Passive immunotherapy for Alzheimer's disease

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 94, P. 102192 - 102192

Published: Jan. 14, 2024

Alzheimer's disease (AD) is the most common neurodegenerative characterized by cognitive impairment with few therapeutic options. Despite many failures in developing AD treatment during past 20 years, significant advances have been achieved passive immunotherapy of very recently. Here, we review characteristics, clinical trial data, and mechanisms action for monoclonal antibodies (mAbs) targeting key players pathogenesis, including amyloid-β (Aβ), tau neuroinflammation modulators. We emphasized efficacy lecanemab donanemab on cognition amyloid clearance patients phase III trials discussed factors that may contribute to side effects anti-Aβ mAbs. In addition, provided important information mAbs or inflammatory regulators trials, indicated against mid-region pathogenic potential AD. conclusion, pathogenesis offers a promising strategy effective treatment.

Language: Английский

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Emerging role of exosomes in cancer therapy: progress and challenges

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 13, 2025

This review highlights recent progress in exosome-based drug delivery for cancer therapy, covering exosome biogenesis, cargo selection mechanisms, and their application across multiple types. As small extracellular vesicles, exosomes exhibit high biocompatibility low immunogenicity, making them ideal vehicles capable of efficiently targeting cells, minimizing off-target damage side effects. aims to explore the potential with a focus on applications chemotherapy, gene immunomodulation. Additionally, challenges related production standardization are analyzed, highlighting importance addressing these issues clinical application. In conclusion, systems offer promising future therapies. Further research should aim enhance efficiency facilitate translation, paving way innovative treatment strategies.

Language: Английский

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Beyond Extracellular Vesicles: Hybrid Membrane Nanovesicles as Emerging Advanced Tools for Biomedical Applications

Advanced Science, Journal Year: 2023, Volume and Issue: 10(32)

Published: Sept. 25, 2023

Extracellular vesicles (EVs), involved in essential physiological and pathological processes of the organism, have emerged as powerful tools for disease treatment owing to their unique natural biological characteristics artificially acquired advantages. However, limited targeting ability, insufficient production yield, low drug-loading capability simplex EVs greatly hindered development clinical translation. Therefore, establishment multifunctional hybrid membrane nanovesicles (HMNVs) with favorable adaptability flexibility has become key expanding practical application EVs. This timely review summarizes current progress HMNVs biomedical applications. Different preparation strategies including physical, chemical, chimera approaches are first discussed. then individually describes diverse types based on homologous or heterologous cell substances, a fusion liposome, well bacterial membrane. Subsequently, specific emphasis is placed highlight applications toward various diseases representative examples. Finally, ongoing challenges prospects currently developed translational briefly presented. will not only stimulate broad interest among researchers from disciplines but also provide valuable insights promising nanoplatforms precision medicine.

Language: Английский

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Cell membrane-camouflaged bufalin targets NOD2 and overcomes multidrug resistance in pancreatic cancer

Drug Resistance Updates, Journal Year: 2023, Volume and Issue: 71, P. 101005 - 101005

Published: Aug. 21, 2023

Multidrug resistance in pancreatic cancer poses a significant challenge clinical treatment. Bufalin (BA), compound found secretions from the glands of toads, may help overcome this problem. However, severe cardiotoxicity thus far has hindered its application. Hence, present study aimed to develop cell membrane-camouflaged and BA-loaded polylactic-co-glycolic acid nanoparticle (CBAP) assess potential counter chemoresistance cancer.The toxicity CBAP was evaluated by electrocardiogram, body weight, distress score, nesting behavior mice. In addition, anticarcinoma activity underlying mechanism were investigated both vitro vivo.CBAP significantly mitigated BA-mediated acute enhanced sensitivity several drugs, such as gemcitabine, 5-fluorouracil, FOLFIRINOX. Mechanistically, directly bound nucleotide-binding oligomerization domain containing protein 2 (NOD2) inhibited expression nuclear factor kappa-light-chain-enhancer activated B cells. This inhibits ATP-binding cassette transporters, which are responsible for cells.Our findings indicate that NOD2. Combining with standard-of-care chemotherapeutics represents safe efficient strategy treatment cancer.

Language: Английский

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Rosacea Topical Treatment and Care: From Traditional to New Drug Delivery Systems

Molecular Pharmaceutics, Journal Year: 2023, Volume and Issue: 20(8), P. 3804 - 3828

Published: July 21, 2023

Rosacea is a multifactorial chronic inflammatory dermatosis characterized by flushing, nontransient erythema, papules and pustules, telangiectasia, phymatous alterations accompanied itching, burning, or stinging, the pathophysiology of which not yet fully understood. Conventional topical treatments usually show limited efficacy due to physical barrier property skin that hinders penetration active ingredients, thereby hampering proper drug delivery respective therapeutic cosmetic effects. New advances regarding physiopathological understanding disease underlying mechanisms suggest potential new ingredients as promising approaches this dermatosis. Additionally, development systems for delivery, particularly nanoparticles treatment care rosacea, has been described. Emphasis placed on their reduced nanometric size, contributes significant improvement in attainment targeted delivery. In addition exposition known pathophysiology, epidemiology, diagnosis, preventive measures, Review covers used control including care, cosmetics, therapies, well future perspectives these strategies.

Language: Английский

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Exosomal mediators in sepsis and inflammatory organ injury: unraveling the role of exosomes in intercellular crosstalk and organ dysfunction

Military Medical Research, Journal Year: 2024, Volume and Issue: 11(1)

Published: April 22, 2024

Abstract Sepsis, a severe systemic inflammatory response to infection, remains leading cause of morbidity and mortality worldwide. Exosomes, as mediators intercellular communication, play pivotal role in the pathogenesis sepsis through modulating immune responses, metabolic reprogramming, coagulopathy, organ dysfunction. This review highlights emerging significance exosomes these processes. Initially, it provides an in-depth insight into exosome biogenesis characterization, laying groundwork for understanding their diverse intricate functions. Subsequently, explores regulatory roles various cells such neutrophils, macrophages, dendritic cells, T B cells. analysis elucidates how are thus contributing complexity pathophysiology. Additionally, this delves regulation metabolism subsequent dysfunction sepsis. It also establishes connection between coagulation cascade, which affects endothelial integrity promotes thrombogenesis Moreover, discusses dual progression resolution sepsis, exploring complex involvement inflammation healing Furthermore, underscores potential biomarkers therapeutic targets. Understanding mechanisms presents new opportunities novel interventions mitigate outcomes emphasizing promise research critical care settings.

Language: Английский

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Inspired by nature: Bioinspired and biomimetic photocatalysts for biomedical applications

Nano Materials Science, Journal Year: 2024, Volume and Issue: unknown

Published: March 1, 2024

The field of photocatalysis has witnessed a significant advancement in the development bioinspired and biomimetic photocatalysts for various biomedical applications, including drug delivery, tissue engineering, cancer therapy, bioimaging. Nature evolved efficient light-harvesting systems energy conversion mechanisms, which serve as benchmark researchers. However, reproducing such complexity harnessing it applications is daunting task. It requires comprehensive understanding underlying biological processes ability to replicate them synthetically. By utilizing light energy, these can trigger specific chemical reactions, leading targeted release, enhanced regeneration, precise imaging structures. In this context, addressing stability, long-term performance, scalability, cost-effectiveness materials crucial their widespread implementation applications. While challenges stability persist, advantages delivery personalized medicine make fascinating area research. purpose review provide analysis evaluation existing research, highlighting advancements, current challenges, advantages, limitations, future prospects biomedicine.

Language: Английский

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Nanoparticle-Facilitated Therapy: Advancing Tools in Peripheral Nerve Regeneration

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 19 - 34

Published: Jan. 1, 2024

Abstract: Peripheral nerve injuries, arising from a diverse range of etiologies such as trauma and underlying medical conditions, pose substantial challenges in both clinical management subsequent restoration functional capacity. Addressing these challenges, nanoparticles have emerged promising therapeutic modality poised to augment the process peripheral regeneration. However, comprehensive elucidation complicated mechanistic foundations responsible for favorable effects nanoparticle-based therapy on regeneration remains imperative. This review aims scrutinize potential innovative carriers promoting repair. encompasses an in-depth exploration classifications synthesis methodologies associated with nanoparticles. Additionally, we discuss summarize multifaceted roles that play, including neuroprotection, facilitation axonal growth, efficient drug delivery mechanisms. Furthermore, present essential considerations highlight synergies integrating emerging technologies. Through this review, indispensable role propelling advancements Keywords: nanoparticle, nanomedicine, biomaterials, regeneration, tissue

Language: Английский

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Opportunities and challenges of engineered exosomes for diabetic wound healing

Giant, Journal Year: 2024, Volume and Issue: 18, P. 100251 - 100251

Published: March 6, 2024

The treatment of diabetic wounds is a major challenge faced by the medical system, and there growing interest in developing innovative therapies to accelerate wound healing. Regenerative medicine with cells has shown promising potential skin repair, regenerative properties primarily attributed paracrine effects secreted products, including exosomes. Compared cell-based approaches, using exosomes as cell-free therapy for chronic several advantages. Exosomes can regulate intercellular communication releasing their contents, mRNA, miRNA, lipids, proteins, which further promote are well explored biomedical application owing advantages such biocompatibility low immunogenicity. However, common method exosome administration through injection, but due rapid clearance rate body, maintaining necessary therapeutic concentration around challenging. Therefore, it develop new biocompatible scaffold carrier extracellular vesicles, allowing them sustain at non-healing sites continuously Engineered kinds modified internal treated molecules, surface decoration or delivered engineered platform. In addition, some researchers have processed exosomes, known decoration, delivery platforms. regular greater promoting this review, we summarize molecular mechanisms from different sources varying modifications Advantages limitations repair were also discussed. Finally, highlight challenges future development directions translating our knowledge into clinical practice.

Language: Английский

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Biomembrane‐coated nanosystems as next‐generation delivery systems for the treatment of gastrointestinal cancers

Bioengineering & Translational Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Abstract Gastrointestinal cancers, a major global cause of cancer‐related mortality and disease burden, are heterogeneous group malignant aliments involving different organs the digestive system. The late clinical diagnosis, genomic tumor heterogeneity, high complexity gastrointestinal microenvironment, along with increasing treatment resistance have been recognized as main contributing factors to current inadequacy interventions poor prognosis cancer patients. In coming years, is unfortunately predicted increase due absence early detection effective therapeutic options. Biomembrane‐coated biomimetic nanoparticles (NPs) recently appointed advanced nanotechnological tools for management cancers. These comprise not only cell‐mimicking nanodevices (the pioneers this top‐down coating technology), but also exosome bacterial mimetics. Due their enhanced bio‐interfacing features, biocompatibility, immune evasion, specific targetability tumorous tissues, these nanostructures successfully exploited provide safer, effective, targeted applications. This review highlights latest research on biomembrane‐coated nanosystems therapy diagnosis most common deadliest subtypes namely colorectal cancer, gastric liver esophageal pancreatic cancer. challenges toward translation mentioned.

Language: Английский

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