Prediction of multivessel coronary artery disease and candidates for stress-only imaging using multivariable models with myocardial perfusion imaging DOI Creative Commons
Yuji Kunita, Kenichi Nakajima,

Tomoaki Nakata

et al.

Annals of Nuclear Medicine, Journal Year: 2022, Volume and Issue: 36(7), P. 674 - 683

Published: June 5, 2022

Selecting patients with coronary multivessel disease (MVD) or no stenosis using myocardial perfusion imaging (MPI) is challenging. We aimed to create a model predict MVD combination of quantitative MPI values and background factors patients. also assessed whether in the same database could be selected who do not require rest studies (stress-only imaging). analyzed data from 1001 had been by stress at 12 centers 463 undergone revascularization Japan. Quantitative based on were obtained cardioREPO software, which included defect scores, left ventricular ejection fractions volumes. Factors clinical backgrounds that investigated univariate multivariate analyses. alone without identify candidates for stress-only imaging. summed score (SSS), end-diastolic volume, hypertension predictive MVD. A logistic regression was created an area under receiver operating characteristics curve (AUC) 0.825. To more specifically three-vessel disease, AUC 0.847 when SSS, diabetes, selected. The mean probabilities abnormality prediction 12%, 24%, 40%, 51% no-, one-, two-, respectively (p < 0.0001). For select imaging, 0.78 end-systolic volume number risk (diabetes, hypertension, chronic kidney history smoking). analysis combining SPECT can MVD, tests. Our models should prove useful applications.

Language: Английский

JCS/CVIT/JCC 2023 Guideline Focused Update on Diagnosis and Treatment of Vasospastic Angina (Coronary Spastic Angina) and Coronary Microvascular Dysfunction DOI Open Access
Seiji Hokimoto, Koichi Kaikita, Satoshi Yasuda

et al.

Circulation Journal, Journal Year: 2023, Volume and Issue: 87(6), P. 879 - 936

Published: March 9, 2023

Language: Английский

Citations

106
Treatment strategies of acute myocardial infarction: updates on revascularization, pharmacological therapy, and beyond DOI Creative Commons
Yuichi Saito, Kazuma Oyama, Kenichi Tsujita

et al.

Journal of Cardiology, Journal Year: 2022, Volume and Issue: 81(2), P. 168 - 178

Published: July 23, 2022

Language: Английский

Citations

83
Role of the renin–angiotensin system in the pathophysiology of coronary heart disease and heart failure: Diagnostic biomarkers and therapy with drugs and natural products DOI Creative Commons

Jinit K. Mehta,

Ginpreet Kaur, Harpal S. Buttar

et al.

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 23, 2023

The renin–angiotensin system (RAS) plays a pivotal role in blood pressure regulation. In some cases, this steering mechanism is affected by various deleterious factors (mainly via the overactivation of RAS) causing cardiovascular damage, including coronary heart disease (CHD) that can ultimately lead to chronic failure (CHF). This not only causes disability and absenteeism from work but also imposes significant healthcare costs globally. incidence diseases has escalated exponentially over years with major outcome form CHD, stroke, CHF. involvement RAS been extensively researched limelight on CHD. may trigger cascade events atherosclerotic mayhem, which CHD related aggravation damaging endothelial lining vessels inflammatory oxidative stress pathways. Although there are diagnostic tests treatments available market, constant need for development procedures therapeutic strategies increase patient compliance reduce associated side effects. review highlights advances treatment domains would help subjugating effects caused conventional therapy.

Language: Английский

Citations

23
JCS/JHFS 2025 Guideline on Diagnosis and Treatment of Heart Failure DOI

Takeshi Kitai,

Shun Kohsaka, Takao Kato

et al.

Journal of Cardiac Failure, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

1
Clinical use of physiological lesion assessment using pressure guidewires: an expert consensus document of the Japanese association of cardiovascular intervention and therapeutics—update 2022 DOI
Yoshiaki Kawase, Hitoshi Matsuo, Shoichi Kuramitsu

et al.

Cardiovascular Intervention and Therapeutics, Journal Year: 2022, Volume and Issue: 37(3), P. 425 - 439

Published: May 11, 2022

Language: Английский

Citations

30
Consensus document on the clinical application of invasive functional coronary angiography from the Japanese Association of Cardiovascular Intervention and Therapeutics DOI Creative Commons
Taku Asano,

Toru Tanigaki,

Kazumasa Ikeda

et al.

Cardiovascular Intervention and Therapeutics, Journal Year: 2024, Volume and Issue: 39(2), P. 109 - 125

Published: Feb. 17, 2024

Abstract Invasive functional coronary angiography (FCA), an angiography-derived physiological index of the significance obstruction, is a novel assessment tool for obstruction that does not require utilization pressure wire. This technology enables operators to rapidly evaluate relevance stenoses during and even after while reducing burden cost complication risks related FCA can be used treatment decision-making revascularization, strategy planning percutaneous intervention, procedure optimization. Currently, various software-computing FCAs are available worldwide, with unique features in their computation algorithms functions. With emerging application this clinical scenarios, Japanese Association Cardiovascular Intervention Therapeutics task force was created outline expert consensus on use FCA. document advocates optimal applications according currently evidence summarizing concept, history, limitations, future perspectives along globally software. Graphical abstract Overview proposed (FCA). The developed computed fluid dynamics (CFD), considering drop across stenosis. CFD analysis performed three-dimensional model derived from angiography, allowing calculation without Another direction development using artificial intelligence throughout entire process, enabling “hands-free” FFR simulation. advantage it eliminates wire, resulting reduced invasiveness, shorter times, medical costs. However, requires high-quality clear visualization lesion. In addition, current version several manual corrections; thus, its reproducibility limited. Further data outcomes FCA, such as intervention (PCI) guidance, warranted. group scenarios advantages technology. QFR, quantitative flow ratio; iFR, instantaneous wave-free CCS, chronic syndrome; ACS, acute MVD, multivessel disease; AMI, myocardial infarction.

Language: Английский

Citations

7
Coronary computed tomography angiography for clinical practice DOI Creative Commons
Kazuki Yoshida, Yuki Tanabe, Takaaki Hosokawa

et al.

Japanese Journal of Radiology, Journal Year: 2024, Volume and Issue: 42(6), P. 555 - 580

Published: March 8, 2024

Coronary artery disease (CAD) is a common condition caused by the accumulation of atherosclerotic plaques. It can be classified into stable CAD or acute coronary syndrome. computed tomography angiography (CCTA) has high negative predictive value and used as first examination for diagnosing CAD, particularly in patients at intermediate-to-high risk. CCTA also adopted syndrome, low-to-intermediate Myocardial ischemia does not always co-exist with stenosis, positive myocardial limited. However, overcome this limitation recent technological advancements such CT perfusion CT-fractional flow reserve. In addition, to assess Thus, indications have expanded, leading an increased demand radiologists. The reporting data system (CAD-RADS) 2.0 was recently proposed standardizing reporting. This RADS evaluates categorizes based on stenosis overall amount plaque links patient management. review, we aimed review major trials guidelines understand its clinical role. Furthermore, introduce CAD-RADS including assessment plaque, other key findings, highlight steps Finally, present research trends perivascular fat attenuation index, artificial intelligence, technology.

Language: Английский

Citations

6
Conflicts of Interest Among Cardiology Clinical Practice Guideline Authors in Japan DOI Creative Commons
Anju Murayama,

Megumi Aizawa,

Keerthana R. Byreddy

et al.

Journal of the American Heart Association, Journal Year: 2024, Volume and Issue: 13(8)

Published: April 12, 2024

Clinical practice guidelines (CPGs) offer disease management recommendations based on scientific evidence. However, financial conflicts of interest between CPG developers and the pharmaceutical industry could bias these recommendations, potentially affecting patient care. Proper is particularly crucial for maintaining integrity CPGs. The study aimed to evaluate extent relationships authors CPGs cardiovascular diseases in Japan.

Language: Английский

Citations

6
Physiological Assessment with iFR prior to FFR Measurement in Left Main Disease DOI Creative Commons
Takayuki Warisawa, Christopher Cook, Yousif Ahmad

et al.

Cardiovascular Intervention and Therapeutics, Journal Year: 2024, Volume and Issue: 39(3), P. 241 - 251

Published: April 20, 2024

Despite guideline-based recommendation of the interchangeable use instantaneous wave-free ratio (iFR) and fractional flow reserve (FFR) to guide revascularization decision-making, iFR/FFR could demonstrate different physiological or clinical outcomes in some specific patient lesion subsets. Therefore, we sought investigate impact difference between iFR FFR-guided decision-making on patients with left main disease (LMD). In this international multicenter registry LMD interrogation, identified 275 whom assessment was performed both iFR/FFR. Major adverse cardiovascular event (MACE) defined as a composite death, non-fatal myocardial infarction, ischemia-driven target revascularization. The receiver-operating characteristic analysis for predict MACE respective deferred performed. 153 deferral, occurred 17.0% patients. optimal cut-off values FFR were 0.88 (specificity:0.74; sensitivity:0.65) 0.76 (specificity:0.81; sensitivity:0.46), respectively. area under curve (AUC) significantly higher than (0.74; 95%CI 0.62-0.85 vs. 0.62; 0.48-0.75; p = 0.012). 122 coronary revascularization, 13.1% 0.92 (specificity:0.93; sensitivity:0.25) 0.81 (specificity:0.047; sensitivity:1.00), AUCs not (0.57; 0.40-0.73 0.46; 0.31-0.61; 0.43). While neither baseline nor predictive performed, iFR-guided deferral seemed be safer deferral.

Language: Английский

Citations

4
No standard modifiable cardiovascular risk factors in acute myocardial infarction: prevalence, pathophysiology, and prognosis DOI Creative Commons
Yuichi Saito,

Kenichi Tsujita,

Yoshio Kobayashi

et al.

Cardiovascular Intervention and Therapeutics, Journal Year: 2024, Volume and Issue: unknown

Published: June 17, 2024

Abstract Standard modifiable cardiovascular risk factors (SMuRFs), such as hypertension, diabetes, dyslipidemia, and current smoking, are associated with the development of atherosclerotic diseases including acute myocardial infarction (MI). Thus, therapeutic approaches against SMuRFs important primary secondary prevention diseases. In patients MI, however, prognosis is counterintuitively poor when lacking. The growing evidence has explored prevalence, pathophysiology, SMuRF-less in MI suggested potential underlying mechanisms. This review article summarizes clinical relevance lack MI.

Language: Английский

Citations

4