Cells,
Journal Year:
2022,
Volume and Issue:
11(3), P. 529 - 529
Published: Feb. 3, 2022
The
development
of
induced
pluripotent
stem
cells
has
brought
unlimited
possibilities
to
the
field
regenerative
medicine.
This
could
be
ideal
for
treating
osteoarthritis
and
other
skeletal
diseases,
because
current
procedures
tend
short-term
solutions.
usage
in
cell-based
regeneration
cartilage
damages
replace
or
improve
on
techniques.
patient’s
specific
non-invasive
collection
tissue
reprogramming
purposes
also
create
a
platform
drug
screening
disease
modelling
an
overview
distinct
abnormalities.
In
this
review,
we
seek
summarise
latest
achievements
chondrogenic
differentiation
modelling.
Clinical and Translational Medicine,
Journal Year:
2021,
Volume and Issue:
11(2)
Published: Jan. 27, 2021
The
coronavirus
disease
2019
(COVID-19),
caused
by
severe
acute
respiratory
syndrome
2
(SARS-CoV-2)
was
identified
in
December
and
has
subsequently
spread
worldwide.
Currently,
there
is
no
effective
method
to
cure
COVID-19.
Mesenchymal
stromal
cells
(MSCs)
may
be
able
effectively
treat
COVID-19,
especially
for
critical
patients.
Menstrual
blood-derived
MSCs
have
recently
received
much
attention
due
their
superior
proliferation
ability
lack
of
ethical
problems.
Forty-four
patients
were
enrolled
from
January
April
2020
a
multicenter,
open-label,
nonrandomized,
parallel-controlled
exploratory
trial.
Twenty-six
allogeneic,
menstrual
MSC
therapy,
concomitant
medications
(experimental
group),
18
only
(control
group).
experimental
group
treated
with
three
infusions
totaling
9
×
10
Stem Cell Research & Therapy,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Aug. 20, 2022
Abstract
Mesenchymal
stem
cells
(MSCs),
coming
from
a
wide
range
of
sources,
have
multi-directional
differentiation
ability.
MSCs
play
vital
roles
in
immunomodulation,
hematopoiesis
and
tissue
repair.
The
microenvironment
often
refers
to
the
intercellular
matrix,
other
cells,
cytokines
humoral
components.
It
is
also
place
for
cells’
interaction.
stability
pivotal
maintaining
cell
proliferation,
differentiation,
metabolism
functional
activities.
Abnormal
changes
components
can
interfere
functions.
In
some
diseases,
interact
with
accelerate
disease
progression.
This
review
will
discuss
characteristics
their
microenvironment,
as
well
interaction
between
disease.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Jan. 25, 2024
Abstract
Adipose
stem
cells
(ASCs)
have
attracted
considerable
attention
as
potential
therapeutic
agents
due
to
their
ability
promote
tissue
regeneration.
However,
limited
repair
capability
has
posed
a
challenge
in
achieving
optimal
outcomes.
Herein,
we
conceive
series
of
lipid
nanoparticles
reprogram
ASCs
with
durable
protein
secretion
capacity
for
enhanced
engineering
and
In
vitro
studies
identify
that
the
isomannide-derived
(DIM1T
LNP)
efficiently
deliver
RNAs
ASCs.
Co-delivery
self-amplifying
RNA
(saRNA)
E3
mRNA
complex
(the
combination
saRNA
is
named
SEC)
using
DIM1T
LNP
modulates
host
immune
responses
against
saRNAs
facilitates
production
proteins
interest
The
LNP-SEC
engineered
(DS-ASCs)
prolong
expression
hepatocyte
growth
factor
(HGF)
C-X-C
motif
chemokine
ligand
12
(CXCL12),
which
show
superior
wound
healing
efficacy
over
wild-type
LNP-mRNA
counterparts
diabetic
cutaneous
model.
Overall,
this
work
suggests
LNPs
an
effective
platform
engineer
generation
ability,
expediting
development
ASCs-based
cell
therapies.
Stem Cell Research & Therapy,
Journal Year:
2020,
Volume and Issue:
11(1)
Published: Nov. 18, 2020
Abstract
Over
the
last
decades,
cancer
survival
rate
has
increased
due
to
personalized
therapies,
discovery
of
targeted
therapeutics
and
novel
biological
agents,
application
palliative
treatments.
Despite
these
advances,
tumor
resistance
chemotherapy
radiation
rapid
progression
metastatic
disease
are
still
seen
in
many
patients.
Evidence
shown
that
stem
cells
(CSCs),
a
sub-population
share
common
characteristics
with
somatic
(SSCs),
contribute
this
therapeutic
failure.
The
most
critical
properties
CSCs
their
self-renewal
ability
capacity
for
differentiation
into
heterogeneous
populations
cells.
Although
only
constitute
low
percentage
total
mass,
can
regrow
mass
on
own.
Initially
identified
leukemia,
have
subsequently
been
found
cancers
breast,
colon,
pancreas,
brain.
Common
genetic
phenotypic
features
both
SSCs
CSCs,
including
upregulated
signaling
pathways
such
as
Notch,
Wnt,
Hedgehog,
TGF-β.
These
play
fundamental
roles
development
well
control
cell
fate
relevant
targeting
CSCs.
differences
expression
membrane
proteins
exosome-delivered
microRNAs
between
also
important
specifically
target
cancer.
Further
research
efforts
should
be
directed
toward
elucidation
improve
existing
therapies
generate
new
clinically
Frontiers in Cellular Neuroscience,
Journal Year:
2021,
Volume and Issue:
15
Published: Feb. 9, 2021
Stroke,
the
most
prevalent
cerebrovascular
disease,
causes
serious
loss
of
neurological
function
and
is
leading
cause
morbidity
mortality
worldwide.
Despite
advances
in
pharmacological
surgical
therapy,
treatment
for
functional
rehabilitation
following
stroke
limited
with
a
consequent
impact
on
quality
life.
Over
past
decades,
mesenchymal
stem
cell
(MSCs)-based
therapy
has
emerged
as
novel
strategy
various
diseases
including
due
to
their
unique
properties
that
include
easy
isolation,
multipotent
differentiation
potential
strong
paracrine
capacity.
Although
MSCs
have
shown
promising
results
stroke,
there
remain
many
challenges
overcome
prior
therapeutic
application.
In
this
review,
we
focus
issues:
scientific
data
from
preclinical
studies
clinical
trials
stroke;
mechanisms
underlying
MSC-based
related
timing
delivery
MSC
senescence.
Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: Sept. 23, 2022
Considering
the
unique
therapeutic
potential
of
mesenchymal
stem
cells
(MSCs),
including
their
immunosuppressive
and
immunomodulatory
properties
as
well
ability
to
improve
tissue
regeneration,
these
have
attracted
attention
scientists
clinicians
for
treatment
different
inflammatory
immune
system
mediated
disorders.
However,
various
clinical
trials
using
MSCs
purpose
are
conflicting
differ
from
results
promising
preclinical
studies.
This
inconsistency
is
caused
by
several
factors
such
poor
migration
homing
capacities,
low
survival
rate,
level
proliferation
differentiation,
donor-dependent
variation
cells.
Enhancement
retention
persistent
effects
remain
a
challenge
overcome
in
MSC-based
therapy.
In
this
review,
we
summarized
approaches
enhance
outcomes
therapy
revised
current
future
perspectives
creation
cellular
products
with
improved
diverse
applications.
Frontiers in Cell and Developmental Biology,
Journal Year:
2022,
Volume and Issue:
9
Published: Jan. 14, 2022
Cellular
therapy
aims
to
replace
damaged
resident
cells
by
restoring
cellular
and
molecular
environments
suitable
for
tissue
repair
regeneration.
Among
several
candidates,
mesenchymal
stem/stromal
(MSCs)
represent
a
critical
component
of
stromal
niches
known
be
involved
in
homeostasis.
In
vitro
,
MSCs
appear
as
fibroblast-like
plastic
adherent
regardless
the
source.
The
therapeutic
value
is
being
explored
conditions,
including
immunological,
inflammatory
degenerative
diseases,
well
cancer.
An
improved
understanding
their
origin
function
would
facilitate
clinical
use.
stemness
still
debated
requires
further
study.
Several
terms
have
been
used
designate
MSCs,
although
consensual
nomenclature
has
yet
determined.
presence
distinct
markers
may
identification
isolation
specific
subpopulations
MSCs.
Regarding
properties,
mechanisms
underlying
immune
trophic
effects
imply
secretion
various
mediators
rather
than
direct
contact.
These
can
packaged
extracellular
vesicles,
thus
paving
way
exploit
cell-free
products
derived
from
Of
importance,
secretome
are
significantly
sensitive
environment.
features,
such
culture
delivery
method,
dose
immunobiology
influence
outcomes.
this
review,
we
will
summarize
recent
findings
related
MSC
properties.
We
also
discuss
main
preclinical
challenges
that
some
optimization
strategies.
