Published: Jan. 1, 2024
Language: Английский
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Sept. 27, 2024
Language: Английский
Citations
4
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: April 11, 2025
Ischemia-reperfusion injury refers to the damage that occurs when blood supply is restored organs or tissues after a period of ischemia. This phenomenon commonly observed in clinical contexts such as organ transplantation and cardiac arrest resuscitation. Among these, hepatic ischemia-reperfusion prevalent complication liver transplantation, significantly impacting functional recovery transplanted potentially leading primary graft dysfunction. With growing demand for transplants limited availability donor organs, effectively addressing essential enhancing success rates, minimizing complications, improving survival. The pathogenesis multifaceted, involving factors oxidative stress inflammatory responses. article focuses on role protein post-translational modifications injury, including phosphorylation, ubiquitination, acetylation, ADP-ribosylation, SUMOylation, crotonylation, palmitoylation, S-nitrosylation. Initially, we examined historical discovery these subsequently investigated their impact cellular signal transduction, enzymatic activity, stability, protein-protein interactions. emphasis this study pivotal progression potential therapeutic targets. aims conduct comprehensive analysis recent advancements research investigate underlying molecular mechanisms, explore future trajectories. Additionally, directions are proposed, exploration interactions between various modifications, identification specific modification sites, development drugs targeting modifications. These efforts aim deepen our understanding pave way innovative interventions.
Language: Английский
Citations
0
Journal of Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: April 12, 2025
Language: Английский
Citations
0
Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 908 - 908
Published: July 25, 2024
Post-translational modifications (PTMs) influence protein functionality by modulating stability, localization, and interactions with other molecules, thereby controlling various cellular processes. Common PTMs include phosphorylation, acetylation, ubiquitination, glycosylation, SUMOylation, methylation, sulfation, nitrosylation. Among these modifications, O-GlcNAcylation has been shown to play a critical role in cancer development progression, especially hepatocellular carcinoma (HCC). This review outlines the of progression HCC. Moreover, we delve into underlying mechanisms HCC highlight compounds that target O-GlcNAc transferase (OGT) O-GlcNAcase (OGA) improve treatment outcomes. Understanding will offer insights potential therapeutic strategies targeting OGT OGA, which could for patients
Language: Английский
Citations
3
Journal of the American Heart Association, Journal Year: 2025, Volume and Issue: unknown
Published: March 26, 2025
Background Genome‐wide association studies have revealed numerous loci associated with coronary artery disease (CAD). However, some potential causal/risk genes remain unidentified, and causal therapies are lacking. Methods Results We integrated multi‐omics data from gene methylation, expression, protein levels using summary data‐based Mendelian randomization colocalization analysis. Candidate were prioritized based on protein‐level associations, probability, links to methylation expression. Single‐cell RNA sequencing used assess differential expression in the arteries of patients CAD. TAGLN2 ( Transgelin 2 ), APOB Apolipoprotein B GIP Glucose‐dependent insulinotropic polypeptide ) identified as most strongly CAD, exhibiting significant association. Higher at specific Cytosine‐phosphate‐Guanine sites negatively correlated its a lower risk whereas higher circulating positively CAD (odds ratio,1.66 [95% CI, 1.32–2.08). These results suggest distinct regulatory mechanisms for . In contrast, showed positive associations risk, DHX58 DExH‐box helicase 58 SWAP70 Switch‐associated 70 decreased risk. Conclusions Our findings provide evidence suggesting that , This work provides novel insights into molecular highlights integrating uncover relationships cannot be fully captured by traditional genome‐wide studies.
Language: Английский
Citations
0
Published: Jan. 1, 2024
Language: Английский
Citations
0