MiRroring the Multiple Potentials of MicroRNAs in Acute Myocardial Infarction DOI Creative Commons

Solenne Paiva,

Onnik Agbulut

Frontiers in Cardiovascular Medicine, Journal Year: 2017, Volume and Issue: 4

Published: Nov. 19, 2017

At present, cardiovascular diseases are depicted to be the leading cause of death worldwide according World Health Organization. In future, projections predict that ischemic heart disease will persist in top main causes illness. Within this alarming context, some tiny master regulators gene expression programs, namely microRNAs carry three promising potentials. fact, miRNAs can prove useful terms biomarkers allowing injury detection, but also therapeutics overcome limitations past strategies and treat lesions. a more creative approach, they even used area human engineered cardiac tissues as maturation tools for cardiomyocytes derived from pluripotent stem cell. Very not only patient-specific cell-based therapies develop biomimetic microsystems modelling drug screening, these cells greatly contribute personalized medicine. To get into matter, focus review lies primarily on acute myocardial infarction biomarkers. Only large cohort studies comprising over one hundred individuals reach potent statistical value were considered. Certain appeared possibly complement protein-based classical risk factors. Some described bear potential discrimination similar symptomatic pathologies. However, differences between pre-analytical analytical approaches substantially influenced miRNA data. Further supported by meta-analysis studies, problematic had addressed. A detailed critical analysis each step define biomarker is provided inspire future improved universal strategy. Interestingly, recurrent set cardiomyocyte-enriched was found, miR-1; miR-133; miR-208a/b miR-499a. Each member myomiRs group displayed roles either individually or combination diagnostic prognostic Furthermore, precise combo shown powerful enough transdifferentiate fibroblasts opening doors therapeutics. Following discoveries, emerged optional transfect order mature cells. Ultimately, multiple potentials carried miR-499a still remain fully unveiled.

Language: Английский

Mesenchymal stem cells-derived extracellular vesicles, via miR-210, improve infarcted cardiac function by promotion of angiogenesis DOI
Na Wang,

Caiyu Chen,

Dezhong Yang

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2017, Volume and Issue: 1863(8), P. 2085 - 2092

Published: Feb. 27, 2017

Language: Английский

Citations

227
Epigenetic Biomarkers in Cardiovascular Diseases DOI Creative Commons
Carolina Soler‐Botija, Carolina Gálvez‐Montón, Antoni Bayés‐Genís

et al.

Frontiers in Genetics, Journal Year: 2019, Volume and Issue: 10

Published: Oct. 9, 2019

Cardiovascular diseases are the number one cause of death worldwide and have a great impact on quality life medical costs. Enormous efforts being made in research to obtain new tools for an efficient quick diagnosis prognosis these diseases. Discoveries epigenetic mechanism related several pathologies, including cardiovascular diseases, with dysregulation. This implications disease progression opens preventive strategies. Advances methodology big data analysis identified novel mechanisms targets involved numerous making possible more individualize maps that would lead personalized treatment. pave way what is called pharmacoepigenetics, which consider differences basis each patient predict drug response develop tailored therapy. Likewise, biomarkers emerged as promising instrument consistent disease. Their good accessibility feasible detection make them suitable implantation clinical practice. However, it major requirement perform multicenter studies large sample population determine confidently reliable be implanted routine. review, therefore, focuses therapies current discoveries controversy aimed improve diagnosis, therapy patients.

Language: Английский

Citations

103
Role of flow-sensitive microRNAs and long noncoding RNAs in vascular dysfunction and atherosclerosis DOI
Sandeep Kumar, Darian Williams,

Sanjoli Sur

et al.

Vascular Pharmacology, Journal Year: 2018, Volume and Issue: 114, P. 76 - 92

Published: Oct. 7, 2018

Language: Английский

Citations

101
Non-coding RNAs as biomarkers for acute myocardial infarction DOI Open Access
Chen Wang, Qing Jing

Acta Pharmacologica Sinica, Journal Year: 2018, Volume and Issue: 39(7), P. 1110 - 1119

Published: April 26, 2018

Language: Английский

Citations

96
The circulating non-coding RNA landscape for biomarker research: lessons and prospects from cardiovascular diseases DOI Open Access
Ewa Stępień, Marina C. Costa,

Szczepan Kurc

et al.

Acta Pharmacologica Sinica, Journal Year: 2018, Volume and Issue: 39(7), P. 1085 - 1099

Published: June 7, 2018

Language: Английский

Citations

95
Systematic review of microRNA biomarkers in acute coronary syndrome and stable coronary artery disease DOI
Amanpreet Kaur, Sharon Mackin, Kenny Schlosser

et al.

Cardiovascular Research, Journal Year: 2019, Volume and Issue: 116(6), P. 1113 - 1124

Published: Nov. 27, 2019

Abstract The aim of this systematic review was to assess dysregulated miRNA biomarkers in coronary artery disease (CAD). Dysregulated microRNA (miRNAs) have been shown be linked cardiovascular pathologies including CAD and may utility as diagnostic prognostic biomarkers. We compared miRNAs identified acute syndrome (ACS) with stable control populations. conducted a search controlled vocabulary free text terms related ACS, Biosis Previews (OvidSP), Cochrane Library (Wiley), Embase Global Health Medline (PubMed OvidSP), Web Science (Clarivate Analytics), ClinicalTrials.gov which yielded 7370 articles. Of these, 140 original articles were appropriate for data extraction. most frequently reported any (miR-1, miR-133a, miR-208a/b, miR-499) are expressed abundantly the heart play crucial roles cardiac physiology. In studies comparing ACS cases patients, miR-21, miR-133a/b, miR-30 family, miR-19, miR-20 ACS. While number feature consistently across their expression both CAD, when controls, certain specifically (miR-499, miR-1, miR-208a/b) (miR-215, miR-487a, miR-502). Thus, miR-133, miR-499 appear potential differentiate diagnosis from especially showed correlation between level concentration gradient myocardial damage. Although these biomarkers, findings should interpreted caution majority predefined candidate-driven assessments limited (PROSPERO registration: CRD42017079744).

Language: Английский

Citations

86
Roles of MicroRNA-122 in Cardiovascular Fibrosis and Related Diseases DOI Open Access
Ying Liu,

Jiawei Song,

Jian-Yu Lin

et al.

Cardiovascular Toxicology, Journal Year: 2020, Volume and Issue: 20(5), P. 463 - 473

Published: Aug. 27, 2020

Language: Английский

Citations

73
Circulatory miR-133b and miR-21 as Novel Biomarkers in Early Prediction and Diagnosis of Coronary Artery Disease DOI Open Access
Dinesh Kumar, Rajiv Narang, Vishnubhatla Sreenivas

et al.

Genes, Journal Year: 2020, Volume and Issue: 11(2), P. 164 - 164

Published: Feb. 5, 2020

While coronary artery disease (CAD) has become a major threat worldwide, the timely biomarker-based early diagnosis of CAD remains unmet clinical challenge. We aimed towards assessing level circulatory microRNAs as candidates novel biomarkers in patients with CAD. A total 147 subjects were recruited which includes 78 angiographically proven CAD, 15 pre-atherosclerotic normal (NCA) and 54 healthy individuals. Quantitative real-time PCR assays performed. MiR-133b was downregulated by 4.6 fold (p < 0.0001) whereas miR-21 upregulated ~2 plasma samples patients. Importantly, both miRNAs showed association severity miR-133b 8.45 acute syndrome (ACS), 3.38 Stable angina (SA) 2.08 NCA. MiR-21 2.46 ACS, 1.90 SA 1.12 Moreover, could significantly differentiate ST-elevation myocardial infarction (STEMI) from Non-STEMI. Area under curve (AUC) for 0.80 >75.6% sensitivity specificity, AUC 0.79 >69.4% specificity. Our results suggest that be possible prediction

Language: Английский

Citations

72
Cardiac Fibrosis in heart failure: Focus on non-invasive diagnosis and emerging therapeutic strategies DOI Creative Commons
Susana Ravassa, Begoña López, Thomas A. Treibel

et al.

Molecular Aspects of Medicine, Journal Year: 2023, Volume and Issue: 93, P. 101194 - 101194

Published: June 27, 2023

Heart failure is a leading cause of mortality and hospitalization worldwide. Cardiac fibrosis, resulting from the excessive deposition collagen fibers, common feature across spectrum conditions converging in heart failure. Eventually, either reparative or reactive nature, long-term cardiac fibrosis contributes to development progression associated with poor clinical outcomes. Despite this, specific antifibrotic therapies are lacking, making an urgent unmet medical need. In this context, better patient phenotyping needed characterize heterogenous features advance toward its personalized management. review, we will describe different phenotypes focus on potential usefulness imaging techniques circulating biomarkers for non-invasive characterization condition tracking impact. We also recapitulate effects existing non-heart drugs discuss strategies under preclinical targeting activation fibroblasts at levels, as well additional extracardiac processes.

Language: Английский

Citations

39
MiR-122-5p inhibits cell migration and invasion in gastric cancer by down-regulating DUSP4 DOI Open Access
Xiaofeng Xu, Feng Gao, Jianjiang Wang

et al.

Cancer Biology & Therapy, Journal Year: 2018, Volume and Issue: 19(5), P. 427 - 435

Published: March 6, 2018

To explore the relationship between miR-122-5p and DUSP4 their effects on gastric cancer (GC) cell mobility invasiveness.Abnormally expressed miRNAs mRNAs were analyzed using microarrays. The mRNA expression levels in GC tissues cells determined by RT-qPCR. target was validated dual luciferase reporter assay. invasiveness respectively observed wound healing assay transwell invasion Western blot immunohistochemistry used for detection of expressions protein MMP2 MMP9 proteins related to migration. migration abilities vivo evaluated according number lung metastatic nodules mice.The significantly down-regulated, whereas up-regulated. Bioinformatics prediction strategies verified binding sites 3'UTR DUSP4. Overexpression knockdown BGC-823 observantly suppressed invasiveness, downregulation promoted metastasis. MiR-122-5p inhibited pulmonary tumor metastasis via DUSP4.MiR-122-5p restrained repressing

Language: Английский

Citations

78