International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(18), P. 9986 - 9986
Published: Sept. 16, 2024
Diabetes
mellitus
(DM)
severely
impairs
skin
wound
healing
capacity,
yet
few
treatment
options
exist
to
enhance
this
process.
N-acetylcysteine
(NAC)
is
an
antioxidant
that
improves
cellular
proliferation
and
enhances
in
healthy
animals,
its
use
the
context
of
type
II
DM
has
not
been
studied.
The
aim
our
research
was
investigate
effect
topically
applied
NAC-enriched
hydrogels
on
a
leptin-deficient
murine
model.
Four
excisional
wounds
were
created
backs
20
db/db
mice
subsequently
treated
with
containing
NAC
at
concentrations
5%,
10%
20%
or
placebo
(control).
Healing
monitored
for
28
days;
photographs
taken
every
third
day.
Wound
tissues
harvested
days
3,
7,
14
undergo
histological
examinations.
Wounds
5%
showed
improved
closure
speed
accompanied
by
increased
dermal
area
microscopic
assessment
compared
other
groups.
Higher
failed
show
beneficial
healing.
early
stages
model
increasing
speed,
likely
mediated
proliferation.
Journal of Biological Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown, P. 108273 - 108273
Published: Feb. 1, 2025
The
taste
system
extends
beyond
the
oral
cavity,
with
various
receptors
found
in
extraoral
organs.
Mice
deficient
receptor
type
1
(TAS1R)
family
member,
TAS1R3,
and
fed
a
high-fat,
high-sugar
diet
showed
high
bone
mass
without
altering
food
consumption.
However,
underlying
mechanisms,
including
cell
types
responsible
for
TAS1R3
expression,
remain
unclear.
Here,
we
demonstrate
expression
function
of
osteoclasts,
which
are
resorption.
Tas1r3
but
not
Tas1r1
or
Tas1r2,
is
evoked
during
osteoclast
differentiation.
Osteoclastogenesis-related
genes
were
downregulated
TAS1R3-deficient
mice,
whereas
opposite
phenotypes
elicited
by
overexpression.
Contrary
to
common
heterodimerization
TAS1R1
TAS1R2,
formed
homodimer
that
functioned
detect
glucose,
enhance
p38
phosphorylation,
induce
osteoclastogenesis.
These
results
provide
novel
insights
into
role
metabolism
suggest
may
be
viable
target
therapeutic
agents
metabolic
diseases.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
13
Published: March 7, 2025
Diabetes
is
a
widespread
metabolic
disorder
that
presents
considerable
challenges
in
its
management.
Recent
advancements
biomaterial
research
have
shed
light
on
innovative
approaches
for
the
treatment
of
diabetes.
This
review
examines
role
biomaterials
diabetes
diagnosis
and
treatment,
as
well
their
application
managing
diabetic
wounds.
By
evaluating
recent
developments
alongside
future
obstacles,
highlights
promising
potential
care,
underscoring
importance
enhancing
patient
outcomes
refining
methodologies.
Journal of Inflammation Research,
Journal Year:
2024,
Volume and Issue:
Volume 17, P. 1607 - 1619
Published: March 1, 2024
Abstract:
Metrnl,
recently
identified
as
an
adipokine,
is
a
secreted
protein
notably
expressed
in
white
adipose
tissue,
barrier
tissues,
and
activated
macrophages.
This
adipokine
plays
pivotal
role
counteracting
obesity-induced
insulin
resistance.
It
enhances
tissue
functionality
by
promoting
adipocyte
differentiation,
activating
metabolic
pathways,
exerting
anti-inflammatory
effects.
Extensive
research
has
Metrnl
key
player
modulating
inflammatory
responses
integral
regulator
of
muscle
regeneration.
These
findings
position
promising
biomarker
potential
therapeutic
target
treating
inflammation-associated
pathologies.
Despite
this,
the
specific
mechanisms
immune-mediated
osteolysis
arthritis
remain
elusive,
warranting
further
investigation.
In
this
review,
we
will
briefly
elaborate
on
anti-inflammation
function
inflammation-related
osteolysis,
arthritis,
pathological
bone
resorption,
which
could
facilitate
Metrnl's
clinical
application
novel
strategy
to
prevent
loss.
While
pathogenesis
elbow
stiffness
remains
current
literature
suggests
that
likely
exerts
its
development.
Keywords:
loss,
stiff
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 3217 - 3232
Published: April 1, 2024
Background:
Skin
wounds
are
a
prevalent
issue
that
can
have
severe
health
consequences
if
not
treated
correctly.
Nanozymes
offer
promising
therapeutic
approach
for
the
treatment
of
skin
wounds,
owing
to
their
advantages
in
regulating
redox
homeostasis
reduce
oxidative
damage
and
kill
bacteria.
These
properties
make
them
an
effective
option
wounds.
However,
most
current
nanozymes
lack
capability
simultaneously
address
inflammation,
stress,
bacterial
infection
during
wound
healing
process.
There
is
still
great
potential
increase
functional
diversity
efficacy.
Methods:
Herein,
copper-doped
hollow
mesopores
cerium
oxide
(Cu-HMCe)
with
multifunctional
antioxidant,
antimicrobial
pro-vascularity
successfully
prepared.
Cu-HMCe
be
efficiently
prepared
through
simple
rapid
solution
method
displays
sound
physiological
stability.
The
biocompatibility,
pro-angiogenic,
antimicrobial,
antioxidant
were
assessed.
Moreover,
full-thickness
defect
model
was
utilized
investigate
capacity,
as
well
anti-inflammatory
pro-angiogenic
vivo.
Results:
Both
vitro
vivo
experiments
substantiated
Cu-HMCe's
remarkable
biocompatibility.
possesses
potent
enzyme-like
catalytic
activity,
effectively
clearing
DPPH
radicals
(with
scavenging
rate
80%),
hydroxyl
radicals,
reactive
oxygen
species.
Additionally,
exhibits
excellent
properties,
over
70%
inhibition
both
E.
coli
S.
aureus
.
collectively
promote
healing,
achieved
closure
90%
on
14th
day.
Conclusion:
results
indicate
exhibited
efficacy
promoting
healing.
This
providing
strategy
repair.
Keywords:
nanozyme,
antioxidation,
antibacterial,
vascularization,
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(10), P. 1255 - 1255
Published: Oct. 4, 2024
Tuberculosis
(TB),
an
infectious
disease
caused
by
Mycobacterium
tuberculosis
(Mtb)
infection,
remains
a
deadly
global
public
health
burden.
The
use
of
recommended
drug
combinations
in
clinic
has
seen
increasing
prevalence
drug-resistant
TB,
adding
to
the
impediments
control
TB.
Therefore,
TB
and
become
one
most
pressing
issues
health,
which
urges
exploration
potential
therapeutic
targets
Pyroptosis,
form
programmed
cell
death
characterized
swelling
rupture,
release
cellular
contents
inflammatory
responses,
been
found
promote
pathogen
clearance
adopt
crucial
roles
bacterial
infections.
It
demonstrated
that
Mtb
can
cause
host
pyroptosis,
these
cells,
are
infected
Mtb,
kill
accompanied
while,
at
same
time,
pyroptosis
also
intracellular
may
potentially
worsen
infection
exacerbating
inflammation.
Here,
we
describe
main
pathways
during
summarize
identified
effectors
regulate
achieve
immune
evasion.
Moreover,
discuss
potentials
serve
as
anti-TB
target,
with
aim
providing
new
ideas
for
development
treatments.
Current Pharmaceutical Biotechnology,
Journal Year:
2023,
Volume and Issue:
25(9), P. 1182 - 1198
Published: Nov. 6, 2023
Nanotechnology
has
provided
nanostructure-based
delivery
of
drugs,
among
which
nanocrystals
have
been
investigated
and
explored
for
feasible
topical
drug
delivery.
Nanocrystals
are
nano-sized
colloidal
carriers,
considered
pure
solid
particles
with
a
maximum
load
very
small
amount
stabilizer.
The
size
or
mean
diameter
the
is
less
than
1
μm
crystalline
character.
Prominent
synthesis
methods
include
utilization
microfluidic-
driven
platforms
as
well
milling
approach,
both
adaptable
adjustable.
shown
high
capacity
loading
negligible
amounts
excipients,
greater
chemical
stability,
lower
toxic
effects,
ease
scale-up,
manufacturing.
They
gained
interest
platforms,
significantly
large
surface
area
skin
makes
it
potential
approach
therapeutic
formulations
different
disorders
including
fungal
bacterial
infections,
psoriasis,
wound
healing,
cancers,
etc.
This
article
explores
preparation
techniques,
applications,
recent
patents
treating
various
conditions.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(18), P. 9986 - 9986
Published: Sept. 16, 2024
Diabetes
mellitus
(DM)
severely
impairs
skin
wound
healing
capacity,
yet
few
treatment
options
exist
to
enhance
this
process.
N-acetylcysteine
(NAC)
is
an
antioxidant
that
improves
cellular
proliferation
and
enhances
in
healthy
animals,
its
use
the
context
of
type
II
DM
has
not
been
studied.
The
aim
our
research
was
investigate
effect
topically
applied
NAC-enriched
hydrogels
on
a
leptin-deficient
murine
model.
Four
excisional
wounds
were
created
backs
20
db/db
mice
subsequently
treated
with
containing
NAC
at
concentrations
5%,
10%
20%
or
placebo
(control).
Healing
monitored
for
28
days;
photographs
taken
every
third
day.
Wound
tissues
harvested
days
3,
7,
14
undergo
histological
examinations.
Wounds
5%
showed
improved
closure
speed
accompanied
by
increased
dermal
area
microscopic
assessment
compared
other
groups.
Higher
failed
show
beneficial
healing.
early
stages
model
increasing
speed,
likely
mediated
proliferation.
