American Journal of Clinical Dermatology,
Journal Year:
2023,
Volume and Issue:
24(5), P. 681 - 694
Published: June 16, 2023
Acne
is
a
common,
chronic
inflammatory
condition
affecting
millions
of
people
worldwide,
with
significant
negative
impact
on
quality
life
and
mental
health.
characterized
by
comedones,
papules,
pustules,
nodulocystic
lesions,
long-lasting
sequelae
including
scarring
dyspigmentation,
the
latter
which
more
common
in
skin
color.
The
four
main
pillars
acne
pathophysiology
include
alteration
sebum
production
concentration,
hyperkeratinization
follicular
unit,
Cutibacterium
acnes
strains,
an
immune
response.
Newer
research
has
provided
greater
insight
into
these
pathophysiologic
categories.
This
understanding
pathogenesis
led
to
numerous
new
emerging
treatment
modalities.
These
modalities
combinations
existing
treatments,
repurposing
agents
historically
used
for
other
conditions,
topical
novel
antibiotics,
oral
probiotics,
various
procedural
devices.
article
will
provide
overview
treatments
their
link
our
current
improved
pathogenesis.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(17), P. 13313 - 13313
Published: Aug. 28, 2023
Psoriasis
is
a
chronic
inflammatory
skin
disorder,
and
current
treatments
include
topical
therapies,
phototherapy,
systemic
immune
modulators,
biologics,
aiming
to
alleviate
symptoms
improve
quality
of
life.
However,
challenges
persist,
such
as
adverse
effects,
treatment
resistance,
high
costs,
variability
in
response
among
individuals.
The
future
psoriasis
shows
promising
emerging
trends.
New
biologic
agents
targeting
novel
pathways,
interleukin
23
inhibitors
like
mirikizumab,
offer
enhanced
efficacy.
Small
molecule
RORγt
ROCK2
provide
additional
options.
Combination
including
biologics
with
methotrexate,
may
response.
Advancements
utilizing
microneedles
nanoparticle-based
carriers
can
enhance
drug
delivery
therapeutic
outcomes.
Biomarkers
multi-omics
technologies
hold
potential
for
personalized
approaches,
thus
aiding
diagnosis,
predicting
response,
guiding
decisions.
Collaboration
researchers,
clinicians,
industry
stakeholders
crucial
translating
these
scientific
breakthroughs
into
clinical
practice.
By
addressing
exploring
trends,
we
optimize
management
the
lives
those
affected
by
this
condition.
Acta Pharmaceutica Sinica B,
Journal Year:
2021,
Volume and Issue:
11(9), P. 2609 - 2644
Published: July 21, 2021
Membrane-disruptive
peptides/peptidomimetics
(MDPs)
are
antimicrobials
or
anticarcinogens
that
present
a
general
killing
mechanism
through
the
physical
disruption
of
cell
membranes,
in
contrast
to
conventional
chemotherapeutic
drugs,
which
act
on
precise
targets
such
as
DNA
specific
enzymes.
Owing
their
rapid
action,
broad-spectrum
activity,
and
mechanisms
action
potentially
hinder
development
resistance,
MDPs
have
been
increasingly
considered
future
therapeutics
drug-resistant
era.
Recently,
growing
experimental
evidence
has
demonstrated
can
also
be
utilized
adjuvants
enhance
therapeutic
effects
other
agents.
In
this
review,
we
evaluate
literature
around
antimicrobial
properties
anticancer
activity
MDPs,
summarize
current
alone
combination
with
Notably,
review
highlights
recent
advances
design
various
MDP-based
drug
delivery
systems
improve
effect
minimize
side
effects,
promote
co-delivery
multiple
chemotherapeutics,
for
more
efficient
therapy.
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(6), P. 1152 - 1152
Published: May 28, 2022
The
ideal
drug
delivery
system
has
a
bioavailability
comparable
to
parenteral
dosage
forms
but
is
as
convenient
and
easy
use
for
the
patient
oral
solid
forms.
In
recent
years,
there
been
increased
interest
in
transdermal
(TDD)
non-invasive
approach
that
generally
regarded
being
administer
more
vulnerable
age
groups,
such
paediatric
geriatric
patients,
while
avoiding
certain
concerns
arise
from
due
poor
absorbability
metabolism
concerns.
However,
despite
its
many
merits,
TDD
remains
restricted
select
few
drugs.
physiology
of
skin
poses
barrier
against
feasible
drugs,
limiting
applicability
only
those
drugs
possess
physicochemical
properties
allowing
them
be
successfully
delivered
transdermally.
Several
techniques
have
developed
enhance
permeability
Both
chemical
(e.g.,
thermal
mechanical)
passive
(vesicle,
nanoparticle,
nanoemulsion,
dispersion,
nanocrystal)
investigated
substances
across
skin.
Furthermore,
hybrid
approaches
combining
penetration
enhancement
technologies
with
physical
are
intensively
researched
improve
permeation
substances.
This
review
aims
summarize
trends
discuss
merits
drawbacks
various
chemical,
physical,
currently
improving
Engineering,
Journal Year:
2023,
Volume and Issue:
unknown
Published: June 1, 2023
Microneedles
(MNs)
can
be
used
for
the
topical
treatment
of
skin
disorders
as
they
directly
deliver
therapeutics
to
site
lesions,
resulting
in
increased
therapeutic
efficacy
while
having
minimum
side
effects.
MNs
are
different
kinds
(e.g.,
small
molecules,
macromolecules,
nanomedicines,
living
cells,
bacteria,
and
exosomes)
treating
various
disorders,
including
superficial
tumors,
wounds,
infections,
inflammatory
diseases,
abnormal
appearance.
The
improved
by
integrating
advantages
multiple
perform
combination
therapy.
Through
careful
designing,
further
modified
with
biomimetic
structures
responsive
drug
release
from
internal
external
stimuli
enhance
transdermal
delivery
efficiency
robust
outcomes.
Some
studies
have
proposed
use
drug-free
a
promising
mechanotherapeutic
strategy
promote
wound
healing,
scar
removal,
hair
regeneration
via
mechanical
communication
pathway.
Although
several
advantages,
practical
application
suffers
problems
related
industrial
manufacture
clinical
evaluation,
making
it
difficult
translation.
In
this
study,
we
summarized
applications,
emerging
challenges,
developmental
prospects
provide
information
on
ways
advance
Macromol—A Journal of Macromolecular Research,
Journal Year:
2024,
Volume and Issue:
4(2), P. 320 - 355
Published: May 15, 2024
The
delivery
of
therapeutical
molecules
through
the
skin,
particularly
to
its
deeper
layers,
is
impaired
due
stratum
corneum
layer,
which
acts
as
a
barrier
foreign
substances.
Thus,
for
past
years,
scientists
have
focused
on
development
more
efficient
methods
deliver
skin
distinct
layers.
Microneedles,
new
class
biomedical
devices,
consist
an
array
microscale
needles.
This
particular
device
has
been
drawing
attention
ability
breach
corneum,
forming
micro-conduits
facilitate
passage
molecules.
microneedle
several
advantages
over
conventional
methods,
such
better
medication
adherence,
easiness,
and
painless
self-administration.
Moreover,
it
possible
swiftly
or
time.
Microneedles
can
vary
in
shape,
size,
composition.
design
process
must
take
into
account
factors,
like
location
delivery,
material,
manufacturing
process.
used
large
number
fields
from
drug
vaccine
application
cosmetics,
therapy,
diagnoses,
tissue
engineering,
sample
extraction,
cancer
research,
wound
healing,
among
others.
ACS Materials Letters,
Journal Year:
2024,
Volume and Issue:
6(3), P. 801 - 821
Published: Feb. 2, 2024
As
a
new
type
of
transdermal
drug
delivery
system
(TDDS),
microneedles
have
garnered
significant
attention
for
their
noninvasiveness,
portability,
controllable
administration,
and
wide-ranging
loading
capacity.
While
initially
designed
administration
via
the
stratum
corneum
minimizing
adverse
reactions
associated
with
systemic
enhancing
patient
compliance,
recently
found
applications
in
multitude
medical
contexts.
Hence,
potential
transcends
mere
delivery.
Recent
reviews
on
extensively
covered
various
aspects,
including
needle
types,
materials,
manufacturing
methods,
as
well
treating
skin
diseases.
This
review
aims
to
provide
comprehensive
overview
diverse
designs
from
different
perspectives,
which
encompass
traditional
integrated
more
intelligent
structurally
optimized
ones
nowadays.
Additionally,
this
offers
analysis
material
properties
utilized
applications,
nondegradable
materials
degradable
materials.
Furthermore,
presents
these
scenarios
such
regeneration
repair,
disease
treatment,
monitoring,
prevention.
Moreover,
discussion
article
highlights
future
clinical
necessary
efforts
required
achieve
widespread
adoption.
serves
valuable
reference
bridging
gap
between
laboratory
setting
practice
terms
using
scenarios.
Nano-Micro Letters,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: Feb. 6, 2025
Abstract
The
use
of
microneedles
(MNs)
has
been
established
as
an
effective
transdermal
drug
delivery
strategy
that
extensively
deployed
for
treating
various
diseases,
including
skin
diseases.
MNs
can
surpass
the
constraints
conventional
methods
by
their
superior
safety
and
efficacy
through
precise
targeting,
while
simultaneously
enabling
painless
delivery.
Currently,
are
increasingly
used
carriers
delivery,
with
loading
insoluble
drugs
to
improve
treatment
efficiency
or
combining
bioactive
substances
construction
efficient
system
maximize
effects
substances.
preparation
diverse,
them
meet
requirements
most
applications.
emergence
addressed
shortcomings
associated
drugs,
expanded
applications
substances,
improved
in
clinical
practice.
This
review
summarizes
current
information
on
application
a
variety
such
psoriasis,
vitiligo,
alopecia,
hypertrophic
scarring,
atopic
dermatitis,
melanoma,
acne,
infections.
future
opportunities
diseases
also
discussed.
Despite
substantial
progress
vectors,
issues
low
poor
mechanical
strength
during
remain
main
challenges.
Therefore,
implementation
MNs-based
therapies
remains
limited,
highlighting
key
research.
