Macromolecular Symposia,
Journal Year:
2024,
Volume and Issue:
413(5)
Published: Oct. 1, 2024
Abstract
Farmers
heavily
treat
crops
with
fertilizers
and
pesticides
in
an
effort
to
maximize
production.
It
causes
a
great
deal
of
ecological
destruction
addition
poor
soil
health.
Crop
poisoning
can
occasionally
arise
from
the
overuse
insecticides.
Some
well‐known
pesticides,
such
as
chlorpyrifos,
carbofuran,
endrin,
are
members
organophosphate,
organochlorine,
carbamates
families
remain
for
extended
periods
time.
Remaining
organochlorine
(OCPs)
thought
be
endocrine
disruptors
carcinogenic.
A
person's
risk
developing
endometriosis,
hypopadias,
cryptorchidism,
malignancies
breast,
lung,
cervix,
prostate
may
increase
if
there
is
accumulation
OCP
their
body.
Reports
have
also
linked
effects
exposure
human
growth,
cerebral
development,
psychomotor
development.
Since
they
no
longer
allowed
manufactured
or
used,
insecticides
raised
concern
because
still
found
large
quantities,
even
remote
locations.
Living
things
become
harmful
over
period
time
when
exposed
chemical
residues.
Pesticide
detrimental
on
food
chain
ecosystem.
entirely
changes
pH
lowers
its
fertility.
Food
products
hazardous
humans
consumed
soon
after
pesticide
application.
This
review
study
raises
important
concerns
about
treated
excessive
that
endanger
Foods,
Journal Year:
2025,
Volume and Issue:
14(6), P. 916 - 916
Published: March 7, 2025
Mytilus
chilensis
is
considered
an
important
food
source
for
the
Chilean
population
and
represents
a
considerable
fraction
of
its
aquacultural
production,
mainly
in
southern
Chile’s
coastal
regions.
This
study
aimed
to
assess
concentrations
total
arsenic
(tAs),
lead
(Pb),
cadmium
(Cd),
their
bioaccessibility,
associated
health
risks
M.
from
Valdivia
River
Estuary
(VRE)
Los
Ríos
Region
Reloncaví
Fjord
(RF)
Lagos
Region.
The
metal
were
quantified
using
Inductively
Coupled
Plasma–Optical
Emission
Spectrometry
(ICP-OES).
tAs,
Cd,
Pb
6682
±
2018,
1592
742,
1208
639
ng/g
d.w.,
respectively.
Variations
observed
across
areas,
months,
sampling
points
but
remained
below
national
international
limits.
No
correlation
was
found
between
environmental
parameters.
bioaccessibility
percentages
tAs
(68
10%),
Cd
(45
21%),
(15
4%).
levels
Chile
do
not
represent
risk
human
health.
Asian Journal of Research in Biochemistry,
Journal Year:
2024,
Volume and Issue:
14(4), P. 111 - 125
Published: June 22, 2024
Cancer
is
a
multifaceted
disease
influenced
by
genetic
mutations
and
environmental
factors,
including
exposure
to
carcinogens.
This
review
presents
an
in-depth
analysis
of
the
mechanisms
driving
cancer
initiation,
focusing
on
roles
carcinogenic
chemicals,
anticancer
therapies,
chemo-preventive
agents.
The
discussion
encompasses
broad
spectrum
carcinogens:
chemical
agents
like
polycyclic
aromatic
hydrocarbons,
physical
such
as
ionizing
radiation,
biological
viruses,
certain
therapeutic
drugs.
multistep
nature
carcinogenesis—comprising
promotion,
progression
phases—is
detailed,
with
emphasis
epigenetic
alterations.
Methods
for
testing
carcinogenicity,
in
vitro
vivo
studies
epidemiological
approaches,
are
highlighted
their
significance
identifying
potential
carcinogens
understanding
mechanisms.
To
classify
regulate
exposures,
also
looks
at
risk
management
plans
regulatory
frameworks
used
agencies
European
Chemicals
Agency
(ECHA),
Environmental
Protection
(EPA),
International
Research
(IARC).
Additionally,
emerging
trends
treatment,
precision
oncology,
immunotherapy,
early
detection
technologies,
explored,
alongside
ongoing
challenges
health
disparities
ethical
issues.
emphasizes
necessity
multidisciplinary
approach,
involving
collaboration
among
researchers,
clinicians,
bodies,
public
organizations,
translate
scientific
findings
into
effective
prevention,
detection,
treatment
strategies.
European Food Science and Engineering,
Journal Year:
2025,
Volume and Issue:
6(1), P. 7 - 17
Published: May 5, 2025
Food
additives
are
substances
intentionally
added
to
food
achieve
specific
technical
or
physical
effects,
such
as
reducing
spoilage,
enhancing
colour,
improving
flavour.
This
review
focused
on
with
carcinogenic
potential
in
humans
animals,
identified
by
the
and
Drug
Administration
(FDA)
International
Agency
for
Research
Cancer
(IARC).
benefit
manufacturers,
processors,
consumers,
including
acids
that
inhibit
microbial
growth
prevent
foodborne
diseases.
Some
commonly
consumed
foods
beverages
contain
compounds
animal
models.
Furthermore,
human
exposure
several
of
these
has
been
associated
increased
cancer
risk.
examined
role
dietary
consumption,
their
classification
direct
indirect
additives,
ecological
impacts.
It
highlights
importance
rigorous
safety
assessment
regulation
protect
public
health,
considering
both
benefits
risks
use
industry.
Abstract
Objective
This
systematic
review
aims
to
synthesize
current
knowledge
on
Propylene
Oxide
(PO)
in
human
exhaled
breath,
examining
its
presence
across
various
biological
matrices
and
exploring
methodologies
for
analysis.
It
seeks
elucidate
the
sources
of
PO
body
understand
individual
variability
detoxification
processes.
Methods
A
comprehensive
literature
search
was
conducted
12
databases
specialized
repositories,
spanning
over
10,000
publications
without
language
restrictions
until
May
16,
2024.
Seventeen
AI
tools
were
employed
enhance
study
identification
analysis,
focusing
both
direct
mentions
indirect
evidence
behavior
detection
body.
Assessment
risk
bias
included
SYRCLE’s
tool
animal
studies,
Newcastle-Ottawa
Scale
cohort
case-control
ROBINS-I
non-randomized
studies.
The
selection
process
yielded
89
encompassing
a
range
research
types
species,
supplemented
by
reviews,
monographs,
editorials
provide
overview.
Results
revealed
limited
concentrations
with
only
one
reference
providing
concrete
data
(0.083
ppb
0.3
following
exposures
10-25
ppm
propylene).
ours,
published
separately,
indicated
significantly
higher
(hundreds
or
even
ppm)
individuals
environmental
sensitivities.
Numerous
references
offered
insights
into
PO’s
persistence
blood
urine.
highlights
enzymes
involved
metabolism,
evolution
analytical
methodologies,
challenges
potential
reviews.
Conclusions
scarcity
breath
underscores
significant
gap
existing
databases.
Directly
indirectly
relevant
indicate
compound
influenced
genetics,
health
status,
microbiome.
emphasizes
difficulties
synthesizing
effects
due
heterogeneous
inputs
complex
exposure
scenarios.
need
advanced
capabilities
reviews
capture
nuanced,
more
effectively
calls
targeted
technological
innovation
sciences.
Enhancing
navigate
scientific
greater
efficacy
can
leverage
PRISMA
guidelines
diverse
minimize
reliability.
approach
will
aid
addressing
interplay
factors
metabolism
toxicity,
ultimately
improving
assessments
intervention
strategies.
Barcelona Respiratory Network,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: March 25, 2024
Outdoor
air
pollution
and
particulate
matter
(PM)
in
outdoor
is
a
major
cause
of
lung
cancer.The
purpose
this
article
to
review
the
current
knowledge
regarding
effects
on
cancer
development
progression.There
clear
substantial
evidence
link
between
ambient
cancer.There
an
interplay
environmental
exposure
host
factors,
especially
those
with
genetic
risk.PM
can
promote
progression
through
inflammatory
immune
mechanisms
pre-existing
oncogenic
mutations,
by
altering
microbiome
metabolic
perturbations.There
urgent
need
support
efforts
improve
quality
reducing
fossil
fuel
use.Health
professionals
policy
decision
makers
play
important
role
supporting
continued
advances
research
implementation
measures
reduce
adverse
health
pollution.
Biosensors,
Journal Year:
2024,
Volume and Issue:
14(9), P. 435 - 435
Published: Sept. 6, 2024
The
liver
has
many
important
functions,
including
the
biotransformation
of
drugs
and
detoxification
human
organism.
As
such,
it
is
also
exposed
to
harmful
substances,
which
leads
disorders
diseases
such
as
cirrhosis.
For
these
reasons,
seems
consider
metabolism
direct
effects
on
when
evaluating
efficacy
new
drugs.
Accordingly,
we
have
developed
an
advanced
in
vitro
model
using
organ-on-a-chip
approach
that
replicates
morphological
functional
features
vivo.
created
can
metabolize
drugs,
demonstrated
two
widely
used
anticancer
5-fluorouracil
(5FU)
capecitabine
(CAP).
In
addition,
best
our
knowledge,
are
first
who
evaluate
not
only
viability
model-building
cells
but
their
cytochrome
P450
activity
albumin
production.
Our
study
brings
hope
properly
drug
at
level.
