Frontiers in Physiology,
Journal Year:
2021,
Volume and Issue:
12
Published: Oct. 21, 2021
Bursicon
is
a
neuropeptide
belonging
to
the
cystine
knot
family
and
composed
of
burs
partner
(pburs)
subunits.
It
can
form
heterodimers
or
homodimers
execute
different
biological
functions.
regulate
cuticle
sclerotization
wing
maturation,
whereas
bursicon
mediate
innate
immunity
midgut
stem
cell
proliferation.
A
recent
study
has
shown
that
potentially
induces
expression
vitellogenin
(Vg)
in
black
tiger
shrimp
Penaeus
monodon;
however,
underlying
mechanism
remains
unknown.
In
this
study,
we
investigated
role
reproductive
physiology
red
flour
beetle,
Tribolium
castaneum.
The
knockdown
burs,
pburs,
its
receptor
T.
castaneum
rickets
(Tcrk)
2-day
pupae
significantly
downregulated
levels
Vg1,
Vg2,
Vg
(VgR)
genes
females
3-
5-day
post-adult
emergence,
leading
abnormal
oocytes
with
limited
content.
silencing
repressed
number
eggs
laid
completely
inhibited
egg
hatch,
pburs
dramatically
decreased
laid,
hatch
rate,
offspring
larval
size,
RNA
interference
(RNAi)
effects
persisted
next
generation.
Furthermore,
insulin/insulin-like
signaling/target
rapamycin
(TOR)
signaling
encoding
insulin
(InR),
protein
kinase
B
(Akt),
TOR,
ribosomal
S6
(S6K).
Most
importantly,
injection
recombinant
(r-pburs)
was
able
upregulate
Vg,
VgR,
InR,
Akt,
S6K,
JH
synthesis
(JHAMT),
Methoprene-tolerant
(Met),
Taiman
(Tai)
normal
rescue
VgR
RNAi
but
failed
Tcrk
females.
We
infer
influence
via
Tcrk,
possibly
by
mediating
juvenile
hormone
(JH)
IIS/TOR
pathway
genes,
thereby
regulating
reproduction
Frontiers in Cell and Developmental Biology,
Journal Year:
2021,
Volume and Issue:
8
Published: Jan. 28, 2021
Vitellogenesis
is
pre-requisite
to
insect
egg
production
and
embryonic
development
after
oviposition.
During
vitellogenesis,
the
yolk
protein
precursor
vitellogenin
(Vg)
mainly
synthesized
in
fat
body,
transported
by
hemolymph
through
intercellular
spaces
(known
as
patency)
follicular
epithelium
reach
membrane
of
maturing
oocytes,
sequestered
into
oocytes
via
receptor-mediated
endocytosis.
Insect
vitellogenesis
governed
two
critical
hormones,
sesquiterpenoid
juvenile
hormone
(JH)
ecdysteriod
20-hydroxyecdysone
(20E).
JH
acts
principal
gonadotropic
stimulate
basal
hemimetabolous
most
holometabolous
insects.
20E
for
some
hymenopterans,
lepidopterans
dipterans.
Furthermore,
microRNA
(miRNA)
nutritional
(amino
acid/Target
Rapamycin
insulin)
pathways
interplay
with
signaling
cascades
control
vitellogenesis.
Revealing
regulatory
mechanisms
underlying
understanding
reproduction
helpful
developing
new
strategies
pest
control.
Here,
we
outline
recent
research
progress
molecular
action
along
role
miRNA
sensor
regulating
We
highlight
advancements
coordination
hormone,
pathways.
Frontiers in Physiology,
Journal Year:
2022,
Volume and Issue:
12
Published: Feb. 10, 2022
In
the
field
of
insect
endocrinology,
juvenile
hormone
(JH)
is
one
most
wondrous
entomological
terms.
As
a
unique
sesquiterpenoid
produced
and
released
by
endocrine
gland,
corpus
allatum
(CA),
JH
critical
regulator
in
multiple
developmental
physiological
processes,
such
as
metamorphosis,
reproduction,
behavior.
Benefited
from
precise
genetic
interventions
simplicity,
fruit
fly,
National Science Review,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 23, 2025
Inter-organelle
communication
coordinates
cellular
homeostasis
and
function.
Juvenile
hormone
(JH)
is
produced
in
the
corpora
allata
(CA)
acts
as
a
gonadotrophic
most
insects.
Using
transcriptomic,
biochemical,
molecular,
genetic
analyses,
here
we
investigated
underlying
mechanism
of
how
inter-organelle
dynamically
orchestrates
JH
biosynthesis
female
reproduction
American
cockroach,
Periplaneta
americana.
The
extracellular
stimuli
insulin
allatostatin
act
through
their
membrane
receptors
antagonistically
regulate
RyR-mediated
Ca2+
release
from
endoplasmic
reticulum
CA
cells.
Ca2+-activated
CaMKII
stimulates
energy
metabolism
mitochondria
partially
via
SLC25A6,
induces
expression
biosynthetic
genes
HMGR,
Jhamt,
Cyp15a1
activating
transcription
factor
CREB,
which
recruits
CBP
for
histone
acetylation
nucleus.
Additionally,
interact
with
CREB-CBP
mitonuclear
to
biosynthesis.
From
perspective
communication,
this
comprehensive
study
significantly
advanced
our
understanding
reproductive
biology
PLoS Genetics,
Journal Year:
2022,
Volume and Issue:
18(6), P. e1010292 - e1010292
Published: June 27, 2022
Juvenile
hormone
(JH)
acts
as
a
gonadotrophic
stimulating
insect
vitellogenesis
and
oogenesis.
Paracellular
transport
of
yolk
proteins
through
intercellular
channels
(patency)
in
the
follicular
epithelium
is
developmentally
regulated
evolutionarily
conserved
process
during
vitellogenesis.
However,
mechanisms
underlying
patency
opening
are
poorly
understood.
Using
migratory
locust
Locusta
migratoria
model
system,
we
report
here
that
JH-regulated
remodeling
zonula
adherens
(ZA),
belt-like
junction
maintaining
physical
linking
between
follicle
cells
controlled
patency.
JH
triggered
phosphorylation
Partitioning
defective
protein
3
(Par3)
via
signaling
cascade
including
G
protein-coupled
receptor
(GPCR),
small
GTPase
Cell
division
cycle
42
(Cdc42)
atypical
Protein
kinase
C
(aPKC).
Par3
resulted
its
disassociation
from
β-Catenin,
cytoplasmic
partner
ZA
core
component
E-Cadherin.
Release
β-Catenin/E-Cadherin
complex
caused
disassembly
at
tricellular
contacts,
consequently
leading
to
enlargement.
This
study
provides
new
insight
into
how
stimulates
egg
production
inducing
paracellular
route
for
vitellogenin
crossing
barrier.
