Brain Behavior and Immunity, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
Language: Английский
Bone Research, Journal Year: 2023, Volume and Issue: 11(1)
Published: Aug. 4, 2023
Abstract Low back pain (LBP) is the world’s leading cause of disability and increasing in prevalence more rapidly than any other condition. Intervertebral disc (IVD) degeneration facet joint osteoarthritis (FJOA) are two common causes LBP, both occur frequently elderly women populations. Moreover, (OA) OA pain, regardless joint, experienced by up to twice as many men, this difference amplified during menopause. Changes estrogen may be an important contributor these states. Receptors for have been found within IVD tissue nearby joints, highlighting potential roles surrounding IVDs joints. In addition, supplementation has shown effective at ameliorating progression, indicating its use a therapeutic agent people with LBP pain. This review comprehensively examines relationship between conditions summarizing recent preclinical clinical findings. The molecular mechanisms which relieve associated FJOA discussed.
Language: Английский
Citations
52
Neurotherapeutics, Journal Year: 2025, Volume and Issue: unknown, P. e00598 - e00598
Published: April 1, 2025
Language: Английский
Citations
2
Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(2), P. 184 - 184
Published: Feb. 7, 2024
Sex hormones and migraine are closely interlinked. Women report higher levels of symptoms during periods sex hormone fluctuation, particularly puberty, pregnancy, perimenopause. Ovarian steroids, such as estrogen progesterone, exert complex effects on the peripheral central nervous systems, including pain, a variety special sensory autonomic functions, affective processing. A panel basic scientists, when challenged to explain what was known about how affect system, focused two hormones: oxytocin. Notably, other hormones, testosterone, vasopressin, less well studied but also highlighted in this review. When discussing new therapeutic agent might be an alternative therapy menopause replacement for treatment, pointed oxytocin delivered nasal spray. Overall, conclusion that progress preclinical study system has been challenging slow, there remain substantial gaps our understanding roles play migraine, opportunities improved or novel agents. Manipulation perhaps through biochemical modifications where its positive selected side minimized, remains theoretical goal, one have impact disease menopause. This review is call action increased interest funding research their metabolites, receptors. Interdisciplinary research, facilitated by collaborative communication network panel, possible strategy achieve goal.
Language: Английский
Citations
11
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2391 - 2391
Published: March 7, 2025
Perimenopausal women have fluctuating estrogen levels, which often trigger a range of symptoms perimenopausal syndromes as levels decrease. Changes in are closely related to pain knee osteoarthritis (KOA), has long been research area great interest women. In recent years, it found that an important role KOA pain, namely, can affect through the regulation inflammatory responses, inhibition cellular senescence and apoptosis, modulation neurotransmitters, may provide new ideas for treatment. This study aims describe mechanism level on perimenopause non-pharmacological measures, such physical therapy, factor traditional Chinese medicine, diet, reference treatment with KOA.
Language: Английский
Citations
1
Archives of Oral Biology, Journal Year: 2024, Volume and Issue: 166, P. 106032 - 106032
Published: June 19, 2024
This study aimed to investigate the correlation between genetic factors and occurrence progression of temporomandibular disorders (TMDs) using a comprehensive review meta-analysis.
Language: Английский
Citations
8
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9867 - 9867
Published: Sept. 12, 2024
The aim of this systematic review is to evaluate the impact estrogen levels on occurrence temporomandibular disorders (TMDs) in humans. Searches were conducted same databases as follows: PubMed, Cochrane Collaboration database, and Scopus database. In accordance with MeSH database previous work, following keywords used: 'estrogens' 'temporomandibular joint disorders'. Twelve studies included assessed for quality evidence. Estrogen are associated pain modulation entire orofacial region. There insufficient evidence either confirm or refute influence TMDs. study was registered under identifier: 10.17605/OSF.IO/BC7QF.
Language: Английский
Citations
8
Journal of Neuroinflammation, Journal Year: 2022, Volume and Issue: 19(1)
Published: June 21, 2022
The pathogenesis of neuropathic pain and the reasons for prolonged unhealing remain unknown. Increasing evidence suggests that sex oestrogen differences play a role in sensitivity, but few studies have focused on receptor which may be an important molecular component contributing to peripheral transduction. We aimed investigate impact receptors nociceptive neuronal response dorsal root ganglion (DRG) spinal horn using spared nerve injury (SNI) rat model chronic pain.We intrathecally (i.t.) administered class antagonists agonists intrathecal administrated male rats with SNI or normal identify main receptor. Moreover, we assessed genes identified through genomic metabolic analysis determine key metabolism point elucidate potential mechanisms mediating continuous sensitization neuroinflammatory responses pain. excitability DRG neurons was detected patch-clamp technique. Primary culture used extract microglia neurons, siRNA transfection silence protein expression. Immunofluorescence, Western blotting, RT-PCR behavioural testing were assess expression, cellular distribution, actions its related signalling molecules.Increasing expression function G protein-coupled (GPER), not receptor-α (ERα) receptor-β (ERβ), neuron microglia, cord, contributed SNI-induced sensitization. Inhibiting GPER alleviated behaviours neuroinflammation by simultaneously downregulating iNOS, IL-1β IL-6 restoring GABAα2 Additionally, positive interaction between β-alanine subsequent accumulation enhances sensation promotes development.GPER activation induces association represses involved post-SNI development. Blocking eliminating prevent
Language: Английский
Citations
25
Pharmacological Research, Journal Year: 2022, Volume and Issue: 185, P. 106492 - 106492
Published: Oct. 10, 2022
Language: Английский
Citations
25
Molecular and Cellular Endocrinology, Journal Year: 2024, Volume and Issue: 591, P. 112270 - 112270
Published: May 14, 2024
Language: Английский
Citations
6
Frontiers in Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 17
Published: Sept. 9, 2024
The transient receptor potential vanilloid 1 (TRPV1) channel plays a dual role in peripheral neuropathic pain (NeuP) by acting as “pain switch” through its sensitization and desensitization. Hyperalgesia, commonly resulting from tissue injury or inflammation, involves the of TRPV1 channels, which modulates sensory transmission primary afferent nociceptors to spinal dorsal horn neurons. In chemotherapy-induced neuropathy (CIPN), is implicated mechanisms due interaction with ion neurotransmitter signaling, oxidative stress. Sensitization root ganglion neurons contributes CIPN development, inhibition channels can reduce mechanical hypersensitivity. diabetic (DPN), involved modulation pathways including reactive oxygen species cytokine production. TRPV1’s TRPA1 further influences chronic onset progression. Therapeutically, capsaicin, agonist, induce analgesia desensitization, while antagonists siRNA targeting show promise preclinical studies. Cannabinoid provides another pathway for alleviating pain. This review summarizes recent research on association NeuP.
Language: Английский
Citations
5