Placental bed research: I. The placental bed: from spiral arteries remodeling to the great obstetrical syndromes

American Journal of Obstetrics and Gynecology, Journal Year: 2019, Volume and Issue: 221(5), P. 437 - 456

Published: June 1, 2019

Language: Английский

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Decidualization of the human endometrium

Reproductive Medicine and Biology, Journal Year: 2018, Volume and Issue: 17(3), P. 220 - 227

Published: Feb. 1, 2018

Abstract Background Decidualization of the human endometrium, which involves a dramatic morphological and functional differentiation endometrial stromal cells ( ESC s), is essential for establishment successful pregnancy. results from complex interplay transcription factors, morphogens, cytokines, cell cycle regulators, signaling pathways. Methods Based on literature review, regulation of, molecular mechanisms involved in, decidualization endometrium are described. Main findings Progesterone, together with proteins that regulated by progesterone and/or cyclic adenosine monophosphate, including homeobox A10, forkhead box O1, signal transducers activators transcription, heart neural crest derivatives expressed transcript 2, forms critical network prerequisite to implantation. Decidualized s contribute microenvironment at feto–maternal interface its direct or indirect influence extracellular matrix remodeling, local immune response, anti‐oxidative stress, angiogenesis (vascular maturation). Impairment this process associated variety pregnancy disorders, infertility, recurrent miscarriages, uteroplacental disorders. Conclusion A deeper understanding expected provide new insights into fields reproductive biology medicine.

Language: Английский

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Defective decidualization during and after severe preeclampsia reveals a possible maternal contribution to the etiology

Proceedings of the National Academy of Sciences, Journal Year: 2017, Volume and Issue: 114(40)

Published: Sept. 18, 2017

Significance We provide evidence of a decidualization defect in the endometrium women with severe preeclampsia (PE) that was detected at time delivery and persisted years after affected pregnancy. went on to link this impaired cytotrophoblast invasion. The transcriptional signature could enable its detection before (or after) conception, which would aid development therapies focused improving perhaps preventing PE.

Language: Английский

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Fertile ground: human endometrial programming and lessons in health and disease

Nature Reviews Endocrinology, Journal Year: 2016, Volume and Issue: 12(11), P. 654 - 667

Published: July 22, 2016

Language: Английский

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Single-cell transcriptomics of the human placenta: inferring the cell communication network of the maternal-fetal interface

Genome Research, Journal Year: 2017, Volume and Issue: 27(3), P. 349 - 361

Published: Feb. 7, 2017

Organismal function is, to a great extent, determined by interactions among their fundamental building blocks, the cells. In this work, we studied cell-cell interactome of fetal placental trophoblast cells and maternal endometrial stromal cells, using single-cell transcriptomics. The interface mediates interaction between two semiallogenic individuals, mother fetus, is thus epitome cell interactions. To study these, inferred assessing gene expression receptor-ligand pairs across types. We find highly cell-type-specific G-protein-coupled receptors, implying that ligand-receptor profiles could be reliable tool for type identification. Furthermore, uterine decidual represent hub with large number potential incoming outgoing signals. Decidual differentiate from precursors, fibroblasts, during preparation pregnancy. show decidualization (even in vitro) enhances ability communicate as most receptors ligands up-regulated have counterpart expressed Among signals transmitted, growth factors immune dominate, suggest delicate balance enhancing suppressive Finally, provides rich resource term intravillous extravillous trophoblasts, including transcriptome multinucleated syncytiotrophoblast.

Language: Английский

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Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium

eLife, Journal Year: 2017, Volume and Issue: 6

Published: Dec. 11, 2017

In cycling human endometrium, menstruation is followed by rapid estrogen-dependent growth. Upon ovulation, progesterone and rising cellular cAMP levels activate the transcription factor Forkhead box O1 (FOXO1) in endometrial stromal cells (EnSCs), leading to cell cycle exit differentiation into decidual that control embryo implantation. Here we show FOXO1 also causes acute senescence of a subpopulation decidualizing EnSCs an IL-8 dependent manner. Selective depletion or enrichment this revealed drives transient inflammatory response associated with receptivity. Further, senescent prevent mesenchymal stem cultures. As progresses, IL-15 activated uterine natural killer (uNK) selectively target clear through granule exocytosis. Our findings reveal governs rejuvenation remodeling at implantation, suggest critical role for uNK maintaining homeostasis endometrium.

Language: Английский

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Modulators of the Balance between M1 and M2 Macrophages during Pregnancy

Frontiers in Immunology, Journal Year: 2017, Volume and Issue: 8

Published: Feb. 9, 2017

Macrophages are a subset of mononuclear phagocytes the innate immune system with high plasticity and heterogeneity. At maternal-fetal interface, macrophages present in all stages pregnancy involved variety activities, including regulation cell decidualization, placental invasion, angiogenesis, parturition, postpartum uterine involution. The activation state function uterine-placental largely dependent on local tissue microenvironment. However, disruption microenvironment can have profound effects macrophage activity subsequently impact outcome. Thus, appropriately timely regulated polarization has been considered key determinant successful pregnancy. Targeting might be an efficient strategy for maintaining homeostasis normal Here, we will review latest findings regarding modulators regulating healthy pregnancies complications, which provide basis macrophage-centered therapeutic strategies.

Language: Английский

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The role of mesenchymal–epithelial transition in endometrial function

Human Reproduction Update, Journal Year: 2018, Volume and Issue: 25(1), P. 114 - 133

Published: Oct. 13, 2018

The human uterine endometrium undergoes significant remodeling and regeneration on a rapid repeated basis, after parturition, menstruation, in some cases, injury. ability of the adult to undergo cyclic differentiation/decidualization is essential for successful reproduction. Multiple key physiologic functions require cells this tissue transition between mesenchymal epithelial phenotypes, processes known as mesenchymal-epithelial (MET) epithelial-mesenchymal (EMT). Although MET/EMT have been widely characterized embryonic development context malignancy, mounting evidence demonstrates importance allowing phenotypic functional flexibility necessary decidualization, regeneration/re-epithelialization embryo implantation.The objective review provide comprehensive summary observations concerning MET EMT their regulation functions, specifically endometrial regeneration, decidualization implantation.Using variations search terms 'mesenchymal-epithelial transition', transformation', 'epithelial-mesenchymal 'uterus', 'endometrial regeneration', decidualization', 'embryo implantation', published literature 1970 2018 was conducted using PubMed database. In addition, we searched reference lists all publications included additional relevant original studies.Multiple studies demonstrate that stromal contribute both cell compartments uterus, implicating role mechanisms responsible re-epithelialization. During morphologic changes consistent with order accommodate implantation. Under influence estradiol, progesterone multiple other factors, fibroblasts acquire epithelioid characteristics, such expanded cytoplasm rough endoplasmic reticulum required greater secretory capacity, rounded nuclei, increased expression junctional proteins which allow cell-cell communication, reorganized actin cytoskeleton. implantation, response maternal embryonic-derived signals, luminal epithelium well decidualized characteristics migration/motility, thus undergoing invading trophoblast.Overall, findings support important roles may be considered unique wound healing model, given its repeatedly repair without scarring or loss function. Future elucidate how scar-free will considerable potential advance tissues.

Language: Английский

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Endometrial function in women with polycystic ovary syndrome: a comprehensive review

Human Reproduction Update, Journal Year: 2020, Volume and Issue: 27(3), P. 584 - 618

Published: Oct. 21, 2020

Abstract BACKGROUND Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility. An endometrial component has been suggested to contribute subfertility and poor reproductive outcomes in affected women. OBJECTIVE AND RATIONALE The aim this review was determine whether there sufficient evidence support that function altered women with PCOS, clinical features PCOS affect endometrium, are evidence-based interventions improve dysfunction SEARCH METHODS extensive literature search performed from 1970 up July 2020 using PubMed Web Science without language restriction. included all titles abstracts assessing a relationship between function, role played by biochemical/hormonal factors related potential aimed PCOS. All published papers were if considered relevant. Studies having specific topic/hypothesis regarding cancer/hyperplasia excluded analysis. OUTCOMES Experimental data suggest endometrium differs when compared healthy controls. Clinical characteristics syndrome, alone and/or combination, may dysregulation expression sex hormone receptors co-receptors, increase insulin-resistance impaired glucose transport utilization, result chronic low-grade inflammation, immune dysfunction, uterine vascularity, abnormal gene cellular abnormalities Among several date, only lifestyle modification, metformin bariatric surgery have highest scientific for benefit. WIDER IMPLICATIONS Endometrial trophoblast invasion placentation can predispose miscarriage pregnancy complications. Thus, patients their health care providers should advise about these risks. Although currently no intervention be universally recommended reverse women, modifications underlying obese insulin resistant patients. Bariatric shown its efficacy severely patients, but careful evaluation benefit/risk ratio warranted. Large scale randomized controlled trials address possibilities.

Language: Английский

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Endometrial Decidualization: The Primary Driver of Pregnancy Health

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(11), P. 4092 - 4092

Published: June 8, 2020

Interventions to prevent pregnancy complications have been largely unsuccessful. We suggest this is because the foundation for a healthy laid prior establishment of at time endometrial decidualization. Humans are one only few mammalian viviparous species in which decidualization begins during latter half each menstrual cycle and therefore independent conceptus. Failure adequately prepare (decidualize) endometrium hormonally, biochemically, immunologically anticipation approaching blastocyst—including downregulation genes involved pro- inflammatory response resisting tissue invasion along with increased expression that promote angiogenesis, foster immune tolerance, facilitate invasion—leads abnormal implantation/placentation ultimately adverse outcome. hypothesize, therefore, primary driver health quality soil, not seed.

Language: Английский

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