Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113705 - 113705
Published: April 1, 2025
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Aug. 12, 2024
Cancer remains a significant risk to human health. Nanomedicine is new multidisciplinary field that garnering lot of interest and investigation. shows great potential for cancer diagnosis treatment. Specifically engineered nanoparticles can be employed as contrast agents in diagnostics enable high sensitivity high-resolution tumor detection by imaging examinations. Novel approaches labeling are also made possible the use nanoprobes nanobiosensors. The achievement targeted medication delivery therapy accomplished through rational design manufacture nanodrug carriers. Nanoparticles have capability effectively transport medications or gene fragments tissues via passive active targeting processes, thus enhancing treatment outcomes while minimizing harm healthy tissues. Simultaneously, context radiation sensitization photothermal enhance therapeutic efficacy malignant tumors. This review presents literature overview summary how nanotechnology used According oncological diseases originating from different systems body combining pathophysiological features cancers at sites, we most recent developments applications. Finally, briefly discuss prospects challenges cancer.
Language: Английский
Citations
87
Viruses, Journal Year: 2023, Volume and Issue: 15(5), P. 1109 - 1109
Published: May 2, 2023
Virus-like particles (VLPs) have gained a lot of interest within the past two decades. The use VLP-based vaccines to protect against three infectious agents—hepatitis B virus, human papillomavirus, and hepatitis E virus—has been approved; they are very efficacious offer long-lasting immune responses. Besides these, VLPs from other viral agents (that infect humans, animals, plants, bacteria) under development. These VLPs, especially those animal viruses, serve as stand-alone viruses which were derived. Additionally, including derived plant bacterial platforms upon display foreign peptide antigens or metabolic diseases such cancer, i.e., can be used develop chimeric VLPs. goal is enhance immunogenicity peptides displayed on not necessarily platforms. This review provides summary VLP for veterinary that approved Furthermore, this summarizes developed tested in pre-clinical studies. Finally, concludes with snapshot advantages hybrid/mosaic over conventional vaccine approaches live-attenuated inactivated vaccines.
Language: Английский
Citations
57
European Journal of Cancer, Journal Year: 2024, Volume and Issue: 199, P. 113564 - 113564
Published: Jan. 20, 2024
Biliary tract cancers (BTCs) encompass a heterogeneous group of rare tumors, including intrahepatic cholangiocarcinoma (iCCA), extrahepatic (eCCA), gallbladder cancer (GBC) and ampullary (AC). The present first-line palliative treatment regimen comprises gemcitabine cisplatin in combination with immunotherapy based on two randomized controlled studies. Despite the thorough investigation these treatments, long-term survival remains low.Moving beyond conventional chemotherapies immunotherapies, realm precision medicine has demonstrated remarkable efficacy malignancies such as breast gastric cancers, characterized by notable HER2 overexpression rates. In context biliary cancer, significant alterations are observed, particularly within eCCA GBC, heightening interest medicine. Various anti-HER2 therapies, trastuzumab, pertuzumab, trastuzumab-deruxtecan, zanidatamab neratinib, have undergone investigation. objective this review is to summarize current evidence outline future directions targeted therapy patients specially cancer.
Language: Английский
Citations
21
Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)
Published: Oct. 10, 2024
Pancreatic cancer remains one of the most aggressive solid tumors. As a systemic disease, despite improvement multi-modality treatment strategies, prognosis pancreatic was not improved dramatically. For resectable or borderline patients, surgical strategy centered on improving R0 resection rate is consensus; however, role neoadjuvant therapy in patients and optimal chemotherapy with without radiotherapy were debated. Postoperative adjuvant gemcitabine/capecitabine mFOLFIRINOX recommended regardless margin status. Chemotherapy as first-line for advanced metastatic included FOLFIRINOX, gemcitabine/nab-paclitaxel, NALIRIFOX regimens whereas 5-FU plus liposomal irinotecan only standard care second-line therapy. Immunotherapy an innovative although anti-PD-1 antibody currently agent approved by MSI-H, dMMR, TMB-high tumors, which represent very small subset cancers. Combination strategies to increase immunogenicity overcome immunosuppressive tumor microenvironment may sensitize immunotherapy. Targeted therapies represented PARP KRAS inhibitors are also under investigation, showing benefits progression-free survival objective response rate. This review discusses current modalities highlights cancer.
Language: Английский
Citations
17
Exploration, Journal Year: 2024, Volume and Issue: 4(6)
Published: March 28, 2024
Abstract Because therapeutic cancer vaccines can, in theory, eliminate tumor cells specifically with relatively low toxicity, they have long been considered for application repressing progression. Traditional containing a single or few discrete epitopes failed the clinic, possibly due to challenges epitope selection, target downregulation, cell heterogeneity, microenvironment immunosuppression, lack of vaccine immunogenicity. Whole membrane vaccines, which provide rich source antigens, are emerging as viable alternatives. Autologous and allogenic cellular evaluated clinical treatments. Tumor membranes (TCMs) an intriguing antigen source, membrane‐accessible targets and, at same time, serve integrated carriers adjuvants other agents. This review provides summary properties technologies TCM vaccines. Characteristics, categories, mechanisms, preparation methods discussed, demonstrable additional benefits derived from combining chemotherapy, sonodynamic therapy, phototherapy, oncolytic viruses. Further research chemistry, biomedicine, immunology, bioinformatics address current drawbacks could facilitate adoption
Language: Английский
Citations
12
Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(5), P. 3321 - 3338
Published: Feb. 16, 2024
Immunotherapy targeting the toll-like receptor 7 (TLR7) is a promising strategy for cancer treatment. Herein, we describe design and synthesis of series imidazoquinoline-based TLR7 agonists assess NF-κB pathway activation using HEK-Blue hTLR7 cells to identify most potent small-molecule agonist, SMU-L11 (EC50 = 0.024 ± 0.002 μM). In vitro experiments demonstrated that specifically activated TLR7, resulting in recruitment MyD88 adaptor protein MAPK signaling pathways. Moreover, was found exert immune-enhancing effects by significantly inducing secretion proinflammatory cytokines murine dendritic cells, macrophages, human peripheral blood mononuclear while promoting M1 macrophage polarization. vivo studies B16-F10 mouse tumor model showed enhanced immune cell augmented CD4+ T CD8+ T-cell proliferation, directly killing inhibiting growth.
Language: Английский
Citations
8
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Aug. 14, 2024
With the COVID-19 pandemic, importance of vaccines has been widely recognized and led to increased research development efforts. Vaccines also play a crucial role in cancer treatment by activating immune system target destroy cells. However, enhancing efficacy remains challenge. Adjuvants, which enhance response antigens improve vaccine effectiveness, have faced limitations recent years, resulting few novel adjuvants being identified. The advancement artificial intelligence (AI) technology drug provided foundation for adjuvant screening application, leading diversification adjuvants. This article reviews significant tumor basic clinical explores use AI screen from databases. findings this review offer valuable insights new next-generation vaccines.
Language: Английский
Citations
8
ACS Omega, Journal Year: 2025, Volume and Issue: 10(4), P. 4007 - 4018
Published: Jan. 22, 2025
Newcastle disease (ND) causes major economic losses in poultry farming Madagascar and many other countries. Previously, vaccines based on attenuated or inactivated viruses (NDV) have been effective against this disease. However, their efficacy has declined due to viral mutations over time. To address this, two new multi-epitope (MEV) designed using immunoinformatics methods. First, 26 conserved epitopes from the fusion protein 22 hemagglutinin-neuraminidase of 12 NDV strains isolated were selected design MEV. These fused with specific linkers. Additionally, adjuvant Avian Beta-Defensins-1 6xHis tag added N- C-terminal ends vaccine formulations, respectively. The antigenicity, allergenicity, solubility, physicochemical properties MEV evaluated. Their three-dimensional structures also modeled. Molecular docking studies dynamic simulations then conducted chicken Toll-like receptor 7 (TLR7) assess binding affinity receptor. Finally, an immunological simulation was carried out ability candidate induce immune response. Through analysis, both MEVs developed study found be highly antigenic, nonallergenic, physicochemically stable. In addition, they showed significant interaction TLR7 They capacity trigger responses promote formation memory cells following immunization. Therefore, these represent promising candidates for control ND. As is silico methods, vitro vivo experiments are required confirm extend results.
Language: Английский
Citations
1
Food Chemistry, Journal Year: 2024, Volume and Issue: 443, P. 138614 - 138614
Published: Jan. 28, 2024
Studies have shown that high hydrostatic pressure (HHP) processing and chlorogenic acid (CA) treatment can effectively reduce food allergenicity. We hypothesize these novel techniques help tackle crayfish allergy examined the impact mechanism of HHP (300 MPa, 15 min) CA (CA:tropomyosin = 1:4000, on allergenicity tropomyosin. Our results revealed CA, rather than HHP, reduced tropomyosin's allergenicity, as evident in alleviation allergic symptoms a mouse model. Spectroscopy molecular docking analyses demonstrated could tropomyosin by covalent or non-covalent binding, altering its secondary structure (2.1 % decrease α-helix; 1.9 increase β-fold) masking linear epitopes. Moreover, CA-treated potentially induced milder reactions up-regulating TLR8. While our supported efficacy alleviating allergy, further exploration is needed to determine clinical effectiveness.
Language: Английский
Citations
8
Discovery Medicine, Journal Year: 2024, Volume and Issue: 36(180), P. 1 - 1
Published: Jan. 1, 2024
The tumor microenvironment (TME) exerts a profound influence on the oncogenesis and progression of various cancers, notably those instigated by human papillomavirus (HPV) Epstein-Barr virus (EBV). etiology HPV EBV-associated malignancies is rooted in intricate interactions that intertwine viral infections, genetic predispositions, distinct TME dynamics. These foster milieu can either support or hinder tumorigenic progression. Gaining in-depth knowledge TME's unique features, including its cellular composition, cytokine profiles, metabolic alterations specific to fundamental innovating more efficacious therapeutic strategies. This review delineates roles EBV shaping expounds upon characteristics EBV-driven cancers. Additionally, we spotlight innovative approaches remodel TME, aiming augment efficacy combatting neoplasms.
Language: Английский
Citations
7