Divergent evolution of sleep functions DOI Creative Commons

Michaela Joyce,

Federica A. Falconio, Laurence Blackhurst

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: May 28, 2023

Abstract Most living organisms have evolved to synchronize their biological activities with the earth’s rotation, a daily regulation of biology and behaviour controlled by an evolutionary conserved molecular machinery known as circadian clock. For most animals, mechanisms are meant maximize exposure positive ( e.g.: social interactions, mating, feeding – generally during day) minimize peril predation, weather, darkness night 1 ). On top regulation, some behaviours also feature second layer homeostatic control acting fail-safe ensure important not ignored. Sleep is one these behaviours: largely clock for its baseline appearance, it at same time modulated poorly understood regulator ensuring animals obey species-specific amount sleep 2 . An often considered main evidence core function beyond trivial (that is: keeping us out trouble limiting our energy expenditure danger 3,4 ) hypothesized that around this mysterious basic function. Here we characterize in group seven species Drosophila genus key distances representing variety ecological niche adaptations. We show spontaneous circadian-driven aspects among all but unexpectedly, not. uncover differences behavioural, cell-biological neuro-pharmacological suggest that, Drosophilids, primarily satisfy role, immobile dangerous hours day. The functions independently, fashion, conserved.

Language: Английский

Pleiotropic function of the oca2 gene underlies the evolution of sleep loss and albinism in cavefish DOI Creative Commons

Morgan O’Gorman,

Sunishka Thakur, Gillian Imrie

et al.

Current Biology, Journal Year: 2021, Volume and Issue: 31(16), P. 3694 - 3701.e4

Published: July 21, 2021

Language: Английский

Citations

47
Lateral hypothalamic neuronal ensembles regulate pre-sleep nest-building behavior DOI Creative Commons
María Inés Sotelo, Jean Tyan,

Chelsea Markunas

et al.

Current Biology, Journal Year: 2022, Volume and Issue: 32(4), P. 806 - 822.e7

Published: Jan. 19, 2022

Language: Английский

Citations

29
Neurophysiological and behavioral synchronization in group-living and sleeping mice DOI Creative Commons
María Inés Sotelo,

Chelsea Markunas,

Tyler Kudlak

et al.

Current Biology, Journal Year: 2023, Volume and Issue: 34(1), P. 132 - 146.e5

Published: Dec. 22, 2023

Language: Английский

Citations

17
Divergent evolution of sleep in Drosophila species DOI Creative Commons

Michaela Joyce,

Federica A. Falconio, Laurence Blackhurst

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 14, 2024

Abstract Living organisms synchronize their biological activities with the earth’s rotation through circadian clock, a molecular mechanism that regulates biology and behavior daily. This synchronization factually maximizes positive (e.g., social interactions, feeding) during safe periods, minimizes exposure to dangers predation, darkness) typically at night. Beyond basic regulation, some behaviors like sleep have an additional layer of homeostatic control, ensuring those essential are fulfilled. While is predominantly governed by secondary regulator, though not well-understood, ensures adherence necessary amounts hints fundamental function beyond simple energy conservation safety. Here we explore regulation across seven Drosophila species diverse ecological niches, revealing while circadian-driven aspects consistent, varies significantly. The findings suggest in Drosophilids, evolved primarily for purposes. more complex, homeostatically regulated functions appear independently species-specific manner, universally conserved. laboratory model may reproduce recapitulate primordial evolution.

Language: Английский

Citations

8
Alzheimer’s disease and sleep disorders: a bidirectional relationship DOI Creative Commons
J Chen,

Guoping Peng,

Binggui Sun

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: 557, P. 12 - 23

Published: Aug. 11, 2024

Alzheimer's disease (AD) is the most prevalent dementia, pathologically featuring abnormal accumulation of amyloid-β (Aβ) and hyperphosphorylated tau, while sleep, divided into rapid eye movement sleep (REM) nonrapid (NREM), plays a key role in consolidating social spatial memory. Emerging evidence has revealed that disorders such as circadian disturbances disruption neuronal rhythm activity are considered both candidate risks consequence AD, suggesting bidirectional relationship between AD. This review will firstly grasp basic knowledge AD pathogenesis, then highlight macrostructural microstructural alteration along with progression, explain interaction Aβ which two critical neuropathological processes well neuroinflammation finally introduce several methods enhancement strategies to reduce AD-associated neuropathology. Although theories about relevant therapeutic mice have been developed recent years, human still limited. More studies on how effectively ameliorate pathology patients by what specific roles play needed.

Language: Английский

Citations

7
Drosophila as a Model to Study the Relationship Between Sleep, Plasticity, and Memory DOI Creative Commons
Stephane Dissel

Frontiers in Physiology, Journal Year: 2020, Volume and Issue: 11

Published: May 28, 2020

Humans spend nearly a third of their life sleeping, yet, despite decades research the function sleep still remains mystery. Sleep has been linked with various biological systems and functions, including metabolism, immunity, cardiovascular system, cognitive functions. Importantly, appears to be present throughout animal kingdom suggesting that it must provide an evolutionary advantage. Among many possible functions sleep, relationship between cognition received lot support. We have all experienced negative effects associated night deprivation. These can include increased emotional reactivity, poor judgment, deficit in attention, impairment learning memory, obviously increase daytime sleepiness. Furthermore, neurological diseases like Alzheimer's disease often disorder component. In some cases, exacerbate progression disease. Thus, is clear plays important role for brain particular, shown play positive consolidation long-term memory while deprivation negatively impacts memory. behavior adapted individual's need influenced by external internal stimuli. addition being adaptive behavior, also modulate plasticity at level synaptic connections neurons neuronal influences sleep. Understanding how modulated stimuli key question neuroscience. order address this question, several models developed. them, fruit fly Drosophila melanogaster its unparalleled genetics proved extremely valuable. excellent model study complex behaviors, learning, This review describes our current knowledge plasticity, using model.

Language: Английский

Citations

44
Sleep loss and addiction DOI
Luis Angel López-Muciño, Fabio García‐García, Jonathan Cueto‐Escobedo

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 141, P. 104832 - 104832

Published: Aug. 18, 2022

Language: Английский

Citations

26
Astrocytic GABA transporter controls sleep by modulating GABAergic signaling in Drosophila circadian neurons DOI Creative Commons
Ratna Chaturvedi,

Tobias Stork,

Chunyan Yuan

et al.

Current Biology, Journal Year: 2022, Volume and Issue: 32(9), P. 1895 - 1908.e5

Published: March 17, 2022

Language: Английский

Citations

25
Novel Husbandry Practices Result in Rapid Rates of Growth and Sexual Maturation Without Impacting Adult Behavior in the Blind Mexican Cavefish DOI
Robert A. Kozol,

Anders Yuiska,

Ji Heon Han

et al.

Zebrafish, Journal Year: 2023, Volume and Issue: 20(2), P. 86 - 94

Published: April 1, 2023

Animal model systems are dependent on the standardization of husbandry protocols that maximize growth and reduce generation time. The Mexican tetra, Astyanax mexicanus, exists as eyed surface blind cave dwelling populations. opportunity for comparative approaches between independently evolved populations has led to rapid A. mexicanus a evolution biomedical research. However, slow inconsistent rate remains major limitation expanded application mexicanus. Fortunately, this temporal can be addressed through changes accelerate rates while maintaining optimal health outcomes. Here, we describe protocol produces in diet, feeding frequency, sorting progressive tank size. This produced robust decreased age sexual maturity comparison our previous protocol. To determine whether impacted behavior, tested fish exploration schooling assays. We found no difference behavior two groups, suggesting increased will not impact natural variation behavioral traits. Taken together, standardized development genetic model.

Language: Английский

Citations

16
Lessons from lonely flies: Molecular and neuronal mechanisms underlying social isolation DOI Creative Commons

R Sai Prathap Yadav,

Faizah Ansari,

Neha Bera

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 156, P. 105504 - 105504

Published: Dec. 6, 2023

Animals respond to changes in the environment which affect their internal state by adapting behaviors. Social isolation is a form of passive environmental stressor that alters animal behaviors across kingdom, including humans, rodents, and fruit flies. known increase violence, disrupt sleep depression leading poor mental physical health. Recent evidence from several model organisms suggests social leads remodeling transcriptional epigenetic landscape behavioral outcomes. In this review, we explore how manipulating experience fly Drosophila melanogaster can shed light on molecular neuronal mechanisms underlying driven We discuss recent advances made using powerful genetic toolkit assays uncover role neuromodulators, sensory modalities, pheromones, circuits mediating isolation. The insights gained these studies could be crucial for developing effective therapeutic interventions future.

Language: Английский

Citations

13