Gut-Resident Lactobacilli Activate Hepatic Nrf2 and Protect Against Oxidative Liver Injury

Cell Metabolism, Journal Year: 2020, Volume and Issue: 31(5), P. 956 - 968.e5

Published: March 25, 2020

Language: Английский

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The Role of Gut Microbiota in Atherosclerosis and Hypertension

Frontiers in Pharmacology, Journal Year: 2018, Volume and Issue: 9

Published: Sept. 25, 2018

In recent years, accumulating evidence has indicated the importance of gut microbiota in maintaining human health. Gut dysbiosis is associated with pathogenesis a number metabolic diseases including obesity, type 2 diabetes mellitus (T2DM), nonalcoholic fatty liver disease (NAFLD) and cardiovascular (CVD). Indeed, CVD become leading cause death worldwide, especially developed countries. this review, we mainly discuss microbiota-involved mechanisms focusing on atherosclerosis hypertension, two major risk factors for serious CVD. Then, briefly prospects microbiota-targeted therapeutic strategies treatment future.

Language: Английский

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Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet–fed mice

Science Translational Medicine, Journal Year: 2016, Volume and Issue: 8(357)

Published: Sept. 21, 2016

Inhibition of the ileal bile acid transporter treats multiple features nonalcoholic steatohepatitis in high-fat diet–fed mice.

Language: Английский

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Understanding the Role of the Gut Microbiome and Microbial Metabolites in Non-Alcoholic Fatty Liver Disease: Current Evidence and Perspectives

Biomolecules, Journal Year: 2021, Volume and Issue: 12(1), P. 56 - 56

Published: Dec. 31, 2021

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic worldwide. NAFLD begins as a relatively benign hepatic steatosis which can evolve to non-alcoholic steatohepatitis (NASH); risk of cirrhosis and hepatocellular carcinoma (HCC) increases when fibrosis present. represents complex process implicating numerous factors—genetic, metabolic, dietary—intertwined in multi-hit etiopathogenetic model. Recent data have highlighted role gut dysbiosis, may render bowel more permeable, leading increased free acid absorption, bacterial migration, parallel release toxic products, lipopolysaccharide (LPS), proinflammatory cytokines that initiate sustain inflammation. Although dysbiosis present each stage, there currently no single microbial signature distinguish or predict patients will from NASH HCC. Using 16S rRNA sequencing, majority with NAFLD/NASH exhibit numbers Bacteroidetes differences presence Firmicutes, resulting decreased F/B ratio studies. They also an proportion species belonging Clostridium, Anaerobacter, Streptococcus, Escherichia, Lactobacillus, whereas Oscillibacter, Flavonifaractor, Odoribacter, Alistipes spp. are less prominent. In comparison healthy controls, show higher abundance Proteobacteria, Enterobacteriaceae, Escherichia spp., while Faecalibacterium prausnitzii Akkermansia muciniphila diminished. Children Oscillospira accompanied by elevated Dorea, Blautia, Prevotella copri, Ruminococcus Gut microbiota composition vary between population groups different stages NAFLD, making any conclusive causative claims about profiles challenging. Moreover, various metabolites be involved pathogenesis such short-chain acids, lipopolysaccharide, bile choline trimethylamine-N-oxide, ammonia. this review, we summarize microbiome pathogenesis, discuss potential preventive therapeutic interventions related microbiome, administration probiotics, prebiotics, synbiotics, antibiotics, bacteriophages, well contribution bariatric surgery fecal transplantation armamentarium against NAFLD. Larger longer-term prospective studies, including well-defined cohorts multi-omics approach, required better identify associations metabolites, occurrence progression.

Language: Английский

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Animal models to study bile acid metabolism

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2018, Volume and Issue: 1865(5), P. 895 - 911

Published: May 18, 2018

Language: Английский

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