Tropical Animal Health and Production, Journal Year: 2024, Volume and Issue: 56(3)
Published: March 19, 2024
Language: Английский
iMeta, Journal Year: 2024, Volume and Issue: 3(1)
Published: Jan. 3, 2024
Pig gastrointestinal tracts harbor a heterogeneous and dynamic ecosystem populated with trillions of microbes, enhancing the ability host to harvest energy from dietary carbohydrates contributing adipogenesis fatness. However, microbial community structure related mechanisms responsible for differences between fatty phenotypes lean pigs remained be comprehensively elucidated. Herein, we first found significant in composition potential functional capacity among different gut locations Jinhua distinct fatness phenotypes. Second, identified that lower exhibited higher levels short-chain acids colon, highlighting their enhanced carbohydrate fermentation capacity. Third, explored expressed carbohydrate-active enzyme (CAZyme) pigs, indicating involvement modulating fat storage. Notably,
Language: Английский
Citations
34
Current Research in Food Science, Journal Year: 2025, Volume and Issue: 10, P. 100972 - 100972
Published: Jan. 1, 2025
Resveratrol (RES), a natural polyphenolic compound, has shown promise in enhancing skeletal muscle regeneration and metabolic function. This study aims to explore the impact of RES on after injury through regulation antioxidant capacity mitochondrial biogenesis. treatment significantly increased ratio tibialis anterior mass body weight, alongside reduced fasting glucose levels. Following cardiotoxin-induced injury, improved regeneration, characterized by greater formation new fibers better structural repair compared control. Notably, gene expression analyses demonstrated that RES-treated mice exhibited elevated levels myogenic markers, such as paired box 7 (Pax7), factor 5 (Myf5), myoblast determination protein (MyoD), Myogenin (MyoG). Concurrently, yes-associated (YAP) increased, underscoring its role regulating satellite cell activity. Transcriptomic analysis identified enriched pathways related biogenesis, with transcription factors higher DNA content mice. Furthermore, enhanced via Kelch-like ECH-associated 1 (KEAP-1)/nuclear erythroid 2-related 2 (NRF2)/heme oxygenase-1 (HO-1) signaling pathway, indicated activities total capacity, Glutathione peroxidase (GSH-PX), superoxidase dismutase (SOD). Collectively, these findings suggest not only promotes but also supports function defenses, positioning it food-derived pharmaceutical for targeting injury.
Language: Английский
Citations
2
Nutrients, Journal Year: 2023, Volume and Issue: 15(8), P. 1802 - 1802
Published: April 7, 2023
A decline in muscle mass and function represents one of the most problematic changes associated with aging, has dramatic effects on autonomy quality life. Several factors contribute to inexorable process sarcopenia, such as mitochondrial autophagy dysfunction, lack regeneration capacity satellite cells. The physiologic motoneuron functionality aging is exacerbated by sedentary lifestyle that accompanies elderly people. Regular physical activity beneficial people, but need well-designed carefully administered training programs improve and, consequently, both functional ability Aging also causes alteration gut microbiota composition some advances research have elucidated interventions via microbiota–muscle axis potential ameliorate sarcopenic phenotype. mechanisms are involved vitamin D atrophy protection, demonstrated decreased muscular related deficiency. Malnutrition, chronic inflammation, deficiencies, an imbalance muscle–gut just a few can lead sarcopenia. Supplementing diet antioxidants, polyunsaturated fatty acids, vitamins, probiotics, prebiotics, proteins, kefir, short-chain acids could be nutritional therapies against Finally, personalized integrated strategy counteract sarcopenia maintain health skeletal muscles suggested this review.
Language: Английский
Citations
37
Chemical Physics Impact, Journal Year: 2023, Volume and Issue: 7, P. 100296 - 100296
Published: Aug. 30, 2023
The profound impact of health challenges related to libido, encompassing sexual dysfunction, hormonal imbalances, relationship difficulties, stress, anxiety, depression, and the effects certain medical conditions or medications, calls for urgent mitigative measures. As a result, this study meticulously explores compound Resveratrol (Res) uncover its substantial properties concerning libido enhancement. was optimized using DFT/ωB97XD/6-311G++(d, p) basis set in different solvents, namely DMSO (dimethyl sulfoxide), ethanol, water. Notably, geometry investigation reveals that structural bond variations can be attributed factors such as solvent polarity, screening effects, hydrogen bonding, solvation energy, conformational preferences. Substantially, Frontier Molecular Orbital (FMO) analysis explored HOMO values resulting 7.59198eV, 7.5514eV, 7.59687eV RES_DMSO, RES_EtOH, RES_H2O, respectively. Correspondingly, their LUMO were found 7.5955eV, 7.5648eV, 7.5982eV, leading respective band gaps 0.0035eV, 0.0133eV, 0.0014eV. Remarkably, RES_H2O displayed smallest energy gap (0.0014eV) among interacting compounds, indicating increased conductivity sensitivity. Furthermore, natural orbital revealed had highest permutation three complexes (376.5 kcal/mol 371.79 378.77 RES_H2O), stronger interaction between donor acceptor orbitals. Finally, molecular docking studies unveiled notable difference binding affinity, with RES exhibiting greater affinity 1UDT at -8.1 compared 1UDU, which demonstrated -6.6 kcal/mol. Thus, has potential reverse erectile dysfunction improve by inhibiting activities phosphodiesterase (1UDT 1UDU), ultimately promoting vasodilatory signals from cGMP smooth muscles penis, enhanced erection. These groundbreaking findings offer promising prospects development new effective drugs combat various conditions.
Language: Английский
Citations
37
Food Chemistry Advances, Journal Year: 2023, Volume and Issue: 3, P. 100539 - 100539
Published: Nov. 21, 2023
Oxidative stress has a significant impact on the occurrence of many chronic diseases. Antioxidants have ability to prevent, postpone or treat effects free radicals. Resveratrol is polyphenol from class stilbenes. The importance this compound determined by its numerous biological properties. strong antioxidant potential special significance, because way it acts in prevention and treatment action direct, inhibiting production reactive species, indirect, influencing activity enzymes. In case analyzing known methods, was observed that RSV had higher capacity than standard used. Also, vitro vivo studies demonstrate neurodegenerative, cardiovascular renal addition, active preeclampsia infertility. An important aspect fact reduce counteract adverse some anticancer agents.
Language: Английский
Citations
30
Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(4), P. 2240 - 2258
Published: Jan. 28, 2024
Abstract Resveratrol, a natural polyphenol in various plants, has gained significant attention for its potential health‐promoting properties. It been demonstrated, after reviewing clinical and vitro studies, that resveratrol possesses potent antioxidant potential. Resveratrol demonstrates cellular component protection by directly neutralizing free radicals (FRs) enhancing the expression of enzymes, thereby mitigating oxidative damage to proteins, lipids, nucleic acids. Clinical trials have shown promising results, indicating supplementation can enhance defenses reduce markers populations. In addition effects, exhibits anti‐inflammatory modulate key inflammatory pathways, such as nuclear factor‐kappa B (NF‐κB) mitogen‐activated protein kinases (MAPKs), suppressing production pro‐inflammatory cytokines chemokines. Furthermore, resveratrol's multimodal effects extend beyond discovered exert regulatory on processes, including apoptosis, cell cycle progression, angiogenesis, immunological responses. The primary aim this review paper is provide thorough overview current knowledge resveratrol, chemical composition, bioaccessibility, effectiveness, utilization nanotechnology bioavailability. From future perspectives, revising administration methods certain contexts understanding underlying systems responsible will require further inquiry. For highest health advanced trial‐based research necessary combinational nano‐delivery resveratrol.
Language: Английский
Citations
15
Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(8), P. 3877 - 3898
Published: May 20, 2024
Abstract Resveratrol is a widely recognized polyphenolic phytochemical found in various plants and their fruits, such as peanuts, grapes, berry fruits. It renowned for its several health advantages. The well known anticancer properties, substantial amount of clinical evidence has also established promise chemotherapeutic agent. This study focuses on assessing the properties resveratrol gaining insight into underlying molecular mechanisms. evaluates biopharmaceutical, toxicological characteristics, utilization to determine suitability further development reliable Therefore, information about preclinical studies was collected from different electronic databases up‐to‐date (2018–2023). Findings this revealed that potent therapeutic benefits against cancers involving mechanisms, induction oxidative stress, cytotoxicity, inhibition cell migration invasion, autophagy, arresting S phase cycle, apoptotic, anti‐angiogenic, antiproliferative effects by regulating pathways including PI3K/AKT, p38/MAPK/ERK, NGFR‐AMPK‐mTOR, so on. However, compound poor oral bioavailability due reduced absorption; limitation overcome applying nanotechnology (nanoformulation resveratrol). Clinical application showed types cancer with no serious adverse effects. We suggest additional extensive check efficacy, safety, long‐term hazards. could involve larger number samples establish drug treatment cancer.
Language: Английский
Citations
10
Ruminants, Journal Year: 2025, Volume and Issue: 5(1), P. 5 - 5
Published: Jan. 21, 2025
This study investigated the effects of Capsicum oleoresin (CAP) on growth performance, nutrient digestibility and meat quality fattening beef cattle. A total 48 Simmental crossbred cattle, selected based body weight (484.7 ± 48.4 kg), were randomly assigned to four treatment groups (each with 12 animals) in a randomized complete block design. In each group, basal diet was supplemented 0 g/d CAP (control), 4 g/d, 8 g/d. The results showed that adding linearly increased dry matter intake (DMI; p = 0.023), led quadratic increase average daily gain (ADG; 0.035) decreased feed-to-gain ratio (F/G; 0.018). apparent CP also increasing dosage (p while ADF decreasing trend 0.054). Additionally, slaughter performance index nutritional composition not affected by amount added > 0.05), pH value addition 0.016). Among all groups, one exhibited highest DMI, ADG, F/G, water-holding capacity, as well lowest cooking loss. conclusion, can be used potential novel feed additive cattle improve digestibility. Under conditions applied this study, per found optimum for
Language: Английский
Citations
1
Foods, Journal Year: 2024, Volume and Issue: 13(24), P. 4131 - 4131
Published: Dec. 20, 2024
Though ubiquitous in nature, polyphenols gained scientific prominence only after the pioneering work of researchers like E. Fischer and K. Freudenberg, who demonstrated their potential beyond traditional applications, such as leather industry. Today, these bioactive compounds are recognized for diverse therapeutic roles, including use adjuvants cancer treatment, prevention, anti-inflammatory antioxidant properties. Additionally, have benefits managing obesity, cardiovascular diseases, neuromodulation. Their synthesis is influenced by environmental genetic factors, with concentrations varying based on intensity variables, well stage ripening. This review provides a comprehensive overview polyphenols, covering classification, chemical structures, bioavailability. The mechanisms influencing bioavailability, bioaccessibility, bioactivity explored detail, alongside an introduction to effects associated metabolic pathways. Specific examples, bioavailability coffee various types onions, analyzed. Despite promising biological activities, significant limitation lies inherently low oral However, systemic circulation by-products formed during digestion present exciting opportunities further research application.
Language: Английский
Citations
7
Poultry Science, Journal Year: 2023, Volume and Issue: 102(10), P. 102968 - 102968
Published: July 27, 2023
This study discusses the effects of resveratrol (RES) on productive performance, immune function and intestinal barrier broiler chickens challenged with lipopolysaccharide (LPS). Two hundred forty 1-day-old male Arbor Acres broilers were randomly divided into 4 groups 6 replicates each, 10 per replicate. experiment used a 2 × factorial design dietary factors (basal diets or basal supplemented 400 mg/kg RES administered from d 1 to 21) stress (intraperitoneal injection 0.5 BW saline LPS at 16, 18 20 age). The results showed that challenge had significant adverse effect average daily gain (ADG) in 16 21 age (P < 0.05), whereas addition diet inhibited LPS-induced decrease ADG 0.05). also alleviated damage broilers, which was manifested by spleen index 0.05) recovery serum immunoglobulin M ileal secretory A content disrupts inflammation, mitigates these different ways. attenuated reduction villus height jejunum ileum caused an abnormal increase plasma D-lactic acid levels effectively mitigated resulted mRNA expression occludin mucosa significantly decreased toll-like receptor 4, nuclear factor kappa-B tumor necrosis alpha tissue stimulated Taken together, this shows exerts its beneficial alleviating damage, relieving inflammation thus improving growth performance.
Language: Английский
Citations
16