Gender Differences in the Interplay between Vitamin D and Microbiota in Allergic and Autoimmune Diseases

Biomedicines, Journal Year: 2024, Volume and Issue: 12(5), P. 1023 - 1023

Published: May 7, 2024

The synergic role of vitamin D and the intestinal microbiota in regulation immune system has been thoroughly described literature. Vitamin deficiency dysbiosis have shown a pathogenetic development numerous immune-mediated allergic diseases. physiological processes underlying aging sex proven to be capable having negative influence both on values biodiversity microbiome. This leads global increase levels systemic inflammatory markers, with potential implications for all diseases conditions. Our review aims collect analyze relationship between microbiome associated it, emphasizing effect mediated by sexual hormones aging.

Language: Английский

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Getting to the Heart of the Matter: Exploring the Intersection of Cardiovascular Disease, Sex and Race and How Exercise, and Gut Microbiota Influence these Relationships

Reviews in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 26(2)

Published: Feb. 20, 2025

Cardiovascular disease (CVD) is the leading cause of death worldwide, with physical inactivity being a known contributor to global rates CVD incidence. incidence, however, not uniform recognized sex differences as well and racial ethnic differences. Furthermore, gut microbiota have been associated CVD, sex, race/ethnicity. Researchers begun examine interplay these complicated yet interrelated topics. This review will present evidence that (risk development), are distinct between sexes racial/ethnic groups, which appear be influenced by acculturation, discrimination, stress, lifestyle factors like exercise. this address beneficial impacts exercise on cardiovascular system provide recommendations for future research in field.

Language: Английский

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Higenamine protects against doxorubicin-induced heart failure by attenuating ferroptosis via modulating the Nrf2/GPX4 signaling pathway

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156670 - 156670

Published: March 1, 2025

Language: Английский

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Multi-omics approach identifies gut microbiota variations associated with depression

npj Biofilms and Microbiomes, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 28, 2025

The gut microbiota plays a potential role in the pathophysiology of depression through gut-brain axis. This cross-sectional study 400 participants from PREDIMED-Plus investigates interplay between and using multi-omics approach. Depression was defined as antidepressant use or high Beck Inventory-II scores. Gut characterized by 16S rRNA sequencing, faecal metabolites were analysed via liquid chromatography-tandem mass spectrometry. Participants with exhibited significant differences microbial composition metabolic profiles. Differentially abundant taxa included Acidaminococcus, Christensenellaceae R-7 group, Megasphaera, among others. Metabolomic analysis revealed 15 significantly altered metabolites, primarily lipids, organic acids, benzenoids, some which correlated features. highlights depression, paving way for future research to determine whether influences reflects changes associated depression.

Language: Английский

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Unraveling the Gut Microbiota: Key Insights into its Role in Gastrointestinal and Cardiovascular Health

Journal of Advances in Medicine and Medical Research, Journal Year: 2024, Volume and Issue: 36(7), P. 34 - 47

Published: June 15, 2024

The human gastrointestinal (GI) tract harbors a diverse and dynamic community of microorganisms known as the gut microbiome, which plays fundamental role in maintaining cardiovascular health. It explores intricate interplay between microbiota, GI health, diseases (CVDs). discusses essential roles microbiome energy metabolism, nutrient absorption, immune regulation, barrier integrity. Dysbiosis, characterized by an imbalance microbiota composition, has been linked to various conditions, including inflammatory bowel (IBD) irritable syndrome (IBS), well CVDs such hypertension, atherosclerosis, heart failure. Therapeutic strategies targeting probiotics, prebiotics, fecal transplantation (FMT), precision nutrition, offer promising avenues for managing diseases. Recent research brought attention significance CVDs, highlighting sex-specific variations, microbial metabolites' impact, potential therapeutic interventions. Challenges research, sample size limitations methodological variability, are addressed, along with opportunities innovation, multi-omics integration personalized medicine guided data. By addressing these challenges leveraging opportunities, can revolutionize healthcare, ushering new era microbiome-informed medicine. This comprehensive analysis offers valuable perspectives into relationship diseases, paving way future clinical applications this burgeoning field.

Language: Английский

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Sex Differences in Gut Microbiota, Hypertension, and Cardiovascular Risk

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 177183 - 177183

Published: Dec. 1, 2024

Language: Английский

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Sex Differences in Cardiovascular Diseases: Exploring the Role of Microbiota and Immunity

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1645 - 1645

Published: July 24, 2024

Cardiovascular diseases (CVDs) are the most common cause of mortality and morbidity in Western countries, thus representing a global health concern. CVDs show different patterns terms prevalence presentation men women. The role sex hormones has been extensively implicated these sex-specific differences, due to presence menstrual cycle menopause Moreover, gut microbiota (GM) cardiovascular health, considering growing evidence that it is involved determining development specific diseases. In particular, gut-derived metabolites have linked kidney disorders, which can turn promote progression CVDs. Considering differences composition GM between women, possible act as mediator regard disparities This narrative review aims comprehensively interplay sex, GM, CVDs, discussing potential mechanisms therapeutic options.

Language: Английский

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Causal relationship between the gut microbiota, immune cells, and coronary heart disease: a mediated Mendelian randomization analysis

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 5, 2024

Background Recent studies have shown that the gut microbiota (GM), immune cells, and coronary heart disease (CHD) are closely related, but causal nature of these relationships is largely unknown. This study aimed to investigate this relationship reveal effect GM cells on risk developing CHD using mediated Mendelian randomization (MR) analysis. Methods First, we searched for data related GM, through published genome-wide association (GWAS). We filtered single nucleotide polymorphisms (SNPs) associated with then performed first MR analysis identify disease-associated intestinal bacteria cells. Subsequently, three analyses were conducted: from CHD, CHD. Each was conducted inverse variance weighting (IVW), MR-Egger regression, weighted median, models, simple models. Results A total six 25 found be In (IVW) method, g__Desulfovibrio.s__Desulfovibrio_piger EM DN (CD4–CD8–) %T ( P < 0.05 OR > 1), 1). Conclusion An increase in abundance leads an amount reduces Our provides some references reducing incidence by regulating

Language: Английский

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Trimethylamine Oxidation into the Proatherogenic Trimethylamine N-Oxide Is Higher in Coronary Heart Disease Men: From the CORDIOPREV Study

The World Journal of Men s Health, Journal Year: 2024, Volume and Issue: 42

Published: Jan. 1, 2024

Cardiovascular disease (CVD) is more prevalent in men than women, but the mechanisms responsible for this are not fully understood. We aimed to evaluate differences trimethylamine (TMA), a microbial metabolite and its oxidized form, N-oxide (TMAO), which thought promote atherosclerosis, between women with coronary heart (CHD), using as reference non-CVD population.

Language: Английский

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Sex differences and testosterone interfere with the structure of the gut microbiota through the bile acid signaling pathway

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 18, 2024

Background The gut microbiome has a significant impact on human wellness, contributing to the emergence and progression of range health issues including inflammatory autoimmune conditions, metabolic disorders, cardiovascular problems, psychiatric disorders. Notably, clinical observations have revealed that these illnesses can display differences in incidence presentation between genders. present study aimed evaluate whether composition microbiota is associated with sex-specific elucidate mechanism. Methods 16S-rRNA-sequencing technology, hormone analysis, transplantation, gonadectomy, treatment were employed investigate correlation sex or hormones. Meanwhile, genes proteins involved bile acid signaling pathway analyzed both liver ileum tissues. Results diversity from jejunum feces level hormones serum differed sexes young middle-aged Sprague Dawley (SD) rats. However, no similar phenomenon was found geriatric Interestingly, young, middle-aged, old rats, bacterial Gut replacement also suggested hormones, particularly testosterone (T), influenced mRNA protein (specifically SHP , FXR CYP7A1 ASBT ) exhibited gender-specific differences, T may play role mediating expression this pathway. Conclusion Sex-specific structure are mediated by through pathway, pointing potential targets for disease prevention management techniques indicating levels alter via

Language: Английский

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