Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 264, P. 116656 - 116656
Published: Aug. 9, 2024
Language: Английский
Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(1), P. 17 - 17
Published: Jan. 9, 2025
The widely available options of different manufacturers in dental implant systems have complicated the selection criteria process for periodontists, necessitating careful consideration various factors when selecting suitable solutions individual patient needs. Optimal requires patient-specific factors, design, and surgical technique. Understanding biomechanical behavior implant-tissue interactions is crucial achieving successful long-lasting therapy. To adequately address this issue improve rigorous from a biomechanically numerical approach, research aims to analyze stress distribution fields, strain patterns, load transfer displacements within system implant-biological interface (gingival bony tissues) titanium three-piece two-one-piece ceramic systems. Thus, three commercially implants designed be placed jaw molar region were considered evaluation through finite element method under both oblique occlusal loading conditions. results exhibited an increasing trend highlight outstanding two-piece dissipate better (6 2 times lower than three- one-piece loads almost 5 1.3 more efficient loading, respectively), minimize peak values (below 100 MPa), reduce patterns compared with other two evaluated designs. On hand, effects generated biological tissues are strongly associated geometry features. This approach could provide promising strategy predicting micro-strains micromotion pieces geometries. Hence, these findings contribute deeper understanding biomechanics spectrum emphasize importance carefully appropriate material accurate performance.
Language: Английский
Citations
1
APL Bioengineering, Journal Year: 2025, Volume and Issue: 9(1)
Published: Jan. 17, 2025
Many cellular functions depend on the physical properties of cell's environment. bacteria have different types surface appendages to enable adhesion and motion various surfaces. Myxococcus xanthus is a social soil bacterium with two distinctly regulated modes motility, termed motility mode, driven by type IV pili, adventurous based focal complexes. How sense surfaces subsequently coordinate their collective remains largely unclear. Using polyacrylamide hydrogels tunable stiffness, we found that wild M. spreads faster stiffer substrates. Here, show using mutants disrupt suppresses this substrate stiffness response, suggesting adhesion-based dependent. We also modifying adding adhesive ligands, chitosan, increases amount flairs, characteristic feature motility. Taken together, hypothesize central role as driving mechanism for sensing.
Language: Английский
Citations
1
Polymers, Journal Year: 2023, Volume and Issue: 15(19), P. 3854 - 3854
Published: Sept. 22, 2023
The utilization of materials in medical implants, serving as substitutes for non-functional biological structures, supporting damaged tissues, or reinforcing active organs, holds significant importance modern healthcare, positively impacting the quality life millions individuals worldwide. However, certain implants may only be required temporarily to aid healing process diseased injured tissues and tissue expansion. Biodegradable metals, including zinc (Zn), magnesium (Mg), iron, others, present a new paradigm realm implant materials. Ongoing research focuses on developing optimized that meet standards, encompassing controllable corrosion rates, sustained mechanical stability, favorable biocompatibility. Achieving these objectives involves refining alloy compositions tailoring processing techniques carefully control microstructures properties. Among under investigation, Mg- Zn-based biodegradable their alloys demonstrate ability provide necessary support during regeneration while gradually degrading over time. Furthermore, essential elements human body, Mg Zn offer additional benefits, promoting wound healing, facilitating cell growth, participating gene generation interacting with various vital functions. This review provides an overview physiological function significance health usage using scaffolds. scaffold qualities, such biodegradation, characteristics, biocompatibility, are also discussed.
Language: Английский
Citations
17
Biosensors, Journal Year: 2024, Volume and Issue: 14(8), P. 407 - 407
Published: Aug. 22, 2024
Challenges in directed differentiation and survival limit the clinical use of stem cells despite their promising therapeutic potential regenerative medicine. Nanotechnology has emerged as a powerful tool to address these challenges enable precise control over cell fate. In particular, nanomaterials can mimic an extracellular matrix provide specific cues guide proliferation field nanotechnology. For instance, recent studies have demonstrated that nanostructured surfaces scaffolds enhance lineage commitment modulated by intracellular regulation external stimulation, such reactive oxygen species (ROS) scavenging, autophagy, or electrical stimulation. Furthermore, nanoframework-based upconversion nanoparticles be used deliver bioactive molecules, growth factors, genetic materials facilitate tissue regeneration. The increasing nanostructures research led development new approaches. Therefore, this review provides overview advances for modulating differentiation, including metal-, carbon-, peptide-based strategies. addition, we highlight nano-enabled technologies applications therapy focusing on improving efficiency therapeutics. We believe will inspire researchers intensify efforts deepen understanding, thereby accelerating modulation, pharmaceutical industry,
Language: Английский
Citations
6
Biomaterials Advances, Journal Year: 2023, Volume and Issue: 154, P. 213653 - 213653
Published: Oct. 10, 2023
Language: Английский
Citations
13
Mechanobiology in Medicine, Journal Year: 2024, Volume and Issue: 2(1), P. 100041 - 100041
Published: Feb. 1, 2024
Type 1 hypersensitivity involves an exaggerated immune reaction triggered by allergen exposure, leading to rapid release of inflammatory mediators. Meanwhile, mechanobiology explores how physical forces influence cellular processes, and recent research underscores its relevance in allergic reactions. This review provides a concise overview hypersensitivity, highlighting the pivotal role mast cells immunoglobulin E (IgE) antibodies orchestrating Recognizing dynamic nature responses allergies, this study subsequently delves into emerging field significance understanding mechanical governing cell behavior. Furthermore, molecular during activation degranulation are explored, elucidating aspects IgE binding cytoskeletal rearrangements. Next, we discuss intricate interplay between extracellular matrix, emphasizing impact matrix stiffness on responses. Additionally, examine key mechanosensitive signaling pathways, including mitogen-activated protein kinase (MAPK) pathway, Rho guanosine triphosphatase (GTPase) integrin-mediated focal adhesion signaling, shedding light their contributions insights potential therapeutic targets biomarkers, paving way for better clinical management
Language: Английский
Citations
5
Small, Journal Year: 2024, Volume and Issue: 20(21)
Published: Jan. 7, 2024
Biological systems perceive and respond to mechanical forces, generating cues regulate life processes. Analyzing biomechanical forces has profound significance for understanding biological functions. Therefore, a series of molecular techniques have been developed, mainly including single-molecule force spectroscopy, traction microscopy, tension sensor systems, which provide indispensable tools advancing the field mechanobiology. DNA molecules with programmable structure well-defined characteristics attached much attention sensors as sensing elements, are designed study present information high sensitivity resolution. In this work, comprehensive overview technology is presented, particular focus on specifically those based DNA. Finally, future development challenges DNA-based looked upon.
Language: Английский
Citations
4
Authorea (Authorea), Journal Year: 2024, Volume and Issue: unknown
Published: Feb. 22, 2024
Type 1 hypersensitivity involves an exaggerated immune reaction triggered by allergen exposure, leading to rapid release of inflammatory mediators. Meanwhile, mechanobiology explores how physical forces influence cellular processes, and recent research underscores its relevance in allergic reactions. This review provides a concise overview hypersensitivity, highlighting the pivotal role mast cells immunoglobulin E (IgE) antibodies orchestrating Recognizing dynamic nature responses allergies, this study subsequently delves into emerging field significance understanding mechanical governing cell behavior. Furthermore, molecular during activation degranulation are explored, elucidating aspects IgE binding cytoskeletal rearrangements. Next, we discuss intricate interplay between extracellular matrix, emphasizing impact matrix stiffness on responses. Additionally, examine key mechanosensitive signaling pathways, including mitogen-activated protein kinase (MAPK) pathway, Rho guanosine triphosphatase (GTPase) integrin-mediated focal adhesion signaling, shedding light their contributions insights potential therapeutic targets biomarkers, paving way for better clinical management reactions.Keywords: hypersensitivity; mechanobiology; mechanosensing; mechanotransduction; allergy.IntroductionType represents prototypical characterized response innocuous substances, known as allergens. is classified immediate or (IgE)-mediated involving mediators upon re-exposure specific The sensitization phase begins when system individuals prone responds first exposure allergens producing [1,2]. These occupy high-affinity receptors surface basophils. Upon subsequent these allergens, crosslink activate basophils, triggering potent such histamine, leukotrienes, cytokines (Figure ) [1,3–5]. results manifestations allergy, ranging from mild symptoms like itching sneezing severe, life-threatening reactions anaphylaxis [1,6]. Common implicated span broad spectrum, environmental pollen, dust mites animal dander, well food nuts, shellfish eggs. insect venom, certain medications latex recognized triggers [7]. pivotal, perceives them foreign mounts response, with exposures heightened sensitivity escalating [8].
Language: Английский
Citations
4
Analytical Sciences, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 7, 2025
Electrochemiluminescence (ECL) is a chemiluminescence phenomenon triggered by electrochemical reactions and widely used for (bio)chemical analyses bioimaging. Compared to fluorescence sensing, ECL sensing reduces background noise eliminating autofluorescence associated with excitation light. In addition, compared conventional imaging scanning microscopes, faster as it requires no scanning. Furthermore, unlike electrode arrays, devices can function without complex wiring, simplifying their construction. These characteristics render useful analytical tool. Recently, has been in vitro cell analysis due high demand biochips regenerative medicine, drug screening, microphysiological systems. This review focuses on recent advancements ECL-based applications the detection of H2O2, respiration activity, adhesion, lipid membranes, bipolar electrochemistry-based devices.
Language: Английский
Citations
0
Measurement, Journal Year: 2025, Volume and Issue: unknown, P. 116990 - 116990
Published: Feb. 1, 2025
Language: Английский
Citations
0