Circulating lipocalin-2 across the adult lifespan DOI Creative Commons
Carlie Bauer, Cassandra Smith, Sara Vogrin

et al.

JBMR Plus, Journal Year: 2024, Volume and Issue: 9(2)

Published: Dec. 10, 2024

Lipocalin-2 (LCN2), a hormone produced by adipocytes, osteoblasts, and renal tubular cells, is implicated in age-related diseases, including cardio-metabolic disease. To understand the role LCN2 may play pathological states, we first need to elucidate relationship between circulating with indices of health during "normal" aging. This study examined serum levels LCN2, age, measures across adult lifespan males females. We conducted pooled cohort analysis 124 community-dwelling (n = 52) females 72) (age 20-87 yr, median BMI 25.92 [23.04, 29.81] kg/m2). Serum was analyzed using two-step chemiluminescent microparticle monoclonal immunoassay. The age evaluated linear regression cubic spline. Simple regressions were performed investigate following variables: BMI, VO2peak, glucose, body composition (DXA). For every 1 yr increase 0.26 mg/L higher (P .007, 95% CI [0.07, 0.45]). Each unit (kg/m2) associated 0.88 .027, [0.10, 1.66]) each VO2peak (mL/kg/min) 0.38 lower (p .003, [-0.63, -0.13]).There no significant sex, glucose or (all p > .05). increased linearly while it decreased as fitness level increased. Future research should build on these findings determine whether can be used biomarker for chronic disease if exercise mitigate changes.

Language: Английский

DNA Methylation in the Adaptive Response to Exercise DOI
Adam J. Bittel, Yi-Wen Chen

Sports Medicine, Journal Year: 2024, Volume and Issue: 54(6), P. 1419 - 1458

Published: April 2, 2024

Language: Английский

Citations

2
Muscle miRNAs are influenced by sex at baseline and in response to exercise DOI Creative Commons
Danielle Hiam, Shanie Landen, Macsue Jacques

et al.

BMC Biology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Nov. 27, 2023

Language: Английский

Citations

6
Decreased sarcoplasmic reticulum phospholipids in human skeletal muscle are associated with metabolic syndrome DOI Creative Commons
Samantha E. Adamson, Sangeeta Adak, Max C. Petersen

et al.

Journal of Lipid Research, Journal Year: 2024, Volume and Issue: 65(3), P. 100519 - 100519

Published: Feb. 13, 2024

Metabolic syndrome affects more than one in three adults and is associated with increased risk of diabetes, cardiovascular disease, all-cause mortality. Muscle insulin resistance a major contributor to the development metabolic syndrome. Studies mice have linked skeletal muscle sarcoplasmic reticulum (SR) phospholipid composition sarco/endoplasmic Ca2+-ATPase (SERCA) activity sensitivity. To determine if presence alters specific phosphatidylcholine (PC) phosphatidylethanolamine (PE) species human (SR), we compared SR from sedentary subjects control without Both total PC PE were significantly decreased patients controls, particularly female participants, but there was no difference PC:PE ratio between groups. Total levels, not levels or ratio, negatively correlated BMI, waist circumference, fat, visceral adipose tissue, triglycerides, fasting HOMA-IR. These findings are consistent existence relationship content humans.

Language: Английский

Citations

0
DNA methylation of exercise-responsive genes differs between trained and untrained men DOI Creative Commons

Carla Geiger,

Maria Needhamsen,

Eric B. Emanuelsson

et al.

BMC Biology, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 4, 2024

Physical activity is well known for its multiple health benefits and although the knowledge of underlying molecular mechanisms increasing, our understanding role epigenetics in long-term training adaptation remains incomplete. In this intervention study, we included individuals with a history > 15 years regular endurance or resistance compared to age-matched untrained controls performing exercise. We examined skeletal muscle DNA methylation genes involved key processes, including myogenesis, gene regulation, angiogenesis metabolism.

Language: Английский

Citations

0
Sex differences in skeletal muscle metabolism in exercise and type 2 diabetes mellitus DOI
Kirstin A. MacGregor, Stian Ellefsen, Nicolas J. Pillon

et al.

Nature Reviews Endocrinology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Language: Английский

Citations

0
Sexual dimorphism in molecular profiles of resting human skeletal muscle and the response to acute exercise and endurance training DOI Creative Commons
Simon I. Dreher, Thomas Goj, Christine von Toerne

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 13, 2024

Abstract Biological sex has a strong impact on skeletal muscle metabolism and performance. By comprehensive investigation of epigenetic, transcriptomic proteomic differences between female male untrained subjects we provide molecular basis for the sexual dimorphism glucose lipid metabolism. The sex-specific multi-OMICs profiles indicate higher degree turnover abundance fast-twitch fibers in males high handling females. Eight-week endurance training equalized initial toward an endurance-trained profile both sexes. females was more resistant to acute exercise challenge since stress-responsive transcripts were predominantly upregulated males. In myotubes from same donors, hardly conserved, but could be partially restored by treatment with hormones. conclusion, after only 8 weeks mitigates deeply rooted common metabolically beneficial response.

Language: Английский

Citations

0
Circulating lipocalin-2 across the adult lifespan DOI Creative Commons
Carlie Bauer, Cassandra Smith, Sara Vogrin

et al.

JBMR Plus, Journal Year: 2024, Volume and Issue: 9(2)

Published: Dec. 10, 2024

Lipocalin-2 (LCN2), a hormone produced by adipocytes, osteoblasts, and renal tubular cells, is implicated in age-related diseases, including cardio-metabolic disease. To understand the role LCN2 may play pathological states, we first need to elucidate relationship between circulating with indices of health during "normal" aging. This study examined serum levels LCN2, age, measures across adult lifespan males females. We conducted pooled cohort analysis 124 community-dwelling (n = 52) females 72) (age 20-87 yr, median BMI 25.92 [23.04, 29.81] kg/m2). Serum was analyzed using two-step chemiluminescent microparticle monoclonal immunoassay. The age evaluated linear regression cubic spline. Simple regressions were performed investigate following variables: BMI, VO2peak, glucose, body composition (DXA). For every 1 yr increase 0.26 mg/L higher (P .007, 95% CI [0.07, 0.45]). Each unit (kg/m2) associated 0.88 .027, [0.10, 1.66]) each VO2peak (mL/kg/min) 0.38 lower (p .003, [-0.63, -0.13]).There no significant sex, glucose or (all p > .05). increased linearly while it decreased as fitness level increased. Future research should build on these findings determine whether can be used biomarker for chronic disease if exercise mitigate changes.

Language: Английский

Citations

0