Environmental Pollution, Journal Year: 2023, Volume and Issue: 334, P. 122211 - 122211
Published: July 14, 2023
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(16), P. 5761 - 5761
Published: Aug. 11, 2020
Bisphenol A (BPA) is an organic synthetic compound serving as a monomer to produce polycarbonate plastic, widely used in the packaging for food and drinks, medical devices, thermal paper, dental materials. BPA can contaminate food, beverage, air, soil. It accumulates several human tissues organs potentially harmful health through different molecular mechanisms. Due its hormone-like properties, may bind estrogen receptors, thereby affecting both body weight tumorigenesis. also affect metabolism cancer progression, by interacting with GPR30, impair male reproductive function, binding androgen receptors. Several transcription factors, including PPARγ, C/EBP, Nrf2, HOX, HAND2, are involved action on fat liver homeostasis, cardiovascular system, cancer. Finally, epigenetic changes, such DNA methylation, histones modification, changes microRNAs expression contribute pathological effects. This review aims provide extensive comprehensive analysis of most recent evidence about potential mechanisms which affects health.
Language: Английский
Citations
329
Chemosphere, Journal Year: 2020, Volume and Issue: 268, P. 129273 - 129273
Published: Dec. 16, 2020
Language: Английский
Citations
225
Journal of Hazardous Materials, Journal Year: 2020, Volume and Issue: 392, P. 122271 - 122271
Published: Feb. 14, 2020
Language: Английский
Citations
215
International Journal of Environmental & Analytical Chemistry, Journal Year: 2021, Volume and Issue: 103(16), P. 3971 - 3987
Published: May 5, 2021
Plastic waste generation in India was around 9.4 million tonnes.year−1 2019 as compared to the global rate of more than 380 2019. Thus, India’s contribution 3.1% plastic generation. Globally, 42% overall plastics produced are consumed by packaging sector and 17% construction sector. Whereas 35% is 23% Bioplastic production 1% out 300 tonnes conventional annually. This review attempts analyse management rules, legislations, policies practices during period 1992–2020. The worldwide trend bioplastic projects reflected studies India, indicating a changed perception bioplastics an alternative source plastics. However, facilitating implementation processing plant involves challenges terms technology, developing standardised framework financial incentives. A legislative for should be developed alongwith action plan energy recovery from waste. Markets not mature India. paper addresses need roadmap towards efficient planning sustainable solutions both bioplastics.
Language: Английский
Citations
112
Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9
Published: Nov. 3, 2022
Bisphenol A (BPA) is a synthetic chemical widely employed to synthesize epoxy resins, polymer materials, and polycarbonate plastics. BPA abundant in the environment, i.e., food containers, water bottles, thermal papers, toys, medical devices, etc., incorporated into soil/water through leaching. Being potent endocrine disrupter, has potential alter several body mechanisms. Studies confirmed its anti-androgen action estrogen-like effects, which impart many negative health impacts, especially on immune system, neuroendocrine process, reproductive mechanism. Moreover, it can also induce mutagenesis carcinogenesis, as per recent scientific research. This review focuses BPA's presence concentrations different environments, sources basic mechanisms of BPA-induced toxicity disruptions. It unique type because association cancer, hormonal disruption, immunosuppression, infertility with BPA. These issues are widespread today, significantly contributes their incidence wide usage daily life utensils other accessories. The discusses researched-based measures cope toxic chemical.
Language: Английский
Citations
111
Integrated Environmental Assessment and Management, Journal Year: 2022, Volume and Issue: 19(1), P. 45 - 62
Published: April 1, 2022
With over 95% of bisphenol-A (BPA) used in the production polycarbonate (PC) and epoxy resins, termed here as BPA-based plastic materials, components, products (MCPs), an investigation human exposure to BPA whole lifecycle MCPs is necessary. This mini-review unpacks implications arising from long-term its potential accumulation across plastics (production, use, management). timely necessary promoting a sustainable circular economy model. Restrictions form bans safety standards are often specific products, while limits rely on traditional toxicological biomonitoring methods that may underestimate health therefore "safety" exposure. Controversies regards the: (a) dose-response curves; (b) complexity sources, release mechanisms, pathways exposure; and/or (c) quality reliability studies, appear currently stifle progress toward regulation MCPs. Due abundance our production, consumption, management systems, there partial inadequate evidence contribution BPA. Yet, end-of-life constitute most critical source require further investigation. Active collaboration among risk assessors, government, policy-makers, researchers needed explore impacts long term introduce restrictions Integr Environ Assess Manag 2023;19:45-62. © 2022 SETAC.
Language: Английский
Citations
88
Environmental Research, Journal Year: 2022, Volume and Issue: 213, P. 113734 - 113734
Published: June 22, 2022
Meat and meat products are often consumed in our daily diet, providing essential nutrients. Contamination by chemical hazards, including bisphenol A (BPA) products, is a concern continuously monitored. BPA well-known for its endocrine-disrupting properties, which may cause potential toxicological effects on reproductive, nervous, immune systems. Dietary consumption the main route of exposure, major contributor. exposure from focus this review. This review found that has been widely detected canned non-canned products. assumed to be predominantly migration can coatings. Relatively low levels observed source contamination these yet definitively identified. recent European Food Safety Authority (EFSA) draft opinion proposed lower tolerable intake 4 μg kg body weight (bw)-1 day-1 0.04 ng day-1, therefore health risks need addressed. investigated at farm, industrial processes, retail levels. Data gaps literature also identified improve future food safety industry. Also, unified risk assessment strategy proposed. Further understanding needed as part reduce risk, more data dose-response relationship will help comprehend adverse humans. research inform public, producers processing industry, policymakers reduction measures, thus, ensuring safety.
Language: Английский
Citations
83
Journal of Cleaner Production, Journal Year: 2023, Volume and Issue: 388, P. 135819 - 135819
Published: Jan. 10, 2023
Language: Английский
Citations
76
Heliyon, Journal Year: 2023, Volume and Issue: 9(7), P. e18140 - e18140
Published: July 1, 2023
Endocrine-disrupting chemicals (EDCs) are a growing public health concern worldwide. Consumption of foodstuffs is currently thought to be one the principal exposure routes EDCs. However, alternative ways human through inhalation and dermal contact. These compounds in food products such as canned food, bottled water, dairy products, fish, meat, egg, vegetables ubiquitous general population. Therefore, understanding EDCs' properties, origin, exposure, toxicological impact, legal aspects vital control their release environment food. The present paper provides an overview EDCs possible disrupting impact on endocrine system other organs.
Language: Английский
Citations
47
Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 448, P. 130908 - 130908
Published: Feb. 2, 2023
Language: Английский
Citations
45