Oncotarget, Journal Year: 2022, Volume and Issue: 13(1), P. 1303 - 1304
Published: Jan. 1, 2022
Language: Английский
Cells, Journal Year: 2022, Volume and Issue: 11(2), P. 186 - 186
Published: Jan. 6, 2022
The use of extracellular vesicles (EV) in nano drug delivery has been demonstrated many previous studies. In this study, we discuss the sources vesicles, including plant, salivary and urinary which are easily available but less sought after compared with blood tissue. Extensive research past decade established that breadth EV applications is wide. However, efforts on standardizing isolation purification methods have not brought us to a point can match potential for clinical use. standardization open doors researchers clinicians alike experiment proposed uses lesser concerns regarding untraceable side effects. It make it easier identify mechanism therapeutic benefits track any unforeseen effects observed.
Language: Английский
Citations
94
Brain Research Bulletin, Journal Year: 2022, Volume and Issue: 190, P. 69 - 83
Published: Sept. 23, 2022
Three different barriers are formed between the cerebrovascular and brain parenchyma: blood-brain barrier (BBB), blood-cerebrospinal fluid (BCSFB), cerebrospinal fluid-brain (CBB). The BBB is main regulator of blood central nervous system (CNS) material exchange. semipermeable nature limits passage larger molecules hydrophilic small molecules, Food Drug Administration (FDA)-approved drugs for CNS have been generally limited to lipid-soluble molecules. Although complexity affects drug delivery, understanding composition function can provide a platform development new methods delivery. This review summarizes classification barrier, role basic structures BBB, transport, destruction mechanisms BBB; discusses advantages disadvantages delivery prospects future strategies.
Language: Английский
Citations
63
The Journal of Physiology, Journal Year: 2022, Volume and Issue: 601(22), P. 4853 - 4872
Published: May 16, 2022
Abstract Exosomes are membrane‐bound vesicles that released by most cells. They carry nucleic acids, cytokines, growth factors, proteins, lipids, and metabolites. responsible for inter‐ intracellular communications their role in drug delivery is well defined. have great potential therapeutic applications, but the clinical use restricted because of limitations standardized procedures isolation, purification, delivery. Bioengineering exosomes could be one approach to achieve standardization reproducible isolation use. important transporters targeted small size, stable structure, non‐immunogenicity, non‐toxic nature, as ability a wide variety compounds. These features can enhanced further bioengineering. In this review, possible exosome bioengineering approaches, biomedical discussed. image
Language: Английский
Citations
47
Cells, Journal Year: 2022, Volume and Issue: 11(13), P. 1989 - 1989
Published: June 21, 2022
Extracellular vesicles (EVs) include a heterogeneous group of natural cell-derived nanostructures that are increasingly regarded as promising biotherapeutic agents and drug delivery vehicles in human medicine. Desirable intrinsic properties EVs including the ability to bypass membranous barriers deliver their unique biomolecular cargo specific cell populations position them fiercely competitive alternatives for currently available therapies artificial platforms. with distinct characteristics can be released from various types into extracellular environment means transmitting bioactive components altering status target cell. Despite existence large number preclinical studies confirming therapeutic efficacy different originated treating several pathological conditions, this review, we first provide brief overview EV biophysical an emphasis on benefits over cell-based synthetic systems. Next, describe detail derived sources, compare advantages disadvantages, recapitulate effects disorders highlight progress made harnessing clinical applications. Finally, knowledge gaps concrete hurdles hinder translation debated futuristic perspective.
Language: Английский
Citations
46
Experimental Hematology and Oncology, Journal Year: 2024, Volume and Issue: 13(1)
Published: Aug. 27, 2024
Abstract In thrombotic diseases, coagulation, anticoagulation, and fibrinolysis are three key physiological processes that interact to maintain blood in an appropriate state within vessels. When these become imbalanced, such as excessive coagulation or reduced anticoagulant function, it can lead the formation of clots. Genetic factors play a significant role onset diseases exhibit regional ethnic variations. The decision whether initiate prophylactic therapy is matter clinicians must carefully consider, leading development various risk assessment scales clinical practice. Given considerable heterogeneity diagnosis treatment, researchers exploring application artificial intelligence medicine, including disease prediction, diagnosis, prevention, patient management. This paper reviews research progress on genetic involved analyzes advantages disadvantages commonly used characteristics ideal scoring scales, explores medical field, along with its future prospects.
Language: Английский
Citations
9
Technology in Cancer Research & Treatment, Journal Year: 2021, Volume and Issue: 20
Published: Jan. 1, 2021
Extracellular vesicles (EVs) are naturally phospholipid enclosed nanovesicles released by many cells in the body. They stable circulation, have low immunogenicity, and act as carriers for functionally active biological molecules. interact with target organs bind to receptors. Their specificity is important use EVs noninvasive diagnostic prognostic tools. play a vital role normal physiology cellular communication. known protect their cargo from degradation, which makes them drug targeted delivery. Using markers tracking path systemic circulation can be revolutionary using We will discuss scope of this paper. Although there limitations isolation storage, high biocompatibility fuel more innovations overcome these challenges.
Language: Английский
Citations
51
AI & Society, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 8, 2025
Language: Английский
Citations
0
Biomicrofluidics, Journal Year: 2022, Volume and Issue: 16(3)
Published: May 1, 2022
Bubbles in microfluidics—even those that appear to be negligibly small—are pervasive and responsible for the failure of many biological chemical experiments. For instance, they block current conduction, damage cell membranes, interfere with detection results. To overcome this unavoidable intractable problem, researchers have developed various methods capturing removing bubbles from microfluidics. Such are multifarious their working principles very different each other. In review, bubble-removing divided into two broad categories: active debubblers (that require external auxiliary equipment) passive (driven by natural processes). category, three main types discussed along advantages disadvantages. Among debubblers, assisted lasers, acoustic generators, negative pressure pumps discussed. driven buoyancy, characteristics gas–liquid interfaces, hydrophilic hydrophobic properties materials Finally, challenges prospects bubble-removal technologies reviewed refer microfluidics inspire further investigations field.
Language: Английский
Citations
16
International Journal of Stem cell Research & Therapy, Journal Year: 2023, Volume and Issue: 10(1)
Published: July 7, 2023
Exosomes are small membrane-bound vesicles that released by various types of cells, including cancer and play a role in intercellular communication. CD9 is protein involved cell signaling adhesion. It found on the surface has been implicated communication between cells their microenvironment. contain bioactive molecules, such as proteins, lipids, nucleic acids. have shown to communication, they progression cancer. There evidence suggest packaging release exosomes cells. be important for formation tetraspanin-enriched microdomains (TEMs) exosomes. These TEMs thought sorting specific molecules into In summary, appears an microenvironment via The precise mechanisms which mediates this still being investigated, but involvement exosome uptake suggests it may promising target development novel therapies. Furthermore, recipient For example, studies CD9-positive can taken up other leading transfer oncogenic promotion progression.
Language: Английский
Citations
9
Ultrasonics Sonochemistry, Journal Year: 2022, Volume and Issue: 89, P. 106158 - 106158
Published: Sept. 1, 2022
The volume of fluid (VOF) and continuous surface force (CSF) methods were used to develop a bubble dynamics model for the simulation oscillation implosion under ultrasound. was calibrated validated by X-ray image data acquired ultrafast synchrotron X-ray. Coupled interactions with bulk graphite freely moving particles also simulated based on model. Simulation experiments quantified instability developed along influence ultrasound pressure fields. Once exceeds certain amplitude, occurs, creating shock waves highly deformed, irregular gas-liquid boundaries smaller fragments. Bubble can produce cyclic impulsive stresses sufficient enough cause µs fatigue exfoliation layers. Bubble-particle interaction simulations reveal underlying mechanisms efficient particle dispersion or wrapping which are all strongly related bubbles properties.
Language: Английский
Citations
14