Fish Species Spinal Cord Injury Models Utility for Research: A Systematic Review of Methodologies and Outcomes DOI Open Access
Kurosh Mojtabavi, Seyed Danial Alizadeh,

Hadi Digaleh

et al.

Archives of Neuroscience, Journal Year: 2024, Volume and Issue: 11(4)

Published: Oct. 27, 2024

Context: Spinal cord injury (SCI) is a devastating condition that results in severe disability and significant comorbidities. The complex pathophysiology of SCI repair difficulties understanding neural regeneration are treatment challenges. Objectives: aim this study to systematically review the diverse applications various fish species as models for research. Evidence Acquisition: PRISMA guidelines were used observational interventional studies utilized models, published from inception July 2023. Two independent reviewers screened performed data extraction. One reviewer assessed risk bias included studies. Results: Five thousand six hundred thirty-three records reviewed, 144 met inclusion criteria categorized by species. majority employed complete transection injuries, with remainder being crush laser electro-ablations, demyelination substances. Zebrafish (Danio rerio) most commonly 102/144 (71%), primarily larval models. Other Lamprey (Petromyzon marinus Lethenteron reissneri); Goldfish (Carassius auratus); European eel (Anguilla Anguilla); Knifefish (Apteronotus leptorhynchus Apteronotus albifrons); Sailfin Molly (Poecilia latipinna); African turquoise killifish (Nothobranchius furzeri). Conclusions: This systematic highlights particularly zebrafish, goldfish, eels, important further defining regenerative processes. These provide less model gain insights into apoptosis glial networks.

Language: Английский

Advances in genetically modified neural stem cell therapy for central nervous system injury and neurological diseases DOI Creative Commons

Xiangwen Tang,

Peng Deng,

Lin Li

et al.

Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 18, 2024

Neural stem cells (NSCs) have increasingly been recognized as the most promising candidates for cell-based therapies central nervous system (CNS) injuries, primarily due to their pluripotent differentiation capabilities, well remarkable secretory and homing properties. In recent years, extensive research efforts initiated explore therapeutic potential of NSC transplantation CNS yielding significant advancements. Nevertheless, owing formation adverse microenvironment at post-injury leading suboptimal survival, differentiation, integration within host neural network transplanted NSCs, NSC-based often fall short achieving optimal outcomes. To address this challenge, genetic modification has developed an attractive strategy improve outcomes therapies. This is mainly attributed its not only enhance capacity NSCs but also boost a range biological activities, such secretion bioactive factors, anti-inflammatory effects, anti-apoptotic properties, immunomodulation, antioxidative functions, angiogenesis. Furthermore, empowers play more robust neuroprotective role in context nerve injury. review, we will provide overview advances roles mechanisms genetically modified with various genes treatment injuries disorders. Also, update on current technical parameters suitable functional recovery clinical studies are summarized.

Language: Английский

Citations

5
Advancements in Stem Cell Therapeutics for Spinal Cord Injury: Theories and Applications DOI Open Access

Pingping Mi,

Yanjie Zhong,

Yao Xu

et al.

Journal of Biosciences and Medicines, Journal Year: 2025, Volume and Issue: 13(01), P. 102 - 131

Published: Jan. 1, 2025

Language: Английский

Citations

0
Mesenchymal stem cells overexpressing neuropeptide S promote the recovery of rats with spinal cord injury by activating the PI3K/AKT/GSK3β signaling pathway DOI Creative Commons
Wenhui Yang, Yilu Li,

Yushi Tang

et al.

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 28, 2025

Transplantation of nasal mucosa-derived mesenchymal stem cells (EMSCs) overexpressing neuropeptide S (NPS) is a promising approach for treating spinal cord injury (SCI). Despite the potential cell therapy, challenges remain regarding survival and differentiation control. We aimed to conduct orthotopic transplantation transected treat rats with complete SCI. In this study, we loaded NPS-overexpressing EMSCs onto hydrogels enhance in vivo promote neuronal both vitro vivo. However, co-culture promoted greater neural (P < 0.01). When transplanted vivo, showed area compared without gene modification within 4 weeks after implantation Compared those other groups, stable overexpression NPS-EMSCs rat model SCI significantly improved treatment effect, reduced glial scar formation, regeneration endogenous proliferation into neurons, motor function. These results indicate that effect may be achieved by through activation PI3K/Akt/GSK3β signaling pathway. Overall, therapeutic rats, strongly supporting clinical applications.

Language: Английский

Citations

0
Advances and New Therapies in Traumatic Spinal Cord Injury DOI Open Access
Antonio Montoto-Marqués,

Jesús Benito-Penalva,

María Elena Ferreiro-Velasco

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2203 - 2203

Published: March 24, 2025

Recovery from traumatic spinal cord injury (tSCI) is challenging due to the limited regenerative capacity of central nervous system restore cells, myelin, and neural connections. At clinical level, fundamental pillars treatment are reduction in secondary damage (neuroprotection) rehabilitation; these tools we have mitigate disability caused by (SCI). To date, treatments on which neuroprotection has been based prevention acute respiratory failure avoid hypoxia, early hemodynamic control, neuroprotective drugs surgical management. Optimizing control ensure adequate perfusion may be key management SCI. While agents like methylprednisolone fallen into disuse, several promising therapies currently being tested trials. In terms treatment, although their impact neurological recovery remains debated, appropriate bone decompression followed duroplasty selected cases increasingly recommended. Advances cell hold significant potential for enhancing both functional outcomes SCI patients. Moreover, emerging neuromodulation techniques, such as transcutaneous epidural stimulation, along with innovations rehabilitation technologies-such robotic systems exoskeletons-are becoming indispensable improving locomotion overall mobility individuals This article provides an update advances against tSCI, cellular therapies, new therapies.

Language: Английский

Citations

0
Tauroursodeoxycholic acid regulates macrophage/monocyte distribution and improves spinal microenvironment to promote nerve regeneration through inhibiting NF-κB signaling pathway in spinal cord injury DOI Creative Commons

Yonghui Hou,

Yage Zhang, Lin Ma

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 10, 2025

Following spinal cord injury (SCI), blood-borne monocytes infiltrate the cord, differentiate into macrophages, and dominate lesion site. Inflammatory responses mediated by macrophages determine nerve regeneration functional recovery after SCI. Tauroursodeoxycholic acid (TUDCA) shows a neuroprotective effect in different SCI animal models. However, underlying mechanism of TUDCA regulating monocytes/macrophages to impact has not been elucidated clearly. This study aims investigate on monocyte/macrophage distribution subacute stage Transwell analysis, Bromodeoxyuridine (BrdU) staining, TUNEL staining were performed evaluate inflammatory response neural stem cells (NSCs) proliferation migration, neuron survival, axon degeneration vitro. H&E RNA sequencing, series immunofluorescent pathological progress, gene expression changes, distribution, treatment mice. We found restored NSCs migration reduced neurons apoptosis promoted wound healing, down-regulated genes related response, up-regulated development Our provided evidence that regulated improved microenvironment promote

Language: Английский

Citations

0
Repeated Intrathecal Injections of Autologous Bone Marrow-Derived Mesenchymal Stem Cells for Spastic Cerebral Palsy: Single-Arm Safety and Preliminary Efficacy Clinical Trial DOI Creative Commons
Mohammadhosein Akhlaghpasand,

Maede Hosseinpoor,

Bardia Hajikarimloo

et al.

Journal of Neurorestoratology, Journal Year: 2025, Volume and Issue: unknown, P. 100207 - 100207

Published: April 1, 2025

Language: Английский

Citations

0
Synergistic Effects of Olfactory Ecto-Mesenchymal Stem Cell Supernatant and Ellagic Acid on Demyelination and Glial Modulation in a Chronic Multiple Sclerosis Model DOI Creative Commons
Fatemeh Tahmasebi, Elmira Roshani Asl, Faezeh Faghihi

et al.

Cellular and Molecular Neurobiology, Journal Year: 2025, Volume and Issue: 45(1)

Published: May 2, 2025

Language: Английский

Citations

0
Tanshinone IIA Promotes Functional Recovery After Spinal Cord Injury by Inhibiting Neuron and Oligodendrocyte Ferroptosis Through the GPX4/ACSL4 Axis DOI

Luchun Xu,

Guozheng Jiang,

Shuyin Tan

et al.

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(3)

Published: May 16, 2025

Language: Английский

Citations

0
Nanomedicine in Neuroprotection, Neuroregeneration, and Blood–Brain Barrier Modulation: A Narrative Review DOI Creative Commons

Antea Kršek,

Ana Jagodic,

Lara Batičić

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(9), P. 1384 - 1384

Published: Aug. 24, 2024

Nanomedicine is a newer, promising approach to promote neuroprotection, neuroregeneration, and modulation of the blood–brain barrier. This review includes integration various nanomaterials in neurological disorders. In addition, gelatin-based hydrogels, which have huge potential due biocompatibility, maintenance porosity, enhanced neural process outgrowth, are reviewed. Chemical modification these especially with guanidine moieties, has shown improved neuron viability underscores tailored biomaterial design applications. further discusses strategies modulate barrier—a factor critically associated effective delivery drugs central nervous system. These advances bring supportive solutions solving conditions innovative therapies for their treatment. Nanomedicine, as applied neuroscience, presents significant leap forward new therapeutic that might help raise treatment management disorders much better levels. Our aim was summarize current state-of-knowledge this field.

Language: Английский

Citations

3
Neural Stem Cell Therapy for Alzheimer’s Disease: A-State-of-the-Art Review DOI Open Access

Abdul Jalil Shah,

Mohammad Younis Dar,

Bisma Jan

et al.

Journal of dementia and Alzheimer's disease, Journal Year: 2024, Volume and Issue: 1(2), P. 109 - 125

Published: Nov. 6, 2024

Alzheimer’s disease (AD) is a brain disorder that more prevalent in developed nations and remains one of most intractable conditions so far. It characterized by gradual onset, prolonged progression, an unclear pathophysiology. At the present time, there are no effective treatments available for disease. However, human neural stem cells (hNSCs) have capacity to substitute lost neurons functional manner, strengthen synaptic networks been compromised, repair damaged brain. Due unavailability restorative therapeutics, significant global burden on economy. When it comes treatment neurodegenerative diseases, NSCs provide potentially game-changing approach treating Through delivery trophic factors promote viability regeneration experimental animals suffering from disorders, these potential facilitate beneficial recuperation. Positive outcomes may be achieved variety ways, including replacement cells, combining secretion neurotrophic factors, formation endogenous transdifferentiation. Conversely, obstacles need overcome before NSC-based can used clinical settings. This review article discusses current developments use (NSCs) (AD). In addition, we highlight difficulties opportunities involved with cell transplant

Language: Английский

Citations

2