3D printed reservoir-like vaginal rings for antibiotic delivery

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125217 - 125217

Published: Jan. 1, 2025

Language: Английский

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Novel development of Poly(2-ethyl-2-oxazoline)-based mucoadhesive buccal film for poorly water-soluble drug delivery via hot-melt extrusion

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 114686 - 114686

Published: March 1, 2025

Language: Английский

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Quality by design approach for fabrication of extended-release buccal films for xerostomia employing hot-melt extrusion technology

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2024, Volume and Issue: 200, P. 114335 - 114335

Published: May 19, 2024

Language: Английский

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Development of multiple structured extended release tablets via hot melt extrusion and dual-nozzle fused deposition modeling 3D printing

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 653, P. 123905 - 123905

Published: Feb. 13, 2024

Language: Английский

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Colon-targeted 3D-Printed mesalamine tablets: Core-shell design and in vitro/ex-vivo evaluation

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 95, P. 105580 - 105580

Published: March 13, 2024

Language: Английский

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Role of rheology in formulation and process design of hot melt extruded amorphous solid dispersions

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 664, P. 124651 - 124651

Published: Aug. 31, 2024

Language: Английский

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Fabrication of suppository shells via hot-melt extrusion paired with fused deposition modeling 3D printing techniques

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 94, P. 105491 - 105491

Published: Feb. 20, 2024

Language: Английский

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Optimization of a Twin screw melt granulation process for fixed dose combination immediate release Tablets: Differential amorphization of one drug and crystalline continuance in the other

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 124717 - 124717

Published: Sept. 1, 2024

Language: Английский

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Advancements in Colon-Targeted Drug Delivery: A Comprehensive Review on Recent Techniques with Emphasis on Hot-Melt Extrusion and 3D Printing Technologies

AAPS PharmSciTech, Journal Year: 2024, Volume and Issue: 25(7)

Published: Oct. 8, 2024

Abstract This review investigates the progression and effectiveness of colon-targeted drug delivery systems, offering a comprehensive understanding colon's anatomy physiological environment. Recognizing distinctive features colon is crucial for successfully formulating oral dosage forms that precisely target specific areas in gastrointestinal tract (GIT) while minimizing side effects through mitigating off-target sites. basis designing effective targeted systems. The article extensively examines diverse approaches to drugs colonic targeting, highlighting key polymers excipients their production. Special emphasis given innovative such as hot-melt extrusion (HME) three-dimensional printing (3D-P), renowned accuracy release kinetics intricate form geometry. However, challenges arise regarding material standardization complex network regulatory clearances required confirm safety effectiveness. provides insights into each application’s advantages potential challenges. Furthermore, it sheds light on local diseases necessitate targeting available marketed products, providing an overview current state Additionally, emphasizes importance testing controlled vitro environment during development phase. It also discusses future directions successful this field. By integrating knowledge across anatomy, formulation techniques, assessment methodologies, valuable resource researchers navigating dynamic field delivery. Graphical

Language: Английский

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Bioavailability Enhancement and Formulation Technologies of Oral Mucosal Dosage Forms: A Review

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 148 - 148

Published: Jan. 22, 2025

The oral mucosa is a versatile surface for drug administration, supporting both local and systemic therapies. Many active substances are effectively absorbed in the cavity, offering an alternative to enteral administration by bypassing harsh gastrointestinal environment hepatic first-pass metabolism. This has made mucosal delivery growing area of research. Enhancing bioavailability ingredients key focus pharmaceutical technology, especially given challenges developing new drugs. Numerous strategies improve compatible with delivery, unique anatomy cavity enabling specialized applications. A variety dosage forms tailored meet therapeutic needs while addressing biopharmaceutical patient compliance challenges. Proper formulation can achieve controlled release, improved bioavailability, convenience. review highlights potential focusing on enhancement methods types production technologies optimized use cavity.

Language: Английский

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