Journal of Photochemistry and Photobiology B Biology, Journal Year: 2024, Volume and Issue: 262, P. 113086 - 113086
Published: Dec. 21, 2024
Language: Английский
SLAS DISCOVERY, Journal Year: 2025, Volume and Issue: unknown, P. 100213 - 100213
Published: Jan. 1, 2025
Brain metastasis (BM) from colon cancer is associated with a poor prognosis and restricted treatment alternatives, largely due to issues related blood-brain barrier (BBB) permeability the negative effects of standard chemotherapy. Nanotechnology improves efficacy by enabling targeted controlled drug delivery. This review article evaluates potential nanotechnology-based therapies for treating BM, emphasizing their capacity cross BBB, diminish metastatic growth, enhance overall survival rates. A multiple studies evaluated nanoparticles (NPs) as carriers chemotherapy, focusing on parameters including particle size, surface charge, drug-loading capacity. The study also reviewed that examined BBB penetration, in vitro tumor accumulation, vivo growth inhibition. In findings indicated NPs accumulate more efficiently BM tissue than healthy brain show significant penetration. vivo, nanotherapy markedly inhibited prolonged relative conventional chemotherapy or control treatments while exhibiting reduced side effects. Recent demonstrated plant extracts can effectively safely synthesize nanomaterials, positioning them viable environmentally friendly precursor nanomaterial production. Nanotechnology-based demonstrate minimizing systemic toxicity, enhancing therapeutic efficacy, facilitating Further research required confirm these implement clinical practice.
Language: Английский
Citations
1
Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)
Published: March 10, 2025
Abstract Astrocytes are a major cell type in the central nervous system (CNS) that play key role regulating homeostatic functions, responding to injuries, and maintaining blood-brain barrier. also regulate neuronal functions survival by modulating myelination degradation of pathological toxic protein aggregates. have recently been proposed possess both autophagic activity active phagocytic capability which largely depend on sufficiently acidified lysosomes for complete cellular cargos. Defective lysosomal acidification astrocytes impairs their resulting accumulation debris, excessive myelin lipids, aggregates, ultimately contributes propagation neuroinflammation neurodegenerative pathology. Restoration impaired represent new neuroprotective strategy therapeutic direction. In this review, we summarize pathogenic factors, including neuroinflammatory signaling, metabolic stressors, lipid mediated toxicity, contribute impairment associated dysfunction astrocytes. We discuss astrocyte-mediated primarily context diseases along with other brain injuries. then highlight re-acidification as restore well degradative capacity conclude providing future perspectives phagocytes crosstalk CNS cells impart or effects.
Language: Английский
Citations
1
Journal of Xenobiotics, Journal Year: 2025, Volume and Issue: 15(2), P. 44 - 44
Published: March 14, 2025
Human cytochrome P450 (CYP) enzymes in the brain represent a crucial frontier neuroscience, with far-reaching implications for drug detoxification, cellular metabolism, and progression of neurodegenerative diseases. The brain’s complex architecture, composed interconnected cell types receptors, drives unique neuronal signaling pathways, modulates enzyme functions, leads to distinct CYP gene expression regulation patterns compared liver. Despite their relatively low levels expression, CYPs exert significant influence on responses, neurotoxin susceptibility, behavior, neurological disease risk. These are essential maintaining homeostasis, mediating cholesterol turnover, synthesizing metabolizing neurochemicals, neurosteroids, neurotransmitters. Moreover, they key participants oxidative stress neuroprotection, inflammation. In addition roles psychotropic drugs, substances abuse, endogenous compounds, impact efficacy, safety, resistance, underscoring importance beyond traditional metabolism. Their involvement critical physiological processes also links them onset Understanding cerebral is vital advancing neuroprotective strategies, personalizing treatments disorders, developing CNS-targeting therapeutics. This review explores emerging enzymes, particularly those within CYP1–3 CYP46 families, highlighting functional diversity pathological consequences dysregulation health. It examines potential CYP-based biomarkers improve diagnosis treatment offering new avenues therapeutic innovation.
Language: Английский
Citations
1
Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: March 19, 2025
Language: Английский
Citations
0
Experimental Cell Research, Journal Year: 2025, Volume and Issue: 449(1), P. 114595 - 114595
Published: May 5, 2025
Language: Английский
Citations
0
Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(7), P. 6820 - 6835
Published: July 2, 2024
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases on a global scale. Historically, this pathology has been linked to cholinergic transmission, and despite scarcity effective therapies, numerous alternative processes targets have proposed as potential avenues for comprehending complex illness. Nevertheless, fundamental pathophysiological mechanisms underpinning AD remain largely enigmatic, with growing body evidence advocating significance muscarinic receptors in modulating brain's capacity adapt generate new memories. This review summarizes current state art field receptors' involvement AD. A specific key factor was relationship between comorbidity emergence mechanisms.
Language: Английский
Citations
3
Journal of Photochemistry and Photobiology B Biology, Journal Year: 2024, Volume and Issue: 262, P. 113086 - 113086
Published: Dec. 21, 2024
Language: Английский
Citations
0