Frontiers in Epidemiology, Journal Year: 2024, Volume and Issue: 4

Published: Nov. 7, 2024

Background The health effects of alcohol consumption, particularly regarding potential protective benefits light to moderate intake compared abstinence, remain a subject ongoing debate. However, epidemiological studies face limitations due imprecise exposure measurements and the for bias through residual confounding reverse causation. To address these limitations, we conducted systematic review Mendelian Randomization (MR) examining causal relationship between consumption cancers, cardiovascular, liver, neurological diseases. Methodology We searched PubMed, ScienceDirect Embase Europe PMC up 05/2024 MR investigating association genetically predicted with liver assessed methodological quality based on key elements design genetic tool. Results included 70 that matched our inclusion criteria. Our showed significant multiple cancers such as oral oropharyngeal, esophageal, colorectal hepatocellular carcinoma cutaneous melanoma. While available did not consistently confirm adverse or other lung cancer, suggested by observational studies. Additionally, confirmed likely effect risk hypertension, atrial fibrillation, myocardial infraction vessels disease. there was no evidence support cognitive function, Alzheimer's disease, amyotrophic lateral sclerosis, reported in while revealed an increased epilepsy sclerosis. provided limited results link Conclusions Despite valuable insights into various outcomes provided, it is worth noting inconsistent ability instrumental variables distinguish abstainers, drinkers makes difficult differentiate U J-shaped vs. linear relationships outcome. Additional research necessary establish formal assessment tools conduct more diverse populations, including non-European ancestries. Systematic Review Registration www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021246154 , Identifier: PROSPERO (CRD42021246154).

Language: Английский