Roseburia hominis improves host metabolism in diet-induced obesity

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 20, 2025

Next-generation live biotherapeutics are promising to aid the treatment of obesity and metabolic diseases. Here, we reported a novel anti-obesity probiotic candidate, Roseburia hominis, that was depleted in stool samples obese subjects compared with lean controls, its abundance negatively correlated body mass index serum triglycerides. Supplementation R. hominis prevented weight gain disorders glucose lipid metabolism, fatty liver, inhibited white adipose tissue expansion brown whitening mice fed high-fat diet, boosted lean-related species. The effects could be partially attributed production nicotinamide riboside upregulation Sirtuin1/mTOR signaling pathway. These results indicated is candidate for development next-generation prevention

Language: Английский

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The NLRP3 inflammasome regulates adipose tissue metabolism

Biochemical Journal, Journal Year: 2020, Volume and Issue: 477(6), P. 1089 - 1107

Published: March 23, 2020

Adipose tissue regulates metabolic homeostasis by participating in endocrine and immune responses addition to storing releasing lipids from adipocytes. Obesity skews adipose adipokine degrades the coordination of adipocyte lipogenesis lipolysis. These defects metabolism can promote ectopic lipid deposition inflammation insulin-sensitive tissues such as skeletal muscle liver. Sustained caloric excess expand white a point maladaptation exacerbating both local systemic inflammation. Multiple sources, instigators propagators occur during obesity. Cross-talk between professional cells (i.e. macrophages) adipocytes) stress metaflammation). Metabolic endogenous danger signals engage pathogen recognition receptors (PRRs) innate system thereby activating pro-inflammatory pathways tissue. The Nod-like receptor protein 3 (NLRP3) inflammasome act sensor wide range pathogen- damage-associated molecular patterns (PAMPs DAMPs). Activation NLRP3 facilitates caspase-1 dependent production cytokines IL-1β IL-18. pyroptotic cell death, but is also involved adipogenesis. This review discusses role immunometabolism relevant disease. Understanding potential sources activation consequences effectors may reveal therapeutic opportunities break or fine-tune connection

Language: Английский

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Maize extract rich in ferulic acid and anthocyanins prevents high-fat-induced obesity in mice by modulating SIRT1, AMPK and IL-6 associated metabolic and inflammatory pathways

The Journal of Nutritional Biochemistry, Journal Year: 2020, Volume and Issue: 79, P. 108343 - 108343

Published: Jan. 10, 2020

Language: Английский

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The Role of Autophagy in White Adipose Tissue Function: Implications for Metabolic Health

Metabolites, Journal Year: 2020, Volume and Issue: 10(5), P. 179 - 179

Published: April 30, 2020

White adipose tissue (WAT) is a highly adaptive endocrine organ that continuously remodels in response to nutritional cues. WAT expands store excess energy by increasing adipocyte number and/or size. Failure expansion has serious consequences on metabolic health resulting altered lipid, glucose, and inflammatory profiles. Besides an impaired adipogenesis, fibrosis low-grade inflammation also characterize dysfunctional WAT. Nevertheless, the precise mechanisms leading expansibility are yet unresolved. Autophagy conserved essential process for cellular homeostasis, which constitutively allows recycling of damaged or long-lived proteins organelles, but induced under stress conditions provide nutrients remove pathogens. By modulating protein organelle content, autophagy cell remodeling, maintenance, survival. In this line, been involved many processes affected during maladaptation, including adipocyte, macrophage function, response, fibrosis. dysregulation related obesity diabetes. However, it remains unclear whether alteration obese diabetic patients cause consequence malfunction. review, current data regarding these issues discussed, focusing evidence from human studies.

Language: Английский

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Adipose Tissue Immunomodulation: A Novel Therapeutic Approach in Cardiovascular and Metabolic Diseases

Frontiers in Cardiovascular Medicine, Journal Year: 2020, Volume and Issue: 7

Published: Nov. 17, 2020

Adipose tissue is a critical regulator of systemic metabolism and bodily homeostasis as it secretes myriad adipokines, including inflammatory anti-inflammatory cytokines. As the main storage pool lipids, subcutaneous visceral adipose tissues undergo marked hypertrophy hyperplasia in response to nutritional excess leading hypoxia, adipokine dysregulation subsequent low-grade inflammation that characterized by increased infiltration activation innate adaptive immune cells. The specific localization, physiology, susceptibility heterogeneity cell population each depot are unique thus dictate possible complications chronic inflammation. Several lines evidence link particularly perivascular, pericardial perirenal development metabolic syndrome, insulin resistance, type 2 diabetes cardiovascular diseases. In addition implication system regulation function, components pivotal detrimental or otherwise favorable remodeling thermogenesis. resident infiltrating cells morphological adaptation based on energy status better comprehension address this review, we discuss role across various physiological pathophysiological states pertain progression diseases associated with disorders. Understanding such mechanisms allows for exploitation tissue-immune crosstalk, exploring how might be targeted strategy treat derangements dysfunctions.

Language: Английский

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