Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(15)
Published: March 26, 2023
Abstract
The
regulation
of
tumor
immunosuppressive
microenvironments
via
precise
drug
delivery
is
a
promising
strategy
for
preventing
recurrence
and
metastasis.
Inspired
by
the
stealth
strategy,
stealthy
nanovehicle
based
on
neutrophil
camouflage
developed
to
achieve
immunotherapy
triggering
pyroptosis.
comprises
anti‐CD11b‐
IR820‐conjugated
bovine
serum
albumin
nanoparticles
loaded
with
decitabine.
Camouflaged
neutrophils,
nanovehicles
efficient
hitchhiking
owing
biotropism
neutrophils
tumors.
fluorescent
signal
molecule,
IR820,
acts
as
navigation
monitor
track
nanovehicle.
released
decitabine
upregulates
gasdermin
E,
laser
irradiation
activates
caspase‐3,
thereby
resulting
in
pyroptosis,
which
improves
system's
adaptive
immune
response.
In
triple‐negative
breast
cancer
animal
model,
it
regulates
microenvironment
effective
induces
long‐lasting
strong
memory
prevent
lung
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Aug. 7, 2023
Cancer
remains
a
highly
lethal
disease
in
the
world.
Currently,
either
conventional
cancer
therapies
or
modern
immunotherapies
are
non-tumor-targeted
therapeutic
approaches
that
cannot
accurately
distinguish
malignant
cells
from
healthy
ones,
giving
rise
to
multiple
undesired
side
effects.
Recent
advances
nanotechnology,
accompanied
by
our
growing
understanding
of
biology
and
nano-bio
interactions,
have
led
development
series
nanocarriers,
which
aim
improve
efficacy
while
reducing
off-target
toxicity
encapsulated
anticancer
agents
through
tumor
tissue-,
cell-,
organelle-specific
targeting.
However,
vast
majority
nanocarriers
do
not
possess
hierarchical
targeting
capability,
their
indices
often
compromised
poor
accumulation,
inefficient
cellular
internalization,
inaccurate
subcellular
localization.
This
Review
outlines
current
prospective
strategies
design
organelle-targeted
nanomedicines,
highlights
latest
progress
technologies
can
dynamically
integrate
these
three
different
stages
static
maximize
outcomes.
Finally,
we
briefly
discuss
challenges
future
opportunities
for
clinical
translation
nanomedicines.
Journal of Multidisciplinary Healthcare,
Journal Year:
2021,
Volume and Issue:
Volume 14, P. 1711 - 1724
Published: July 1, 2021
Abstract:
Nanomedicine
is
an
advanced
version
of
Paul
Ehrlich’s
“magic
bulletâ€
concept.
Targeted
drug
delivery
a
system
specifying
the
moiety
directly
into
its
targeted
body
area
(organ,
cellular,
and
subcellular
level
specific
tissue)
to
overcome
aspecific
toxic
effect
conventional
delivery,
thereby
reducing
amount
required
for
therapeutic
efficacy.
To
achieve
this
objective,
magic
bullet
concept
was
developed
pushed
scientists
investigate
more
than
century,
leading
envisioning
different
nanometer-sized
devices
—
today’s
nanomedicine.
Different
carrier
systems
are
being
used
investigated,
which
include
colloidal
(vesicular
multiparticulate)
carriers,
polymers,
cellular/subcellular
systems.
This
review
addresses
need
advantages
targeting,
with
basic
principles,
strategies,
Recent
advances,
challenges,
future
perspectives
also
highlighted.
Keywords:
nanoparticles,
nanosomes
Journal of Nanobiotechnology,
Journal Year:
2021,
Volume and Issue:
19(1)
Published: Aug. 12, 2021
Abstract
Exosomes
are
lipid
bilayer
membrane
vesicles
and
emerging
as
competent
nanocarriers
for
drug
delivery.
The
clinical
translation
of
exosomes
faces
many
challenges
such
massive
production,
standard
isolation,
loading,
stability
quality
control.
In
recent
years,
artificial
based
on
nanobiotechnology
to
overcome
the
limitations
natural
exosomes.
Major
types
include
‘nanovesicles
(NVs)’,
‘exosome-mimetic
(EM)’
‘hybrid
(HEs)’,
which
obtained
by
top-down,
bottom-up
biohybrid
strategies,
respectively.
Artificial
powerful
alternatives
Here,
we
outline
advances
in
through
discuss
their
strengths,
future
perspectives.
development
holds
great
values
translational
nanomedicine.
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: May 10, 2022
Artificial
intelligence
is
an
advanced
method
to
identify
novel
anticancer
targets
and
discover
drugs
from
biology
networks
because
the
can
effectively
preserve
quantify
interaction
between
components
of
cell
systems
underlying
human
diseases
such
as
cancer.
Here,
we
review
discuss
how
employ
artificial
approaches
drugs.
First,
describe
scope
analysis
for
target
investigations.
Second,
basic
principles
theory
commonly
used
network-based
machine
learning-based
algorithms.
Finally,
showcase
applications
in
cancer
identification
drug
discovery.
Taken
together,
models
have
provided
us
with
a
quantitative
framework
study
relationship
network
characteristics
cancer,
thereby
leading
potential
discovery
candidates.
Acta Pharmaceutica Sinica B,
Journal Year:
2022,
Volume and Issue:
12(7), P. 3028 - 3048
Published: March 1, 2022
Compared
with
traditional
drug
therapy,
nanomedicines
exhibit
intriguing
biological
features
to
increase
therapeutic
efficiency,
reduce
toxicity
and
achieve
targeting
delivery.
This
review
provides
a
snapshot
of
that
have
been
currently
launched
or
in
the
clinical
trials,
which
manifests
diversified
trend
carrier
types,
applied
indications
mechanisms
action.
From
perspective
indications,
this
article
presents
an
overview
applications
involving
prevention,
diagnosis
treatment
various
diseases,
include
cancer,
infections,
blood
disorders,
cardiovascular
immuno-associated
diseases
nervous
system
etc.
Moreover,
some
considerations
perspectives
research
development
facilitate
their
translations
clinic.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(21), P. 20825 - 20849
Published: Nov. 3, 2023
Understanding
the
in
vivo
transport
of
nanoparticles
provides
guidelines
for
designing
nanomedicines
with
higher
efficacy
and
fewer
side
effects.
Among
many
factors,
size
plays
a
key
role
controlling
their
behaviors
due
to
existence
various
physiological
thresholds
within
body
size-dependent
nano-bio
interactions.
Encouraged
by
evolving
discoveries
nanoparticle-size-dependent
biological
effects,
we
believe
that
it
is
necessary
systematically
summarize
size-scaling
laws
nanoparticle
vivo.
In
this
review,
summarized
effect
on
along
journey
body:
begin
administration
via
different
delivery
routes,
followed
targeting
intended
tissues
including
tumors
other
organs,
eventually
clearance
through
liver
or
kidneys.
We
outlined
tools
investigating
as
well.
Finally,
discussed
how
may
leverage
tackle
some
challenges
nanomedicine
translation
also
raised
important
size-related
questions
remain
be
answered
future.
Small,
Journal Year:
2022,
Volume and Issue:
18(16)
Published: Jan. 27, 2022
Abstract
Ultrasmall
nanoparticles
are
often
grouped
under
the
broad
umbrella
term
of
“nanoparticles”
when
reported
in
literature.
However,
for
biomedical
applications,
their
small
sizes
give
them
intimate
interactions
with
biological
species
and
endow
unique
functional
physiochemical
properties.
Carbon
quantum
dots
(CQDs)
an
emerging
class
ultrasmall
which
have
demonstrated
considerable
biocompatibility
been
employed
as
potent
theragnostic
platforms.
These
particles
find
application
increasing
drug
solubility
targeting,
along
facilitating
passage
drugs
across
impermeable
membranes
(i.e.,
blood
brain
barrier).
Further
functionality
can
be
triggered
by
various
environmental
conditions
or
external
stimuli
pH,
temperature,
near
Infrared
(NIR)
light,
ultrasound),
intrinsic
fluorescence
is
valuable
diagnostic
applications.
The
focus
this
review
to
shed
light
on
therapeutic
potential
CQDs
identify
how
they
travel
through
body,
reach
site
action,
administer
effect,
excreted.
Investigation
into
toxicity
compatibility
larger
nanoparticle
carriers
also
examined.
future
applications
promising
due
multifunctional
attributes
documented
biocompatibility.
As
nanomaterial
platforms
become
more
commonplace
clinical
treatments,
commercialization
CQD
therapeutics
anticipated.
