Mitochondrial damage-associated molecular patterns: New perspectives for mitochondria and inflammatory bowel diseases

Mucosal Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Mitochondria are key regulators of inflammatory responses and mitochondrial dysfunction is closely linked to various diseases. Increasing genetic experimental evidence suggests that mitochondria play a critical role in bowel disease (IBD). In the complex environment intestinal tract, epithelial cells (IECs) their possess unique phenotypic features, shaping each other regulating homeostasis inflammation through diverse mechanisms. Here, we focus on IBD induced by damage-associated molecular patterns (mtDAMPs), which comprise components metabolic products. The pathogenic mechanisms mtDAMP signaling pathways mediated two major mtDAMPs, DNA (mtDNA) reactive oxygen species (mtROS), discussed.

Language: Английский

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Bioengineered Versatile Heterojunctions as Stress Busters Targeting Matrix Degradation and Ferroptosis for Osteoarthritis Therapy

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Abstract Osteoarthritis (OA) is a chronic joint disease characterized by degeneration of articular cartilage, with the underlying mechanism being inability chondrocytes to maintain homeostasis in response changing stress. The stress triggered excess ROS from various factors critical regulating chondrocyte survival and fate. In this study, 2D Mo 4/3 B 2‐ X MBene cerium‐gallic acid metal‐polyphenol network (MPN) together cartilage‐targeted shell hyaluronic WYRGRL (HW) are utilized development bio‐heterojunction MBene@MPN‐HW (MBM‐HW) through self‐assembly. MBM‐HW not only demonstrates superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) enzyme mimicking capabilities effectively scavenge ROS, but also exhibits dual‐responsive release cartilage‐targeting properties. Importantly, both vivo vitro experiments indicate that could alleviate oxidative stress, protect mitochondrial function, suppress cartilage matrix ferroptosis, thereby slowing progression OA. Mechanistically, it demonstrated attenuate Perk/eIF2α cascade mediated integrated restrain maintaining homeostasis. Overall, work underscores robust stress‐relieving capacity MBM‐HW, providing novel approach for treatment

Language: Английский

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The association between Dietary Index for Gut Microbiota and sarcopenia: the mediating role of Dietary Inflammatory Index

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 31, 2025

Background Given the global changes in environmental and dietary habits, understanding potential impact of factors diet-related inflammation on skeletal muscle diseases, including sarcopenia, is crucial. Investigating these relationships can aid development more effective prevention strategies. This study used Dietary Index for Gut Microbiota (DI-GM) Inflammatory (DII) as variables. DI-GM a scoring system to assess influence diet health. Additionally, DII quantifies inflammatory diet. explores association between sarcopenia evaluates whether moderates this relationship. Methods conducted cross-sectional analysis 9,470 participants from 2011–2018 NHANES database. Multivariable logistic regression, restricted cubic splines (RCS), subgroup were employed examine prevalence sarcopenia. mediation was performed investigate associations DII, DI-GM, Results A total included study, whom 823 (7%) had After adjusting all variables using multivariable each one-unit increase associated with 15% decrease (OR = 0.85, 95% CI: 0.77, 0.94), while 28% 1.28, 1.17, 1.41). Furthermore, results remained robust when divided into tertiles. RCS revealed significant linear relationship The also showed that above robust. Mediation 55% mediated by ( P < 0.001). Conclusion Adhering recommendations based may reduce appears mediate relationship, suggesting an anti-inflammatory could offer benefits.

Language: Английский

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Region-specific mitophagy in nucleus pulposus, annulus fibrosus, and cartilage endplate of intervertebral disc degeneration: mechanisms and therapeutic strategies

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 1, 2025

Intervertebral disc degeneration (IVDD) is a prevalent condition contributing to various spinal disorders, posing significant global health burden. Mitophagy plays crucial role in maintaining mitochondrial quantity and quality closely associated with the onset progression of IVDD. Well-documented region-specific mitophagy mechanisms IVDD are guiding development therapeutic strategies. In nucleus pulposus (NP), impaired mitochondria lead apoptosis, oxidative stress, senescence, extracellular matrix degradation synthesis, excessive autophagy, inflammation, instability, pyroptosis, key regulatory targets including AMPK, PGC-1α, SIRT1, SIRT3, Progerin, p65, Mfn2, FOXO3, NDUFA4L2, SLC39A7, ITGα5/β1, Nrf2, NLRP3 inflammasome. annulus fibrosus (AF), damage induces apoptosis stress mediated by while cartilage endplate (CEP), dysfunction similarly triggers stress. These mechanistic insights highlight strategies such as activating Parkin-dependent Ub-independent pathways for NP, enhancing AF, targeting Parkin-mediated CEP. include use natural ingredients, hormonal modulation, gene editing technologies, targeted compounds, manipulation related proteins. This review summarizes different regions intervertebral highlights approaches using modulators ameliorate It discusses complex underscores its potential target. The objective provide valuable scientific basis mitochondrial-targeted drugs anti-IVDD.

Language: Английский

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Unraveling the triad of immunotherapy, tumor microenvironment, and skeletal muscle biomechanics in oncology

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 2, 2025

The intricate interaction between skeletal muscle biomechanics, the tumor microenvironment, and immunotherapy constitutes a pivotal research focus oncology. This work provides comprehensive review of methodologies for evaluating including handheld dynamometry, advanced imaging techniques, electrical impedance myography, elastography, single-fiber experiments to assess quality performance. Furthermore, it elucidates mechanisms, applications, limitations various modalities, immune checkpoint inhibitors, adoptive cell therapy, cancer vaccines, combined chemoimmunotherapy, while examining their effects on function systemic responses. Key findings indicate that although is effective in augmenting antitumor immunity, frequently induces muscle-related adverse such as weakness, fatigue, or damage, primarily mediated by cytokine release activation. underscores significance niches within microenvironment influencing treatment outcomes proposes strategies optimize therapy through personalized regimens combinatorial approaches. highlights need further formation interactions muscle-tumor. Our crucial advancing efficacy immunotherapy, reducing effects, ultimately improving survival rates life patients with cancer.

Language: Английский

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The BATF2-ATF3 axis exacerbates intervertebral disc degeneration via inducing mitochondrial dysfunction

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 156, P. 114661 - 114661

Published: April 22, 2025

Language: Английский

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Mitochondria-targeted delivery of zinc-coordinated resveratrol nanoparticles rescues the osteogenic potential of periodontal ligament stem cells compromised by inflammation for periodontal wound healing

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 503, P. 158296 - 158296

Published: Dec. 4, 2024

Language: Английский

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Gan-Mai-Da-Zao-Tang attenuates age-induced skeletal muscle wasting and improves mitochondrial function in mice

Journal of Traditional and Complementary Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

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