Delayed gut microbiota maturation in the first year of life is a hallmark of pediatric allergic disease

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Aug. 29, 2023

Allergic diseases affect millions of people worldwide. An increase in their prevalence has been associated with alterations the gut microbiome, i.e., microorganisms and genes within gastrointestinal tract. Maturation infant immune system microbiota occur parallel; thus, conformation microbiome may determine if tolerant programming arises infant. Here we show, using deeply phenotyped participants CHILD birth cohort (n = 1115), that there are early-life influences features which uniformly four distinct allergic diagnoses at 5 years: atopic dermatitis (AD, n 367), asthma (As, 165), food allergy (FA, 136), rhinitis (AR, 187). In a subset shotgun metagenomic metabolomic profiling 589), discover impaired 1-year maturation be universal to pediatric allergies (AD p 0.000014; As 0.0073; FA 0.00083; AR 0.0021). Extending this, find core set functional metabolic imbalances characterized by compromised mucous integrity, elevated oxidative activity, decreased secondary fermentation, trace amines, significant mediator between age 1 year years (βindirect -2.28; 0.0020). Microbiota thus provides focal point identify deviations from normative development predict prevent disease.

Language: Английский

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CCL17/TARC in autoimmunity and inflammation—not just a T‐cell chemokine

Immunology and Cell Biology, Journal Year: 2023, Volume and Issue: 101(7), P. 600 - 609

Published: March 28, 2023

Abstract Chemokine (C–C) ligand 17 (CCL17) was first identified as thymus‐ and activation‐regulated chemokine when it found to be constitutively expressed in the thymus a T‐cell chemokine. This chemoattractant molecule has subsequently been at elevated levels range of autoimmune inflammatory diseases, well cancer. CCL17 is C–C receptor type 4 (CCR4) ligand, with 22 being other major and, CCR4 highly on helper T cells, can play role T‐cell–driven usually considered via its chemotactic activity 2 cells; however, given that also by cell types there expression many broader biology suggested. In this review, we summarize CCL17, regulation potential contribution pathogenesis various preclinical models. Reference made, for example, recent literature indicating control pain part granulocyte macrophage–colony‐stimulating factor/CCL17 pathway lymphocyte‐independent models thus not The review discusses biomarker therapeutic target human disorders.

Language: Английский

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Factors associated with severity of atopic dermatitis – a Finnish cross‐sectional study

Journal of the European Academy of Dermatology and Venereology, Journal Year: 2022, Volume and Issue: 36(11), P. 2130 - 2139

Published: June 29, 2022

Severity-associated factors in atopic dermatitis (AD) have focussed on early onset, concomitant diseases, markers of Th2-shifted inflammation and filaggrin mutations.To investigate associated with severe AD Finnish patients.We conducted a single-centre, cross-sectional observational study 502 patients aged 4.79 to 79.90 years (mean 32.08 years). Disease severity was assessed the Rajka-Langeland score EASI clinical signs were evaluated. Data regarding relatives, other comorbidities gathered retrospectively. We investigated total serum IgE-levels, panel null mutations functional variants genes skin barrier defects.Factors more frequent included onset (P = 0.004, 95%CI 0.000-0.024), male sex 0.002, 0.000-0.11), history smoking 0.012, asthma 0.001, 0.000-0.011), palmar hyperlinearity 0.013, 0.014-0.059), hand 0.020, 0.000-0.029) contact allergy 0.042, 0.037-0.096). Body mass indices < 0.000, 0.000-0.011) IgE-levels higher AD. No differences observed for allergic rhinitis, conjunctivitis, food allergy, peanut prick positivity, keratosis pilaris, herpes simplex infections, gene variants.Severity determinants seem be early-onset, sex, smoking, overweight, asthma, hyperlinearity, high IgE-levels. A sub-typing relation confirmed may useful course prediction, prognosis targeted management.

Language: Английский

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Helicobacter pylori Infection Does Not Protect Against Allergic Diseases: Evidence From a Pediatric Cohort From Northern Sardinia, Italy

Helicobacter, Journal Year: 2024, Volume and Issue: 29(3)

Published: May 1, 2024

The "hygiene hypothesis" states that reduced exposure to microbial antigens due an excessively hygienic environment can increase the risk of developing autoimmune diseases, including atopic disorders and asthma. In recent decades, there has been a progressive decline in prevalence numerous microorganisms following improved hygienic-sanitary conditions. More specifically, several studies reported inverse association between reduction Helicobacter pylori infection rise asthma allergic disorders.

Language: Английский

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Comparative efficacy of biologics for patients with inadequately controlled asthma: A network meta-analysis

World Allergy Organization Journal, Journal Year: 2024, Volume and Issue: 17(7), P. 100934 - 100934

Published: July 1, 2024

Language: Английский

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Multimorbidity in adult patients diagnosed with atopic dermatitis

Dermatology Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Atopic dermatitis (AD) may be associated with other diseases, which could impact the patient's overall health. The aim of this study was to assess comorbidities observed in patients diagnosed AD and psoriasis compared healthy patients. Patients over 18 years old were recruited using medical databases dermatology clinics. Initially, 378 selected via an analysis ICD-10 codes. Ultimately, 231 atopic included group based on their fulfillment Hanifin Rajka criteria. They 104 women 127 men age range 18-62. In AD, lifestyle diseases such as obesity atherosclerosis occurred significantly less frequently than without including those dermatoses. addition, allergic asthma type 2 diabetes more often (p<0.05). some patients, are prevalent, these diabetes.

Language: Английский

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A Single Multiplex CytoBas Assay Incorporating Eight Major Components for Accurate Detection of Allergen Sensitization in Asthma and Allergic Rhinitis

Allergy, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Allergic rhinitis and asthma can be triggered by a variety of aeroallergens, including house dust mites (HDM), tree grass pollen, household pets. Identification the relevant allergen is critical for lifestyle changes treatments, immunotherapy. We here assessed diagnostic performance clinical utility single flow cytometry staining basophils with major aeroallergen components (AeroDiff CytoBas). In 156 atopic patients allergic rhinitis/asthma 21 non-atopic individuals, allergen-specific IgE levels were determined ImmunoCAP, component-specific ELISA. PBMCs analyzed basophil markers eight fluorochrome-conjugated component tetramers. Patients stratified sensitization to each four allergens. Allergen-component in multiplex CytoBas assay serology performed similarly Der p 2, Lol 1, Fel d Can f 1 (ROC AUC: 0.76-0.97 vs. 0.73-0.93). had greater accuracy than (p < 0.001) HDM using or pollen 5 Phl 1. Furthermore, combined evaluation 2 was 96.3% sensitive 90.7% specific sensitization. The achieved 95.4% sensitivity 96.4% specificity ryegrass AeroDiff has similar superior compared singleplex serology, additional advantage evaluate multiple This enables precise efficient component-resolved diagnosis guide personalized treatment and/or asthma.

Language: Английский

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Modelling Asthma Treatment Dynamics: Insights from the g-Formula

Clinical Epidemiology, Journal Year: 2025, Volume and Issue: Volume 17, P. 265 - 276

Published: March 1, 2025

Purpose: The g-formula offers a promising approach to analyze long-term dynamic asthma treatment trajectories. This study investigates whether the can simulate real-world trajectories and predicts subgroup differences in switching behavior. Patients Methods: retrospective cohort identified individuals aged 16- 45 years who initiated inhaled medication Netherlands between 1994 2021, from IADB.nl pharmacy dispensing database. We used combined with logistic regression predict their associations various patient characteristics, such as age, sex, chronic drug for atopic diseases (ATD), cardiovascular (CVD), thyroid diseases, arthritis, diabetes, gastroesophageal reflux disease (GERD), mental health problems (MHP), immunosuppressants. Results: simulations predicted 76% of switch treatment, on average 2.3 times, first occurring after 8.3 months, which agrees observations (77%, times 7.9 respectively). Fewer 45-year-olds switched compared 16-year-olds (74% vs 78%, p < 0.001), but they earlier (8.1 8.6 0.001) more frequently (2.4 0.001). Women were likely men. ATD, CVD, MHP, or GERD significantly less often (p 0.05). Conclusion: effectively simulates found higher male decrease overall These patients might benefit intervention closer monitoring reduce delays progression. Keywords: asthma, medication, steps, trajectories, g-formula, prediction

Language: Английский

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Medication-related perceptions of children and adolescents with severe asthma and moderate-to-severe atopic dermatitis: a non-interventional exploratory study

Allergy Asthma and Clinical Immunology, Journal Year: 2025, Volume and Issue: 21(1)

Published: April 7, 2025

Abstract Background Severe asthma and moderate-to-severe atopic dermatitis can significantly impact the lives of children adolescents. However, real-world data on pediatric patients’ perceptions their medication are limited. Methods This non-interventional cross-sectional study at a university hospital explored perceptions. We included patients aged between 6 17 with severe and/or dermatitis. For treated dupilumab, minimum dupilumab treatment duration 16 weeks was required. conducted one structured interview per patient, based questionnaire consisting open questions ratings 6-point Likert scales (response scale range: “0: not all” to “5: very strongly”). Results The 57 participants (severe asthma: n = 31; dermatitis: 21; both: 5) who reported “rather moderate” burden (median: 2; Q25/Q75: 0.3/2.8) or (3; 1.5/3.5). They experienced current medications as helpful” (asthma: 4; 3/5; 3/5). Twelve (21%) refusing take because reluctance, but all resumed treatment. All receiving therapy ( 16) an improvement in disease within maximum 2.5 months after starting median fear injection decreased from 3 (0/5) before first 0.5 (0/1) time survey. Conclusions In this real-world, interview-based study, we found that perceived highly beneficial for Furthermore, seemed respond well terms both less injection. Trial registration DRKSID DRKS00028092

Language: Английский

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Insomnia Associated With Increased Risk of Atopic Dermatitis: A Two‐Sample Mendelian Randomization Study

Brain and Behavior, Journal Year: 2025, Volume and Issue: 15(5)

Published: May 1, 2025

ABSTRACT Background The causal relationships between sleep traits and allergic diseases remain unclear. This study sought to explore their associations using Mendelian randomization (MR) analysis. Methods utilized summary‐level data from genome‐wide association studies (GWAS) selected genetic variants associated with as instrumental variables (IVs). For the primary analysis, inverse‐variance weighted (IVW) method was utilized. To further evaluate effects, we applied median, mode, MR‐Egger regression. Sensitivity analyses, such linkage disequilibrium score (LDSC) regression, Cochran's Q test, leave‐one‐out MR‐PRESSO, were carried out confirm result robustness. Results IVW analysis revealed that genetically predicted insomnia causally a higher risk of atopic dermatitis (OR = 1.79, 95% CI: 1.17‐2.74, P 0.01), preferring an evening chronotype lower rhinitis (IVW: OR 0.99, 0.99‐1.00, 0.02). LDSC identified significant correlation (r g 0.107, 0.039), but not ‐0.036, 0.339). No connections other diseases. intercept test did indicate pleiotropy, except for asthma. Conclusion Chronotype efficacy sleep‐based interventions in disease management.

Language: Английский

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