Nano based drug delivery systems: recent developments and future prospects

Journal of Nanobiotechnology, Journal Year: 2018, Volume and Issue: 16(1)

Published: Sept. 19, 2018

Nanomedicine and nano delivery systems are a relatively new but rapidly developing science where materials in the nanoscale range employed to serve as means of diagnostic tools or deliver therapeutic agents specific targeted sites controlled manner. Nanotechnology offers multiple benefits treating chronic human diseases by site-specific, target-oriented precise medicines. Recently, there number outstanding applications nanomedicine (chemotherapeutic agents, biological immunotherapeutic etc.) treatment various diseases. The current review, presents an updated summary recent advances field nanomedicines based drug through comprehensive scrutiny discovery application nanomaterials improving both efficacy novel old drugs (e.g., natural products) selective diagnosis disease marker molecules. opportunities challenges from synthetic/natural sources their clinical also discussed. In addition, we have included information regarding trends perspectives area.

Language: Английский

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Nanomaterials for cancer therapy: current progress and perspectives

Journal of Hematology & Oncology, Journal Year: 2021, Volume and Issue: 14(1)

Published: May 31, 2021

Abstract Cancer is a disease with complex pathological process. Current chemotherapy faces problems such as lack of specificity, cytotoxicity, induction multi-drug resistance and stem-like cells growth. Nanomaterials are materials in the nanorange 1–100 nm which possess unique optical, magnetic, electrical properties. used cancer therapy can be classified into several main categories. Targeting cells, tumor microenvironment, immune system, these nanomaterials have been modified for wide range therapies to overcome toxicity enhance drug capacity well bioavailability. Although number studies has increasing, approved nano-drugs not increased much over years. To better improve clinical translation, further research needed targeted delivery by nano-carriers reduce toxicity, permeability retention effects, minimize shielding effect protein corona. This review summarizes novel fabricated use, discusses current limitations obstacles that hinder translation from provides suggestions more efficient adoption therapy.

Language: Английский

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Smart Nanoparticles for Drug Delivery Application: Development of Versatile Nanocarrier Platforms in Biotechnology and Nanomedicine

Journal of Nanomaterials, Journal Year: 2019, Volume and Issue: 2019, P. 1 - 26

Published: Feb. 27, 2019

The study of nanostructured drug delivery systems allows the development novel platforms for efficient transport and controlled release molecules in harsh microenvironment diseased tissues living systems, thus offering a wide range functional nanoplatforms smart application biotechnology nanomedicine. This article highlights recent advances nanocarriers composed organic (including polymeric micelles vesicles, liposomes, dendrimers, hydrogels) inorganic quantum dots, gold mesoporous silica nanoparticles) materials. Despite remarkable developments synthetic methodologies, most all nanocarriers’ action is associated with number unwanted side effects that diminish their use nanomedicine applications. some critical issues design engineering nanocarrier applications, arising from complex environment multiform interactions established within specific biological media.

Language: Английский

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Targeted drug delivery strategies for precision medicines

Nature Reviews Materials, Journal Year: 2021, Volume and Issue: 6(4), P. 351 - 370

Published: Feb. 2, 2021

Language: Английский

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Polymeric Nanoparticles for Drug Delivery: Recent Developments and Future Prospects

Nanomaterials, Journal Year: 2020, Volume and Issue: 10(7), P. 1403 - 1403

Published: July 19, 2020

The complexity of some diseases-as well as the inherent toxicity certain drugs-has led to an increasing interest in development and optimization drug-delivery systems. Polymeric nanoparticles stand out a key tool improve drug bioavailability or specific delivery at site action. versatility polymers makes them potentially ideal for fulfilling requirements each particular system. In this review, summary state-of-the-art panorama polymeric systems has been conducted, focusing mainly on those applications which corresponding disease involves important morbidity, considerable reduction life quality patients-or even high mortality. A revision use ocular delivery, cancer diagnosis treatment, nutraceutical was carried out, short discussion about future prospects these is included.

Language: Английский

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Nanoparticles for Cancer Therapy: Current Progress and Challenges

Nanoscale Research Letters, Journal Year: 2021, Volume and Issue: 16(1)

Published: Dec. 1, 2021

Abstract Cancer is one of the leading causes death and morbidity with a complex pathophysiology. Traditional cancer therapies include chemotherapy, radiation therapy, targeted immunotherapy. However, limitations such as lack specificity, cytotoxicity, multi-drug resistance pose substantial challenge for favorable treatment. The advent nanotechnology has revolutionized arena diagnosis Nanoparticles (1–100 nm) can be used to treat due their specific advantages biocompatibility, reduced toxicity, more excellent stability, enhanced permeability retention effect, precise targeting. are classified into several main categories. nanoparticle drug delivery system particular utilizes tumor environment characteristics. not only solve conventional treatment but also overcome multidrug resistance. Additionally, new mechanisms unraveled studied, nanoparticles being investigated vigorously. Various therapeutic implications nanoformulations have created brand perspectives most research limited in vivo vitro studies, number approved nanodrugs much amplified over years. This review discusses numerous types nanoparticles, targeting mechanisms, nanotherapeutics oncological Further, we summarize current perspective, advantages, challenges clinical translation.

Language: Английский

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Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers

Advanced Drug Delivery Reviews, Journal Year: 2020, Volume and Issue: 157, P. 142 - 160

Published: Jan. 1, 2020

Language: Английский

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Nanomedicine review: clinical developments in liposomal applications

Cancer Nanotechnology, Journal Year: 2019, Volume and Issue: 10(1)

Published: Dec. 1, 2019

Abstract Background In recent years, disease treatment has evolved strategies that require increase in pharmaceutical agent’s efficacy and selectivity while decreasing their toxicity normal tissues. These requirements have led to the development of nanoscale liposome systems for drug release. This review focuses on lipid features, pharmacological properties liposomal formulations clinical studies application. Main body Several lipids are available, but could affect or efficiency formulations. Many been developed currently market. Proper selection is essential effect be improved. Most use mainly zwitterionic, cationic anionic lipids, PEG and/or cholesterol, which different effects stability, pharmacokinetics delivery formulation. Clinical trials shown liposomes pharmacologically pharmacokinetically more efficient than drug-alone treating acute myeloid leukemia, hepatitis A, pain management, ovary, gastric breast lung cancer, among others. Conclusion Liposomal less toxic drugs alone better parameters. Although they seem first choice various diseases, further research about dosage regimen regarding dose time needs carried out.

Language: Английский

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Biodegradable Polymeric Nanoparticles for Drug Delivery to Solid Tumors

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: Feb. 3, 2021

Advances in nanotechnology have favored the development of novel colloidal formulations able to modulate pharmacological and biopharmaceutical properties drugs. The peculiar physico-chemical technological nanomaterial-based therapeutics allowed for several successful applications treatment cancer. size, shape, charge patterning nanoscale therapeutic molecules are parameters that need be investigated modulated order promote optimize cell tissue interaction. In this review, use polymeric nanoparticles as drug delivery systems anticancer compounds, their ability efficiently localized specific tumor tissues been described. nanoencapsulation antitumor active compounds is a promising approach improve efficacy various treatments.

Language: Английский

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The versatile biomedical applications of bismuth-based nanoparticles and composites: therapeutic, diagnostic, biosensing, and regenerative properties

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(4), P. 1253 - 1321

Published: Jan. 1, 2020

Bismuth-containing nanomaterials offer a new opportunity to move beyond current achievements in the fields of drug delivery, diagnosis, cancer therapy, biosensing, and tissue engineering. This review describes emerging applications perspective these nanoparticles.

Language: Английский

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