Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 472, P. 144866 - 144866
Published: July 17, 2023
Language: Английский
Cells, Journal Year: 2020, Volume and Issue: 9(5), P. 1157 - 1157
Published: May 7, 2020
Exosomes are nano-sized vesicles that serve as mediators for cell-to-cell communication. With their unique nucleic acids, proteins, and lipids cargo compositions reflect the characteristics of producer cells, exosomes can be utilized cell-free therapeutics. Among derived from various cellular origins, mesenchymal stem cell-derived (MSC-exosomes) have gained great attention due to immunomodulatory regenerative functions. Indeed, many studies shown anti-inflammatory, anti-aging wound healing effects MSC-exosomes in vitro vivo models. In addition, recent advances field exosome biology enabled development specific guidelines quality control methods, which will ultimately lead clinical application exosomes. This review highlights investigate therapeutic potential relevant mode actions skin diseases, well measures required exosome-derived
Language: Английский
Citations
411
Life, Journal Year: 2021, Volume and Issue: 11(7), P. 665 - 665
Published: July 7, 2021
The skin is the biggest organ of human body which acts as a protective barrier against deleterious agents. When this damaged, organism promotes healing process with several molecular and cellular mechanisms, in order to restore physiological structure skin. control wound depends on correct balance among its different mechanisms. Any disruption these mechanisms can lead problems delay healing. impairment linked underlying factors well aging, nutrition, hypoxia, stress, infections, drugs, genetics, chronic diseases. Over years, numerous studies have been conducted discover approach best therapies for healing, including surgical procedures non-surgical treatments such topical formulations, dressings, or substitutes. Thus, general necessary facilitate direction further studies. This work provides updated concepts that interfere, used
Language: Английский
Citations
182
Acta Biomaterialia, Journal Year: 2020, Volume and Issue: 121, P. 119 - 133
Published: Dec. 5, 2020
Language: Английский
Citations
175
Exploration, Journal Year: 2023, Volume and Issue: 3(5)
Published: May 31, 2023
Tumor surgical resection is the major strategy for cancer treatment. Meanwhile, perioperative treatment especially postoperative adjuvant anticancer strategies play essential roles in satisfying therapeutic results and rapid recovery. Postoperative tumor recurrence, metastasis, bleeding, inter-tissue adhesion, infection, delayed wound healing are vital risks that could lead to poor prognosis or even failure. Therefore, methods targeting these complications desperate need. In situ biomaterial-based drug delivery platforms promising candidates recovery, resulting from their excellent properties including good biocompatibility, adaptive shape, limited systemic effect, designable function, easy loading. this review, we focus on introducing gel/hydrogel-based biomaterial involving properties, advantages, synthesis procedures. Based loaded contents gel/hydrogel such as drugs, immunologic agents, cell components, multifunctional nanoparticles, further discuss applications of recurrence metastasis inhibition. Finally, other functions aiming at fast recovery were introduced, hemostasis, antibacterial adhesion prevention, tissue repair, healing. conclusion, a developing platform treatment, exhibiting gratifying effects inconspicuous toxicity normal tissues, which deserves research exploration.
Language: Английский
Citations
92
Molecules, Journal Year: 2023, Volume and Issue: 28(2), P. 598 - 598
Published: Jan. 6, 2023
A wound is the loss of normal integrity, structure, and functions skin due to a physical, chemical, or mechanical agent. Wound repair consists an orderly complex process divided into four phases: coagulation, inflammation, proliferation, remodeling. The potential natural products in treatment wounds has been reported numerous studies, emphasizing those with antioxidant, anti-inflammatory, antimicrobial properties, e.g., alkaloids, saponins, terpenes, essential oils, polyphenols from different plant sources, since these compounds can interact various stages healing process. This review addresses most current vitro vivo studies on products, as well main mechanisms involved this activity. We observed sufficient evidence activity wounds; however, we also found that there no consensus effective concentrations which exert For reason, it important work establishing optimal doses, appropriate route administration. In addition, more research should be carried out discover possible side effects behavior clinical trials.
Language: Английский
Citations
90
Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 21
Published: Feb. 3, 2022
The skin is a critical organ for the maintenance of integrity and protection organism. When wound occurs, sequence healing mechanisms triggered to reconstruct wounded area. β-caryophyllene sesquiterpene in Copaifera langsdorffii oleoresin with antioxidant anti-inflammatory potential. On basis previous studies C. langsdorffii, was selected evaluate its potential pharmacological mechanisms. excision model used male Wistar rats macroscopic, histological, immunohistochemical biochemical analyses were performed samples, comparing β-caryophyllene-treated group reference drugs. results showed macroscopic retraction wounds treated β-caryophyllene. Biochemical assays revealed increasing levels IL-10 GPx decreasing pro-inflammatory molecules, including TNF-α, IFN-γ, IL-1β IL-6. After treatment, enhanced re-epithelialization, through increase laminin-γ2 desmoglein-3 immunolabeling. also act remodeling mechanism, collagen content Masson’s trichrome staining. These findings indicated wound-healing topical formulation rat wounds, mediated by antioxidant, re-epithelialization
Language: Английский
Citations
86
Science Advances, Journal Year: 2023, Volume and Issue: 9(28)
Published: July 14, 2023
Diabetic wounds with complex pathological features and a difficult-to-heal nature remain formidable challenge. To address this challenge, we design fabricate self-powered enzyme-linked microneedle (MN) patch composed of anode cathode MN arrays, which respectively contain glucose oxidase (GOx) horseradish peroxidase (HRP) encapsulated in ZIF-8 nanoparticles. The enzymatic cascade reaction the can effectively reduce local hyperglycemia diabetic while generating stable microcurrents to promote rapid healing wounds. Therefore, treated exhibit rapid, complete, scar-preventative healing, be attributed synergistic actions hypoglycemic, antibacterial, anti-inflammatory, bioelectrical stimulation. In brief, is an effective method rapidly wound prevent scar formation.
Language: Английский
Citations
84
Journal of the European Academy of Dermatology and Venereology, Journal Year: 2023, Volume and Issue: 37(S3), P. 7 - 15
Published: Jan. 13, 2023
Abstract Skin wounds are common and represent a major public health economical problem, with risks of complications significant negative impact on the quality life patients. Cutaneous wound healing is tightly regulated process resulting in restoration tissue integrity. Wound involves interaction several skin, immune vascular cells, growth factors cytokines. However, external actors can play an important role healing, such as skin microbiome, which microbial commensal collection bacteria, fungi viruses inhabiting skin. Indeed, recent advances have featured interactions, within environment, between different species host system. This article reviews relationship microbiome process. Although cutaneous potential entry site for infection, either detrimental or beneficial healing. Thus, targeting could essential part management.
Language: Английский
Citations
74
Journal of Tissue Engineering, Journal Year: 2023, Volume and Issue: 14
Published: Jan. 1, 2023
Scars caused by skin injuries after burns, wounds, abrasions and operations have serious physical psychological effects on patients. In recent years, the research of scar free wound repair has been greatly expanded. However, understanding complex mechanisms healing, in which various cells, cytokines mechanical force interact, is critical to developing a treatment that can achieve scarless healing. Therefore, this paper reviews types mechanism formation healing process, current progress dual consideration prevention, some strategies for repair.
Language: Английский
Citations
53
Cells, Journal Year: 2023, Volume and Issue: 12(3), P. 345 - 345
Published: Jan. 17, 2023
Burn injury induces a complex inflammatory response, both locally and systemically, is not yet completely unravelled understood. In order to enable the development of accurate treatment options, it paramount importance fully understand post-burn immunology. Research in last decades describes insights into prolonged excessive response that could exist after severe milder burn trauma this differs from none-burn acute trauma. Persistent activity complement, phase proteins pro- anti-inflammatory mediators, changes lymphocyte activity, activation stress infiltration immune cells have all been related local systemic pathology. This “narrative” review explores current state knowledge, focusing on immunology post-burn, further questions how linked clinical outcome. Moreover, illustrates complexity existing gaps knowledge underlying mechanisms
Language: Английский
Citations
49