Bisphenol Analogues Other Than BPA: Environmental Occurrence, Human Exposure, and Toxicity—A Review

Environmental Science & Technology, Journal Year: 2016, Volume and Issue: 50(11), P. 5438 - 5453

Published: May 4, 2016

Numerous studies have investigated the environmental occurrence, human exposure, and toxicity of bisphenol A (BPA). Following stringent regulations on production usage BPA, several analogues been produced as a replacement for BPA in various applications. The present review outlines current state knowledge occurrence (other than BPA) environment, consumer products foodstuffs, exposure biomonitoring, toxicity. Whereas was still major analogue found most monitoring studies, BPF BPS were also frequently detected. Elevated concentrations BPAF, BPF, (i.e., similar to or greater that reported abiotic environment urine from some regions. Many exhibit endocrine disrupting effects, cytotoxicity, genotoxicity, reproductive toxicity, dioxin-like neurotoxicity laboratory studies. BPB, shown estrogenic and/or antiandrogenic activities even BPA. Knowledge gaps research needs identified, which include elucidation occurrences, persistence, fate BPA), sources pathways effects systems mammary gland, mechanisms coexposure multiple analogues, metabolic products, impact modification

Language: Английский

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Plastics and microplastics in the oceans: From emerging pollutants to emerged threat

Marine Environmental Research, Journal Year: 2016, Volume and Issue: 128, P. 2 - 11

Published: May 17, 2016

Language: Английский

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Overview of known plastic packaging-associated chemicals and their hazards

The Science of The Total Environment, Journal Year: 2018, Volume and Issue: 651, P. 3253 - 3268

Published: Oct. 3, 2018

Global plastics production has reached 380 million metric tons in 2015, with around 40% used for packaging. Plastic packaging is diverse and made of multiple polymers numerous additives, along other components, such as adhesives or coatings. Further, can contain residues from substances during manufacturing, solvents, non-intentionally added (NIAS), impurities, oligomers, degradation products. To characterize risks chemicals potentially released use, disposal, and/or recycling packaging, comprehensive information on all involved needed. Here, we present a database Chemicals associated Packaging (CPPdb), which includes manufacturing final articles. The CPPdb lists 906 likely plastic 3377 that are possibly associated. Of the 63 rank highest human health hazards 68 environmental according to harmonized hazard classifications assigned by European Agency within Classification, Labeling (CLP) regulation implementing United Nations' Globally Harmonized System (GHS). 7 classified Union persistent, bioaccumulative, toxic (PBT), very bioaccumulative (vPvB), 15 endocrine disrupting (EDC). Thirty-four also recognized EDC potential recent report Nations Environment Programme. identified hazardous monomers, intermediates, surfactants, plasticizers, stabilizers, biocides, flame retardants, accelerators, colorants, among functions. Our work was challenged lack transparency incompleteness publicly available both use toxicity substances. most here should be assessed detail candidates substitution.

Language: Английский

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Bisphenol A: Food Exposure and Impact on Human Health

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2018, Volume and Issue: 17(6), P. 1503 - 1517

Published: Sept. 5, 2018

Abstract Bisphenol A (BPA) is an industrial compound used extensively to produce synthetic polymers, such as epoxy resins, which are incorporated into the inner coating of metal cans, and also manufacture polycarbonates with applications in bottles, including bottles water. Several studies have reported on transfer this food. Regarding human exposure BPA, food intake can be considered most serious among all routes, not only because it potentially reaches more people different age groups (including infants, especially vulnerable group), but inadvertently occurs over long time periods. BPA endocrine disruptor several proposed a relationship between appearance adverse health effects, cancer, infertility, diabetes, obesity, others. In 2015 however, European Food Safety Authority concluded its last scientific opinion that does pose any risk exposed population's health. Therefore, EU regards authorized product contact material. Although through apparently below set limits, research potential negative effects still ongoing. This review contains recent vitro vivo toxicity harmful health, intends address namely dietary impact

Language: Английский

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Exposure to Bisphenol A, Bisphenol F, and Bisphenol S in U.S. Adults and Children: The National Health and Nutrition Examination Survey 2013–2014

ACS Omega, Journal Year: 2018, Volume and Issue: 3(6), P. 6523 - 6532

Published: June 18, 2018

Bisphenol F (BPF) and bisphenol S (BPS) are replacing A (BPA) in the manufacturing of products containing polycarbonates epoxy resins. Data on current human exposure levels these substitutes needed to aid assessment their health risks. This study analyzed urinary adults (N = 1808) children 868) participating National Health Nutrition Examination Survey (NHANES) 2013–2014 investigated demographic lifestyle factors associated with bisphenols. BPA, BPS, BPF were detected 95.7, 89.4, 66.5% randomly selected urine samples as part NHANES 2013–2014, respectively. Median BPA U.S. adult higher (1.24 μg/L) than BPS (0.35 0.37 μg/L, respectively). For children, median also (1.25 (0.32 0.29 The limits detection for BPF, 0.2, 0.1 Urinary showed associations gender, race/ethnicity, family income, physical activity, smoking, and/or alcohol intake that depended specific bisphenol. results this indicate general population is almost ubiquitous. Because exposures differ across population, further studies environmental, consumer, affecting warranted.

Language: Английский

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Occurrence of bisphenol S in the environment and implications for human exposure: A short review

The Science of The Total Environment, Journal Year: 2017, Volume and Issue: 615, P. 87 - 98

Published: Oct. 17, 2017

Language: Английский

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Occurrence, toxicity and ecological risk of Bisphenol A analogues in aquatic environment – A review

Ecotoxicology and Environmental Safety, Journal Year: 2020, Volume and Issue: 208, P. 111481 - 111481

Published: Oct. 23, 2020

Bisphenol analogues (BPs) have been widely applied to industry as the substitutes for bisphenol A (BPA), which detected frequently in surface water, sediment, sewage and sludge. The presence of BPs natural environment could pose risks aquatic ecosystem human health. This study outlined occurrence, toxicity manifested their potential ecological risk throughout world. As BPA was losing its dominance, while were occupying a large part, especially S (BPS), F (BPF) AF (BPAF). In some heavily polluted areas, concentration reached µg/L environment, effluent plants higher than that water. content sludge sediment more aqueous phase. All other BPS P (BPP) had moderate toxicity. current data supports exposure may adverse effects on dysfunction endocrine system such thyroid hormone concentration, enzyme activity, even cell dysfunction, gene damage chromosomal abnormalities. According quotient (RQ), BPF shows highest China, Japan South Korea, followed by BPS. occurrence bisphenols neurotoxicity organisms merit further investigation.

Language: Английский

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Exposure to endocrine disruptors during adulthood: consequences for female fertility

Journal of Endocrinology, Journal Year: 2017, Volume and Issue: 233(3), P. R109 - R129

Published: March 30, 2017

Endocrine disrupting chemicals are ubiquitous that exhibit endocrine properties in both humans and animals. Female reproduction is an important process, which regulated by hormones susceptible to the effects of exposure chemicals. Disruptions female reproductive functions may result subfertility, infertility, improper hormone production, estrous menstrual cycle abnormalities, anovulation, early senescence. This review summarizes a variety synthetic on fertility during adult life. The covered this pesticides (organochlorines, organophosphates, carbamates, pyrethroids, triazines), heavy metals (arsenic, lead, mercury), diethylstilbesterol, plasticizer alternatives (di-(2-ethylhexyl) phthalate bisphenol A alternatives), 2,3,7,8-tetrachlorodibenzo-p-dioxin, nonylphenol, polychlorinated biphenyls, triclosan, parabens. focuses hypothalamus, pituitary, ovary, uterus because together they regulate normal onset literature shows several have abilities females life, causing abnormalities

Language: Английский

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Effects of bisphenol A and its analogs on reproductive health: A mini review

Reproductive Toxicology, Journal Year: 2018, Volume and Issue: 79, P. 96 - 123

Published: June 18, 2018

Language: Английский

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Exposure to endocrine-disrupting chemicals in the USA: a population-based disease burden and cost analysis

The Lancet Diabetes & Endocrinology, Journal Year: 2016, Volume and Issue: 4(12), P. 996 - 1003

Published: Oct. 19, 2016

Language: Английский

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