The Innovation Life,
Journal Year:
2023,
Volume and Issue:
1(1), P. 100015 - 100015
Published: Jan. 1, 2023
<p>Endogenous
gaseous
signaling
molecules,
nitric
oxide
(NO),
carbon
monoxide
(CO),
and
hydrogen
sulfide
(H<sub>2</sub>S),
collectively
called
gasotransmitters,
regulate
various
physiological
pathophysiological
processes.
Thus,
they
offer
significant
advantages
over
traditional
small-molecule
drugs
in
treating
bone
diseases.
However,
their
clinical
use
is
limited
by
nature,
extensive
reactivity,
short
half-life.
Also,
these
gasotransmitters
behave
as
a
double-edged
sword,
providing
therapeutic
effects
at
concentrates
while
exhibiting
acute
toxicity
high
concentrations.
Therefore,
controlled,
sustained,
even
targeted
delivery
of
highly
desirable.
In
this
review,
we
emphasize
recent
advances
gasotransmitter
materials,
including
the
gas-releasing
molecules
platforms.
We
further
focus
on
application
diseases,
implant-associate
infection,
immunomodulation,
regeneration,
osteoporosis,
arthritis,
aiming
to
provide
references
for
development
novel
strategies
diseases.</p>
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(5), P. 5140 - 5156
Published: Feb. 21, 2023
The
favorable
microstructure
and
bioactivity
of
tissue-engineered
bone
scaffolds
are
closely
associated
with
the
regenerative
efficacy
defects.
For
treatment
large
defects,
however,
most
them
fail
to
meet
requirements
such
as
adequate
mechanical
strength,
highly
porous
structure,
excellent
angiogenic
osteogenic
activities.
Herein,
inspired
by
characteristics
a
"flowerbed",
we
construct
short
nanofiber
aggregates-enriched
dual-factor
delivery
scaffold
via
3D
printing
electrospinning
techniques
for
guiding
vascularized
regeneration.
By
assembly
nanofibers
containing
dimethyloxalylglycine
(DMOG)-loaded
mesoporous
silica
nanoparticles
printed
strontium-contained
hydroxyapatite/polycaprolactone
(SrHA@PCL)
scaffold,
an
adjustable
structure
can
be
easily
realized
changing
density
nanofibers,
while
strong
compressive
strength
will
acquired
due
framework
role
SrHA@PCL.
Owing
different
degradation
performance
between
electrospun
microfilaments,
sequential
release
behavior
DMOG
Sr
ions
is
achieved.
Both
in
vivo
vitro
results
demonstrate
that
has
biocompatibility,
significantly
promotes
angiogenesis
osteogenesis
stimulating
endothelial
cells
osteoblasts,
effectively
accelerates
tissue
ingrowth
regeneration
through
activating
hypoxia
inducible
factor-1α
pathway
immunoregulatory
effect.
Overall,
this
study
provided
promising
strategy
constructing
microenvironment-matched
biomimetic
Bioactive Materials,
Journal Year:
2023,
Volume and Issue:
27, P. 15 - 57
Published: March 27, 2023
Titanium
(Ti)
and
its
alloys
have
been
widely
used
as
orthopedic
implants,
because
of
their
favorable
mechanical
properties,
corrosion
resistance
biocompatibility.
Despite
significant
success
in
various
clinical
applications,
the
probability
failure,
degradation
revision
is
undesirably
high,
especially
for
patients
with
low
bone
density,
insufficient
quantity
or
osteoporosis,
which
renders
studies
on
surface
modification
Ti
still
active
to
further
improve
results.
It
discerned
that
physicochemical
properties
directly
influence
even
control
dynamic
interaction
subsequently
determines
rejection
implants.
Therefore,
it
crucial
endow
bulk
materials
specific
high
bioactivity
can
be
performed
by
realize
osseointegration.
This
article
first
reviews
characteristics
conventional
techniques
involving
mechanical,
physical
chemical
treatments
based
formation
mechanism
modified
coatings.
Such
methods
are
able
but
surfaces
static
state
cannot
respond
biological
cascades
from
living
cells
tissues.
Hence,
beyond
traditional
design,
responsive
avenues
then
emerging.
The
stimuli
sources
functionalization
originate
environmental
triggers
physiological
triggers.
In
short,
this
review
surveys
recent
developments
engineering
materials,
a
emphasis
advances
functionality,
provides
perspectives
improving
biocompatibility
Advanced Science,
Journal Year:
2023,
Volume and Issue:
11(2)
Published: Nov. 7, 2023
Abstract
The
treatment
of
bone
defects
remains
a
substantial
clinical
challenge
due
to
the
lack
spatiotemporal
management
immune
microenvironment,
revascularization,
and
osteogenic
differentiation.
Herein,
deferoxamine
(DFO)‐loaded
black
phosphorus
nanosheets
decorated
by
polydopamine
layer
are
prepared
(BPPD)
compounded
into
gelatin
methacrylate/sodium
alginate
methacrylate
(GA)
hybrid
hydrogel
as
smart‐responsive
therapeutic
system
(GA/BPPD)
for
accelerated
regeneration.
BPPD
nanocomposites
served
bioactive
components
near‐infrared
(NIR)
photothermal
agents,
which
conferred
with
excellent
NIR/pH
dual‐responsive
properties,
realizing
stimuli‐responsive
release
DFO
PO
4
3
−
during
Under
action
NIR‐triggered
mild
therapy,
GA/BPPD
exhibited
positive
effect
on
promoting
osteogenesis
angiogenesis,
eliminating
excessive
reactive
oxygen
species,
inducing
macrophage
polarization
M2
phenotype.
More
significantly,
through
polarization‐induced
osteoimmune
this
platform
could
also
drive
functional
cytokine
secretion
enhanced
angiogenesis
osteogenesis.
In
vivo
experiments
further
demonstrated
that
facilitate
healing
attenuating
local
inflammatory
response,
increasing
pro‐healing
factors,
stimulating
endogenous
cell
recruitment,
accelerating
revascularization.
Collectively,
proposed
intelligent
provides
promising
strategy
reshape
damaged
tissue
microenvironment
augmented
Small,
Journal Year:
2023,
Volume and Issue:
19(28)
Published: May 16, 2023
Abstract
A
photoactivated
bone
scaffold
integrated
with
minimally
invasive
implantation
and
mild
thermal‐stimulation
capability
shows
great
promise
in
the
repair
regeneration
of
irregularly
damaged
tissues.
Developing
multifunctional
photothermal
biomaterials
that
can
simultaneously
serve
as
both
controllable
thermal
stimulators
biodegradable
engineering
scaffolds
for
immunomodulation,
infection
therapy,
impaired
remains
an
enormous
challenge.
Herein,
injectable
photocurable
hydrogel
therapeutic
platform
(AMAD/MP)
based
on
alginate
methacrylate,
alginate‐graft‐dopamine,
polydopamine
(PDA)‐functionalized
Ti3C2
MXene
(MXene@PDA)
nanosheets
is
rationally
designed
near‐infrared
(NIR)‐mediated
synergistic
osteogenesis,
bacterial
elimination.
The
optimized
AMAD/MP
exhibits
favorable
biocompatibility,
osteogenic
activity,
immunomodulatory
functions
vitro.
proper
immune
microenvironment
provided
by
could
further
modulate
balance
M1/M2
phenotypes
macrophages,
thereby
suppressing
reactive
oxygen
species‐induced
inflammatory
status.
Significantly,
this
stimulation
efficiently
attenuates
local
reactions
promotes
new
formation
without
addition
exogenous
cells,
cytokines,
or
growth
factors.
This
work
highlights
potential
application
advanced
providing
on‐demand
cues
tissue
regenerative
medicine.
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(9), P. 12273 - 12293
Published: Feb. 22, 2023
Ideal
periosteum
materials
are
required
to
participate
in
a
sequence
of
bone
repair-related
physiological
events,
including
the
initial
immune
response,
endogenous
stem
cell
recruitment,
angiogenesis,
and
osteogenesis.
However,
conventional
tissue-engineered
periosteal
have
difficulty
achieving
these
functions
by
simply
mimicking
via
structural
design
or
loading
exogenous
cells,
cytokines,
growth
factors.
Herein,
we
present
novel
biomimetic
preparation
strategy
comprehensively
enhance
regeneration
effect
using
functionalized
piezoelectric
materials.
The
resulting
possessing
an
excellent
improved
physicochemical
properties
was
prepared
biocompatible
biodegradable
poly(3-hydroxybutyric
acid-co-3-hydrovaleric
acid)
(PHBV)
polymer
matrix,
antioxidized
polydopamine-modified
hydroxyapatite
(PHA),
barium
titanate
(PBT),
which
were
further
incorporated
into
matrix
fabricate
multifunctional
simple
one-step
spin-coating
method.
addition
PHA
PBT
dramatically
enhanced
biological
periosteum,
surface
hydrophilicity
roughness,
mechanical
performance,
tunable
degradation
behavior,
stable
desired
electrical
stimulations,
is
conducive
accelerating
regeneration.
Benefiting
from
stimulation
bioactive
components,
as-fabricated
demonstrated
favorable
biocompatibility,
osteogenic
activity,
immunomodulatory
vitro,
not
only
promoted
adhesion,
proliferation,
spreading
as
well
osteogenesis
mesenchymal
cells
(MSCs)
but
also
effectively
induced
M2
macrophage
polarization,
thereby
suppressing
reactive
oxygen
species
(ROS)-induced
inflammatory
reactions.
Through
vivo
experiments,
with
synergistically
accelerated
formation
new
rat
critical-sized
cranial
defect
model.
whole
almost
completely
covered
at
8
weeks
post
treatment,
thickness
close
that
host
bone.
Collectively,
its
properties,
developed
here
represents
method
rapidly
regenerate
tissue
stimulation.
Military Medical Research,
Journal Year:
2023,
Volume and Issue:
10(1)
Published: July 31, 2023
Most
bone-related
injuries
to
grassroots
troops
are
caused
by
training
or
accidental
injuries.
To
establish
preventive
measures
reduce
all
kinds
of
trauma
and
improve
the
combat
effectiveness
troops,
it
is
imperative
develop
new
strategies
scaffolds
promote
bone
regeneration.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(9), P. 7204 - 7222
Published: Feb. 19, 2024
Commercial
collagen
membranes
face
difficulty
in
guided
bone
regeneration
(GBR)
due
to
the
absence
of
hierarchical
structural
design,
effective
interface
management,
and
diverse
bioactivity.
Herein,
a
Janus
membrane
called
SrJM
is
developed
that
consists
porous
enhance
osteogenic
function
dense
maintain
barrier
function.
Specifically,
biomimetic
intrafibrillar
mineralization
with
strontium
apatite
realized
by
liquid
precursors
amorphous
phosphate.
Polycaprolactone
methacryloyl
further
integrated
on
one
side
as
face,
which
endows
mechanical
support
prolonged
lifespan.
In
vitro
experiments
demonstrate
acts
strong
against
fibroblasts,
while
significantly
promotes
cell
adhesion
differentiation
through
activation
calcium-sensitive
receptor/integrin/Wnt
signaling
pathways.
Meanwhile,
effectively
enhances
osteogenesis
angiogenesis
recruiting
stem
cells
modulating
osteoimmune
response,
thus
creating
an
ideal
microenvironment
for
regeneration.
vivo
studies
verify
defect
region
completely
repaired
newly
formed
vascularized
bone.
Overall,
outstanding
performance
supports
its
ongoing
development
multifunctional
GBR
membrane,
this
study
provides
versatile
strategy
fabricating
collagen-based
biomaterials
hard
tissue
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 5, 2025
MXene-based
materials
have
attracted
significant
interest
due
to
their
distinct
physical
and
chemical
properties,
which
are
relevant
fields
such
as
energy
storage,
environmental
science,
biomedicine.
MXene
has
shown
potential
in
the
area
of
tissue
regenerative
medicine.
However,
research
on
its
applications
regeneration
is
still
early
stages,
with
a
notable
absence
comprehensive
reviews.
This
review
begins
detailed
description
intrinsic
properties
MXene,
followed
by
discussion
various
nanostructures
that
can
form,
spanning
from
0
3
dimensions.
The
focus
then
shifts
biomaterials
engineering,
particularly
immunomodulation,
wound
healing,
bone
regeneration,
nerve
regeneration.
MXene's
physicochemical
including
conductivity,
photothermal
characteristics,
antibacterial
facilitate
interactions
different
cell
types,
influencing
biological
processes.
These
highlight
modulating
cellular
functions
essential
for
Although
developing,
versatile
structural
attributes
suggest
role
advancing
