role lipid metabolism neurodegeneration offer potential therapeutic targets diseases, including

Language: Английский

Citations

2
The early diagnosis of Alzheimer's disease: Blood‐based panel biomarker discovery by proteomics and metabolomics DOI Creative Commons
Yun Dong, Xun Song, Xiao Wang

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(11)

Published: Nov. 1, 2024

Abstract Diagnosis and prediction of Alzheimer's disease (AD) are increasingly pressing in the early stage because biomarker‐targeted therapies may be most effective. AD largely depends on clinical symptoms AD. Currently, cerebrospinal fluid biomarkers neuroimaging techniques considered for detection diagnosis. However, these diagnosis results could provide indications middle and/or late stages rather than stage, another limitation is complexity attached to limited access, cost, perceived invasiveness. Therefore, still poses immense challenges, development novel needed urgent intervention before onset obvious phenotypes Blood‐based enable earlier diagnose aid prognosis various substances blood vulnerable pathophysiology. The application a systematic biological paradigm based high‐throughput has demonstrated accurate alterations molecular levels during processes, such as protein metabolite levels, which facilitate identification at an stage. Notably, proteomics metabolomics have been used identify candidate This review summarizes data potential blood‐based identified by that closest implementation discusses current challenges future work candidates achieve aim screening We also overview diagnosis, drug target discovery even promising therapeutic approaches

Language: Английский

Citations

2
Predicting Deterioration in Mild Cognitive Impairment with Survival Transformers, Extreme Gradient Boosting and Cox Proportional Hazard Modelling DOI

Henry Musto,

Daniel Stamate, Doina Logofătu

et al.

Lecture notes in computer science, Journal Year: 2024, Volume and Issue: unknown, P. 359 - 372

Published: Jan. 1, 2024

Language: Английский

Citations

1
Molecular profiling of a rat model of vascular dementia: Evidences from proteomics, metabolomics and experimental validations DOI

Jingji Wang,

Xueqing Wang,

Jun Yang

et al.

Brain Research, Journal Year: 2024, Volume and Issue: 1846, P. 149254 - 149254

Published: Sept. 26, 2024

Language: Английский

Citations

1
Integrating omics data and machine learning techniques for precision detection of oral squamous cell carcinoma: evaluating single biomarkers DOI Creative Commons
Yilan Sun,

Guozhen Cheng,

Dongliang Wei

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 3, 2024

Early detection of oral squamous cell carcinoma (OSCC) is critical for improving clinical outcomes. Precision diagnostics integrating metabolomics and machine learning offer promising non-invasive solutions identifying tumor-derived biomarkers.

Language: Английский

Citations

1
Identification of Blood Biomarkers Related to Energy Metabolism and Construction of Diagnostic Prediction Model Based on Three Independent Alzheimer’s Disease Cohorts DOI Creative Commons
Hongqi Wang,

Jilai Li,

Wen‐Jun Tu

et al.

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 100(4), P. 1261 - 1287

Published: July 30, 2024

Blood biomarkers are crucial for the diagnosis and therapy of Alzheimer's disease (AD). Energy metabolism disturbances closely related to AD. However, research on blood energy is still insufficient.

Language: Английский

Citations

0
Circulating sphingolipids in relation to cognitive decline and incident dementia: The Cardiovascular Health Study DOI Creative Commons
Kristine F. Moseholm, Héléne T. Cronjé, Manja Koch

et al.

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring, Journal Year: 2024, Volume and Issue: 16(3)

Published: July 1, 2024

Whether circulating levels of sphingolipids are prospectively associated with cognitive decline and dementia risk is uncertain.

Language: Английский

Citations

0
Factors associated with acquiring exercise habits through health guidance for metabolic syndrome among middle-aged Japanese workers: A machine learning approach DOI Creative Commons

Jiawei Wan,

Kyohsuke Wakaba, Takeshi Onoue

et al.

Preventive Medicine Reports, Journal Year: 2024, Volume and Issue: 48, P. 102915 - 102915

Published: Oct. 19, 2024

Language: Английский

Citations

0
Timing of biomarker changes preceding Alzheimer’s disease: for diagnosis, treatment or prevention? DOI
Meina Quan

Science China Life Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 12, 2024

Language: Английский

Citations

0