Epigenetics in Neurodegenerative Diseases

Sub-cellular biochemistry/Subcellular biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 73 - 109

Published: Jan. 1, 2025

Language: Английский

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Development and validation of a frailty risk model for patients with mild cognitive impairment

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 30, 2025

The study aims to develop and validate an effective model for predicting frailty risk in individuals with mild cognitive impairment (MCI). cross-sectional analysis employed nationally representative data from CHARLS 2013–2015. sample was randomly divided into training (70%) validation sets (30%). least absolute shrinkage selection operator (LASSO) multivariable logistic regression were used identify independent predictors establish a nomogram predict the occurrence of frailty. receiver operating characteristic (ROC) curve, calibration decision curve (DCA) evaluate performance nomogram. A total 3,196 MCI patients analyzed, 803 (25.1%) exhibited symptoms Multivariate revealed that age, activities daily living (ADL) score, depression grip strength, cardiovascular disease (CVD), liver disease, pain, hearing, vision associated factors patients. based on these achieved AUC values 0.810 (95% CI 0.780, 0.840) set 0.791 0.760, 0.820) set. Calibration curves showed good agreement between observed values. Hosmer-Lemeshow test results P = 0.396 0.518, respectively. ROC further validated robust predictive ability application this may facilitate early clinical interventions, thereby potentially reducing incidence among significantly enhancing their long-term health outcomes.

Language: Английский

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Association between depressive status and mild cognitive impairment in middle-aged and elderly Chinese adults from CHARLS study

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 13, 2025

Background The potential association between depressive status and the risk of mild cognitive impairment (MCI) remains unclear, especially in absence prospective evidence. This study aims to elucidate impact either depression score or on MCI using longitudinal data from China Health Retirement Longitudinal Study (CHARLS). Methods included 5,766 participants CHARLS followed 2011 2015. We calculated baseline 10-item Center for Epidemiologic Studies Depression Scale (CESD-10) after 3 years follow-up through four dimensions: orientation, memory, calculation, draw. collected sociological characteristics health-related factors as covariates, multivariate-adjusted logistics regression models (odds ratios (OR) 95% confidence intervals (CI)) restricted cubic splines (RCS) estimate effect risk. Results observed 724 new cases at follow-up. Logistics analysis showed that with had a 58% higher developing than those without (OR = 1.58, 95%CI: 1.35-1.85), positive persisted adjusting covariates such population 1.24, 1.04-1.48). also dose-response relationship risk, 11~20 21~30 scores having progressively compared 0~10 (p trend < 0.05), 3% increase each 1-point 1.03, 1.01-1.04). RCS nonlinear non-linearity 0.001), increasing score. In addition, stratified analyses based sex, age, marital status, residence, BMI, nighttime sleep, smoking alcohol drinking serological indicators, comorbidities no interaction > 0.05) other serum total cholesterol levels 0.008). Conclusions Among middle-aged elderly adults CHARLS, is an independent factor MCI, indicating individuals more severe symptoms are likely suffer MCI. Early screening CESD-10 may help identify high early intervention reduce incidence Alzheimer’s disease, thereby reducing social care burden ageing population.

Language: Английский

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An Anti-Inflammatory Diet and Its Potential Benefit for Individuals with Mental Disorders and Neurodegenerative Diseases—A Narrative Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2646 - 2646

Published: Aug. 10, 2024

This narrative review synthesizes current evidence regarding anti-inflammatory dietary patterns and their potential benefits for individuals with mental disorders neurodegenerative diseases. Chronic low-grade inflammation is increasingly recognized as a key factor in the etiology progression of these conditions. The examines neuroprotective properties components food groups, focusing on whole foods rather than specific nutrients or supplements. Key showing include fruits vegetables (especially berries leafy greens), grains, legumes, fatty fish rich omega-3, nuts (particularly walnuts), olive oil, fermented foods. These are generally antioxidants, fiber, bioactive compounds that may help modulate inflammation, support gut health, promote neuroprotection. Conversely, ultra-processed foods, red meat, sugary beverages be harmful. Based this evidence, we designed Brain Anti-Inflammatory Nutrition (BrAIN) diet. mechanisms diet modulation microbiota gut-brain axis, regulation inflammatory pathways, reduction oxidative stress, promotion neuroplasticity. BrAIN shows promise an aid to manage disorders.

Language: Английский

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A Brief History of the Progress in Our Understanding of Genetics and Lifestyle, Especially Diet, in the Risk of Alzheimer’s Disease

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 100(s1), P. S165 - S178

Published: Aug. 6, 2024

The two major determining factors for Alzheimer's disease (AD) are genetics and lifestyle. Alleles of the apolipoprotein E (APOE) gene play important roles in development late-onset AD, with APOEɛ4 increasing risk, APOEɛ3 being neutral, APOEɛ2 reducing risk. Several modifiable lifestyle have been studied terms how they can modify risk AD. Among these dietary pattern, nutritional supplements such as omega-3 fatty acids, B vitamins, physical exercise, obesity, vitamin D. Western diet increases while patterns Mediterranean vegetarian/vegan diets reduce Foods associated reduced include coffee, fruits vegetables, whole grains legumes, fish, meat ultraprocessed foods increased especially when lead to obesity. In multi-country ecological studies, amount national has highest correlation history research regarding on AD is emphasized this review. be modified starting at least by mid-life. People greater genetic would benefit more choosing and/or delay incidence

Language: Английский

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A systematic review of lifestyle-based interventions for managing Alzheimer's disease: Insights from randomized controlled trials

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

Background Alzheimer's disease (AD) presents a significant challenge in healthcare, prompting exploration into non-pharmacological interventions to complement traditional treatments. Objective This systematic review explores the efficacy of lifestyle-based managing AD. Methods A comprehensive literature search was conducted PubMed, Web Science, and Scopus between 2018 2023, selecting randomized controlled trials examining factors such as exercise, diet, stress, cognitive training AD patients. Results The revealed physical exercise predominant intervention, accompanied by dietary modifications, training, therapies mindfulness music. While demonstrated improvements quality life, its benefits were limited. Modified diets, Atkins ketogenic, displayed inconsistent effects on function but influenced other health-related parameters. Additionally, probiotic therapy novel technologies explored. Conclusions Despite some showing promise enhancing slowing progression, uncertainties remain regarding dose-response relationship, underlying mechanisms, potential synergistic effects. Moreover, consideration genetic sex-based disparities is warranted. synthesis underscores need for further research elucidate nuances effectively. PROSPERO registration number CRD42023432823

Language: Английский

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Lifestyle Medicine and the Far Horizon: Before, Since, and Beyond

American Journal of Lifestyle Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

The American College of Lifestyle Medicine was founded just over 20 years ago. As the organization grew, it incubated an impressive array structures and processes to foster professional standards, training, credentialing, networking, scholarship. A compelling accelerating drumbeat peer-reviewed publications has demonstrated advancing base evidence in which lifestyle medicine practice is rooted. Despite all this good effort, however, indicators population health that matter most—longevity vitality healthspan, life years—have largely trended away from, rather than toward, aspirations. course ACLM introduced area great allure tremendous promise professionals seeking beyond reactive disease care. processes, structures, knowledge are place advance goals longevity at level. Needed, still, means translating accumulated into power routine, effective action. Those us committed full potential both as have promises yet keep miles go before we sleep. We can, see light on horizon from here.

Language: Английский

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Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: the need for rigor

Alzheimer s Research & Therapy, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 1, 2025

We consider the recent publication by Ornish and colleagues rigor expected for interventional clinical trials. contend that lifestyle intervention trials should strive same as drug highlight opportunities to improve in this example, particularly design, data analysis, of results other studies.

Language: Английский

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The Role of Gut Microbiota-Derived Trimethylamine N-Oxide in the Pathogenesis and Treatment of Mild Cognitive Impairment

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1373 - 1373

Published: Feb. 6, 2025

Mild cognitive impairment (MCI) represents a transitional stage between normal aging and dementia, often considered critical for dementia prevention. Despite its significance, no effective clinical treatment MCI has yet been established. Emerging evidence demonstrated strong association trimethylamine-N-oxide (TMAO), prominent metabolite derived from the gut microbiota, MCI, highlighting potential as biomarker therapeutic target. TMAO implicated in increasing risk through influence on factors such hypertension, cardiovascular disease, depression, diabetes, stroke. Moreover, it contributes to by promoting oxidative stress, disrupting blood–brain barrier, impairing synaptic plasticity, inducing inflammation, causing mitochondrial metabolic disturbances, facilitating abnormal protein aggregation. This review further explores strategies targeting mitigate progression.

Language: Английский

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Is provision of substantial dietary interventions for brain health ethical?

Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 16, 2025

We argue that the provision of substantial dietary modifications to individuals who wish maximize their brain health is ethically permitted, despite evidence for such an intervention being not yet fully conclusive. However, we a burdensome therapy with weak and potential harms, balanced communication, informed consent follow-up are necessary components ethical lifestyle changes. Moreover, should be discussed as value alongside non-health priorities achieve balance avoid healthism.

Language: Английский

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