Mental health and the effects on methylation of stress-related genes in front-line versus other health care professionals during the second wave of COVID-19 pandemic: an Italian pilot study

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2022, Volume and Issue: 273(2), P. 347 - 356

Published: Aug. 24, 2022

Healthcare workers experienced high degree of stress during COVID-19. Purpose the present article is to compare mental health (depressive and Post-Traumatic-Stress-Disorders-PTSD-symptoms) epigenetics aspects (degree methylation stress-related genes) in front-line healthcare professionals versus working non-COVID-19 wards. Sixty-eight were included study: 39 COVID-19 wards (cases) 29 non-COVID (controls). From all participants, demographic clinical information collected by an ad-hoc questionnaire. Depressive PTSD symptoms evaluated Patient Health Questionnaire-9 (PHQ-9) Impact Event Scale-Revised (IES-R), respectively. Methylation analyses 9 promoter/regulatory regions genes known be implicated depression/PTSD (ADCYAP1, BDNF, CRHR1, DRD2, IGF2, LSD1/KDM1A, NR3C1, OXTR, SLC6A4) performed on DNA from blood samples MassARRAY EpiTYPER platform, with MassCleave settings. Controls showed more frequent lifetime history anxiety/depression respect cases (χ2 = 5.72, p 0.03). On contrary, controls presented higher PHQ-9 (t 2.13, 0.04), sleep item 2.26, 0.03), IES-R total 2.17, intrusion 2.46, 0.02), avoidance 1.99, 0.05) mean scores. levels at DRD2 LSD1 was significantly (p < 0.01, 0.03 0.03, respectively). Frontline negative effects pandemic than non-frontline workers. increased regulating HPA axis (CRHR1) dopamine neurotransmission (DRD2 LSD1), thus supporting involvement these biological processes indicating that can modulated conditions, such as pandemic.

Language: Английский

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The positive impact of COVID-19 on critical care: from unprecedented challenges to transformative changes, from the perspective of young intensivists

Annals of Intensive Care, Journal Year: 2023, Volume and Issue: 13(1)

Published: April 11, 2023

Abstract Over the past 2 years, SARS-CoV-2 infection has resulted in numerous hospitalizations and deaths worldwide. As young intensivists, we have been at forefront of fight against COVID-19 pandemic it an intense learning experience affecting all aspects our specialty. Critical care was put forward as a priority managed to adapt influx patients growing demand for beds, financial material resources, thereby highlighting its flexibility central role healthcare system. Intensivists assumed essential unprecedented public life, which important when claiming indispensable human investments. Physicians researchers around world worked hand-in-hand advance research better manage this disease by integrating rapidly body evidence into guidelines. Our daily ethical practices communication with families were challenged massive restricted visitation policies, forcing us improve collaboration other specialties innovate new channels. However, picture not bright, some these achievements are already fading over time despite ongoing hospital crisis. In addition, demonstrated need working conditions well-being critical workers cope current shortage resources. Despite gloomy atmosphere, remain optimistic. ten-key points review, outline vision on how capitalize lasting impact face future challenges foster transformative changes better.

Language: Английский

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Mental health, functioning and quality of life between work in the office and work from home employees during first wave of COVID19 in Brazil

Trends in Psychiatry and Psychotherapy, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Coronavirus disease 2019 (COVID-19) was declared a global pandemic early in 2020, followed by period during which governments imposed strict social distancing measures to slow transmission. However, most essential services remained open, and those working offices faced higher risk of infection compared at home. We compare the occurrence potential determinants mental health outcomes, functioning, quality life (QoL) subset sample Brazilian individuals who worked from home office first wave COVID-19.

Language: Английский

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The impact of COVID-19 workload on psychological distress amongst Canadian intensive care unit healthcare workers during the 1st wave of the COVID-19 pandemic: A longitudinal cohort study

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(3), P. e0290749 - e0290749

Published: March 7, 2024

Intensive care unit healthcare workers (ICU HCW) are at risk of mental health disorders during emerging disease outbreaks. Numerous cross-sectional studies have reported psychological distress, anxiety, and depression amongst ICU HCW the COVID-19 pandemic. However, few followed longitudinally, none these examined association between workload health. We conducted a longitudinal cohort study 309 Canadian from April 2020 to August 2020, 1 st wave Psychological distress was assessed using General Health Questionnaire 12-item scale (GHQ-12) 3 timepoints: acceleration phase (T1), deceleration (T2), after had passed (T3). Clinically relevant defined as GHQ-12 score ≥ 3, identified in 64.7% participants T1, 41.0% T2, 34.6% T3. not associated with T1. At number patients (odds ratio [OR]: 1.06, 95% confidence interval [CI]: 1.00, 1.13) while T3, when patient numbers were low, it weekly hospital shifts exposure (OR: 1.33, CI: 1.09, 1.64). When analyzed longitudinally mixed effects model, pandemic timepoint stronger predictor 0.24, 0.15, 0.40 for T2 OR: 0.16, 0.09, 0.27 T3) than workload. Participants who showed persistent T3 compared those recovery Persistent higher 1.97, CI:1.33, 3.09) but 0.86, 0.76, 0.95). In summary, clinically observed majority decreased rapidly progressed. working more ICU. future outbreaks, minimizing direct may help alleviate symptoms individuals distress.

Language: Английский

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Prevalence and associated factors of mental health outcomes among healthcare workers in Northern Colombia: A cross-sectional and multi-centre study

Journal of Affective Disorders Reports, Journal Year: 2022, Volume and Issue: 10, P. 100415 - 100415

Published: Aug. 19, 2022

Mental health outcomes in Healthcare Workers (HCWs) has been few evaluated during COVID-19 pandemic low-and middle-income countries. Our aim was carry-out a study to identify the prevalence of stress, anxiety, depressive symptoms HCWs and associated factors severe illness northern region Colombia.A cross-sectional, hospital-based survey conducted assess mental 1,149 Colombia. The used Perceived Stress Scale (PSS-10), 7-item Generalized Anxiety Disorder (GAD-7), 9-item Patient Health Questionnaire (PHQ-9) evaluate depression symptoms, respectively.682 completed questionnaire. 58,21% (397/682) were nurses, 31,23% physicians (213/682), 10,56% (72/682) other professionals. proportion with 59,97%, 44,87%, 23,02%, respectively. emergency room Intensive Care Units (ICU) have 2-3-fold increase risk stress. Staff ICU 64% more likely anxiety 97% symptoms.Including only Colombia; non-probabilistic sample, cross-sectional design causality.A higher on reported There are work areas related such as room. Hospitals patient-care institutions Latin-America needs consider physical outbreaks staff at-risk implementing support strategies mitigate adverse outcomes.

Language: Английский

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Prevalence of psychological distress in nurses, physicians and leaders working in intensive care units during the COVID-19 pandemic: a national one-year follow-up study

BMJ Open, Journal Year: 2023, Volume and Issue: 13(12), P. e075190 - e075190

Published: Dec. 1, 2023

Objective To report and compare psychological distress as symptoms of anxiety, depression post-traumatic stress among intensive care units’ (ICU) nurses, physicians leaders at 12 months after the baseline survey (spring 2020), during COVID-19 pandemic in Norway. Furthermore, to analyse which demographic COVID ICU-related factors have a significant impact on months. Design Prospective, longitudinal, observational cohort study. Setting Nationwide, 27 28 hospitals with ICUs Participants Nurses, their leaders. At month follow-up 287 (59.3%) 484 participants responded. Primary secondary outcome measures Symptoms anxiety using Hopkins Checklist-10 (HSCL-10). disease checklist for Diagnostic Statistical Manual Mental Disorders 5 (PCL-5). Demographics (included previous depression) (professional preparations, emotional experience support) impacting Results Psychological distress, defined caseness either or both HSCL-10 PCL-5, did not change significantly was present 13.6% 13.2% follow-up. Nurses reported higher levels than Adjusted demographics baseline, fear infection were associated Previous depression, feeling loneliness more stress. Conclusion One year into professionals frequently nurses. Fear infection, distress. Protective equipment peer support are recommended mitigate Trial registration number ClinicalTrials.gov. Identifier: NCT04372056 .

Language: Английский

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Rates and predictors of mental health care utilisation in patients following a prolonged stay on intensive care unit: a prospective cohort study

BMJ Open, Journal Year: 2023, Volume and Issue: 13(1), P. e063468 - e063468

Published: Jan. 1, 2023

Objectives An acute critical illness and secondary complications may necessitate a prolonged treatment on an intensive care unit (ICU). As long-term consequences, ICU survivors suffer from both physical psychological sequelae. To improve the aftercare of these patients, present study aimed to assess use mental healthcare associated factors following stay. Methods N=197 patients with primary diagnosis polyneuropathy/myopathy were enrolled within 4 weeks (T1) interviewed three (T2) six (T3) months transfer acute-care postacute ICU. Symptoms current major depression/post-traumatic stress disorder (PTSD) assessed using Structured Clinical Interview for Diagnostic Statistical Manual Mental Disorders. The potential need healthcare, its past reasons non-use raised. Results Full syndromal subsyndromal depression/PTSD diagnosed in 8.3%/15.6% at T2, 12.2%/23.5% T3. About 29% reported utilisation. Considering somatic complaints, more important was common reason healthcare. Female gender, previous number sepsis episodes pension receipt increased chance utilisation, pre-existing decreased it. Conclusion Every fourth patient surviving treatement makes . Particularly male disorders should be targeted preventively, receiving specific psychoeducation about sequelae options post-ICU. Trial registration DRKS00003386.

Language: Английский

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What clinical practices for intensive care psychologists in France? A national survey

Critical Care, Journal Year: 2024, Volume and Issue: 28(1)

Published: June 20, 2024

Language: Английский

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Gender sensitivity of the COVID-19 mental health research in Europe: a scoping review

International Journal for Equity in Health, Journal Year: 2024, Volume and Issue: 23(1)

Published: Oct. 10, 2024

Abstract Background The integration of sex and gender aspects into the research process has been recognized as crucial to generation valid data. During coronavirus pandemic, a great deal addressed mental state hospital staff, they constituted population at risk for infection distress. However, it is still unknown how dimension was included. We aimed appraise measure qualitatively extent sensitivity. Methods In this scoping review, we searched MEDLINE, EMBASE, CINAHL PsycINFO Social Sciences Citation Index (SSCI) from database inception November 11, 2021. All quantitative studies with primary data published in English, German, or Spanish based European Union were selected. Included had have assessed health staff using validated psychometric scales depression, anxiety, PTSD symptoms, distress, suicidal behavior, insomnia, substance abuse aggressive behavior. Two independent reviewers applied eligibility criteria each title/abstract reviewed, full text article, performed extraction. A sensitivity assessment tool developed validated, consisting 18 items followed by final qualitative assessment. included article. Results Three thousand one hundred twelve identified, which 72 analysis. most common design cross-sectional (75.0%) them conducted Italy (31.9%). Among results, only study behaviors none disorders behaviors. Sex used erroneously 83.3% studies, described participants determined. Most articles (71.8%) did not include sex/gender literature review discuss sex/gender-related findings theoretical background (86.1%). analysis, 37.5% provided disaggregated data, but 3 advanced modeling statistics, such interaction overall assessment, papers rated good terms sensitivity, rest fair (16.7%) poor (79.2%). identified stereotypes present explaining results. None analyzed results non-binary individuals. Conclusions Studies on during pandemic adequately integrate dimension, despite institutional commitment gendered effect pandemic. development future interventions population, use generalizability current evidence should be done cautiously.

Language: Английский

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Mental Health Support for Hospital Staff during the COVID-19 Pandemic: Characteristics of the Services and Feedback from the Providers

Healthcare, Journal Year: 2022, Volume and Issue: 10(7), P. 1337 - 1337

Published: July 18, 2022

French authorities created mental health support services to accompany HCWs during the pandemic. We aimed obtain feedback from staff providing these within hospitals identify positive and negative features avenues for improvement. A mixed-methods study was performed between 1 April 30 June 2020. contacted 77 centres those services. developed a questionnaire containing questions about service (quantitative part), with open enable providers (qualitative part). Of centres, 36 had services; 77.8% were specifically epidemic. Services staffed principally by psychologists, mainly used telephone platform, median opening time of 8 h/day. Thirty-seven professionals provided feedback, most aged 35–49 years. For 86.5%, it their first such support. Median self-reported comfort level (interquartiles 3–10), 95% would do again. Respondents reported (i) difficulties work organisation, clinical situations, lack recognition (ii) desire training. This suggests that needs be adapted HCWs, both in terms content timing delivery.

Language: Английский

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