Journal of Tissue Engineering,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 1, 2024
Neuropathic
pain
(NP)
is
a
debilitating
condition
stemming
from
damage
to
the
somatosensory
system
frequently
caused
by
nerve
injuries
or
lesions.
While
existing
treatments
are
widely
employed,
they
often
lead
side
effects
and
lack
specificity.
This
study
aimed
alleviate
NP
developing
an
innovative
sustained-release
thermosensitive
hydrogel
system.
The
incorporates
hyaluronic
acid
(HA)/Pluronic
F127
injectable
bupivacaine
(Bup,
B)
in
combination
with
poly(lactic-co-glycolic
acid;
PLGA)/modified
magnesium
hydroxide
(MH)/luteolin
(Lut;
PML)
microspheres
(PML@B/Gel).
PML@B/Gel
was
designed
for
localized
prolonged
co-delivery
of
Bup
Lut
as
anesthetic
anti-inflammatory
agent,
respectively.
Our
studies
demonstrated
that
had
exceptional
biocompatibility,
anti-inflammatory,
antioxidant
properties.
In
addition,
it
exhibited
efficient
relief
vitro
cellular
assays.
Moreover,
this
functional
showed
substantial
sustained
drug
release
while
diminishing
microglial
activation.
Consequently,
effectively
mitigated
mechanical
allodynia
thermal
hyperalgesia
vivo
rat
models
chronic
constriction
injury
(CCI).
Based
on
our
research
findings,
emerges
promising
therapeutic
approach
protracted
treatment
NP.
Sustainability,
Journal Year:
2024,
Volume and Issue:
16(2), P. 857 - 857
Published: Jan. 19, 2024
The
modification
of
cellulose
woven
fabrics
and
viscose
nonwovens
was
carried
out
with
the
aim
preparing
sustainable
coatings
from
biodegradable
natural
polymers.
polymers
represents
an
ecological
alternative
to
other
textile
modifications,
such
as
sol-gel
process.
Coatings
were
prepared
erythritol,
gelatin,
collagen
in
various
formulations
addition
propolis
alginate
fibers
a
plasticizer
(glycerin).
morphology
materials
determined
before
after
Dino-Lite.
Moreover,
pH
value,
drop
test
method,
angle
recovery
angle,
thickness,
mass
per
unit
area
monitored
modification.
results
have
shown
that
modifications
had
no
significant
effect
on
thickness
or
area.
In
contrast,
larger
proportion,
they
show
hydrophilic
properties,
which
favor
their
application
for
medical
purposes—for
example;
absorption
exudates
wound
dressings;
etc.
addition,
due
neutral
slightly
alkaline
values
modified
samples,
can
be
suitable
external
skin.
samples
proved
did
not
tend
crease
retained
elasticity
very
pleasant
feel
(fabric
hand),
making
them
even
more
everyday
applications.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(40), P. 10163 - 10197
Published: Jan. 1, 2024
Diabetic
wounds
pose
a
significant
challenge
in
healthcare
due
to
impaired
healing
and
increased
risk
of
complications.
In
recent
years,
various
drug
delivery
systems
with
stimuli-responsive
features
have
been
developed
address
these
issues.
These
enable
precise
dosage
control
tailored
release,
promoting
comprehensive
tissue
repair
regeneration.
This
review
explores
targeted
therapeutic
agents,
such
as
carboxymethyl
chitosan-alginate
hydrogel
formulations,
nanofiber
mats,
core-shell
nanostructures,
for
diabetic
wound
healing.
Additionally,
the
integration
nanotechnology
multifunctional
biomimetic
scaffolds
shows
promise
enhancing
outcomes.
Future
research
should
focus
on
optimizing
design,
materials,
printing
parameters
3D-bio-printed
dressings,
well
exploring
combined
strategies
involving
simultaneous
release
antibiotics
nitric
oxide
improved
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(3), P. 857 - 857
Published: March 6, 2023
Hydrogel-based
dressings
exhibit
suitable
features
for
successful
wound
healing,
including
flexibility,
high
water-vapor
permeability
and
moisture
retention,
exudate
absorption
capacity.
Moreover,
enriching
the
hydrogel
matrix
with
additional
therapeutic
components
has
potential
to
generate
synergistic
results.
Thus,
present
study
centered
on
diabetic
healing
using
a
Matrigel-enriched
alginate
embedded
polylactic
acid
(PLA)
microspheres
containing
hydrogen
peroxide
(H2O2).
The
synthesis
physicochemical
characterization
of
samples,
performed
evidence
their
compositional
microstructural
features,
swelling,
oxygen-entrapping
capacity,
were
reported.
For
investigating
three-fold
goal
designed
(i.e.,
releasing
oxygen
at
site
maintaining
moist
environment
faster
ensuring
significant
amount
exudate,
providing
biocompatibility),
in
vivo
biological
tests
wounds
mice
approached.
Evaluating
multiple
aspects
during
process,
obtained
composite
material
proved
its
efficiency
dressing
applications
by
accelerating
promoting
angiogenesis
skin
injuries.
Biomaterials Research,
Journal Year:
2023,
Volume and Issue:
27(1)
Published: Feb. 9, 2023
The
secretomes
of
mesenchymal
stem
cells
(MSCs)
have
great
therapeutic
potential
and
thereby
their
efficient
delivery
into
the
target
site
is
particular
interest.
Here,
we
propose
a
new
strategy
hMSCs-derived
for
advanced
wound
healing
upon
harnessing
working
principle
extracellular
matrix
(ECM)-growth
factors
interaction
in
vivo.
We
prepared
an
alginate
hydrogel
based
patch,
where
it
contains
both
human
MSC-derived
ECM.
ECM
was
obtained
from
decellularization
vitro
cultured
lung
fibroblasts.
solution
blended
with
suspension,
crosslinked,
air-dried,
then
rehydrated
contained
concentrated
conditioned
media
(CCM)
as
highly
saturated
form
(CM).
tested
four
different
groups,
or
without
to
investigate
not
only
role
but
effect
secretomes.
reserved
many,
diverse
bioactive
factors,
such
VEGF,
HGF,
IGFBPs,
IL-6,
IL-8.
Alginate/ECM/CCM
(AEC)
patch
could
hold
significantly
larger
amount
release
them
longer
than
other
groups.
Our
AEC
most
effective
stimulating
cell
migration
proliferation
collagen
synthesis
dermal
fibroblasts
vitro.
Moreover,
patch-treated
full-thickness
skin
wounds
disclosed
better
indications:
recruitment,
neovascularization,
epidermis
thickness,
keratinocyte
migration,
mature
deposition,
assessed
via
histology
(H&E,
Herovici
staining)
immunofluorescence,
respectively.
In
particular,
our
enabled
phenotype
shift
myofibroblast
fibroblast
over
time
led
blood
vessel
formation
at
14
day.
believe
that
certainly
contributed
generate
secretomes-enriched
milieu
ECM-secretomes
interactions
be
delivered
more
efficiently,
exerting
significant
impact
either
individually
collectively
during
process.
Wound Repair and Regeneration,
Journal Year:
2023,
Volume and Issue:
31(3), P. 367 - 383
Published: March 3, 2023
Abstract
Mesenchymal
stem/stromal
cells
(MSCs)
are
a
heterogenous
population
of
multipotent
and
highly
secretory
currently
being
investigated
in
the
field
wound
healing
for
their
ability
to
augment
tissue
responses.
The
adaptive
response
MSC
populations
rigid
substrate
current
2D
culture
systems
has
been
considered
result
deterioration
regenerative
‘stem‐like’
properties.
In
this
study,
we
characterise
how
improved
adipose‐derived
mesenchymal
stem
(ASCs)
within
tissue‐mimetic
3D
hydrogel
system,
that
is
mechanically
similar
native
adipose
tissue,
enhances
capabilities.
Notably,
system
contains
porous
microarchitecture
permits
mass
transport,
enabling
efficient
collection
secreted
cellular
compounds.
By
utilising
ASCs
retained
significantly
higher
expression
ASC
markers
while
demonstrating
significant
reduction
senescent
populations,
relative
2D.
Additionally,
resulted
enhanced
activity
with
increases
secretion
proteinaceous
factors,
antioxidants
extracellular
vesicles
(EVs)
conditioned
media
(CM)
fraction.
Lastly,
treatment
cells,
keratinocytes
(KCs)
fibroblasts
(FBs),
ASC‐CM
from
augmented
functional
activity,
increasing
KC
FB
metabolic,
proliferative
migratory
activity.
This
study
demonstrates
potential
beneficial
role
more
closely
mimics
mechanics,
subsequently
phenotype
augments
capabilities
secretome.
Gels,
Journal Year:
2024,
Volume and Issue:
10(2), P. 152 - 152
Published: Feb. 19, 2024
Immediate
burn
wound
care
is
a
critical
factor
influencing
the
outcomes
of
treatment.
In
this
study,
we
developed
spray-type
alginate
hydrogel
dressing
that
promotes
healing,
reduces
pain,
and
increases
convenience
use
in
treatment
emergency.
We
investigated
efficiency
newly
on
healing
process.
efficacy
for
30
Sprague
Dawley
rats.
Four
deep,
round
second-degree
wounds
(diameter,
1.5
cm)
were
created
bilaterally
dorsum
rat’s
trunk;
rats
divided
into
four
groups,
which
different
materials
applied
as
follows:
group
A,
gauze
(control);
B,
Mepilex™
C,
2.25%
hydrogel;
D,
2.5%
hydrogel.
The
gross
findings
each
compared
by
tracing
remaining
performing
visual
histological
observations
biochemical
analysis
proteins
associated
with
at
time
period.
wounds,
groups
C
D
showed
significantly
higher
contraction,
epithelialization,
rates.
Histologically,
an
improved
arrangement
collagen
fibers
thick
epithelial
layer
14
days
after
initial
formation.
Group
CD31,
TGF-β,
fibronectin
expression
Western
blot
analyses
day
14.
This
study
suggests
effective
material
care.
Journal of Functional Biomaterials,
Journal Year:
2025,
Volume and Issue:
16(1), P. 20 - 20
Published: Jan. 10, 2025
In
recent
years,
several
studies
have
focused
on
the
development
of
sustainable,
biocompatible,
and
biodegradable
films
with
potential
applications
in
wound
healing
dressing
systems.
Natural
macromolecules,
particularly
proteins,
emerged
as
attractive
alternatives
to
synthetic
polymers
due
their
biocompatibility,
biodegradability,
low
immunogenicity,
adaptability.
Among
these
keratin,
extracted
from
waste
wool,
fibroin,
derived
Bombyx
mori
cocoons,
exhibit
exceptional
properties
such
mechanical
strength,
cell
adhesion
capabilities,
suitability
for
various
fabrication
methods.
These
proteins
can
also
be
functionalized
antimicrobial,
antioxidant,
anti-inflammatory
compounds,
making
them
highly
versatile
biomedical
applications.
This
review
highlights
promising
keratin-
fibroin-based
innovative
platforms
healing,
emphasizing
advantages
prospects
they
offer
creating
next-generation
devices.
