Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Nov. 15, 2024
Pyroptosis
is
a
lytic
and
inflammatory
form
of
gasdermin
protein-mediated
programmed
cell
death
that
typically
initiated
by
inflammasomes.
The
inflammasome
response
an
effective
mechanism
for
eradicating
germs
cancer
cells
in
the
event
cellular
injury.
family
responsible
initiating
pyroptosis,
process
which
holes
are
made
membrane
to
allow
chemicals
escape.
Mounting
evidence
indicates
pyroptosis
critical
controlling
development
cancer.
In
this
review,
we
provide
general
overview
examine
relationship
between
primary
elements
tumors,
stress
necessity
pyroptosis-targeted
therapy
tumors.
Furthermore,
explore
its
dual
nature
as
double-edged
sword
capable
both
inhibiting
facilitating
growth
cancer,
depending
on
specific
conditions.
Ultimately,
phenomenon
has
positive
negative
effects
Using
impact
reasonable
manner
may
facilitate
investigation
into
initiation
progression
tumors
offer
insights
novel
treatments
centered
pyroptosis.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(8), P. 1917 - 1917
Published: Aug. 21, 2024
Icaritin
(ICT),
a
natural
compound
extracted
from
the
dried
leaves
of
genus
Epimedium,
possesses
antitumor
and
immunomodulatory
properties.
However,
mechanisms
through
which
ICT
modulates
pyroptosis
immune
response
in
hepatocellular
carcinoma
(HCC)
remain
unclear.
This
study
demonstrated
that
exhibits
pyroptosis-inducing
anti-hepatocarcinoma
effects.
Specifically,
caspase1-GSDMD
caspase3-GSDME
pathways
were
found
to
be
involved
ICT-triggered
pyroptosis.
Furthermore,
promoted
co-cultivation
HepG2
cells
macrophages,
regulating
release
inflammatory
cytokines
transformation
macrophages
into
proinflammatory
phenotype.
In
Hepa1-6+Luc
liver
cancer
model,
treatment
significantly
increased
expression
cleaved-caspase1,
cleaved-caspase3,
granzyme
B,
modulated
cytokine
secretion,
stimulated
CD8+
T
cell
infiltration,
resulting
reduction
tumor
growth.
conclusion,
findings
this
research
suggested
may
modulate
HCC
subsequently
regulate
microenvironment
tumor.
These
observations
expand
understanding
pharmacological
mechanism
ICT,
as
well
therapy
cancer.
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
28, P. 101191 - 101191
Published: Aug. 7, 2024
Contemporary
progress
in
tumor
immunotherapy
has
solidified
its
role
as
an
effective
approach
combating
cancer.
Nonetheless,
the
prevalent
"immune
cold"
state
within
microenvironment
poses
a
substantial
barrier
to
efficacy.
Addressing
this,
pyroptosis-a
gasdermin-mediated
programmed
cell
death
characterized
by
inflammatory
profile-emerges
crucial
mechanism.
It
catalyzes
release
of
vast
quantities
pro-inflammatory
cytokines
and
immunogens,
potentially
transforming
immunosuppressive
"cold"
tumors
into
reactive
"hot"
ones.
Herein,
we
will
initially
present
overview
pyroptosis
distinct
form
death,
along
with
molecular
mechanisms.
Subsequently,
focus
on
introducing
how
activators
are
utilized
field
immunotherapy.
Insights
gained
from
applications
could
lead
development
safe
efficient
activators,
significantly
enriching
arsenal
for
Nano Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 1, 2024
The
design
and
synthesis
of
nanomedicines
capable
regulating
programmed
cell
death
patterns
to
enhance
antitumor
efficacy
remain
significant
challenges
in
cancer
therapy.
In
this
study,
we
developed
intelligent
DNA
nanospheres
(NS)
distinguishing
tiny
pH
changes
between
different
endosomal
compartments
regulate
pyroptosis
or
apoptosis.
These
NS
are
self-assembled
from
two
multifunctional
modules,
enabling
tumor
targeting,
acid-responsive
disassembly,
photodynamic
therapy
(PDT)
activation.
By
modifying
the
embedded
i-motif
sequence,
can
be
activated
early
endosomes
(EE)
lysosomes
(Ly),
producing
singlet
oxygen
(
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 4, 2024
Abstract
Pyroptosis,
an
inflammatory
cell
death,
has
attracted
great
attention
for
potentiating
a
strong
immune
response
against
tumor
cells.
However,
developing
powerful
pyroptosis
inducers
and
then
activating
specific
still
remains
challenging.
Herein,
PEG‐CuP‐COF@∆St
nanosystem
is
rationally
designed,
consisting
of
PEG‐CuP‐COF
nanozyme
tumor‐targeting
bacteria
the
Salmonella
Typhimurium
strain
VNP20009
(ΔSt),
with
affinity
hypoxic
microenvironment.
The
nanozymes
possessed
excellent
sonodynamic
performance
multienzyme‐mimicking
activities
to
generate
reactive
oxygen
species
(ROS)
induce
potent
pyroptosis.
superoxide
dismutase‐
peroxidase‐mimicking
catalytically
produced
hydrogen
peroxide
(H
2
O
)
hydroxyl
radicals
(•OH)
which
have
important
value
in
triggering
acute
responses
Moreover,
showed
outstanding
glutathione
activities,
impairing
antioxidant
defense
cells
enhancing
efficiency
by
making
them
more
vulnerable
ROS‐induced
damage.
During
vivo
studies,
its
self‐driven
property
exhibited
impressive
capability
activated
Caspase‐3/gasdermin
E‐dependent
inhibit
growth.
More
importantly,
it
induced
memory
effect
prevent
bone
metastasis.
In
summary,
this
study
introduces
innovative
approach
combinatorial
sono‐catalytic
immunotherapy
using
bacteria‐mediated
delivery
as
inducers.
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Nov. 15, 2024
Pyroptosis
is
a
lytic
and
inflammatory
form
of
gasdermin
protein-mediated
programmed
cell
death
that
typically
initiated
by
inflammasomes.
The
inflammasome
response
an
effective
mechanism
for
eradicating
germs
cancer
cells
in
the
event
cellular
injury.
family
responsible
initiating
pyroptosis,
process
which
holes
are
made
membrane
to
allow
chemicals
escape.
Mounting
evidence
indicates
pyroptosis
critical
controlling
development
cancer.
In
this
review,
we
provide
general
overview
examine
relationship
between
primary
elements
tumors,
stress
necessity
pyroptosis-targeted
therapy
tumors.
Furthermore,
explore
its
dual
nature
as
double-edged
sword
capable
both
inhibiting
facilitating
growth
cancer,
depending
on
specific
conditions.
Ultimately,
phenomenon
has
positive
negative
effects
Using
impact
reasonable
manner
may
facilitate
investigation
into
initiation
progression
tumors
offer
insights
novel
treatments
centered
pyroptosis.
