Changing profiles of the burden of Alzheimer's disease and other dementias attributable to smoking in the belt and road initiative countries: A secondary analysis of global burden of disease 2019 DOI Creative Commons
Zheng Luo, Xin He, H.‐J. Lv

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(6), P. e27935 - e27935

Published: March 1, 2024

ObjectivesThis study was aimed at analyzing the burden and trend of Alzheimer's disease other dementias attributed to smoking (SADD) in Belt Road Initiative (BRI) countries during 1990–2019.MethodsData from The 2019 Global Burden Disease Study used extract information on SADD terms numbers age-standardized rate mortality (ASMR) disability-adjusted life years (ASDALR) BRI for 1990–2019. average annual percent change (AAPC) analyze temporal trends ASDALR 1990 final decade by Joinpoint regression analysis.ResultsThe DALYs were highest China, India, Russian Federation Lebanon, Montenegro Bosnia, Herzegovina 2019. From 2019, China had increased 55.50/105 66.18/105, but decreased 2010 while that India declined 32.84/105 29.35/105, showed fastest increase Federation, with AAPC 1.97% (95% confidence interval [CI]: 1.77%, 2.16%), decline Sri Lanka, −2.69% CI: 2.79%, −2.59%). ASMR a substantial 1990–2019 both globally different socio-demographic index (SDI) regions (all P < 0.05, except high-middle-SDI region). Compared rates males, females significantly greater 20 countries(all 0.05). In age group 20–54 years, decreasing only 13 members low-SDI region 0.05).ConclusionUnder premise eliminating differences, mobilizing resources country itself, organization, will help reduce global achieve healthy sustainable development.

Language: Английский

Global, regional, and national burden of neurological disorders in 204 countries and territories worldwide DOI Creative Commons
Yi Huang,

Yongan Li,

Haiyan Pan

et al.

Journal of Global Health, Journal Year: 2023, Volume and Issue: 13

Published: Nov. 29, 2023

We aimed to determine the incidence and disability-adjusted life-years (DALYs) of neurological disorders worldwide from 1990 2019.We obtained age-standardised DALY rates in 204 countries territories 2019 Global Burden Disease (GBD) database. determined trends stratified by age, sex, region, country, Social Development Index (SDI) risk factors contributing DALYs associated with these disorders.The largest increases 1990-2019 occurred four regions (East Asia: estimated annual percentage change (EAPC) = 0.19, tropical Latin America: EAPC 0.07, Southern 0.03, Western Europe: 0.03) three (China: 0.20, Ecuador: 0.13, Italy: 0.13). observed for Parkinson disease, idiopathic epilepsy, bipolar disorder, Alzheimer disease other dementias. High-SDI showed highest depression, motor neuron disorders.There is a need control increase East Asia, America, Europe, particularly China, Ecuador, Italy.

Language: Английский

Citations

72
Neuropathogenesis-on-chips for neurodegenerative diseases DOI Creative Commons
Sarnai Amartumur, Huong Mai Nguyen, Thuy Huynh

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 12, 2024

Abstract Developing diagnostics and treatments for neurodegenerative diseases (NDs) is challenging due to multifactorial pathogenesis that progresses gradually. Advanced in vitro systems recapitulate patient-like pathophysiology are emerging as alternatives conventional animal-based models. In this review, we explore the interconnected pathogenic features of different types ND, discuss general strategy modelling NDs using a microfluidic chip, introduce organoid-on-a-chip next advanced relevant model. Lastly, overview how these models being applied academic industrial drug development. The integration chips, stem cells, biotechnological devices promises provide valuable insights biomedical research developing diagnostic therapeutic solutions NDs.

Language: Английский

Citations

26
Exploring the causal relationships between type 2 diabetes and neurological disorders using a Mendelian randomization strategy DOI Creative Commons

Yongfang Wei,

Shuling Xu,

Zhaoquan Wu

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(46), P. e40412 - e40412

Published: Nov. 15, 2024

While there is ample evidence indicating an increased occurrence of general neurological conditions among individuals with diabetes, has been limited exploration into the cause-and-effect connection between type 2 diabetes (T2D) and specific disorders, including like carpal tunnel syndrome Bell’s palsy. We used Mendelian randomization (MR) approach to investigate causal effects T2D on 67 diseases. primarily utilized inverse-variance weighted method for analysis, also employed median MR-Egger methods in our study. To detect correct potential outliers, MR-PRESSO analysis was used. Heterogeneity assessed using Cochrane Q-values. The MR analyses found a possible relationship risk increase 8 diseases at suggestive level ( P < .05). Notably, positive findings that met false discovery rate threshold, nerve, nerve root, plexus disorders (odds ratio [OR] = 1.11; 95% confidence interval [CI] 1.08–1.15); (OR 1.05; CI 1.03–1.07) 1.10; 1.05–1.16) were identified. Our affirm association certain disorders.

Language: Английский

Citations

20
Burden of diet-related chronic diseases in Chinese and Japanese adults attributable to dietary risk factors from 1990 to 2021: a systematic analysis of the Global Burden of Disease Study 2021 DOI Creative Commons

Minyan Wang,

Huan Ma,

Qin Chu

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 24, 2025

Background Chronic diseases are a major cause of death, contributing significantly to the global disease burden. The growing aging population and chronic burden in China Japan have substantial impact on health outcomes. Dietary factors, as key modifiable elements, particularly important. Therefore, we aimed analyze compare dietary factors develop measures reduce this Methods According WHO classification diseases, selected cardiovascular neoplasms, diabetes for analysis. We collected relevant data from GBD database, described analyzed by age, gender, year, created bar trend charts. conducted comparative analysis influencing these three generating heatmaps. joinpoint model was used time trends 1990 2021. Results From 2021, neoplasms declined varying degrees, while continued increase. main risk factor is high red meat diet, high-sodium especially China. In addition, consumption appears serve protective both Chinese Japanese populations. Regarding diabetes, associated with whereas characterized high-processed diet. Conclusion By comparing related Japan, study proposes strategies national healthy diets, such reducing sodium, processed meat, intake increasing whole grains, vegetables, fruit intake. attention should be given status elderly, along targeted education initiatives.

Language: Английский

Citations

2
Global, Regional, and National Disease Burden and Prediction Analysis of Colorectal Cancer Attributable to Tobacco, Alcohol, and Obesity From 1990 to 2030 DOI Creative Commons

Yuqi Deng,

Yajie Wang,

Jinsai Yang

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 26, 2025

Colorectal cancer (CRC) ranks among the highest in incidence and mortality rates globally. A significant portion of cases deaths can be attributed to modifiable risk factors, with smoking, alcohol use, high body mass index (BMI) being three most prominent. However, impact these factors on across regions, genders, age groups remains insufficiently characterized. Utilizing data from Global Burden Disease (GBD) study 2019, restrictive cubic splines (RCS) quantile regression analyses are applied explore relationship between Socio-Demographic Index (SDI) ASMR or ASDR. Additionally, gender differences, changes different SDI levels, group trends BMI over 30-year period analyzed. The Bayesian age-period-cohort (BAPC) model is employed predict 2020 2030, aiming epidemiological sociodemographic transitions disease burden BMI. In number colorectal globally attributable as consumption, obesity increased 142,931, 52,495, 85,882 respectively, collectively accounting for approximately one-third all cancer-related deaths. Notably, there an upward trend early-onset associated factors. To reduce cancer, it recommended enhance health education, promote smoking cessation moderation, increase coverage participation screening, which crucial lowering rates. These findings vital development public policies intervention measures global burden. They provide guidance prevention worldwide.

Language: Английский

Citations

1
The burden of migraine and tension-type headache in Asia from 1990 to 2021 DOI Creative Commons
Yuhong Zhao,

Yujie Yi,

Hong Zhou

et al.

The Journal of Headache and Pain, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 10, 2025

In recent years, headache diseases have spread throughout the world, causing great suffering and even severe disability to patients, increasing burden on health care systems. However, studies of specific regions are rare. The purpose our study is comprehensively analyze current situation trends in Asia between 1990 2021, provide details Asia, scientific data support development strategies. Data from Global Burden Disease (GBD) 2021 database were used calculate incidence, prevalence disability-adjusted life years (DALYs) disorders 2021. Differences ages, sexes countries also assessed, we evaluated correlation epidemiological sociodemographic indices (SDIs). there approximately 683,514,637 cases migraine Asia. Meanwhile, now 1,130,221,326 associated with tension-type (TTH) Specifically, age-standardized DALYs (ASDR) [607 per 100,000 people (95% UI: 70 − 1,363)] for highest Southeast ASDR [422 86–938)] was lowest high-income Asia-Pacific region. [67 18–236)] TTH Central [43 13–141)] East addition, women key population prevalence. negative positive correlations SDI, respectively. Headache pose a serious threat quality safety patients society, this impact will continue grow. Our findings suggest that active public awareness, improved guidelines, better disease management necessary expand healthcare system's attention disorders, thereby gain greater advantage combating future.

Language: Английский

Citations

1
Is migraine a common manifestation of CADASIL? Arguments Pros DOI Creative Commons
Hugues Chabriat

The Journal of Headache and Pain, Journal Year: 2025, Volume and Issue: 26(1)

Published: April 1, 2025

Abstract Background Migraine with aura (MA) is a hallmark feature of CADASIL, hereditary small-vessel disease caused by NOTCH3 mutations. While MA prevalent in its underlying mechanisms remain unclear, and the links observed can be questioned or debated. This study examined prevalence, clinical characteristics, pathophysiology patients CADASIL. Methods Clinical experimental data were reviewed to assess sex differences, pathophysiological insights from CADASIL models confirm indisputable between migraine this unique genetic model cerebral small vessel disease. Results was 10–20 times more than general population, frequent atypical prolonged auras. The altered distribution delayed onset suggest disease-specific mechanisms. Experimental also revealed heightened susceptibility cortical spreading depression (CSD) preclinical models, linked greater fragility maintaining ionic homeostasis. Conclusion high prevalence distinct features, as well obtained at level, strongly support causal relationship mediated neurovascular dysfunction Accumulating condition sheds new light on much-debated cerebrovascular diseases.

Language: Английский

Citations

1
Microneedle-mediated drug delivery for neurological diseases DOI

Shuna Tan,

Yitian Wang, Wei Xuan

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 661, P. 124400 - 124400

Published: June 29, 2024

Language: Английский

Citations

6
The impact of physical exercise on neuroinflammation mechanism in Alzheimer’s disease DOI Creative Commons
Junhui Hu,

Baiqing Huang,

Kang Chen

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Aug. 21, 2024

Introduction Alzheimer’s disease (AD), a major cause of dementia globally, imposes significant societal and personal costs. This review explores the efficacy physical exercise as non-pharmacological intervention to mitigate impacts AD. Methods draws on recent studies that investigate effects neuroinflammation neuronal enhancement in individuals with Results Consistent alters neuroinflammatory pathways, enhances cognitive functions, bolsters brain health among AD patients. It favorably influences activation states microglia astrocytes, fortifies integrity blood-brain barrier, attenuates gut inflammation associated These changes are substantial improvements performance indicators. Discussion The findings underscore potential integrating into comprehensive management strategies. Emphasizing necessity for further research, this advocates refinement regimens maximize their enduring benefits decelerating progression

Language: Английский

Citations

5
Exosomes: The endogenous nanomaterials packed with potential for diagnosis and treatment of neurologic disorders DOI
Xuelin Tang, Yuxuan He,

Jinchi Liu

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 239, P. 113938 - 113938

Published: May 3, 2024

Language: Английский

Citations

4