Tackling Non–Small Cell Lung Cancer in Young Adults: From Risk Factors and Genetic Susceptibility to Lung Cancer Profile and Outcomes

American Society of Clinical Oncology Educational Book, Journal Year: 2024, Volume and Issue: 44(3)

Published: May 24, 2024

Lung cancer has traditionally been associated with advanced age; however, its increasing incidence among young adults raises concerning questions regarding etiology and unique considerations for this population. In contrast to the older population, onset of lung at younger age may be attributed a complex interplay incompletely understood individual susceptibility prevalent environmental risk factors beyond tobacco smoke exposure, such as radon gas air pollution, which are widespread globally. Consequently, leads distinct clinical molecular profiles, requiring tailored approach. Furthermore, diagnosis represents threatening event during prime years person's life, prompting concern about career development, social aspects, fertility aspirations, physical independence. This poses significant additional challenges health care professionals in field that remains underexplored. comprehensive review recognizes entity, exploring characteristics, diverse predisposing factors, priorities terms quality aim providing practical support oncologists enhancing our understanding under-researched

Language: Английский

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Sexual health and emotional wellbeing of patients with haematological malignancies: general review

The Lancet Haematology, Journal Year: 2024, Volume and Issue: 11(10), P. e770 - e779

Published: Sept. 20, 2024

Language: Английский

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Survivorship Considerations and Management in the Adolescent and Young Adult Sarcoma Population: A Review

Current Oncology, Journal Year: 2025, Volume and Issue: 32(4), P. 214 - 214

Published: April 3, 2025

Soft tissue sarcoma (STS) has an 2–8% incidence for all malignant tumors in the adolescent and young adult (AYA) population, which are patients from ages 15 to 39. As most STS aggressive, they require multimodal management with surgery, radiation chemotherapy. This article discusses survivorship considerations this population of cancer who complete therapy. The lasting side effects include surgical radiation-related morbidity, chemotherapy toxicity, early late secondary on other organ systems, such as cardiac endocrine dysfunction, development cancers. long-term psychologic practical impacts those have received a diagnosis prime their life fertility, mental health, relationship, education career implications. Although there is paucity data some these areas, we present existing guidelines available. serves comprehensive review wide array treatment intended providers participating care AYA survivors, oncologists, primary therapists.

Language: Английский

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Effect of nursing application of emotion freedom technique on perceived stress, resilience and sexual satisfaction among women after mastectomy

BMC Nursing, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 15, 2025

Abstract Background A breast cancer diagnosis extends beyond physical health concerns, profoundly impacting a woman’s psychological well-being, resilience and sexual satisfaction. Mastectomy intensifies these challenges, potentially affecting overall quality of life long-term well-being. Understanding the interrelationships between perceived stress, satisfaction is crucial for designing targeted interventions that effectively support mastectomized women. This study evaluates effectiveness Emotional Freedom Technique in mitigating enhancing improving well-being post-mastectomy. Methods quasi-experimental pretest-posttest design was employed with convenient sample 112 Egyptian women who had undergone mastectomy. Participants were recruited from Outpatient Oncology Clinic at Beni-Suef University Hospital. Data collected over six months (January–June 2024) analyzed using SPSS version 26.0. The intervention consisted structured EFT sessions delivered weeks. Paired t-tests assessed pre- post-intervention differences, while Pearson Spearman correlation analyses examined relationships variables to accommodate different data distributions. Results Post-intervention assessments revealed statistically significant improvements. Perceived stress scores decreased 32.42 ± 1.70 17.27 2.96 (t = 49.130, p < 0.001, Cohen’s d 3.2), increased 11.53 1.67 31.46 5.48 36.454, 2.8) improved 17.03 1.55 31.00 4.31 13.245, 2.5). Strong negative correlations found both ( r -0.692, 0.001) -0.835, 0.001), strongly positively correlated 0.890, 0.001). Conclusion cost-effective, non-invasive significantly reduces enhances improves To optimize clinical integration, healthcare institutions should develop training programs nurses, incorporating theoretical foundations, hands-on practice competency assessments. Standardized protocols be established guide implementation post-mastectomy care. Further research explore effects broader applicability across diverse settings. Clinical trial number NCT06583629 on 4/9/2024.

Language: Английский

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An internet-delivered psychoeducational intervention (Fex-Can 2.0) targeting fertility-related distress and sexual dysfunction in young adults diagnosed with cancer: Study protocol of a randomized controlled trial with an internal pilot phase

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0322368 - e0322368

Published: April 29, 2025

Background While previous literature has continuously demonstrated the negative effects of cancer and its treatment on fertility sexuality, evidence-based interventions to alleviate fertility-related distress sexual dysfunction are lacking. This study protocol describes internal pilot randomized controlled trial an internet-delivered psychoeducational intervention: Fex-Can 2.0. The primary objective is determine efficacy 2.0 in terms reduction at end 12-week intervention. will assess feasibility study, determined according pre-specified progression criteria individual interviews. Methods a design, with phase. intervention group receive 2.0, consisting psychoeducational- behavior change content. control be allocated standard care. Primary outcomes (RCAC) function satisfaction (PROMIS SexFS Brief Sexual Profile). Secondary include body image (BIS), emotional (HADS), health-related quality life (EORTC QLQ-C30), need frustration scale (NSFS), fertility- sex-related knowledge, self-efficacy related sex life. Outcomes assessed baseline, directly after intervention, 12 weeks later. During pilot, data recruitment, collection, drop out, adherence collected feasibility. Semi-structured interviews conducted further acceptability Conclusions aims evaluate whether superior care, reducing young adults diagnosed cancer. If proven efficacious, may valuable resource health potential significantly improve care experiencing and/or following Trial registration ClinicalTrials.gov ISRCTN18040643

Language: Английский

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Sexual quality of life of adolescents and young adult breast cancer survivors

ESMO Open, Journal Year: 2024, Volume and Issue: 9(2), P. 102234 - 102234

Published: Jan. 27, 2024

Background

With increasing survival rates of adolescents and young adults (AYAs) with breast cancer, health-related quality life (HRQoL) becomes more important. An important aspect HRQoL is sexual QoL. This study examined long-term QoL AYA cancer survivors, compared scores that other identified factors associated survivors.

Materials methods

Data the SURVAYA were utilized for secondary analyses. Sexual was assessed using European Organization Research Treatment Cancer Quality Life survivorship core questionnaire (EORTC QLQ-SURV100). Descriptive statistics used to describe Linear regression models constructed examine effect type on identify

Results

Of 4010 944 had cancer. Mean survivors ranged from 34.5 60.0 functional domains 25.2 41.5 symptom-orientated domains. reported significantly lower types all Age, time since diagnosis, relationship status, educational level, chemotherapy, hormonal therapy, surgery, body image, coping

Conclusions

experience decreased in long term (5-20 years) after diagnosis worse score types, indicating a clear need invest supportive care interventions those at risk, enhance well-being.

Language: Английский

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Prevalence and Impact of Sexual Complaints on Depressive Symptoms in Adolescents and Young Adults with Cancer: A Cross-Sectional Sub-Study

Journal of Adolescent and Young Adult Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Purpose: Adolescents and young adults (AYAs) diagnosed with cancer face unique psychosocial challenges, including sexual complaints. Despite the prevalence of these issues, they are underexplored in AYA oncology care. The aim this study is firstly to examine complaints among AYAs across genders, age groups, types cancer. Second, we explore association between depressive symptoms. Methods: This cross-sectional sub-study included 305 (aged 15-39 at diagnosis) actively affiliated department Copenhagen University Hospital-Rigshospitalet. Participants completed questionnaires assessing Sexual problems, distress, satisfaction, willingness discuss issues were analyzed alongside demographic, clinical, treatment data. Univariate multivariable regression analyses evaluated associations Results: problems affected 63.9% AYAs, 49.5% experienced 58.4% dissatisfied their lives. Younger reported higher satisfaction than older AYAs. dissatisfaction, reluctance associated increased symptoms univariate analysis. In model, distress remained independently symptoms, diagnosis, civil status, type, pain. Conclusion: complaints, particularly prevalent significantly Integrating routine discussions about health into care could probably improve mental outcomes overall quality life for vulnerable group. Future research should focus on targeted interventions address interconnected challenges.

Language: Английский

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Adapting an Adolescent and Young Adult Program Housed in a Quaternary Cancer Centre to a Regional Cancer Centre: Creating Equitable Access to Developmentally Tailored Support

Current Oncology, Journal Year: 2024, Volume and Issue: 31(3), P. 1266 - 1277

Published: Feb. 27, 2024

Adolescents and young adults (AYAs) with cancer, representing those between 15 39 years of age, face distinctive challenges balancing their life stage the physical, emotional, social impacts a cancer diagnosis. These include fertility concerns, disruptions to educational occupational pursuits, issues related body image sexual health, need for age-appropriate psychosocial support within communities. The Princess Margaret Cancer Centre (PM), quaternary care center, established specialized AYA program in 2014, offering holistic developmentally tailored currently, efforts are underway expand this other regions province address equitable access. establishment process involves securing funding, conducting an environmental scan, identifying service gaps, developing clinical pathways, implementing supportive care. An accessible should also consider determinants location, intersectionality, interdisciplinary health approach understanding inequities oncology This paper describes processes implemented faced creating community-based beyond major resource-rich cities intersectionality.

Language: Английский

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Mind the Gap: A Multiprong Approach to Minimizing the Gap in Outcomes Among Adolescents and Young Adults With Cancer

Journal of Clinical Oncology, Journal Year: 2023, Volume and Issue: 42(6), P. 617 - 620

Published: Dec. 7, 2023

Article Tools OVERVIEWS Special Series: Adolescents and Young Adults with Cancer OPTIONS & TOOLS Export Citation Track Add To Favorites Rights Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.23.02240 Journal of Clinical Oncology - published online before print December 7, 2023 PMID: 38060999 Mind the Gap: A Multiprong Approach to Minimizing Gap in Outcomes Among With Melissa M. Hudson , MD1xMelissa HudsonSearch for by this author Smita Bhatia MD, MPH, FASCO2xSmita BhatiaSearch Show More 1St Jude Children's Research Hospital, Memphis, TN2University Alabama at Birmingham, AL https://doi.org/10.1200/JCO.23.02240 First Page Full Text PDF Figures Tables © American Society OncologyAUTHOR CONTRIBUTIONSConception design: All authorsData analysis interpretation: HudsonManuscript writing: authorsFinal approval manuscript: authorsAccountable all aspects work: authorsAUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS INTERESTMind CancerThe following represents disclosure information provided authors manuscript. relationships are considered compensated unless otherwise noted. Relationships self-held I = Immediate Family Member, Inst My Institution. may not relate subject matter For more about ASCO's conflict interest policy, please refer www.asco.org/rwc or ascopubs.org/jco/authors/author-center.Open Payments is a public database containing reported companies payments made US-licensed physicians (Open Payments).Melissa HudsonEmployment: Consolidated Medical Practices MemphisConsulting Advisory Role: Information Exchange Network, Princess Máxima Center, VIVA Foundation SingaporeSmita BhatiaThis an Associate Editor Oncology. policy recused from having any role peer review manuscript.No other potential conflicts were reported.

Language: Английский

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Antineoplastic Therapy Administration Safety Standards for Adult and Pediatric Oncology: ASCO-ONS Standards

JCO Oncology Practice, Journal Year: 2024, Volume and Issue: 20(10), P. 1314 - 1330

Published: May 22, 2024

ASCO Standards are evidence-based standards to provide frameworks for best practices in cancer care, following the development process as outlined Policies and Procedures Manual . follow Conflict of Interest Policy Clinical Practice Guidelines other guidance (“Guidance”) provided by is not a comprehensive or definitive guide treatment options. It intended voluntary use providers should be used conjunction with independent professional judgment. Guidance may applicable all patients, interventions, diseases stages diseases. based on review analysis relevant literature, statement standard care. does endorse third-party drugs, devices, services, therapies assumes no responsibility any harm arising from related this information. See complete disclaimer Appendix 1 (online only) more. PURPOSE To update ASCO-Oncology Nursing Society (ONS) antineoplastic therapy administration safety adult pediatric oncology highlight current populations various routes location. METHODS ONS convened multidisciplinary Expert Panel representation multiple organizations conduct literature reviews add needed. The evidence base was combined opinion ASCO-ONS develop guidance. Public comments were solicited considered preparation final manuscript. RESULTS presented here include clarification expansion existing home changes processes ordering, preparing, administering therapy; advent immune effector cellular importance social determinants health; fertility preservation; pregnancy avoidance. In addition, have added fourth verification. STANDARDS which health care those involved aspects patient can safely deliver therapy, increase quality reduce medical errors. Additional information available at www.asco.org/standards www.ons.org/onf

Language: Английский

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