Identification of Primary Organophosphate Esters Contributing to Enhanced Risk of Gestational Diabetes Mellitus Based on a Case-Control Study DOI
Yun Deng,

Shujun Yi,

Wenya Liu

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 24, 2024

Epidemiological studies on associations of organophosphate ester (OPE) exposure and gestational diabetes mellitus (GDM) risk, which remain rare inconclusive, were carried out with a case-control population comprising 287 GDM 313 non-GDM pregnant women recruited from Tianjin. The group suffered distinctly higher serum concentrations tri-

Language: Английский

Recent advances of mass spectrometry-based analytical methods for endocrine disrupting chemicals in human matrices DOI

Mengjie Yue,

Xiaolu Zhou,

Jiatong Fan

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 171, P. 117523 - 117523

Published: Jan. 5, 2024

Language: Английский

Citations

13
Association of co-exposure to organophosphate esters and per- and polyfluoroalkyl substances and mixture with cardiovascular-kidney-liver-metabolic biomarkers among Chinese adults DOI Creative Commons
Yanbing Li,

Yi Lv,

Zexuan Jiang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 280, P. 116524 - 116524

Published: June 5, 2024

Organophosphate esters (OPEs) and Per- polyfluoroalkyl substances (PFAS) are ubiquitous environmental contaminants with common exposure sources, leading to their widespread presence in human body. However, evidence on co-exposure OPEs PFAS its impact cardiovascular-kidney-liver-metabolic biomarkers remains limited.

Language: Английский

Citations

7
Environmental endocrine disruptor-induced mitochondrial dysfunction: a potential mechanism underlying diabetes and its complications DOI Creative Commons
Kunhui He, Rumeng Chen,

Shuling Xu

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 15, 2024

Diabetes and its complications significantly affect individuals’ quality of life. The etiology diabetes mellitus associated is complex not yet fully understood. There an increasing emphasis on investigating the effects endocrine disruptors diabetes, as these substances can impact cellular processes, energy production, utilization, ultimately leading to disturbances in homeostasis. Mitochondria play a crucial role generation, any impairment organelles increase susceptibility diabetes. This review examines most recent epidemiological pathogenic evidence concerning link between including complications. analysis suggests that disruptor-induced mitochondrial dysfunction—characterized by disruptions electron transport chain, dysregulation calcium ions (Ca 2+ ), overproduction reactive oxygen species (ROS), initiation signaling pathways related apoptosis—may be key mechanisms connecting development

Language: Английский

Citations

5
Exposome-Wide Ranking to Uncover Environmental Chemicals Associated with Dyslipidemia: A Panel Study in Healthy Older Chinese Adults from the BAPE Study DOI Creative Commons
Enmin Ding,

Fuchang Deng,

Jianlong Fang

et al.

Environmental Health Perspectives, Journal Year: 2024, Volume and Issue: 132(9)

Published: Sept. 1, 2024

Environmental contaminants (ECs) are increasingly recognized as crucial drivers of dyslipidemia and cardiovascular disease (CVD), but the comprehensive impact spectrum interlinking mechanisms remain uncertain.

Language: Английский

Citations

5
Mediating Role of Glucose-Lipid Metabolism in the Association between the Increased Risk of Coronary Heart Disease and Exposure to Organophosphate Esters, Phthalates, and Polycyclic Aromatic Hydrocarbons DOI Creative Commons
Duo Zhang, Xiang Liu, Jiazichao Tu

et al.

Environment & Health, Journal Year: 2024, Volume and Issue: 2(3), P. 170 - 179

Published: Feb. 5, 2024

There is a lack of human evidence concerning the cardiovascular effects combined exposure to endocrine disruptors. This case-control study sought investigate coronary heart disease (CHD) associations with organophosphate flame retardants (OFRs), phthalates (PAEs), and polycyclic aromatic hydrocarbons (PAHs) among 148 adults coronary-angiography-diagnosed CHD 320 healthy from southern China. The mediating role glucose-lipid metabolism was also explored. Bayesian kernel machine regression suggested that when status fixed 75th percentile median value as reference, OFRs, PAEs, PAHs associated an 84% (95% CI: 36%–134%), 132% (12%–252%), 214% (89%–331%) increased risk developing CHD, respectively. Weighted quantile sum indicated urinary bis(2-butoxyethyl) phosphate (BBOEP), dibutyl (DBP), monoisononyl phthalate (miNP), metabolites phenanthrene may be major contributors overall effect mixtures. In further analyses on identified chemical factors, mediation increase via elevating total cholesterol blood glucose, while DiNP mainly associates serum lipids. Besides, we observed slight oxidative DNA damage between BBOEP CHD. These results provide potential direction for experimental studies. Longitudinal needed clarify causation results.

Language: Английский

Citations

4
Organophosphate ester flame retardants and plasticizers affect the phenotype and function of HepG2 liver cells DOI Creative Commons
Dongwei Yu, Barbara F. Hales, Bernard Robaire

et al.

Toxicological Sciences, Journal Year: 2024, Volume and Issue: 199(2), P. 261 - 275

Published: March 22, 2024

Abstract Exposure to the organophosphate esters (OPEs), used as flame retardants and plasticizers, is associated with a variety of adverse health effects including an increase in incidence fatty liver diseases. The goal this study was investigate six OPEs, all detected Canadian house dust, on phenotype function HepG2 cells. We high-content imaging these OPEs cell survival, mitochondria, oxidative stress, lipid droplets, lysosomes. Effects autophagy/lipophagy pathway were evaluated using confocal microscopy. triaryl (isopropylated triphenylphosphate [IPPP], tris(methylphenyl) phosphate [TMPP], triphenyl [TPHP]) more cytotoxic than non-triaryl (tris(2-butoxyethyl) [TBOEP], tris(1-chloro-2-propyl) [TCIPP], tris(1,3-dichloro-2-propyl) [TDCIPP]). most increased total reduced reactive oxygen species, droplet areas lysosomal intensity. Potency ranking done lowest benchmark concentration/administered equivalent dose method toxicological prioritization index analyses integrate phenotypic endpoints. IPPP, TBOEP, TPHP ranked potent whereas TMPP, TCIPP, TDCIPP relatively less bioactive. Confocal microscopic analysis demonstrated that IPPP colocalization droplets (PLIN2), lysosomes (LAMP1), autophagosomes (p62), disrupting autophagy. In contrast, TBOEP rescued cells from bafilomycin A1-induced inhibition autophagy and/or autophagic flux. Together, data demonstrate have Further, OPE-induced dysregulation may contribute association between OPE exposure homeostasis.

Language: Английский

Citations

4
Organophosphate esters in milk across thirteen countries from 2020 to 2023: Concentrations, sources, temporal trends and ToxPi priority to humans DOI

Yuxin Liu,

Hongting Li,

Yuhan Yin

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 473, P. 134632 - 134632

Published: May 21, 2024

Language: Английский

Citations

4
Associations of prenatal organophosphate esters exposure with risk of eczema in early childhood, mediating role of gut microbiota DOI
Yuhan Zhou, Liyi Zhang, Ling Lin

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 487, P. 137250 - 137250

Published: Jan. 17, 2025

Language: Английский

Citations

0
A Putative Adverse Outcome Pathway Linking Diesel Engine Exhaust with Increased Risks of Metabolism-Related Diseases: A Metabolomics-Based Molecular Epidemiology Study DOI Creative Commons
Yuanyuan Chen, Yanting Li, Wen Gu

et al.

Environmental Technology & Innovation, Journal Year: 2025, Volume and Issue: 38, P. 104116 - 104116

Published: Feb. 27, 2025

Language: Английский

Citations

0
Association between exposure to organophosphate esters and cognitive function in older adults in the United States: NHANES 2011–2014 DOI Creative Commons
Bin Jiang,

Ruipeng Lin,

Tongyan Wang

et al.

BMC Geriatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 19, 2025

Organophosphate esters (OPEs) are widely used as an alternative to the brominated flame retardant polybrominated diphenyl ethers. The effects of OPEs on cognitive abilities older adults remain unclear. A cross-sectional study was conducted using data from National Health and Nutrition Examination Survey 2011–2014. Cognitive function assessed Consortium Establish a Registry for Alzheimer's Disease (CERAD) word learning test, CERAD recall Animal Fluency Test (AFT), Digit Symbol Substitution (DSST). OPE metabolites with detection rates above 50% were included in study. Weighted multiple linear regression, weighted quantile sum (WQS) Bayesian kernel machine regression (BKMR) models examine individual mixed exposures function. total 762 included. model revealed positive association between Ln DPHP, BDCPP, BCPP DSST score, while negative observed DBUP score. In WQS model, index correlated score (β = 2.65, 95% CI: 0.40 ~ 4.90, P 0.02), DPHP having highest weight. results BKMR analysis indicated borderline statistical significance increase when mixture is set specific 90th percentile compared all concentrations median. Overall exposure associated improved United States. Further prospective studies large sample sizes needed confirm these results.

Language: Английский

Citations

0