The relationship between COVID‐19 viral load and disease severity: A systematic review

Immunity Inflammation and Disease, Journal Year: 2021, Volume and Issue: 10(3)

Published: Dec. 13, 2021

Abstract Introduction Patients with COVID‐19 may present different viral loads levels. However, the relationship between load and disease severity in is still unknown. Therefore, this study aimed to systematically review association SARS‐CoV‐2 severity. Methods The relevant studies using keywords of “COVID‐19” “viral load” were searched databases PubMed, Scopus, Google Scholar, Web Science. A two‐step title/abstract screening process was carried out eligible included study. Results Thirty‐four from initial 1015 records. vast majority have utilized real‐time reverse transcription‐polymerase chain reaction nasopharyngeal/respiratory swabs report load. Viral commonly reported either as cycle threshold ( C t ) or log 10 RNA copies/ml. Conclusion results inconclusive about load, a similar number approved opposed hypothesis. denote direct older age higher which known risk factor for mortality. patients serve mechanism any possible relationships There positive correlation its transmissibility. Nonetheless, further are recommended precisely characterize matter.

Language: Английский

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Retracted: COVID‐19 mortality and its predictors in the elderly: A systematic review

Health Science Reports, Journal Year: 2022, Volume and Issue: 5(3)

Published: May 1, 2022

Abstract Background and Aims Older people have higher rates of comorbidities may experience more severe inflammatory responses; therefore, are at risk death. Herein, we aimed to systematically review the mortality in coronavirus disease 2019 (COVID‐19) patients its predictors this age group. Methods We searched PubMed, Web Science, Science Direct using relevant keywords. Retrieved records underwent a two‐step screening process consisting title/abstract full‐text screenings identify eligible studies. Results Summarizing findings 35 studies demonstrated that older compared younger population. A articles revealed increasing age, body mass index, male gender, dementia, impairment or dependency daily activities, presence consolidations on chest X‐ray, hypoxemic respiratory failure, lower oxygen saturation admission were factors for High d ‐dimer levels, 25‐hydroxy vitamin D serum deficiencies, high C‐reactive protein (≥5 mg/L) levels plus any other abnormalities lymphocyte, blood urea nitrogen lactate dehydrogenase, platelet count poor prognosis elderly. Studies also shown previous treatment with renin–angiotensin–aldosterone system inhibitors, pharmacological treatments disorders, antibiotics, corticosteroids, K antagonist, antihistamines, azithromycin, Itolizumab (an anti‐CD6 monoclonal antibody) combination antivirals reduces COVID‐19 worsening mortality. Vaccination against seasonal influenza might reduce Conclusion Overall, critical consideration is necessary care management aged population considering drastic contrasts manifestation groups. Mortality from independently associated patient's age. Elderly vulnerable outcomes. Thus, strict preventive measures, timely diagnosis, aggressive therapeutic/nontherapeutic great importance acute distress syndrome complications people.

Language: Английский

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Novel Systemic Inflammation Markers to Predict COVID-19 Prognosis

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: Oct. 22, 2021

Coronavirus disease 2019 (COVID-19) has resulted in a global pandemic, challenging both the medical and scientific community for development of novel vaccines greater understanding effects SARS-CoV-2 virus. COVID-19 been associated with pronounced out-of-control inflammatory response. Studies have sought to understand response markers prognosticate disease. Herein, we aimed review evidence 11 groups systemic risk-stratifying patients prognosticating outcomes related COVID-19. Numerous studies demonstrated effectiveness neutrophil lymphocyte ratio (NLR) patient outcomes, including but not limited severe disease, hospitalization, intensive care unit (ICU) admission, intubation, death. A few outperformed NLR predicting 1) immune-inflammation index (SII), 2) prognostic nutritional (PNI), 3) C-reactive protein (CRP) albumin (CAR) high-sensitivity CAR (hsCAR), 4) CRP prealbumin (CPAR) CPAR (hsCPAR). However, there are number comparing these markers, such conclusions require larger validation studies. Overall, suggests that most studied able predict prognosis, however seems be robust marker.

Language: Английский

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Retracted: Impact of COVID‐19 pandemic on routine vaccination coverage of children and adolescents: A systematic review

Health Science Reports, Journal Year: 2022, Volume and Issue: 5(2)

Published: Feb. 18, 2022

Scientists and healthcare workers have expressed their concerns on the impacts of COVID-19 pandemic vaccination coverage in children adolescents. Therefore, we aimed to systematically review studies addressing this issue worldwide.

Language: Английский

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Characterization of SARS-CoV-2 different variants and related morbidity and mortality: a systematic review

European journal of medical research, Journal Year: 2021, Volume and Issue: 26(1)

Published: June 8, 2021

Coronavirus Disease-2019 (SARS-CoV-2) started its devastating trajectory into a global pandemic in Wuhan, China, December 2019. Ever since, several variants of SARS-CoV-2 have been identified. In the present review, we aimed to characterize different and explore related morbidity mortality.A systematic review including current evidence mortality was conducted through search utilizing keywords online databases Scopus, PubMed, Web Science, Science Direct; retrieved all papers reports published English from 2019 September 2020.A identified articles has shown three main genomic variants, type A, B, C. also clades S, V, G. Studies demonstrated that C14408T A23403G alterations Nsp12 S proteins are most prominent world, leading life-threatening mutations.The spike D614G amino acid change become common variant since From missense mutations found Gujarat genomes, C28854T, deleterious mutation nucleocapsid (N) gene significantly associated with patients' mortality. The other significant (G25563T) is patients located Orf3a potential role viral pathogenesis.Overall, researchers changing clinical manifestations increasing transmissibility, morbidity, COVID-19. This should be considered practice interventions combat prevent

Language: Английский

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The effects of hyperbaric oxygen therapy (HBOT) on coronavirus disease-2019 (COVID-19): a systematic review

European journal of medical research, Journal Year: 2021, Volume and Issue: 26(1)

Published: Aug. 19, 2021

Abstract Background Oxygenation serves as a cornerstone in the treatment of COVID-19, and several methods have been extensively studied so far. Herein, we aimed to systematically review studies discussing hyperbaric oxygen therapy (HBOT) examine its reported efficacy adverse events patients with COVID-19. Methods We searched retrieved relevant articles using keywords on online databases, including PubMed, Scopus, Embase, Web Science, Cochrane databases up April 11th, 2021. The records underwent two-step title/abstract full-text screening process, eligible papers were identified. National Institutes health (NIH) quality assessment tool was used for this study. This study registered International Prospective Register Systematic Reviews (PROSPERO) ID CRD42021269821. Results Eight from three countries included. All included had good fair scores, no poor systematic (Good: n = 5, Fair: 3). Studies divided into clinical trials case reports/series. Most HBOT less than 1.5–2 absolute atmospheres (ATA) 90 min sessions thereafter decreased 60 min. Trials demonstrated most recovered after receiving HBOT, blood saturation increased HBOT. Conclusion Overall, seems be safe effective oxygenation method However, there is limited knowledge evidence regarding effects mechanism COVID-19 treatment, further evaluations require extensive well-designed studies.

Language: Английский

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Genetic polymorphisms associated with susceptibility to COVID-19 disease and severity: A systematic review and meta-analysis

PLoS ONE, Journal Year: 2022, Volume and Issue: 17(7), P. e0270627 - e0270627

Published: July 6, 2022

Although advanced age and presence of comorbidities significantly impact the variation observed in clinical symptoms COVID-19, it has been suggested that genetic variants may also be involved disease. Thus, aim this study was to perform a systematic review with meta-analysis literature identify polymorphisms are likely contribute COVID-19 pathogenesis. Pubmed, Embase GWAS Catalog repositories were systematically searched retrieve articles investigated associations between COVID-19. For analyzed 3 or more studies, pooled OR 95% CI calculated using random fixed effect models Stata Software. Sixty-four eligible included review. In total, 8 7 candidate genes 74 alleles HLA loci studies. The HLA-A*30 CCR5 rs333Del associated protection against infection, while APOE rs429358C allele risk for Regarding severity, HLA-A*33, ACE1 Ins, TMPRSS2 rs12329760T severe forms, HLA-B*38, HLA-C*6, ApoE forms conclusion, ApoE, ACE1, TMPRSS2, CCR5, appear susceptibility and/or severity

Language: Английский

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Systematic review and meta-analysis of human genetic variants contributing to COVID-19 susceptibility and severity

Gene, Journal Year: 2022, Volume and Issue: 844, P. 146790 - 146790

Published: Aug. 17, 2022

Language: Английский

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COVID-19 Infection in Children and Infants: Current Status on Therapies and Vaccines

Children, Journal Year: 2022, Volume and Issue: 9(2), P. 249 - 249

Published: Feb. 12, 2022

Since the beginning in December 2019, SARS-CoV-2 outbreak appeared to affect mostly adult population, sparing vast majority of children who only showed mild symptoms. The purpose this investigation is assess status on mechanisms that give and infants variation epidemiology compared population its impact therapies vaccines are aimed towards them. A literature review, including vitro studies, reviews, published guidelines clinical trials was performed. Clinical concerned topics allowed a descriptive synthesis be produced. Four underlying were found may play key role providing COVID-19 protection babies. No available yet for therapy due insufficient data; support remains most used. Only two approved by World Health Organization used from 12 years age, there currently no efficacy or safety data below age years. frame infection milder adolescents. This section can act as vectors reservoirs transmission infection; therefore, paramount. More evidence required guide safely vaccination campaign.

Language: Английский

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COVID-19 mortality in patients with immunodeficiency and its predictors: a systematic review

European journal of medical research, Journal Year: 2022, Volume and Issue: 27(1)

Published: Oct. 8, 2022

Abstract Introduction Patients with immunodeficiency are usually more prone to worse outcomes of infectious diseases. However, there some disagreements in the context COVID-19, for example, patients human virus (HIV). Herein, we aimed systematically review risk and predictors COVID-19 mortality people primary or secondary immunodeficiency. Methods PubMed, Scopus, Web Science, Science Direct were searched. We followed a two-step screening process identify eligible results. first reviewed title abstract records unqualified studies removed. Then, their full texts evaluated based on coherence purpose inclusion/exclusion criteria, those qualitative synthesis included. Results Twenty-two articles included, which investigated total 109,326 immunodeficiencies. Three pediatric infant population, while other conducted adult population. Overall, both conflicted as reported higher mentioned lower rates Conclusions two points view types The is classical viewpoint that all immunodeficient at infection leading rate. second found might play less important even an inverse role by lowering severity inflammatory response. it take note comorbidities, such DM, HTN, CAD, ESRD, history respiratory infection, etc., demographic factors, obesity age > 70 years, they appear influence rate, especially

Language: Английский

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