Mechanistic Insight into Orthodontic Tooth Movement Based on Animal Studies: A Critical Review DOI Open Access
Hyeran Helen Jeon,

Hellen S. Teixeira,

Andrew Tsai

et al.

Journal of Clinical Medicine, Journal Year: 2021, Volume and Issue: 10(8), P. 1733 - 1733

Published: April 16, 2021

Alveolar bone remodeling in orthodontic tooth movement (OTM) is a highly regulated process that coordinates resorption by osteoclasts and new formation osteoblasts. Mechanisms involved OTM include mechano-sensing, sterile inflammation-mediated osteoclastogenesis on the compression side tensile force-induced osteogenesis tension side. Several intracellular signaling pathways mechanosensors including cilia ion channels transduce mechanical force into biochemical signals stimulate of or To date, many studies were performed vitro using human gingival crevicular fluid samples. Thus, use transgenic animals very helpful examining cause effect relationship. Key cell types participate mediating response to periodontal ligament fibroblasts, mesenchymal stem cells, osteoblasts, osteocytes, osteoclasts. Intercellular cellular processes needed for receptor activator nuclear factor-κB ligand (RANKL), tumor necrosis factor-α (TNF-α), dickkopf Wnt pathway inhibitor 1 (DKK1), sclerostin, transforming growth factor beta (TGF-β), morphogenetic proteins (BMPs). In this review, we critically summarize current animal models order provide mechanistic insight events molecular regulation OTM.

Language: Английский

The Hippo signalling pathway and its implications in human health and diseases DOI Creative Commons

Minyang Fu,

Yuan Hu,

Tianxia Lan

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Nov. 8, 2022

Abstract As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in regulation of numerous biological processes. Thus, substantial efforts have been made to understand upstream signals that influence activity pathway, as well its physiological functions, such cell proliferation and differentiation, organ growth, embryogenesis, tissue regeneration/wound healing. However, dysregulation can cause variety diseases, including cancer, eye cardiac pulmonary renal hepatic immune dysfunction. Therefore, therapeutic strategies target dysregulated components might be promising approaches for treatment wide spectrum diseases. Here, we review key critical functions controlled by pathway. Additionally, diseases associated with alterations potential therapies targeting will discussed.

Language: Английский

Citations

335
The extracellular matrix in development DOI Creative Commons
David A. Cruz Walma, Kenneth M. Yamada

Development, Journal Year: 2020, Volume and Issue: 147(10)

Published: May 15, 2020

ABSTRACT As the crucial non-cellular component of tissues, extracellular matrix (ECM) provides both physical support and signaling regulation to cells. Some ECM molecules provide a fibrillar environment around cells, while others sheet-like basement membrane scaffold beneath epithelial In this Review, we focus on recent studies investigating mechanical, biophysical cues provided developing tissues by different types in variety organisms. addition, discuss how helps regulate tissue morphology during embryonic development governing key elements cell shape, adhesion, migration differentiation.

Language: Английский

Citations

323
Crosstalk between mechanotransduction and metabolism DOI
Patrizia Romani, Lorea Valcárcel-Jiménez, Christian Frezza

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2020, Volume and Issue: 22(1), P. 22 - 38

Published: Nov. 13, 2020

Language: Английский

Citations

299
Mechanical regulation of chromatin and transcription DOI
Sirio Dupont, Sara A. Wickström

Nature Reviews Genetics, Journal Year: 2022, Volume and Issue: 23(10), P. 624 - 643

Published: May 23, 2022

Language: Английский

Citations

143
Inhibition of ferroptosis and iron accumulation alleviates pulmonary fibrosis in a bleomycin model DOI Creative Commons

Zhuo Pei,

Yifei Qin, Xianghui Fu

et al.

Redox Biology, Journal Year: 2022, Volume and Issue: 57, P. 102509 - 102509

Published: Oct. 18, 2022

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease characterized by excessive proliferation of fibroblasts and accumulation extracellular matrix (ECM). Ferroptosis novel form cell death the lethal iron lipid peroxidation, which associated with many diseases. Our study addressed potential role played ferroptosis in progression fibrosis. We found that inducers injury, namely, bleomycin (BLM) lipopolysaccharide (LPS), induced lung epithelial cells. Both inhibitor liproxstatin-1 (Lip-1) chelator deferoxamine (DFO) alleviated symptoms or LPS. TGF-β stimulation upregulated expression transferrin receptor protein 1 (TFRC) human fibroblast line (MRC-5) mouse primary fibroblasts, resulting increased intracellular Fe2+, promoted transformation into myofibroblasts. Mechanistically, enhanced nuclear localization transcriptional coactivator tafazzin (TAZ), combined transcription factor TEA domain (TEAD)-4 to promote TFRC. In addition, elevated Fe2+ failed induce might be related regulation export metabolism. Finally, we specifically knocked out TFRC mice, compared those control were reduced knockout mice after induction. Collectively, these findings suggest therapeutic inhibitors chelators treating

Language: Английский

Citations

132
Biomaterial-induced pathway modulation for bone regeneration DOI Creative Commons
Steven Vermeulen, Zeinab Tahmasebi Birgani, Pamela Habibović

et al.

Biomaterials, Journal Year: 2022, Volume and Issue: 283, P. 121431 - 121431

Published: Feb. 18, 2022

Embryogenic developmental processes involve a tightly controlled regulation between mechanical forces and biochemical cues such as growth factors, matrix proteins, cytokines. This interplay remains essential in the mature body, with aberrant pathway signaling leading to abnormalities atherosclerosis cardiovascular system, inflammation tendon tissue, or osteoporosis bone. The aim of bone regenerative strategies is develop tools procedures that will harness body's own self-repair ability order successfully regenerate even very large complex defects restore normal function. To achieve this, understanding pathways govern progenitor differentiation towards osteogenic lineages, their phenotypical maintenance, construction functional tissue imperative subsequently therapies mimic these processes. While body literature exists describes how stimuli guide cell behavior culture dish, due lack an appropriate environment, signals are often insufficient inappropriate for achieving desirable response body. Moreover, rarely rely on stimulus, factor alone, instead comprise carrier biomaterial introduces different microenvironment from dish. Therefore, this review, we discuss which biomaterials elicit influence relevant regeneration describe mechanisms behind effects, inspire development novel, more effective therapies.

Language: Английский

Citations

75
Hippo pathway dysregulation in gastric cancer: from Helicobacter pylori infection to tumor promotion and progression DOI Creative Commons
Beatrice Messina, Federica Lo Sardo, Stefano Scalera

et al.

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(1)

Published: Jan. 12, 2023

Abstract The Hippo pathway plays a critical role for balancing proliferation and differentiation, thus regulating tissue homeostasis. acts through kinase cascade whose final effectors are the Yes-associated protein (YAP) its paralog transcriptional co‑activator with PDZ‑binding motif (TAZ). In response to variety of upstream signals, YAP TAZ activate program that modulates cellular proliferation, repair after injury, stem cell fate decision, cytoskeletal reorganization. signaling is often dysregulated in gastric cancer Helicobacter pylori-induced infection, suggesting putative deregulation since early stages disease. this review, we summarize architecture regulation discuss how dysregulation fuels onset progression cancer. setting, also focus on crosstalk between other established oncogenic pathways. Lastly, provide insights into therapeutic approaches targeting aberrant YAP/TAZ activation related clinical perspectives challenges.

Language: Английский

Citations

47
Trends in mechanobiology guided tissue engineering and tools to study cell-substrate interactions: a brief review DOI Creative Commons
Arun Rajendran,

D. Sankar,

Sivashanmugam Amirthalingam

et al.

Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)

Published: Feb. 9, 2023

Sensing the mechanical properties of substrates or matrix by cells and tissues, subsequent downstream responses at cellular, nuclear epigenetic levels outcomes are beginning to get unraveled more recently. There have been various instances where researchers established underlying connection between cellular mechanosignalling pathways physiology, differentiation, also tissue pathology. It has now accepted that mechanosignalling, alone in combination with classical pathways, could play a significant role fate determination, development, organization tissues. Furthermore, as mechanobiology is gaining traction, so do techniques ponder gain insights into still pathways. This review would briefly discuss some interesting works wherein it shown specific alteration lead determination stem differentiated such osteoblasts, adipocytes, tenocytes, cardiomyocytes, neurons, how these being utilized for development organoids. cover developed employed explore effects including imaging mechanosensing proteins, atomic force microscopy (AFM), quartz crystal microbalance dissipation measurements (QCMD), traction (TFM), microdevice arrays, Spatio-temporal image analysis, optical tweezer measurements, mechanoscanning ion conductance (mSICM), acoustofluidic interferometric device (AID) forth. provide who work on exploiting control functions engineering regenerative applications, will shed light advancements be unravel unknown field mechanobiology.

Language: Английский

Citations

43
Role of YAP/TAZ in Cell Lineage Fate Determination and Related Signaling Pathways DOI Creative Commons
Boon Chin Heng, Xuehui Zhang, Dominique Aubel

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2020, Volume and Issue: 8

Published: July 30, 2020

The penultimate effectors of the Hippo signaling pathways YAP and TAZ, are transcriptional co-activator proteins that play key roles in many diverse biological processes, ranging from cell proliferation, tumorigenesis, mechanosensing lineage fate determination, to wound healing regeneration. In this review, we discuss regulatory mechanisms by which YAP/TAZ control stem/progenitor differentiation into various major lineages interest tissue engineering regenerative medicine applications. Of particular is role maintaining delicate balance between quiescence, self-renewal, proliferation endogenous adult stem cells within tissues/organs during early development, normal homeostasis regeneration/healing. Finally, will consider how increasing knowledge might influence trajectory future progress medicine.

Language: Английский

Citations

98
NOTCH-YAP1/TEAD-DNMT1 Axis Drives Hepatocyte Reprogramming Into Intrahepatic Cholangiocarcinoma DOI Creative Commons
Shikai Hu, Laura Molina, Junyan Tao

et al.

Gastroenterology, Journal Year: 2022, Volume and Issue: 163(2), P. 449 - 465

Published: May 10, 2022

Language: Английский

Citations

55