Nanoarchitectonics: what's coming next after nanotechnology?

Nanoscale Horizons, Journal Year: 2021, Volume and Issue: 6(5), P. 364 - 378

Published: Jan. 1, 2021

The nanoarchitectonics concept has the ability to bridge nanoscale science and visual size materials. final goal of approaches is creation living-creature-like functional material systems from simple objects.

Language: Английский

---

There is still plenty of room for layer-by-layer assembly for constructing nanoarchitectonics-based materials and devices

Physical Chemistry Chemical Physics, Journal Year: 2021, Volume and Issue: 24(7), P. 4097 - 4115

Published: Dec. 2, 2021

While the layer-by-layer (LbL) assembly method has already reached a certain maturity, there is still plenty of room for expanding its usefulness fabrication nanoarchitectonics-based materials and devices.

Language: Английский

---

Contemporary Approaches for Amide Bond Formation

Advanced Synthesis & Catalysis, Journal Year: 2023, Volume and Issue: 365(24), P. 4359 - 4391

Published: Nov. 7, 2023

Abstract Amide bond construction has garnered significant interest in recent decades due to amides being one of the most prevalent functional groups among bioactive molecules. Out thirty‐seven new drugs approved by FDA 2022, eleven are small molecules containing at least amide bond. Additionally, there nineteen large as drugs, some which have peptide structures, and therefore, also bear bonds. In years, multiple teams embraced challenge developing more efficient methods for formation. This dedication led numerous publications appearing monthly prestigious journals, showcasing advancements this field. The primary goal review is present viable strategies constructing It crucial differentiate between formation synthesis; hence, focus on describing specific forming C(O)−N particular, concentrates developed within last six years. There a particular emphasis approaches that consider thought process when selecting starting materials groups. approach ensures coverage all common chemical transformations yield

Language: Английский

---

Nanoarchitectonics for Coordination Asymmetry and Related Chemistry

Bulletin of the Chemical Society of Japan, Journal Year: 2020, Volume and Issue: 94(3), P. 839 - 859

Published: Dec. 14, 2020

Abstract Nanoarchitectonics is a concept envisioned to produce functional materials from nanoscale units through fusion of nanotechnology with other scientific disciplines. For component selection, coordination complexes metallic elements have wider variety element selection because cover ca. 80% the periodic table elements. Application nanoarchitectonics approaches chemistry leads huge expansion this much range Especially, asymmetry strategy architects asymmetrical and/or chiral structures electronic states formation metal complexes, leading material systems in certain anisotropy and selectivity. This review article presents collecting recent examples field asymmetry. Introduced are classified into several categories various viewpoints: (i) basic molecular designs; (ii) specific features depending on interfacial media, space contact bio-functions; (iii) functions; (iv) supporting techniques such as analyses theory.

Language: Английский

---

Nanoarchitectonics Intelligence with atomic switch and neuromorphic network system

Applied Physics Express, Journal Year: 2022, Volume and Issue: 15(10), P. 100101 - 100101

Published: Sept. 15, 2022

Abstract An emerging concept of “nanoarchitectonics” has been proposed as a way to apply the progress nanotechnology materials science. In introductory parts, we briefly explain in understanding through nanotechnology, overview nanoarchitectonics, effects nanoarchitectonics on development functional and devices, outline intelligence main subject this review paper. following sections, process constructing intelligent devices based atomic switches, which behavior atoms determines device functions, by integrating them with nanoarchitectonics. The contents are categorized into (i) basic operation switch, (ii) artificial synapse, (iii) neuromorphic network system, (iv) hetero-signal conversion, (v) decision making device, (vi) switch practical uses. switches were originally relatively simple ON/OFF binary-type electrical but their potential multi-level resistive memory for synapses applications. Furthermore, network-structured complex have regression pathways structure resemble cranial neural circuits. For example, A decision-making that reproduces human thinking principle different from brain circuits was developed using proton-conductive electrochemical cells. progressively usages including application harsh environments (e.g. high temperature, low space). Efforts toward information processing applications tell remarkable success stories linking control motion brain-like nanoarchitecture regulations.

Language: Английский

---

Regulation of stem cell fate and function by using bioactive materials with nanoarchitectonics for regenerative medicine

Science and Technology of Advanced Materials, Journal Year: 2022, Volume and Issue: 23(1), P. 393 - 412

Published: June 6, 2022

Nanoarchitectonics has emerged as a post-nanotechnology concept. As one of the applications nanoarchitectonics, this review paper discusses control stem cell fate and function an important issue. For hybrid nanoarchitectonics involving living cells, it is crucial to understand how biomaterials their nanoarchitected structures regulate behaviours fates cells. In review, for regulation are firstly discussed. Besides multipotent differentiation, immunomodulation biological mesenchymal cells (MSCs). MSCs can modulate immune treat multiple immune- inflammation-mediated diseases. The following sections summarize recent advances immunomodulatory functions by biophysical signals. third part, we discussed direct self-organization pluripotent organoid. Bioactive materials constructed which mimic cues in vivo microenvironment such elasticity, viscoelasticity, biodegradation, fluidity, topography, geometry, etc. Stem interpret these different cytoskeletal forces. forces lead substantial transcription protein expression, affect function. Regulations could not be utilized only tissue repair regenerative medicine but also potentially production advanced systems. Materials with integration related substances would have high impacts science technology materials.

Language: Английский

---

Plant Antimicrobial Peptides (PAMPs): Features, Applications, Production, Expression, and Challenges

Molecules, Journal Year: 2022, Volume and Issue: 27(12), P. 3703 - 3703

Published: June 9, 2022

The quest for an extraordinary array of defense strategies is imperative to reduce the challenges microbial attacks on plants and animals. Plant antimicrobial peptides (PAMPs) are a subset (AMPs). PAMPs elicit against prevent drug resistance pathogens given their wide spectrum activity, excellent structural stability, diverse mechanism action. This review aimed identify applications, features, production, expression, using its structure–activity relationship. discovery techniques used these were also explored provide insight into significance in genomics, transcriptomics, proteomics, expression disease-causing pathogens. creates awareness as potential therapeutic agents medical pharmaceutical fields, such sensitive treatment bacterial fungal diseases others utilization preserving crops available transgenic methods agronomical field. safe handle easy recycle with use proteases convert them more potent sustainable development.

Language: Английский

---

Plant antimicrobial peptides: a comprehensive review of their classification, production, mode of action, functions, applications, and challenges

Food & Function, Journal Year: 2023, Volume and Issue: 14(12), P. 5492 - 5515

Published: Jan. 1, 2023

The emergence of pathogens resistant to conventional antibiotics and the growing interest in developing alternative natural antimicrobial agents have prompted a search for plant-derived peptides (PAMPs) recent years.

Language: Английский

---

Nanoarchitectonics Revolution and Evolution: From Small Science to Big Technology

Small Science, Journal Year: 2020, Volume and Issue: 1(1)

Published: Dec. 6, 2020

Along with the progresses of material syntheses, importance structural regulation is realized to rationally improve efficiencies and specificities in target functions. Small science necessary for advanced systems. A novel concept, nanoarchitectonics, combine nanotechnology other scientific disciplines synthesize a functional system contributions small objects, nano‐units, recently proposed. Based on facts knowledge nanoscale objects explored by nanotechnology, systems are constructed using nano‐units aid research fields, such as organic chemistry, supramolecular materials science, biology. The introduction nanoarchitectonics essences construction can produce unusual systems, brain‐like information processing based atomic‐level reactions, diffusions, aggregations. Probe‐tip‐mediated reactions also possible precise site selectivity. coupling equilibrium self‐assemblies non‐equilibrium fabrication processes results variously structured hierarchical structures even from simple 0D fullerenes. Especially, interfacial directly bridge nanoscopic functions macroscopic actions, including facile contact nanostructures living cells. This review article overviews origin future, atoms materials, big technology.

Language: Английский

---

Peptide Bond-Forming Reaction via Amino Acid Silyl Esters: New Catalytic Reactivity of an Aminosilane

ACS Catalysis, Journal Year: 2020, Volume and Issue: 10(16), P. 9594 - 9603

Published: July 31, 2020

The epimerization-free formation of peptide bonds is crucial for the development therapeutics and pharmaceuticals. Herein, we report a hydrosilane-mediated approach construction between most amino acids under ambient conditions. This concise protocol with an original silylating reagent HSi(OCH(CF3)2)3 facilitates use bearing broad variety functional groups without any epimerization. Moreover, catalytic system using aminosilane catalyst enables not only acceleration in silylation carboxylic but also amide synthesis minimal substrate (electrophile/nucleophile/silylating = 1:1:1) waste production (hydrogen gas siloxane). These simple powerful approaches are established as potentially general paradigm desired peptides high yields.

Language: Английский

---