Stroke Studies in Large Animals: Prospects of Mitochondrial Transplantation and Enhancing Efficiency using Hydrogels and Nanoparticle-assisted Delivery
Ageing Research Reviews,
Journal Year:
2024,
Volume and Issue:
100, P. 102469 - 102469
Published: Aug. 25, 2024
Language: Английский
Near Infrared‐Mediated Intracellular NADH Delivery Strengthens Mitochondrial Function and Stability in Muscle Dysfunction Model
Hui Bang Cho,
No information about this author
Hye‐Ryoung Kim,
No information about this author
Sujeong Lee
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et al.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 31, 2025
Abstract
Mitochondrial
transfer
emerges
as
a
promising
therapy
for
the
restoration
of
mitochondrial
function
in
damaged
cells,
mainly
due
to
its
limited
immunogenicity.
However,
isolated
mitochondria
rapidly
lose
because
they
produce
little
energy
outside
cells.
Therefore,
this
study
investigates
whether
near
infrared
(NIR)‐mediated
nicotinamide
adenine
dinucleotide
(NADH)
pre‐treatment
enhances
and
stability
mitochondria‐donor
cells
prior
transplantation.
Clinical
applications
NADH,
an
essential
electron
donor
oxidative
phosphorylation
process,
are
restricted
cellular
uptake
NADH.
To
address
this,
photo‐mediated
method
optimizes
direct
NADH
delivery
into
increases
absorption.
L6
treated
with
irradiated
NIR
enhanced
uptake,
significantly
improving
production
function.
Importantly,
improved
functional
characteristics
maintained
even
after
isolation
from
Primed
mitochondria,
i.e.,
those
by
NIR‐mediated
(P‐MT),
encapsulated
fusogenic
liposomes
delivered
muscle
dysfunction.
Compared
conventional
P‐MT
promote
greater
recovery
regeneration.
These
findings
suggest
that
is
effective
strategy
function,
has
potential
lead
novel
treatments
disorders
degeneration.
Language: Английский
Organoids as 3D Models for Studying Exogenous Mitochondrial Transplantation
Advances in experimental medicine and biology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Language: Английский
Mitochondrial-based therapies for neurodegenerative diseases: a review of the current literature
Al-Hassan Soliman Wadan,
No information about this author
Ahmed Shaaban,
No information about this author
Mohamed El‐Sadek
No information about this author
et al.
Naunyn-Schmiedeberg s Archives of Pharmacology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 31, 2025
Abstract
Neurodegenerative
disorders
present
significant
challenges
to
modern
medicine
because
of
their
complex
etiology,
pathogenesis,
and
progressive
nature,
which
complicate
practical
treatment
approaches.
Mitochondrial
dysfunction
is
an
important
contributor
the
pathophysiology
various
neurodegenerative
illnesses,
including
Alzheimer’s
disease
(AD),
Parkinson’s
(PD),
amyotrophic
lateral
sclerosis
(ALS).
This
review
paper
examines
current
literature
highlighting
multifaceted
functions
mitochondria,
energy
production,
calcium
signaling,
apoptosis
regulation,
mitochondrial
biogenesis,
dynamics,
axonal
transport,
endoplasmic
reticulum–mitochondrial
interactions,
mitophagy,
proteostasis,
crucial
involvement
in
neuronal
health.
The
emphasizes
increasing
recognition
as
a
critical
factor
progression
disorders,
marking
shift
from
traditional
symptom
management
innovative
mitochondrial-based
therapies.
By
discussing
mechanisms,
quality
control
(MQC)
processes
impact
oxidative
stress,
this
highlights
need
for
novel
therapeutic
strategies
restore
function,
protect
connections
integrity,
slow
progression.
comprehensive
aims
provide
insights
into
potential
interventions
that
could
transform
landscape
diseases,
addressing
symptoms
underlying
pathophysiological
changes.
Language: Английский
Mitochondria for Cardiovascular Therapy: A Deep Dive into Drug Targets and Therapeutic Approaches
Current Pharmacology Reports,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: April 4, 2025
Language: Английский
Future Directions in Reactive Oxygen Species Research
Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Journal Year:
2025,
Volume and Issue:
unknown, P. 507 - 528
Published: Jan. 3, 2025
Reactive
oxygen
species
(ROS)
are
crucial
for
immune
defense
and
cellular
signaling,
but
their
overproduction
can
damage
cells
contribute
to
diseases.
Understanding
this
duality
is
essential
developing
ROS-based
therapies.
Future
treatments
might
target
specific
ROS
types
or
production
mechanisms,
offering
promise
conditions
like
neurodegeneration,
cardiovascular
diseases,
certain
cancers.
Controlled
generation
could
enable
targeted
cancer
cell
killing
signaling
pathway
activation.
biomarkers
aid
in
early
disease
diagnosis
treatment
monitoring.
However,
challenges
include
the
complexity
of
biology,
lack
sensitive
detection
tools,
difficulties
translating
research
clinical
settings.
Advanced
techniques
precise
measurement
visualization
needed,
along
with
ethical
considerations
ensure
safety
efficacy.
Collaborative
efforts
vital
unlock
potential
novel
therapeutic
approaches.
Language: Английский
Mitochondrial transfer in endothelial cells and vascular health
Trends in Cell Biology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 1, 2025
Language: Английский
Mitochondrial and photosynthetic therapy: A crucial strategy for remodeling cellular metabolic function
Bioengineering & Translational Medicine,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 19, 2025
Abstract
Extranuclear
organelle
transplantation,
an
emerging
field
in
cell
biology
and
bioengineering,
presents
innovative
therapeutic
possibilities
by
transferring
organelles
such
as
mitochondria
between
cells
or
across
species.
In
living
organisms,
chloroplasts
are
closely
related
to
converting
substances
energy
within
cells.
Transplantation
therapy
of
seeks
rebuild
metabolic
function
diseased
damaged
has
broad
application
potential
treating
diseases.
The
therapies
provide
a
distinctive
technology
for
cellular
restoration
targeting
generation
at
the
level,
which
will
offer
new
resources
animal
At
present,
mitochondrial
transplantation
been
applied
novel
approach
rescue
patients
clinical
settings,
chloroplast‐based
endows
utilize
light
(photosynthetic
cells).
this
review,
we
discuss
exciting
development
prospects
photosynthetic
biomedicine.
extranuclear
would
exert
profound
impacts
on
biological
therapy.
Language: Английский
Therapeutic potential of human mesenchymal stromal cell-derived mitochondria in a rat model of post-surgical digestive fistula: towards an energetic nano-biotherapy
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 3, 2024
Abstract
Background
Tissue
regeneration
heavily
relies
on
cellular
energy
production,
with
mitochondria
playing
a
crucial
role.
Dysfunctional
are
implicated
in
various
degenerative
diseases,
driving
interest
targeting
mitochondrial
transplantation
for
tissue
repair.
Wound
healing
is
highly
compromised
gastrointestinal
conditions
resulting
fistula
development,
particularly
after
sleeve
gastrectomy.
Human
mesenchymal
stem/stromal
cells
(hMSCs)
and
their
cell-free
products
such
as
offer
potential
benefits
due
to
therapeutic
properties
production.
Here
we
investigated
the
advantage
of
hMSCs-derived
nano-biotherapy
rat
model
post-surgical
healing.
Methods
Viable
structurally
intact
were
isolated
from
hMSCs
before
exposure
human
colonic
epithelial
(HCEC-1CT)
culture
or
into
post-operative
fistula.
Results
Our
findings
reveal
significant
dose-dependent
improvement
metabolic
activity
ATP
content
recipient
cells.
Assessment
external
orifice
developed
following
post
gastrectomy
fistula,
revealed
substantial
all
transplanted
rats
compared
control
group.
Conclusion
highlight
This
research
contributes
advancing
regenerative
strategies
conditions,
offering
new
insights
mitochondrial-based
therapies
enhancing
wound
Language: Английский