A deformable SIS/HA composite hydrogel coaxial scaffold promotes alveolar bone regeneration after tooth extraction

Bioactive Materials, Journal Year: 2024, Volume and Issue: 46, P. 97 - 117

Published: Dec. 10, 2024

Language: Английский

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Comparison of Autogenous Tooth Graft With Polylactic Co-Glycolic Acid In Post-Extraction Socket For Alveolar Ridge Preservation:A Randomized Control Trial

Journal of Oral and Maxillofacial Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Buccal application of microneedles coated with an optimized hydrogel containing naproxen and dexamethasone

Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Language: Английский

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Evaluation and comparison of autologous particulate dentin with demineralized freeze dried bone allograft in ridge preservation procedures – a prospective clinical study

Clinical Oral Investigations, Journal Year: 2024, Volume and Issue: 28(9)

Published: Aug. 21, 2024

Language: Английский

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Mimicking Osteoid 3D Porous Dense Microfiber Silk Fibroin Embedded Poly(vinyl alcohol) Scaffold for Alveolar Ridge Preservation

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 12

Published: Nov. 13, 2024

Abstract Alveolar ridge loss presents difficulties for implant placement and stability. To address this, alveolar preservation (ARP) is required to maintain bone avoid the need augmentation using socket grafting. In this study, a scaffold ARP was created by fabricating 3D porous dense microfiber silk fibroin (mSF) embedded in poly(vinyl alcohol) (PVA), which mimics osteoid template. The research utilized freeze–thawing technique create mimicked incorporating different amounts of mSF into PVA, namely, 1%, 3%, 5% 7%. Subsequently, profilometer machine scanning electron microscope were employed examine morphology size all groups. Thermal characteristics crystalline structure analyzed before assessing water contact angle, swelling behavior, degradation mechanical properties. experiment evaluated biological performance examining efficacy osteoblast cell adhesion, proliferation, viability, protein synthesis, alkaline phosphatase (ALP) activity calcium synthesis. Finally, ability cells regulate matrix deposition on assessed mimicking dynamic environment rat mesenchymal stem cells. findings suggest that PVA enhances interconnective pore size, thermal behavior scaffold. hydrophilicity decreased with an increase proportion mSF, while higher resulted increased characteristics. Incorporating greater specifically 7%, led reduced rate degradation. addition remarkable properties excellent osteoconductive activity.

Language: Английский

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Challenges and Innovations in Alveolar Bone Regeneration: A Narrative Review on Materials, Techniques, Clinical Outcomes, and Future Directions

Medicina, Journal Year: 2024, Volume and Issue: 61(1), P. 20 - 20

Published: Dec. 27, 2024

This review explores the recent advancements and ongoing challenges in regenerating alveolar bone, which is essential for dental implants periodontal health. It examines traditional techniques like guided bone regeneration grafting, alongside newer methods such as stem cell therapy, gene 3D bioprinting. Each approach considered its strengths supporting growth integration, especially cases where complex defects make difficult. also looks at different biomaterials, from bioactive scaffolds to nanomaterials, assessing how well they encourage healing. Personalized treatments, customized 3D-printed scaffolds, show promise enhancing formation tissue compatibility. Additionally, signaling molecules, morphogenetic proteins, play a crucial role guiding process of remodeling. Despite these advances, remain-particularly with severe loss refining biomaterials more reliable, long-term outcomes. proposes combining advanced materials, regenerative technologies, personalized approaches achieve effective consistent outcomes oral maxillofacial surgery.

Language: Английский

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Evaluation and comparison of autologous particulate dentin with demineralized freeze dried bone allograft in ridge preservation procedures – A prospective clinical study

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 25, 2024

Objectives To compare the effectiveness of Autologous Particulate Dentin (APD) with Demineralized Freeze-Dried Bone Allograft (DFDBA) in ridge preservation, using radiographic and clinical parameters. Materials Methods Thirty subjects indication mandibular posterior teeth extraction were randomly assigned to either a test or control group. After atraumatic extraction, preservation was performed APD mixed i-PRF group DFDBA Both groups had sockets sealed an A-PRF membrane. Clinical parameters (plaque index, gingival healing index) (vertical height, horizontal width) assessed at baseline 6 months CBCT. Results The exhibited lesser reduction dimensions compared (p < 0.001). showed significant decrease from There no statistical difference between > Conclusions grafts resulted improvements parameters, specifically vertical height width, Relevance particulate dentin is promising, versatile substitute for regenerative procedures. While more research on its long-term efficacy application needed, current evidence suggests it could significantly improve patient care outcomes.

Language: Английский

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Soft Tissue Augmentation After Tooth Extraction Improves Implant Health: Findings From a Clinical Trial

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 6, 2024

Background Soft tissue augmentation is a critical procedure in dental implantology aimed at improving peri-implant health and aesthetics. Various materials are used for this purpose, but their comparative effectiveness remains under-researched. This study to evaluate the effects of soft utilizing two different after tooth extraction on clinical radiographic outcomes. Methodology A randomized controlled trial was conducted with 30 participants requiring non-restorable mandibular posterior teeth. Participants were randomly assigned receive connective graft (CTG), Fibro-gide (FG), or spontaneous healing (SH) 1:1:1 allocation ratio. Two months post-treatment, implants placed. Six functional loading implant, assessed using Plaque Accumulation Index, bleeding probing (BOP), pocket depth, mucosal recession, marginal bone level. Results At six-month follow-up, SH group exhibited significantly higher Index BOP percentages (6.43 ± 1.23 70%, respectively) compared CTG (0.40 0.32 8.3%, FG (0.45 0.44 9.7%, respectively). The mean depth also control (5.13 0.64 mm), while groups showed minimal changes (3.83 0.39 mm both groups). Additionally, gingival recession (0.65 0.18 mm) (0.03 0.08 Radiographic analysis revealed greater loss 0.05 groups, which demonstrated (0.17 0.20 0.00 mm, Conclusions findings indicate that as effective maintaining health, outperforming SH. These suggest can be viable alternative extraction, offering new option clinicians management sites before implant placement.

Language: Английский

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Alveolar bone healing patterns in chronic kidney failure and kidney transplant recipients: A pixel intensity and fractal analyses

Special Care in Dentistry, Journal Year: 2024, Volume and Issue: 45(1)

Published: Sept. 25, 2024

Abstract Aims To assess and compare radiographically the alveolar bone after tooth extractions in individuals with chronic kidney failure undergoing hemodialysis (CKFh), those submitted to transplantation (KT), without disease (CG) by using fractal analysis (FA) pixel intensity (PI). Methods results Periapical radiographs of 48 CKFh (87 extracted teeth), 12 KT (26 teeth 29 control [76 teeth] were analyzed at 7 60 days extraction. Fractal dimension (FD) PI assessed evaluate trabecular structural complexity mineral content. The difference FD values between 7th 60th postoperative (0.03 ± 0.08) was significantly lower compared (0.09 0.10) controls (0.15 0.06). As for values, (4.55 10.24) groups (9.88 15.90) showed group (17.93 11.86) same period. These indicate a gain density alveolus other groups. Conclusions Overall content thickness plane x‐ray beam controls, reflecting need careful consideration recommending rehabilitation dental implants these patients. Particular attention should be given potential challenges oral

Language: Английский

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Stem Cell-Laden Engineered Patch: Advances and Applications in Tissue Regeneration

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

Stem cell-based therapies are emerging as significant approaches in tissue engineering and regenerative medicine, applicable to both fundamental scientific research clinical practice. Despite remarkable results studies, challenges such poor standardization of graft tissues, limited sources, reduced functionality have hindered the effectiveness these therapies. In this review, we summarize involved fabricating stem cell assisted patches substantial strategies for designing cell-laden engineered (SCP) complement existing We then outline potential applications SCP advancing regeneration medicine. By combining living cells with patches, can enhance functions components, particularly applications. Finally, addressed current challenges, ethical considerations, high costs, regulatory hurdles proposed future directions overcome barriers.

Language: Английский

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