European Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 958, P. 176013 - 176013
Published: Aug. 24, 2023
Language: Английский
Nature Reviews Materials, Journal Year: 2022, Volume and Issue: 7(7), P. 557 - 574
Published: Feb. 28, 2022
Language: Английский
Citations
331
Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)
Published: Aug. 7, 2023
Cancer remains a highly lethal disease in the world. Currently, either conventional cancer therapies or modern immunotherapies are non-tumor-targeted therapeutic approaches that cannot accurately distinguish malignant cells from healthy ones, giving rise to multiple undesired side effects. Recent advances nanotechnology, accompanied by our growing understanding of biology and nano-bio interactions, have led development series nanocarriers, which aim improve efficacy while reducing off-target toxicity encapsulated anticancer agents through tumor tissue-, cell-, organelle-specific targeting. However, vast majority nanocarriers do not possess hierarchical targeting capability, their indices often compromised poor accumulation, inefficient cellular internalization, inaccurate subcellular localization. This Review outlines current prospective strategies design organelle-targeted nanomedicines, highlights latest progress technologies can dynamically integrate these three different stages static maximize outcomes. Finally, we briefly discuss challenges future opportunities for clinical translation nanomedicines.
Language: Английский
Citations
313
Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 1(1), P. 60 - 78
Published: Jan. 19, 2023
Language: Английский
Citations
294
Journal of Multidisciplinary Healthcare, Journal Year: 2021, Volume and Issue: Volume 14, P. 1711 - 1724
Published: July 1, 2021
Abstract: Nanomedicine is an advanced version of Paul Ehrlich’s “magic bullet†concept. Targeted drug delivery a system specifying the moiety directly into its targeted body area (organ, cellular, and subcellular level specific tissue) to overcome aspecific toxic effect conventional delivery, thereby reducing amount required for therapeutic efficacy. To achieve this objective, magic bullet concept was developed pushed scientists investigate more than century, leading envisioning different nanometer-sized devices — today’s nanomedicine. Different carrier systems are being used investigated, which include colloidal (vesicular multiparticulate) carriers, polymers, cellular/subcellular systems. This review addresses need advantages targeting, with basic principles, strategies, Recent advances, challenges, future perspectives also highlighted. Keywords: nanoparticles, nanosomes
Language: Английский
Citations
261
Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)
Published: May 10, 2022
Artificial intelligence is an advanced method to identify novel anticancer targets and discover drugs from biology networks because the can effectively preserve quantify interaction between components of cell systems underlying human diseases such as cancer. Here, we review discuss how employ artificial approaches drugs. First, describe scope analysis for target investigations. Second, basic principles theory commonly used network-based machine learning-based algorithms. Finally, showcase applications in cancer identification drug discovery. Taken together, models have provided us with a quantitative framework study relationship network characteristics cancer, thereby leading potential discovery candidates.
Language: Английский
Citations
236
Journal of Nanobiotechnology, Journal Year: 2021, Volume and Issue: 19(1)
Published: Aug. 12, 2021
Abstract Exosomes are lipid bilayer membrane vesicles and emerging as competent nanocarriers for drug delivery. The clinical translation of exosomes faces many challenges such massive production, standard isolation, loading, stability quality control. In recent years, artificial based on nanobiotechnology to overcome the limitations natural exosomes. Major types include ‘nanovesicles (NVs)’, ‘exosome-mimetic (EM)’ ‘hybrid (HEs)’, which obtained by top-down, bottom-up biohybrid strategies, respectively. Artificial powerful alternatives Here, we outline advances in through discuss their strengths, future perspectives. development holds great values translational nanomedicine.
Language: Английский
Citations
235
ACS Nano, Journal Year: 2023, Volume and Issue: 17(21), P. 20825 - 20849
Published: Nov. 3, 2023
Understanding the in vivo transport of nanoparticles provides guidelines for designing nanomedicines with higher efficacy and fewer side effects. Among many factors, size plays a key role controlling their behaviors due to existence various physiological thresholds within body size-dependent nano-bio interactions. Encouraged by evolving discoveries nanoparticle-size-dependent biological effects, we believe that it is necessary systematically summarize size-scaling laws nanoparticle vivo. In this review, summarized effect on along journey body: begin administration via different delivery routes, followed targeting intended tissues including tumors other organs, eventually clearance through liver or kidneys. We outlined tools investigating as well. Finally, discussed how may leverage tackle some challenges nanomedicine translation also raised important size-related questions remain be answered future.
Language: Английский
Citations
228
Acta Pharmaceutica Sinica B, Journal Year: 2022, Volume and Issue: 12(7), P. 3028 - 3048
Published: March 1, 2022
Compared with traditional drug therapy, nanomedicines exhibit intriguing biological features to increase therapeutic efficiency, reduce toxicity and achieve targeting delivery. This review provides a snapshot of that have been currently launched or in the clinical trials, which manifests diversified trend carrier types, applied indications mechanisms action. From perspective indications, this article presents an overview applications involving prevention, diagnosis treatment various diseases, include cancer, infections, blood disorders, cardiovascular immuno-associated diseases nervous system etc. Moreover, some considerations perspectives research development facilitate their translations clinic.
Language: Английский
Citations
215
Small, Journal Year: 2022, Volume and Issue: 18(16)
Published: Jan. 27, 2022
Abstract Ultrasmall nanoparticles are often grouped under the broad umbrella term of “nanoparticles” when reported in literature. However, for biomedical applications, their small sizes give them intimate interactions with biological species and endow unique functional physiochemical properties. Carbon quantum dots (CQDs) an emerging class ultrasmall which have demonstrated considerable biocompatibility been employed as potent theragnostic platforms. These particles find application increasing drug solubility targeting, along facilitating passage drugs across impermeable membranes (i.e., blood brain barrier). Further functionality can be triggered by various environmental conditions or external stimuli pH, temperature, near Infrared (NIR) light, ultrasound), intrinsic fluorescence is valuable diagnostic applications. The focus this review to shed light on therapeutic potential CQDs identify how they travel through body, reach site action, administer effect, excreted. Investigation into toxicity compatibility larger nanoparticle carriers also examined. future applications promising due multifunctional attributes documented biocompatibility. As nanomaterial platforms become more commonplace clinical treatments, commercialization CQD therapeutics anticipated.
Language: Английский
Citations
156
Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 185, P. 114238 - 114238
Published: March 31, 2022
Language: Английский
Citations
150