Acta Physiologica,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 12, 2024
Abstract
A
unique
interplay
between
body
and
environment
embeds
reflects
host–microbiome
interactions
that
contribute
to
sex‐differential
disease
susceptibility,
symptomatology,
treatment
outcomes.
These
differences
derive
from
individual
biological
factors,
such
as
sex
hormone
action,
sex‐divergent
immune
processes,
X‐linked
gene
dosage
effects,
epigenetics,
well
their
interaction
across
the
lifespan.
The
gut
microbiome
is
increasingly
recognized
a
moderator
of
several
systems
are
thus
impacted
by
its
function
composition.
In
humans,
components
further
interact
with
gender‐specific
exposures
dietary
preferences,
stressors,
life
experiences
form
complex
whole,
requiring
innovative
methodologies
disentangle.
Here,
we
summarize
current
knowledge
among
hormones,
microbiota,
system,
vascular
health
relevance
for
epidemiology
cardiovascular
diseases.
We
outline
clinical
implications,
identify
gaps,
place
emphasis
on
required
future
studies
address
these
gaps.
addition,
provide
an
overview
caveats
associated
conducting
research
require
consideration
sex/gender
differences.
While
previous
work
has
inspected
separately,
here
call
attention
translational
utility
combined
perspective
research,
gender
medicine,
biology.
Cells,
Journal Year:
2024,
Volume and Issue:
13(17), P. 1437 - 1437
Published: Aug. 27, 2024
The
gut
microbiota
plays
an
essential
role
in
maintaining
immune
homeostasis
and
influencing
the
landscape
within
tumor
microenvironment.
This
review
aims
to
elucidate
interactions
between
dynamics,
with
a
focus
on
colorectal
cancer
(CRC).
spans
foundational
concepts
of
immuno-microbial
interplay,
factors
microbiome
composition,
evidence
linking
immunotherapy
outcomes.
Gut
modulates
anti-cancer
immunity
through
several
mechanisms,
including
enhancement
surveillance
modulation
inflammatory
responses.
Specific
microbial
species
their
metabolic
byproducts
can
significantly
influence
efficacy
immunotherapies.
Furthermore,
diversity
correlates
clinical
outcomes
CRC,
suggesting
potential
as
valuable
biomarker
for
predicting
response
immunotherapy.
Conclusions:
Understanding
relationship
responses
offers
novel
therapeutic
strategies
development.
not
only
influences
natural
history
treatment
CRC
but
also
serves
critical
modulator
activity.
Further
exploration
into
microbiome's
could
enhance
effectiveness
existing
treatments
guide
development
new
modalities.
Biomaterials Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Advancement
of
vascular
models
from
simple
2D
culture
to
complex
vessel-on-a-chip
platforms
through
integration
microfluidics,
biomimetic
hydrogels,
and
3D
bioprinting,
enabling
controlled
investigation
thrombosis
mechanisms.
Microscopy and Microanalysis,
Journal Year:
2024,
Volume and Issue:
30(3), P. 419 - 439
Published: May 31, 2024
Abstract
Human
umbilical
vein
endothelial
cells
(HUVECs)
are
primary
isolated
from
the
of
an
cord,
extensively
used
in
cardiovascular
studies
and
medical
research.
These
cells,
retaining
characteristics
vivo,
serve
as
a
valuable
cellular
model
system
for
understanding
vascular
biology,
dysfunction,
pathophysiology
diseases
such
atherosclerosis,
responses
to
different
drugs
or
treatments.
Transmission
electron
microscopy
(TEM)
has
been
cornerstone
revealing
detailed
architecture
multiple
systems
including
HUVECs,
allowing
researchers
visualize
subcellular
organelles,
membrane
structures,
cytoskeletal
elements.
Among
them,
endoplasmic
reticulum,
Golgi
apparatus,
mitochondria,
nucleus
can
be
meticulously
examined
recognize
alterations
indicative
various
stimuli.
Importantly,
Weibel–Palade
bodies
characteristic
secretory
organelles
found
which
easily
distinguished
TEM.
distinctive
structures
also
dynamically
react
factors
through
regulated
exocytosis,
resulting
complete
selective
release
their
contents.
This
review
summarizes
ultrastructural
features
HUVECs
highlights
utility
TEM
pivotal
tool
analyzing
diverse
research
frameworks,
contributing
insights
into
comprehension
HUVEC
behavior
enriching
our
knowledge
complexity
biology.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: June 4, 2024
Abstract
Gut
microbiota
plays
a
crucial
role
in
gastrointestinal
tumors.
Additionally,
gut
microbes
influence
the
progression
of
esophageal
cancer.
However,
major
bacterial
genera
that
affect
invasion
and
metastasis
cancer
remain
unknown,
underlying
mechanisms
unclear.
Here,
we
investigated
flora
metabolites
patients
with
squamous
cell
carcinoma
found
abundant
Bacteroides
increased
secretion
entry
surface
antigen
lipopolysaccharide
(LPS)
into
blood,
causing
inflammatory
changes
body.
We
confirmed
these
results
mouse
model
4NQO-induced
situ
further
identified
epithelial–mesenchymal
transition
(EMT)
occurrence
TLR4/Myd88/NF-κB
pathway
activation
vitro
experiments
revealed
LPS
from
fragile
promoted
proliferation,
migration,
invasion,
induced
EMT
by
activating
pathway.
These
reveal
are
closely
associated
through
higher
response
level
signaling
both
common
to
inflammation
tumors
LPS,
providing
new
biological
target
for
prevention
or
treatment.
Microbial Biotechnology,
Journal Year:
2024,
Volume and Issue:
17(5)
Published: May 1, 2024
Abstract
Immunotherapies
have
revolutionized
cancer
treatment.
These
treatments
rely
on
immune
cell
activation
in
tumours,
which
limits
the
number
of
patients
that
respond.
Inflammatory
molecules,
like
lipopolysaccharides
(LPS),
can
activate
innate
cells,
convert
tumour
microenvironments
from
cold
to
hot,
and
increase
therapeutic
efficacy.
However,
systemic
delivery
(LPS)
induce
cytokine
storm.
In
this
work,
we
developed
immune‐controlling
Salmonella
(ICS)
only
produce
LPS
tumours
after
colonization
clearance.
We
tuned
expression
msbB
,
controls
production
immunogenic
LPS,
by
optimizing
its
ribosomal
binding
sites
protein
degradation
tags.
This
genetic
system
induced
a
controllable
inflammatory
response
increased
dendritic
cross‐presentation
vitro.
The
strong
off
state
did
not
TNFα
prevented
adverse
events
when
injected
into
mice.
accumulation
ICS
intravenous
injection
focused
responses
specifically
tumours.
Tumour‐specific
infiltration
activated
monocytes
neutrophils,
levels
IL‐6,
CD8
T
cells
draining
lymph
nodes.
reduced
growth
mouse
survival.
By
increasing
efficacy
bacterial
anti‐cancer
therapy,
localized
could
provide
options
with
immune‐resistant
cancers.
Neuroglia,
Journal Year:
2024,
Volume and Issue:
5(3), P. 254 - 273
Published: Aug. 1, 2024
The
human
central
nervous
system
is
convolutedly
connected
to
the
gut
microbiome,
a
diverse
community
of
microorganisms
residing
in
gastrointestinal
tract.
Recent
research
has
highlighted
bidirectional
communication
between
microbiome
and
neuroglial
cells,
which
include
astrocytes,
microglia,
oligodendrocytes,
ependymal
cells.
These
cells
are
essential
for
maintaining
CNS
homeostasis,
supporting
neuronal
function,
responding
pathological
conditions.
This
review
examines
interactions
neuroglia,
emphasizing
their
critical
roles
brain
health
development
neurological
disorders.
Dysbiosis,
or
imbalance
been
associated
with
various
psychiatric
conditions,
such
as
autism
spectrum
disorder,
anxiety,
depression,
neurodegenerative
diseases
like
Alzheimer’s
Parkinson’s.
influences
function
through
microbial
metabolites,
immune
modulation,
neuroinflammatory
responses.
Understanding
these
paves
way
new
therapeutic
targets
strategies
preventing
treating
scoping
aims
highlight
mechanisms
microbiome-neuroglia
axis
its
potential
target.
Journal of Inflammation Research,
Journal Year:
2025,
Volume and Issue:
Volume 18, P. 737 - 750
Published: Jan. 1, 2025
Coagulopathy
in
sepsis
is
common
and
associated
with
high
mortality.
Although
immunothrombosis
necessary
for
infection
control,
excessive
thrombus
formation
can
trigger
a
systemic
thrombo-inflammatory
response.
Immunothrombosis
plays
core
role
sepsis-induced
coagulopathy,
research
has
revealed
complex
interplay
between
inflammation
coagulation.
Different
mechanisms
underlying
sepsis-related
coagulopathy
are
discussed,
including
factors
contributing
to
the
imbalance
of
pro-
anticoagulation
relevant
endothelial
cells.
The
potential
therapeutic
implications
anticoagulants
on
these
discussed.
This
review
contributes
our
understanding
pathogenesis
patients
sepsis.
Recent
studies
suggest
that
cells
play
an
important
immunoregulation
hemostasis.
Meanwhile,
non-anticoagulation
effects
anticoagulants,
especially
heparin,
which
act
septic
patients,
have
been
partially
revealed.
We
believe
further
insights
into
will
help
physicians
evaluate
patient
conditions
effectively,
leading
advanced
early
recognition
better
decision-making
treatment
