Auricular Neuromodulation for Mass Vagus Nerve Stimulation: Insights From SOS COVID-19 a Multicentric, Randomized, Controlled, Double-Blind French Pilot Study DOI Creative Commons
Claire-Marie Rangon,

Régine Barruet,

Abdelmadjid Mazouni

et al.

Frontiers in Physiology, Journal Year: 2021, Volume and Issue: 12

Published: Aug. 2, 2021

Importance: An exacerbated inflammatory response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is believed be one of the major causes morbidity and mortality disease 2019 (COVID-19). Neuromodulation therapy, based on vagus nerve stimulation, was recently hypothesized control both SARS-CoV-2 replication ensuing inflammation likely through inhibition nuclear factor kappa-light-chain-enhancer activated B cells pathway could improve clinical outcomes as an adjunct treatment. We proposed test it by stimulation auricular branch nerve, i.e., neuromodulation (AN), a non-invasive procedure insertion semipermanent needles ears. Objective: The aim this study assess effect AN in patients affected COVID-19. Design, Setting, Participants: A multicenter, randomized, placebo-controlled, double-blind trial included 31 with failure due COVID-19 requiring hospitalization. Within 72 h after admission, received either ( n = 14) or sham (SN, 15) addition conventional treatments. Main Outcome Measures: primary endpoint rate benefit conferred at Day 14 (D14) assessed 7-point Clinical Progression Scale. secondary impact transfer intensive care unit (ICU) survival D14. Results: well-tolerated without any reported side effects but no significant improvement for measures p > 0.3) 0.05) endpoints interim analysis. None AN-treated died SN group did (81 years). Two (73 79 years, respectively) SN-treated patient (59 years) were transferred ICU. Remarkably, older more representation males than arm (i.e., median age 75 vs. 65 79% male 47%). Conclusion: procedure, which used within admission COVID-19, safe successfully implemented during first two waves France. Nevertheless, not significantly outcome our small preliminary study. It pertinent explore further validate mass vagal solution forthcoming pandemics. Trial Registration: [ https://clinicaltrials.gov/ ], identifier [NCT04341415].

Language: Английский

Heart rate variability and cardiac autonomic functions in post-COVID period DOI Open Access
Lale Dinç Asarcıklı, Mert İlker Hayıroğlu, Altuğ Ösken

et al.

Journal of Interventional Cardiac Electrophysiology, Journal Year: 2022, Volume and Issue: 63(3), P. 715 - 721

Published: Feb. 1, 2022

Language: Английский

Citations

100
Heart-rate-variability (HRV), predicts outcomes in COVID-19 DOI Creative Commons

Maartje B. A. Mol,

Maud T. A. Strous, Frits van Osch

et al.

PLoS ONE, Journal Year: 2021, Volume and Issue: 16(10), P. e0258841 - e0258841

Published: Oct. 28, 2021

Patients with COVID-19 present a variety of clinical manifestations, ranging from mild or asymptomatic disease to severe illness and death. Whilst previous studies have clarified these several other aspects COVID-19, one the ongoing challenges regarding is determine which patients are at risk adverse outcomes infection. It hypothesized that this result insufficient inhibition immune response, vagus nerve being an important neuro-immuno-modulator inflammation. Vagus activity can be non-invasively indexed by heart-rate-variability (HRV). Therefore, we aimed assess prognostic value HRV, as surrogate marker for activity, in predicting mortality intensive care unit (ICU) referral, hospitalized COVID-19.A retrospective cohort study including all consecutive (n = 271) diagnosed between March 2020 May 2020, without history cardiac arrhythmias (including atrial ventricular premature contractions), pacemaker, current bradycardia (heart rate <50 bpm) tachycardia >110 bpm). HRV was based on 10s ECG recorded admission. 3-week survival ICU referral were examined.HRV standard deviation normal heartbeat intervals (SDNN) predicted (H.R. 0.53 95%CI: 0.31-0.92). This protective role observed only aged 70 years older, not younger patients. below median also within first week hospitalization (H.R 0.51, 0.29-0.90, P 0.021).Higher predicts greater chances survival, especially older independent major factors. Low indication admission after hospitalization.

Language: Английский

Citations

104
Heart rate variability as a marker of cardiovascular dysautonomia in post-COVID-19 syndrome using artificial intelligence DOI Creative Commons
Bhushan Shah, Shekhar Kunal, Ankit Bansal

et al.

Indian Pacing and Electrophysiology Journal, Journal Year: 2022, Volume and Issue: 22(2), P. 70 - 76

Published: Jan. 30, 2022

Cardiovascular dysautonomia comprising postural orthostatic tachycardia syndrome (POTS) and hypotension (OH) is one of the presentations in COVID-19 recovered subjects. We aim to determine prevalence cardiovascular post patients evaluate an Artificial Intelligence (AI) model identify time domain heart rate variability (HRV) measures most suitable for short term ECG these subjects.This observational study enrolled 92 recently subjects who underwent measurement blood pressure response standing up from supine position a 12-lead recording 60 s period during paced breathing. Using feature extraction, features including those HRV (RMSSD SDNN) were obtained. An AI was constructed with ShAP interpretability representing state. In addition, 120 healthy volunteers as controls.Cardiovascular present 15.21% (OH:13.04%; POTS:2.17%). Patients OH had significantly lower higher inflammatory markers. (RMSSD) compared controls (13.9 ± 11.8 ms vs 19.9 19.5 ms; P = 0.01) inverse correlation between Multiple perceptron best performing HRV(RMSSD) being top distinguishing controls.Present showed that common controls. The able distinguish

Language: Английский

Citations

70
Autonomic Dysfunction during Acute SARS-CoV-2 Infection: A Systematic Review DOI Open Access
Irene Scala, Pier Andrea Rizzo, Simone Bellavia

et al.

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(13), P. 3883 - 3883

Published: July 4, 2022

Although autonomic dysfunction (AD) after the recovery from Coronavirus disease 2019 (COVID-19) has been thoroughly described, few data are available regarding involvement of nervous system (ANS) during acute phase SARS-CoV-2 infection. The primary aim this review was to summarize current knowledge AD occurring COVID-19. Secondarily, we aimed clarify prognostic value ANS and role parameters in predicting According PRISMA guidelines, performed a systematic across Scopus PubMed databases, resulting 1585 records. records check analysis included reports’ references allowed us include 22 articles. studies were widely heterogeneous for study population, dysautonomia assessment, COVID-19 severity. Heart rate variability tool most frequently chosen analyze parameters, followed by automated pupillometry. Most found COVID-19, often related worse outcome. Further needed evidence emerging suggests that complex imbalance is prominent feature leading poor prognosis.

Language: Английский

Citations

33
Heart rate variability comparison between young males after 4–6 weeks from the end of SARS-CoV-2 infection and controls DOI Creative Commons
Mateusz Soliński, Agnieszka Pawlak, Monika Petelczyc

et al.

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: May 25, 2022

Due to the prolonged inflammatory process induced by infection of novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), indices autonomic nervous system dysfunction may persist long after viral shedding. Previous studies showed significant changes in HRV parameters (including fatal) SARS-CoV-2. However, few have comprehensively examined individuals who previously presented as asymptomatic or mildly symptomatic cases COVID-19. In this study, we 5-7 weeks following positive confirmation SARS-CoV-2 infection. Sixty-five ECG Holter recordings from young (mean age 22.6 ± 3.4 years), physically fit male subjects 4-6 second negative test (considered be start recovery) and twenty-six control 23.2 2.9 years) were considered study. Night-time RR time series extracted signals. Selected linear well nonlinear calculated. We found differences Porta's symbolic analysis V0 V2 (p < 0.001), α2 very low-frequency component (VLF; p = 0.022) peak (from PRSA method; 0.012). These caused activity parasympathetic coupling rhythm with heart rate due an increase pulmonary arterial vascular resistance. The results suggest that group parameters, reflect functional state system, are measurable a beginning recovery even post-COVID group-a active population. indicate sensitive markers which used long-term monitoring patients recovery.

Language: Английский

Citations

29
Impact of long COVID on the heart rate variability at rest and during deep breathing maneuver DOI Creative Commons
Andréa Lúcia Gonçalves da Silva, Luana dos Passos Vieira,

Luiza Scheffer Dias

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Dec. 20, 2023

Abstract While the majority of individuals with coronavirus disease 2019 (COVID-19) recover completely, a significant percentage experience persistent symptom, which has been characterized as Long COVID and may be associated cardiac autonomic dysfunction. We evaluated heart rate variability (HRV) at rest during deep-breathing (M-RSA) in patients COVID. Case–control design involved 21 20 controls; HRV was (POLAR system) supine position M-RSA expressed time domain non-linear analysis. In we found reduction measures COVID’ compared to controls for: Mean_iRR ( p < 0.001), STD_iRR 0.001); STD_HR SD1 SD2 alpha2 0.001). rMSSD RR_tri-index 0.001) except for highest Mean_HR 0.001. conclusion, reduced deep breathing. These findings imply impairment control when symptoms COVID-19 persist following initial recovery.

Language: Английский

Citations

21
Analgesia nociception index and high frequency variability index: promising indicators of relative parasympathetic tone DOI Open Access
Keisuke Yoshida, Shinju Obara, Satoki Inoue

et al.

Journal of Anesthesia, Journal Year: 2022, Volume and Issue: 37(1), P. 130 - 137

Published: Oct. 22, 2022

Language: Английский

Citations

26
Heart rate variability is reduced in COVID‐19 survivors and associated with physical activity and fatigue DOI Creative Commons
Michael H. Haischer,

Lauren E. Opielinski,

Lindsey M. Mirkes

et al.

Physiological Reports, Journal Year: 2024, Volume and Issue: 12(2)

Published: Jan. 1, 2024

Abstract Reduced heart rate variability (HRV) and fatigue are common after COVID‐19 infection both potentially influenced by physical activity (PA). We compared resting HRV, PA from accelerometers questionnaires, self‐reported in 41 survivors (~8 months postinfection, 38 ± 17 years) with matched controls. Differences HRV were observed on acceleration capacity ( p = 0.041), deceleration 0.032), high‐frequency peak frequency 0.019), absolute low‐frequency power 0.042), relative very 0.012), SD2 (from Poincare plot; 0.047), DFA2 (slope of long‐term detrended fluctuation analysis; 0.004). Fatigue was greater < 0.001) no differences PA. Moderate‐vigorous (MVPA) (Standardized Beta −0.427, 0.003) steps per day −0.402, 0.007) associated controlling for age, sex, body fat percentage. correlated to less MVPA (Spearman's rho 0.342, 0.031) fewer (rho 0.329, 0.038) survivors, indirectly linked through these mediators (Estimate −0.20; 0.040). present a model showing the complex relations between PA, that provides foundation strategies improve outcomes rehabilitation infection.

Language: Английский

Citations

6
Endothelial function, arterial stiffness and heart rate variability of patients with cardiovascular diseases hospitalized due to COVID-19 DOI
Cláudia Regina da Silva Araújo, Juliana Fernandes, Débora Sidrônio Caetano

et al.

Heart & Lung, Journal Year: 2023, Volume and Issue: 58, P. 210 - 216

Published: Jan. 2, 2023

Language: Английский

Citations

13
The Impact of SARS-CoV-2 Infection on Heart Rate Variability: A Systematic Review of Observational Studies with Control Groups DOI Open Access
Chan‐Young Kwon

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(2), P. 909 - 909

Published: Jan. 4, 2023

Autonomic nervous system (ANS) dysfunction can arise after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and heart rate variability (HRV) tests assess its integrity. This review investigated the relationship between impact of SARS-CoV-2 on HRV parameters. Comprehensive searches were conducted in four electronic databases. Observational studies with a control group reporting direct parameters July 2022 included. A total 17 observational included this review. The square root mean squared differences successive NN intervals (RMSSD) was most frequently investigated. Some found that decreases RMSSD high frequency (HF) power associated or poor prognosis COVID-19. Also, increases normalized unit HF related to death critically ill COVID-19 patients. findings showed infection, severity COVID-19, are likely be reflected some HRV-related However, considerable heterogeneity highlighted. methodological quality not optimal. suggest rigorous accurate measurements highly needed topic.

Language: Английский

Citations

11