Research progress on the relationship between intestinal microecology and intestinal bowel disease DOI Creative Commons
Qian-Hui Fu, Tianyuan Song, Xiaoqin Ma

et al.

Animal Models and Experimental Medicine, Journal Year: 2022, Volume and Issue: 5(4), P. 297 - 310

Published: Aug. 1, 2022

Abstract Intestinal microecology is the main component of human microecology. consists intestinal microbiota, epithelial cells, and mucosal immune system. These components are interdependent establish a complex interaction network that restricts each other. According to impact on body, there three categories symbiotic bacteria, opportunistic pathogens, pathogenic bacteria. The participates in digestion absorption, material metabolism, inhibits growth microorganisms. It also acts as body's natural barrier, regulates innate immunity intestine, controls barrier function, cells' physiological activities such hyperplasia or apoptosis. When steady‐state balance disturbed, existing core microbiota changes leads obesity, diabetes, many other diseases, especially irritable bowel syndrome, inflammatory disease (IBD), colorectal malignancy. including tumors, particularly closely related This article systematically discusses research progress relationship between IBD from pathogenesis, treatment methods IBD, microbiota.

Language: Английский

Extending and improving metagenomic taxonomic profiling with uncharacterized species using MetaPhlAn 4 DOI Creative Commons
Aitor Blanco‐Míguez, Francesco Beghini, Fabio Cumbo

et al.

Nature Biotechnology, Journal Year: 2023, Volume and Issue: 41(11), P. 1633 - 1644

Published: Feb. 23, 2023

Abstract Metagenomic assembly enables new organism discovery from microbial communities, but it can only capture few abundant organisms most metagenomes. Here we present MetaPhlAn 4, which integrates information metagenome assemblies and isolate genomes for more comprehensive metagenomic taxonomic profiling. From a curated collection of 1.01 M prokaryotic reference metagenome-assembled genomes, define unique marker genes 26,970 species-level genome bins, 4,992 them taxonomically unidentified at the species level. 4 explains ~20% reads in international human gut microbiomes >40% less-characterized environments such as rumen microbiome proves accurate than available alternatives on synthetic evaluations while also reliably quantifying with no cultured isolates. Application method to >24,500 metagenomes highlights previously undetected be strong biomarkers host conditions lifestyles mouse shows that even uncharacterized genetically profiled resolution single strains.

Language: Английский

Citations

561
Gut microbiome affects the response to anti-PD-1 immunotherapy in patients with hepatocellular carcinoma DOI Creative Commons
Yi Zheng, Tingting Wang, Xiaoxuan Tu

et al.

Journal for ImmunoTherapy of Cancer, Journal Year: 2019, Volume and Issue: 7(1)

Published: July 23, 2019

Checkpoint-blockade immunotherapy targeting programmed cell death protein 1 (PD-1) has recently shown promising efficacy in hepatocellular carcinoma (HCC). However, the factors affecting and predicting response to anti-PD-1 HCC are still unclear. Herein, we report dynamic variation characteristics specificities of gut microbiome during using metagenomic sequencing.Fecal samples from patients responding showed higher taxa richness more gene counts than those non-responders. For analysis immunotherapy, dissimilarity beta diversity became prominent across as early Week 6. In non-responders, Proteobacteria increased 3, predominant at 12. Twenty responder-enriched species, including Akkermansia muciniphila Ruminococcaceae spp., were further identified. The related functional genes metabolic pathway analysis, such carbohydrate metabolism methanogenesis, verified potential bioactivities species.Gut may have a critical impact on responses treated with immunotherapy. provide predictions outcomes HCC, which is for disease-monitoring treatment decision-making.

Language: Английский

Citations

405
Smoking and microbiome in oral, airway, gut and some systemic diseases DOI Creative Commons
Chunrong Huang, Guochao Shi

Journal of Translational Medicine, Journal Year: 2019, Volume and Issue: 17(1)

Published: July 15, 2019

The human microbiome harbors a diverse array of microbes which establishes mutually beneficial relation with the host in healthy conditions, however, dynamic homeostasis is influenced by both and environmental factors. Smoking contributes to modifications oral, lung gut microbiome, leading various diseases, such as periodontitis, asthma, chronic obstructive pulmonary disease, Crohn's ulcerative colitis cancers. However, exact causal relationship between smoking alteration remains be further explored.

Language: Английский

Citations

263
The Gut Microbiota: Emerging Evidence in Autoimmune Diseases DOI
Xuan Zhang, Beidi Chen, Lidan Zhao

et al.

Trends in Molecular Medicine, Journal Year: 2020, Volume and Issue: 26(9), P. 862 - 873

Published: May 10, 2020

Language: Английский

Citations

173
Activation of the interleukin-23/interleukin-17 signalling pathway in autoinflammatory and autoimmune uveitis DOI
Zhenyu Zhong, Guannan Su,

Aize Kijlstra

et al.

Progress in Retinal and Eye Research, Journal Year: 2020, Volume and Issue: 80, P. 100866 - 100866

Published: May 16, 2020

Language: Английский

Citations

169
An Autoimmunogenic and Proinflammatory Profile Defined by the Gut Microbiota of Patients With Untreated Systemic Lupus Erythematosus DOI
Beidi Chen, Xinmiao Jia,

Jia‐yue Xu

et al.

Arthritis & Rheumatology, Journal Year: 2020, Volume and Issue: 73(2), P. 232 - 243

Published: Oct. 30, 2020

Objective Changes in gut microbiota have been linked to systemic lupus erythematosus (SLE), but knowledge is limited. Our study aimed provide an in‐depth understanding of the contribution immunopathogenesis SLE. Methods Fecal metagenomes from 117 patients with untreated SLE and 52 posttreatment were aligned 115 matched healthy controls analyzed by whole‐genome profiling. For comparison, we assessed fecal metagenome MRL/ lpr mice. The oral origin species that existed was documented single‐nucleotide polymorphism–based strain‐level analyses. Functional validation assays performed demonstrate molecular mimicry newly found microbial peptides. Results Gut individuals displayed significant differences composition function compared controls. Certain species, including Clostridium ATCC BAA‐442 as well Atopobium rimae , Shuttleworthia satelles Actinomyces massiliensis Bacteroides fragilis leptum enriched reduced after treatment. Enhanced lipopolysaccharide biosynthesis branched chain amino acid observed patients. findings mice consistent our human subjects. Interestingly, some demonstrated proinflammatory capacities peptides derived SLE‐enriched species. Conclusion This provides detailed information on SLE, their functional signatures, similarities murine counterparts, origin, definition autoantigen‐mimicking data microbiome‐altering approaches may offer valuable adjuvant therapies

Language: Английский

Citations

167
Probiotic Mixture of Lactobacillus plantarum Strains Improves Lipid Metabolism and Gut Microbiota Structure in High Fat Diet-Fed Mice DOI Creative Commons
Huizhen Li, Fei Liu, Jingjing Lu

et al.

Frontiers in Microbiology, Journal Year: 2020, Volume and Issue: 11

Published: March 26, 2020

The global prevalence of obesity is rising year by year, which has become a public health problem worldwide. In recent years, animal studies and clinical have shown that some lactic acid bacteria possess an anti-obesity effect. our previous study, mixed lactobacilli (

Language: Английский

Citations

148
Gut microbiota-mediated secondary bile acids regulate dendritic cells to attenuate autoimmune uveitis through TGR5 signaling DOI Creative Commons
Jianping Hu,

Chaokui Wang,

Xinyue Huang

et al.

Cell Reports, Journal Year: 2021, Volume and Issue: 36(12), P. 109726 - 109726

Published: Sept. 1, 2021

Gut microbiota-mediated secondary bile acids (BAs) play an important role in energy balance and host metabolism via G protein-coupled receptors and/or nuclear receptors. Emerging evidence suggests that BAs are for maintaining innate immune responses these However, the effect of on autoimmune uveitis is still unknown. Here, we demonstrate decreased microbiota-related BA concentration feces serum animals with experimental (EAU). Restoration gut pool attenuates severity EAU association inhibition factor κB (NF-κB)-related pro-inflammatory cytokines dendritic cells (DCs). TGR5 deficiency partially reverses inhibitory deoxycholic acid (DCA) DCs. signaling also inhibits NF-κB activation cyclic AMP (cAMP)-protein kinase A (PKA) pathway Additionally, both DCA agonists inhibit human monocyte-derived DC activation. Taken together, our results suggest plays adaptive might be a therapeutic target uveitis.

Language: Английский

Citations

132
Microbiome signatures of progression toward celiac disease onset in at-risk children in a longitudinal prospective cohort study DOI Creative Commons
Maureen M. Leonard, Francesco Valitutti, Hiren Karathia

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2021, Volume and Issue: 118(29)

Published: July 12, 2021

Significance The incidence of chronic inflammatory autoimmune conditions, such as celiac disease (CD), is increasing at an alarming rate. CD the only condition for which trigger, gluten, known. However, its etiology and pathogenesis remain incompletely defined recent studies suggest other environmental stimuli may play a key role in pathogenesis. Here, we prospectively examine trajectory gut microbiota starting 18 mo before onset 10 infants who developed did not. We identified alterations microbiota, functional pathways, metabolome onset, suggesting our approach be used prediction with ultimate goal identifying early preventive interventions to reestablish tolerance prevent autoimmunity.

Language: Английский

Citations

113
Safety and efficacy of fecal microbiota transplantation for treatment of systemic lupus erythematosus: An EXPLORER trial DOI
Cancan Huang, Ping Yi,

Zhu Ming

et al.

Journal of Autoimmunity, Journal Year: 2022, Volume and Issue: 130, P. 102844 - 102844

Published: June 1, 2022

Language: Английский

Citations

90