A potential interaction between the SARS-CoV-2 spike protein and nicotinic acetylcholine receptors

Biophysical Journal, Journal Year: 2021, Volume and Issue: 120(6), P. 983 - 993

Published: Feb. 18, 2021

Language: Английский

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Is the heart rate variability monitoring using the analgesia nociception index a predictor of illness severity and mortality in critically ill patients with COVID-19? A pilot study

PLoS ONE, Journal Year: 2021, Volume and Issue: 16(3), P. e0249128 - e0249128

Published: March 24, 2021

The analysis of heart rate variability (HRV) has proven to be an important tool for the management autonomous nerve system in both surgical and critically ill patients. We conducted this study show different spectral frequency time domain parameters HRV as a prospective predictor patients, particular COVID-19 patients who are on mechanical ventilation. hypothesis is that most severely have depletion sympathetic nervous predominance parasympathetic activity reflecting remaining compensatory anti-inflammatory response.A single-center, prospective, observational pilot which included admitted Surgical Intensive Care Unit was conducted. normalized high-frequency component (HFnu), i.e. ANIm, standard deviation RR intervals (SDNN), Energy, were recorded using analgesia nociception index monitor (ANI). To estimate severity mortality we used SOFA score date discharge or death.A total fourteen finally study. ANIm higher non-survivor group (p = 0.003) correlated with IL-6 levels 0.020). Energy inversely 0.039) fewer survival days 0.046). A limit value at 80 predicted mortalities sensitivity 100% specificity 85.7%. In case 0.41 ms all predictive values 71.4%.A low autonomic activity, SDNN system, HFnu due associated worse prognosis, mortality, levels.

Language: Английский

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Orthostatic Intolerance in Adults Reporting Long COVID Symptoms Was Not Associated With Postural Orthostatic Tachycardia Syndrome

Frontiers in Physiology, Journal Year: 2022, Volume and Issue: 13

Published: March 4, 2022

In this observational cross-sectional study, we investigated predictors of orthostatic intolerance (OI) in adults reporting long COVID symptoms. Participants underwent a 3-min active stand (AS) with Finapres ® NOVA, followed by 10-min unmedicated 70° head-up tilt test. Eighty-five participants were included (mean age 46 years, range 25–78; 74% women), which 56 (66%) reported OI during AS (OI ). seemed associated female sex, more fatigue and depressive symptoms, greater inability to perform activities daily living (ADL), as well higher heart rate (HR) at the lowest systolic blood pressure (SBP) point before first minute post-stand HR nadir : 88 vs. 75 bpm, P = 0.004). regression model also including age, fatigue, depression, ADL inability, peak after SBP, was only predictor (OR 1.09, 95% CI: 1.01–1.18, 0.027). Twenty-two (26%) had initial (iOH) 5 (6%) classical (cOH ) hypotension, but neither correlated . Seventy-one proceeded tilt, 28 (39%) Of 53 who 7 (13%) an increase >30 bpm without cOH (2 > 120 bpm), six did not report conclusion, on AS, 1 min equalised non-OI group. Despite these differences, POTS infrequent (2%). ClinicalTrials.gov Identifier: NCT05027724 (retrospectively registered August 30, 2021).

Language: Английский

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Neural dysregulation in post-COVID fatigue

Brain Communications, Journal Year: 2023, Volume and Issue: 5(3)

Published: Jan. 1, 2023

Abstract Following infection with SARS-CoV-2, a substantial minority of people develop lingering after-effects known as ‘long COVID’. Fatigue is common complaint impact on daily life, but the neural mechanisms behind post-COVID fatigue remain unclear. We recruited 37 volunteers self-reported after mild COVID and carried out battery behavioural neurophysiological tests assessing central, peripheral autonomic nervous systems. In comparison age- sex-matched without (n = 52), we show underactivity in specific cortical circuits, dysregulation function myopathic change skeletal muscle. Cluster analysis revealed no subgroupings, suggesting single entity individual variation, rather than small number distinct syndromes. Based our analysis, were also able to exclude sensory feedback circuits descending neuromodulatory control. These abnormalities objective may aid development novel approaches for disease monitoring.

Language: Английский

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Coagulopathies after Vaccination against SARS-CoV-2 May Be Derived from a Combined Effect of SARS-CoV-2 Spike Protein and Adenovirus Vector-Triggered Signaling Pathways

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(19), P. 10791 - 10791

Published: Oct. 6, 2021

Novel coronavirus SARS-CoV-2 has resulted in a global pandemic with worldwide 6-digit infection rates and thousands of death tolls daily. Enormous efforts are undertaken to achieve high coverage immunization reach herd immunity order stop the spread infection. Several vaccines based on mRNA, viral vectors, or inactivated virus have been approved being applied worldwide. However, recent increased numbers normally very rare types thromboses associated thrombocytopenia reported, particularly context adenoviral vector vaccine ChAdOx1 nCoV-19 from Astra Zeneca. The statistical prevalence these side effects seems correlate this particular type, i.e., vector-based vaccines, but exact molecular mechanisms still not clear. present review summarizes current data hypotheses for cellular into one integrated hypothesis indicating that coagulopathies, including thromboses, thrombocytopenia, other related effects, correlated an interplay two components vaccine, spike antigen vector, innate immune systems, which under certain circumstances can imitate picture limited COVID-19 pathological picture.

Language: Английский

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Is the post-COVID-19 syndrome a severe impairment of acetylcholine-orchestrated neuromodulation that responds to nicotine administration?

Bioelectronic Medicine, Journal Year: 2023, Volume and Issue: 9(1)

Published: Jan. 18, 2023

Following a SARS-CoV-2 infection, many individuals suffer from post-COVID-19 syndrome. It makes them unable to proceed with common everyday activities due weakness, memory lapses, pain, dyspnea and other unspecific physical complaints. Several investigators could demonstrate that the related spike glycoprotein (SGP) attaches not only ACE-2 receptors but also shows DNA sections highly affine nicotinic acetylcholine (nAChRs). The nAChR is principal structure of cholinergic neuromodulation responsible for coordinated neuronal network interaction. Non-intrinsic viral attachment compromises integrative interneuronal communication substantially. This explains cognitive, neuromuscular mood impairment, as well vegetative symptoms, characterizing agonist ligand nicotine an up 30-fold higher affinity nACHRs than (ACh). We therefore hypothesize this molecule displace virus pave way unimpaired signal transmission. Treating several suffering syndrome patch application, we witnessed improvements ranging immediate substantial complete remission in matter days.

Language: Английский

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Correction: Is the heart rate variability monitoring using the analgesia nociception index a predictor of illness severity and mortality in critically ill patients with COVID-19? A pilot study

PLoS ONE, Journal Year: 2021, Volume and Issue: 16(5), P. e0252259 - e0252259

Published: May 20, 2021

There is an error in the Conclusion subsection of Abstract.The correct sentence is: A low autonomic nervous system activity, i.e. SDNN or Energy, and a predominance parasympathetic system, high HFnu ANIm, due to sympathetic depletion COVID-19 patients are associated with worse prognosis, higher mortality, IL-6 levels.

Language: Английский

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The impact of long COVID on heart rate variability: a cross-sectional study

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 24, 2025

Long-term COVID-19 (LC), which may affect the autonomic nervous system (ANS), is term for symptoms that some patients had an additional month after contracting virus. Therefore, during LC phase, ANS status was evaluated in with mild-to-moderate using heart rate variability (HRV), a measurement of function. A cross-sectional research 173 participants - both positive and negative – conducted. Based on self-reports, were classified as to whether they or not. 5-minute ECG recorder data detection response report used measure ANS. There notable age differences across groups (p = 0.034). Patients under 25 years lower HRV categorized very-low-frequency (VLF) domain 0.012). Compared group without LC, higher number people aberrant neuroactivity 0.048). Mild-to-moderate young middle develop dysfunction one infection.

Language: Английский

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Long-term impact of COVID-19 on cardiac and pulmonary autonomic function in hypertensive individuals

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Objective Long-term impact of COVID-19 on cardiac and pulmonary autonomic function in patients with systemic arterial hypertension (SAH) was evaluated a cross-sectional study 52 individuals. Methods Participants were allocated to two groups based history. They underwent heart rate variability the 24-hour Holter, lung assessed by spirometry functional capacity (CF) cardiopulmonary exercise test. Results Was revealed worsened COVID-19-recovered SAH patients, indicated lower forced expiratory volume first second (FEV1) rates [2.3 (1.9–2.6) vs. 2.5 (2.2–3.0), p < 0.05)] FEV1/[81.8 (77.5–83.9) vs. 84.6 (80.8–87.7) 0.05)], 30% showing restrictive disorder. However, no significant differences found control. A positive moderate association between VO_2peak FEV1 noted (r = 0.50 0.05), 0V% index negative =-0,55 0.05). Conclusion Findings suggest mild may not cause long-term HRV changes. there is worsening function, presence mainly disorder cases.

Language: Английский

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A Translational Perspective of Maternal Immune Activation by SARS-CoV-2 on the Potential Prenatal Origin of Neurodevelopmental Disorders: The Role of the Cholinergic Anti-inflammatory Pathway

Frontiers in Psychology, Journal Year: 2021, Volume and Issue: 12

Published: March 31, 2021

The emergent Coronavirus Disease 2019 (COVID-19) caused by the Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) could produce a maternal immune activation (MIA) via inflammatory response during gestation that may impair fetal neurodevelopment and lead to postnatal adulthood mental illness behavioral dysfunctions. However, so far, limited evidence exists regarding long-term physiological, immunological, neurodevelopmental modifications produced SARS-CoV-2 in human maternal-fetal binomial and, particularly, offspring. Relevant findings derived from epidemiological preclinical models show MIA is indeed linked an increased risk of disorders We hypothesize gestational infection triggered increases risks leading newborn, which can affect childhood quality life. In particular, disruption either or cholinergic anti-inflammatory pathway (CAP) cause exacerbate severity COVID-19 binomial. From translational perspective, this paper, we discuss possible manifestation subsequent considering role fetal-maternal cytokine cross-talk CAP. Specifically, highlight urgent need studies as well multicenter international databanks psychophysiological data obtained pre-, during, post-infection pregnant women their

Language: Английский

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