Gene, Journal Year: 2022, Volume and Issue: 851, P. 147011 - 147011
Published: Oct. 27, 2022
Language: Английский
Biomarker Research, Journal Year: 2021, Volume and Issue: 9(1)
Published: March 12, 2021
miRNA-21 is among the most abundant and highly conserved microRNAs (miRNAs) recognized. It expressed in essentially all cells where it performs vital regulatory roles health disease. also frequently claimed to be a biomarker of diseases such as cancer heart disease bodily-fluid based miRNA studies. Here we dissociate its contributions cellular physiology pathology from potential biomarker. We show how has been specific predictive or prognostic by at least 29 diseases. Thus, no specificity any one As result, should not considered viable candidate biomarker, despite continued evaluation such. This theme multiple assignments shared with other common, ubiquitous miRNAs concerning for them well.
Language: Английский
Citations
183
Frontiers in Cardiovascular Medicine, Journal Year: 2021, Volume and Issue: 8
Published: Oct. 27, 2021
miR-21 is a 22-nucleotide long microRNA that matches target mRNAs in complementary base pairing fashion and regulates gene expression by repressing or degrading mRNAs. involved various cardiomyopathies, including heart failure, dilated cardiomyopathy, myocardial infarction, diabetic cardiomyopathy. Expression levels of notably change both circulation provide cardiac protection after injury. In the meantime, also tightly links to dysfunctions such as hypertrophy fibrosis. This review focuses on pattern its functions diseased-heart further discusses feasibility biomarker therapeutic cardiomyopathies.
Language: Английский
Citations
75
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1673 - 1673
Published: Jan. 30, 2024
Cardiovascular diseases (CVD) are a group of disorders that affect the heart and blood vessels. They include conditions such as myocardial infarction, coronary artery disease, failure, arrhythmia, congenital defects. CVDs leading cause death worldwide. Therefore, new medical interventions aim to prevent, treat, or manage prime importance. MicroRNAs (miRNAs) small non-coding RNAs regulate gene expression at posttranscriptional level play important roles in various biological processes, including cardiac development, function, disease. Moreover, miRNAs can also act biomarkers therapeutic targets. In order identify characterize their target genes, scientists take advantage computational tools bioinformatic algorithms, which assist analyzing miRNA profiles, functions, interactions different conditions. Indeed, combination research algorithms has opened avenues for understanding treating CVDs. this review, we summarize current knowledge on development CVDs, discuss challenges opportunities, provide some examples recent bioinformatics cardiovascular biology medicine.
Language: Английский
Citations
9
Cells, Journal Year: 2021, Volume and Issue: 10(7), P. 1655 - 1655
Published: July 1, 2021
MicroRNAs (miRNAs) have a prominent role in virtually every aspect of cell biology. Due to the small size mature miRNAs, high degree similarity between miRNA family members, and low abundance miRNAs body fluids, expression profiling is technically challenging. Biosensors based on electrochemical detection for nucleic acids are novel category inexpensive very sensitive diagnostic tools. On other hand, after recognizing target sequence, specific CRISPR-associated proteins, including orthologues Cas12, Cas13, Cas14, exhibit collateral nonspecific catalytic activities that can be employed ultrasensitive acid from clinically relevant samples. Recently, several platforms been developed, connecting benefits enzyme-assisted signal amplification enzyme-free biosensing technologies with CRISPR-based approaches detection. Together, they provide sensitivity, precision, fewer limitations diagnosis through efficient sensors at cost simple miniaturized readout. This review provides an overview developed successfully applied
Language: Английский
Citations
51
Journal of Cardiovascular Development and Disease, Journal Year: 2021, Volume and Issue: 8(2), P. 22 - 22
Published: Feb. 19, 2021
Cardiovascular diseases are the leading cause of death worldwide in different cohorts. It is well known that miRNAs have a crucial role regulating development cardiovascular physiology, thus impacting pathophysiology heart diseases. MiRNAs also been reported to be associated with cardiac reactions, myocardial infarction (MCI) and ultimately failure (HF). To prevent these diseases, proper timely diagnosis dysfunction pivotal. Though there many symptoms an irregular condition though some biomarkers available may indicate disease, authentic, specific sensitive markers need hour. In recent times, proven promising candidates this regard. They potent as they can easily detected body fluids (blood, urine, etc.) due their remarkable stability presence apoptotic bodies exosomes. Existing studies suggest valuable biomarkers. A single biomarker insufficient diagnose coronary artery disease (CAD) or acute (AMI); thus, combination prove fruitful. Therefore, review aims highlight circulating miRNA diagnostic prognostic such (CAD), (MI) atherosclerosis.
Language: Английский
Citations
47
Biomolecules, Journal Year: 2021, Volume and Issue: 11(7), P. 962 - 962
Published: June 29, 2021
Extracellular circulating microRNAs (miRNAs) are currently a focus of interest as non-invasive biomarkers cardiovascular pathologies, including coronary artery disease (CAD) and acute syndromes (ACS): myocardial infarction with without ST-segment elevation (STEMI NSTEMI) unstable angina (UA). However, the current data for some miRNAs controversial inconsistent, probably due to pre-analytical methodological variances in different studies. In this work, we fulfilled basic requirements provided miRNA studies application stable CAD ACS research. We used quantitative PCR determine relative plasma levels eight that potentially associated atherosclerosis. cohort 136 adult clinic patients outpatient controls, found miR-21-5p miR-146a-5p were significantly elevated patients, level miR-17-5p was decreased compared both healthy controls hypertensive CAD. Within patient group, no differences these between positive negative troponin, nor any STEMI NSTEMI. Our results indicate increased can be considered general lowered biomarker
Language: Английский
Citations
46
Biomaterials, Journal Year: 2024, Volume and Issue: 308, P. 122544 - 122544
Published: March 31, 2024
Language: Английский
Citations
7
Frontiers in Cardiovascular Medicine, Journal Year: 2022, Volume and Issue: 9
Published: July 5, 2022
Regulatory molecule microRNAs (miRNAs) have been implicated in myocardial fibrosis. However, the specific mechanism by which they lead to fibrosis remains unclear. This study aimed explore roles of miR-208b, miR-21 and transforming growth factor-β1 (TGF-β1)/Smad-3 signaling pathway components cardiac development.
Language: Английский
Citations
23
Acta Cardiologica, Journal Year: 2024, Volume and Issue: 79(7), P. 813 - 823
Published: Aug. 8, 2024
Background Coronary artery disease (CAD) remains the leading cause of mortality and morbidity around world. Despite significant progress in diagnosis treatment cardiovascular diseases, still there is a clinical need to identify novel biomarkers for early CAD. The aim study investigate circulating miRNAs CAD patients potential detection therapeutic management
Language: Английский
Citations
5
Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: Jan. 26, 2024
Abstract Several large cohort studies in cardiovascular disease (CVD) patients have shown an increased incidence of cancer. Previous a myocardial infarction (MI) mouse model reported colon, breast, and lung cancer growth. The potential mechanisms could be due to secreted cardiokines micro-RNAs from pathological hearts immune cell reprogramming. A study MI-induced heart failure (HF) demonstrated increase cardiac expression SerpinA3, resulting enhanced proliferation colon cells. In HF mice with cancer, the attenuation tumor sensitivity ferroptosis via secretion miR-22-3p cardiomyocytes was demonstrated. MI breast reprogramming toward immunosuppressive state shown. However, renal no impact on addition MI, hypertrophy promote growth cardiokine potentially involved, periostin, tissue serum model, proliferation. Since concept that CVD influence initiation progression several types is quite new challenging regarding future therapeutic preventive strategies, further are needed elucidate underlying which will enable more effective risk stratification development interventions prevent patients.
Language: Английский
Citations
4